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• 業績を更新しました。（2023年5月）
• メンバーを更新しました。（2023年3月）
• 業績を更新しました。（2021年10月）
• メンバーを更新しました。（2020年9月）
• ​HPを開設しました。（2017年4月）

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研究内容

　今後高齢者が爆発的に増加することが推測され、同時に認知症の患者の急速な増加も予想されます。よって認知症を正確に診断し、治療を開始することが患者の増加を抑える上で必要となります。共同利用推進室では特にアルツハイマー病に着目し、生体試料を用いたアルツハイマー病の診断法の開発を試みます。

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メンバー

• 室長　　　　　　渡邉淳
• 研究員　　　　　山内夢叶
• 研究補助者　　　松崎三記子
• 客員研究員　　　脇田英明
• 客員研究員　　　杉本昌隆

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1. Nishikimi A, Nakagawa T, Fujiwara M, Watanabe K, Watanabe A, Komatsu A, Yasuoka M, Watanabe R, Naya M, Oshima H, Kitagawa Y, Tokuda H, Kondo I, Niida S, Sakurai T, Kojima M, Arai H. Humoral and cellular responses to the third COVID-19 BNT162b2 vaccine dose in research institute workers in Japan. J. Infect., Feb;86(2):e33-e35. doi: 10.1016/j.jinf.2022.10.026. Epub 2022 Oct 21, 2023
2. Yasuno F, Kimura Y, Ogata A, Ikenuma H, Abe J, Minami H, Nihashi T, Yokoi K, Hattori S, Shimoda N, Watanabe A, Kasuga K, Ikeuchi T, Takeda A, Sakurai T, Ito K, Kato T. Involvement of inflammation in the medial temporal region in the development of agitation in Alzheimer's disease: an in vivo positron emission tomography study. Psychogeriatrics. Jan;23(1):126-135. doi: 10.1111/psyg.12915. Epub 2022 Nov 20, 2022
3. Yasuno F, Watanabe A, Kimura Y, Yamauchi Y, Ogata A, Ikenuma H, Abe J, Minami H, Nihashi T, Yokoi K, Hattori S, Shimoda N, Kasuga K, Ikeuchi T, Takeda A, Sakurai T, Ito K, Kato T. Estimation of blood-based biomarkers of glial activation related to neuroinflammation. Brain Behav Immun Health., 2022 Nov 5;26:100549. doi: 10.1016/j.bbih.2022.100549. eCollection 2022 Dec.
4. Zhou C, Jung CG, Kim MJ, Watanabe A, Abdelhamid M, Taslima F, Michikawa M. Insulin Deficiency Increases Sirt2 Level in Streptozotocin-Treated Alzheimer's Disease-Like Mouse Model: Increased Sirt2 Induces Tau Phosphorylation Through ERK Activation. Molecular Neurobiology, Sep;59(9):5408-5425, 2022
5. Nishikimi A, Watanabe K, Watanabe A, Yasuoka M, Watanabe R, Fujiwara M, Oshima H, Nakagawa T, Kitagawa Y, Tokuda H, Washimi Y, Niida S, Kojima M. Immune responses to COVID-19 vaccine BNT162b2 in workers at a research institute in Japan: 6-month follow-up survey. J. Infect., Aug;85(2):174-211, 2022
6. Nishikimi A, Watanabe K, Watanabe A, Yasuoka M, Watanabe R, Oshima H, Kitagawa Y, Tokuda H, Niida S, Kojima M. Prevalence of SARS-CoV-2 antibodies after one-year follow up among workers in a research institute in Japan. J. Infect., Jan;84(1):e23-e25, 2022
7. Nishikimi A, Kojima M, Watanabe K, Watanabe A, Yasuoka M, Oshima H, Tokuda H, Niida S. Seroprevalence of antibodies against SARS-CoV-2 among workers in a national research institute and hospital in Central Japan. GHM. Open 1: 40-42, 2021
8. Takahashi Y, Wakita H, Mizutani K, Watanabe A, Sonoda S, Tomimoto H. Selective accumulation of adiponectin in the cerebral cortex under chronic cerebral hypoperfusion in the rat. NeuroReport., 31:148-155, 2020
9. Mikawa R, Okuno A, Yoshimi T, Watanabe A, Maruyama M, Takikawa O. Partial Identification of Amyloid-β Degrading Activity in Human Serum. Nagoya J. Med. Sci., 81:55-64, 2019
10. Iida M, Matsuno YK, Watanabe A, Maruyama M, Kameyama A, Yamakoshi K. A sialo-oligosaccharide-rich mucin-like molecule specifically detected in the submandibular glands of aged mice.  Arch. Oral. Biol., 97:52-58, 2019
11. Kameyama A, Yamakoshi K, Watanabe A. A rapid separation and characterization of mucins from mouse submandibular glands by supported molecular matrix electrophoresisanalysis. Biochim. Biophys. Acta. Proteins. Proteom., 1867(1) :76-81, 2019
12. Matsuoka K, Kohara Y, Naoe Y, Watanabe A, Ito M, Ikeda K, Takeshita S. WAIF1 is a cell‐surface CTHRC1 binding protein coupling bone resorption and formation. J. Bone. Miner. Res., 33:1500-1512, 2018
13. Funato H, Miyoshi C, Fujiyama T, Kanda T, Sato M, Wang Z, Ma J, Nakane S, Tomita J, Ikkyu A, Kakizaki M, Hotta-Hirashima N, Kanno S, Komiya H, Asano F, Honda T, Kim SJ, Harano K, Muramoto H, Yonezawa T, Mizuno S, Miyazaki S, Connor L, Kumar V, Miura I, Suzuki T, Watanabe A, Abe M, Sugiyama F, Takahashi S, Sakimura K, Hayashi Y, Liu Q, Kume K, Wakana S, Takahashi JS, Yanagisawa M. Forward-genetics analysis of sleep in randomly mutagenized mice. Nature, 539:378-383, 2016
