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代謝・内分泌研究部

2023年

  1. Ida H, Onuma T, Nakashima D, Mizutani D, Hori T, Ueda K, Hioki T, Kim W, Enomoto Y, Doi T, Matsushima-Nishiwaki R, Yamaguchi S, Tachi J, Tanabe K, Ogura S, Iwama T, Kozawa O, Tokuda H. Tramadol regulates the activation of human platelets via Rac but not Rho/Rho-kinase. PLoS One. 2023;18:e0279011.
  2. Sugimoto T, Tokuda H, Miura H, Kawashima S, Ando T, Kuroda Y, Matsumoto N, Fujita K, Uchida K, Kishino Y, Sakurai T. Cross-sectional association of metrics derived from continuous glucose monitoring with cognitive performance in older adults with type 2 diabetes. Diabetes Obes. Metab. 2023;25:222-228.
  3. Nishikimi A, Nakagawa T, Fujiwara M, Watanabe K, Watanabe A, Komatsu A, Yasuoka M, Watanabe R, Naya M, Oshima H, Kitagawa Y, Tokuda H, Kondo I, Niida S, Sakurai T, Kojima M, Arai H. Humoral and cellular responses to the third COVID-19 BNT162b2 vaccine dose in research institute workers in Japan. J. Infect. 2023;86:e33-e35.
  4. Kuroyanagi G, Hioki T, Tachi J, Matsushima-Nishiwaki R, Iida H, Kozawa O, Tokuda H. Oncostatin M stimulates prostaglandin D2-induced osteoprotegerin and interleukin-6 synthesis in osteoblasts. Prostaglandins Leukot. Essent. Fatty Acids. 2023;192:102575.
  5. Hioki T, Kuroyanagi G, Matsushima-Nishiwaki R, Kozawa O, Tokuda H. Oncostatin M attenuates tumor necrosis factor-alfa-induced synthesis of macrophage-colony stimulating factor via suppression of Akt in osteoblasts. Connect. Tissue Res. 2023;64:139-147.
  6. Li J, Nakagawa T, Kojima M, Nishikimi A, Tokuda H, Nishimura K, Umezawa J, Tanaka S, Inoue M, Ohmagari N, Yamaguchi K, Takeda K, Yamamoto S, Konishi M, Miyo K, Mizoue T. Underlying medical conditions and anti-SARS-CoV-2 spike IgG antibody titers after two doses of BNT162b2 vaccination: A cross-sectional study. PLoS One. 2023;18:e0283658.
  7. Enomoto Y, Onuma T, Hori T, Tanabe K, Ueda K, Mizutani D, Doi T, Matsushima-Nishiwaki R, Ogura S, Iida H, Iwama T, Kozawa O, Tokuda H. Synergy by ristocetin and CXCL12 in human platelet activation: Divergent regulation by Rho/Rho kinase and Rac. Int. J. Mol. Sci. 2023;24:9716.
  8. Kuroyanagi G, Hioki T, Tachi J, Matsushima-Nishiwaki R, Iida H, Tokuda H, Kozawa O. Resveratrol inhibits basic fibroblast growth factor-induced macrophage colony-stimulating factor synthesis via the PI3-kinase/Akt pathway in osteoblasts. Biosci. Biotechnol. Biochem. 2023;87:1462-1469. 
  9. Sugimoto T, Tokuda H, Miura H, Kawashima S, Omura T, Ando T, Kuroda Y, Matsumoto N, Fujita K, Uchida K, Kishino Y, Sakurai T. Longitudinal association of continuous glucose monitoring-derived metrics with cognitive decline in older adults with type 2 diabetes: A 1-year prospective observational study. Diabetes Obes. Metab. 2023;25:3831-3836.
  10. Kuroyanagi G, Hioki T, Matsushima-Nishiwaki R, Kozawa O, Tokuda H. HSP70 inhibitor amplifies the bFGF‑induced release of IL‑6 in osteoblasts. Mol. Med. Rep. 2023;28:230. 
  11. Hioki T, Tachi J, Ueda K, Matsushima-Nishiwaki R, Iida H, Kozawa O, Tokuda H. Oncostatin M enhances osteoprotegerin synthesis but reduces macrophage colony‑stimulating factor synthesis in bFGF‑stimulated osteoblast‑like cells. Exp. Ther. Med. 2023;27:34.
  12. Kawai Y, Watanabe Y, Omae Y, Miyahara R, Khor SS, Noiri E, Kitajima K, Shimanuki H, Gatanaga H, Hata K, Hattori K, Iida A, Ishibashi-Ueda H, Kaname T, Kanto T, Matsumura R, Miyo K, Noguchi M, Ozaki K, Sugiyama M, Takahashi A, Tokuda H, Tomita T, Umezawa A, Watanabe H, Yoshida S, Goto Y, Maruoka Y, Matsubara Y, Niida S, Mizokami M, Tokunaga K. Exploring the genetic diversity of the Japanese population: Insights from a large-scale whole genome sequencing analysis. PLoS Genet. 2023;19:e1010625.
  13. Omura T, Katsumi A, Kawashima S, Naya M, Tokuda H. Prolonged COVID-19 infection in a patient with complete remission from follicular lymphoma with hyperosmolar hyperglycemic syndrome. Geriatrics. 2023;8:110.