14. Umeda M, Hiramoto M, Watanabe A, Tsunoda N, Imai T. Arginine-induced insulin secretion in endoplasmic reticulum. Biochem. Biophys. Res. Commun.,466, 717-722, 2015
15. Hiramoto M, Udagawa H, Watanabe A, Miyazawa K, Ishibashi N, Kawaguchi M, Uebanso T, Nishimura W, Nammo T, Yasuda K. Allele comparative analysis of type 2 diabetes-associated SNPs identifies allele-specific DNA-binding proteins for the KCNQ1 locus.  Int. J. MOL. MED., 36, 222-230, 2015
16. Zou K, Liu J, Watanabe A, Liu S, Hiraga S, Matsumoto Y, Miura Y, Tanabe C, Maeda T, Terayama Y, Takahashi S, Michikawa M,Komano H.  Aβ43 is the earliest depositing Aβspecies in APP transgenic mouse brain and is converted to Aβ41 by two active domains of ACE.  Am. J. Pathol., 182, 2322-2331, 2013
17. Yamamoto Y, Craggs LJL, Watanabe A, Booth T, Attems J, Low RWC, Oakley AE, Kalaria RN. Brain Microvascular Accumulation and Distribution of the NOTCH3 ectodomain and GOM in CADASIL J. Neuropathol. Exp. Neurol., 72, 416-431, 2013
18. Kawagishi H, Hashimoto M, Nakamura H, Tsugawa T, Watanabe A, Kontoyiannis D, Sugimoto M. HuR maintains replicative lifespan by repressing ARF tumor suppressor. Mol. Cell. Biol., 33, 1886-1900, 2013
19. Murakami M, Imabayashi K, Watanabe A, Takeuchi N, Ishizaka R, Iohara K, Yamamato T, Nakamura H, Nakashima M. Identification of novel function of vimentin for quality standard for regenerated pulp tissue. J Endod., 38, 920-926, 2012
20. Iohara K, Imabayashi K, Ishizaka R, Watanabe A, Nabekura J, Ito M, Matsushita K, Nakamura H, Nakashima M. Complete Pulp Regeneration After Pulpectomy by Transplantation of CD105(+) Stem Cells with Stromal Cell-Derived Factor-1. Tissue Eng Part A., 17, 1911-1920, 2011
21. Nakamura H, Kawagishi H, Watanabe A, Sugimoto K, Maruyama M, Sugimoto M.  Cooperative role of the RNA-binding proteins Hzf and HuR in p53 activation. Mol. Cell. Biol., 31, 1997-2009, 2011
22. Minagawa H, Watanabe A, Akatsu H, Adachi K, Ohtsuka C, Terayama Y, Hosono T, Takahashi S, Wakita H, Jung CG, Komano H, Michikawa M. Homocysteine, another risk factor for Alzheimer's disease, impairs apolipoprotein E3 function. J. Biol. Chem., 285, 38382-38388, 2010
23. Takahashi K, Adachi K, Kunimoto S, Wakita H, Takeda K, Watanabe A. Potent inhibitors of amyloid β fibrillization, 4,5-dianilinophthalimide and staurosporine aglycone, enhance degradation of preformed aggregates of mutant Notch3. Biochem. Biophys. Res. Commun., 402, 54-58, 2010
24. Hiramoto M, Maekawa N, Kuge T, Ayabe F, Watanabe A, Masaike Y, Hatakeyama M, Handa H, Imai T. High-performance affinity chromatography method for identification of L-arginine interacting factors using magnetic nanobeads. Biomed. Chromatogr., 24,606-612, 2010
25. Fukata Y, Lovero KL, Iwanaga T, Watanabe A, Yokoi N, Tabuchi K, Shigemoto R, Nicoll RA, Fukata M.Disruption of leucine-rich glioma inactivated 1–linked synaptic complex causes abnormal synaptic transmission and epilepsy. Proc. Natl. Acad. Sci. U S A.,107, 3799-3804, 2010
26. Takahashi K, Adachi K, Yoshizaki K, Kunimoto S, Kalaria RN, Watanabe A. Mutations in Notch3 cause the formation and retention of aggregates in the endoplasmic reticulum, leading to impaired cell proliferation. Hum. Mol. Genet.,19, 79-89, 2010
27. Zou K, Maeda T, Watanabe A, Liu J, Liu S, Oba R, Satoh Y, Komano H, Michikawa M. Aβ42-to-Aβ40- and angiotensin-converting activities in different domains of angiotensin –converting enzyme. J. Biol. Chem. 284, 31914-31920, 2009
28. NakamuraT, Watanabe A, Fujino T, Hosono T, Michikawa M. Apolipoprotein E4 (1-272) fragment is associated with mitochondrial proteins and affects mitochondrial function in neuronal cells. Mol. Neurodegener. 4,35, 2009
29. Minagawa H, Gong JS, Jung CG, Watanabe A, Lund-Katz S, Phillips MC, Saito H, Michikawa M. Mechanism underlying apolipoprotein E (ApoE) isoform-dependent lipid efflux from neural cells in culture. J. Neurosci. Res. 87, 2498-2508, 2009
30. Yoshizaki K, Adachi K, Kataoka S, Watanabe A, Tabira T, Takahashi K, Wakita H.   Chronic cerebral hypoperfusion induced by unilateral common carotid artery occlusion causes delayed white matter lesions and cognitive impairment in adult mice. Exp. Neurol. 210, 585-591, 2008

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共用機器

第一研究棟３階 共同利用実験室

第二研究棟３階 共同利用室

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掲示板

工事中です。

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