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2022年

欧文原著​

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  1. Hioki T, Kuroyanagi G, Fujita K, Sakai G, Kawabata T, Kim W, Tachi J, Matsushima-Nishiwaki R, Iida H, Kozawa O, Tokuda H. Incretins enhance PGF2alfa-induced synthesis of IL-6 and osteoprotegerin in osteoblasts. Horm. Metab. Res. 2022;54:42-49.
  2. Nishikimi A, Watanabe K, Watanabe A, Yasuoka M, Watanabe R, Oshima H, Kitagawa Y, Tokuda H, Niida S, Kojima M. Prevalence of SARS-CoV-2 antibodies after one-year follow up among workers in a research institute in Japan. J. Infect. 2022;84:e23-e25.
  3. Mizutani D, Tokuda H, Onuma T, Uematsu K, Nakashima D, Ueda K, Doi T, Enomoto Y,Matsushima-Nishiwaki R, Ogura S, Iida H, Kozawa O, Iwama T. Amyloid-beta protein negatively regulates human platelet activation induced by thrombin receptor-activating protein. Biosci. Biotechnol. Biochem. 2022;86:185-198.
  4. Doi T, Hioki T, Tachi J, Ueda K, Matsushima-Nishiwaki R, Iida H, Ogura S, Kozawa O, Tokuda H. Oncostatin M reduces the synthesis of macrophage-colony stimulating factor stimulated by TGF-beta via suppression of p44/p42 MAP kinase and JNK in osteoblasts. Biomed. Res. 2022;43:41-51.
  5. Kuroyanagi G, Tokuda H, Fujita K, Kawabata T, Sakai G, Kim W, Hioki T, Tachi J, Matsushima-Nishiwaki R, Otsuka T, Iida H, Kozawa O. Upregulation of TGF-beta-induced HSP27 by HSP90 inhibitors in osteoblasts. BMC Musculoskelet Disord. 2022;23:495.
  6. Doi T, Hori T, Onuma T, Mizutani D, Ueda K, Enomoto Y, Matsushima-Nishiwaki R, Tanabe K, Hioki T, Tokuda H, Iwama T, Iida H, Kozawa O, Ogura S. Thrombopoietin and collagen in low doses cooperatively induce human platelet activation. Acute. Med. Surg. 2022;9:e769.
  7. Kuroyanagi G, Kawabata T, Tokuda H, Fujita K, Matsushima-Nishiwaki R,  Sakai G, Tachi J, Hioki T, Kim W, Iida H, Otsuka T, Kozawa O. Attenuation by HSP90 inhibitors of EGF-elicited migration of osteoblasts: Involvement of p44/p42 MAP kinase. Connect. Tissue Res. 2022;63:359-369.
  8. Nishikimi A, Watanabe K, Watanabe A, Yasuoka M, Watanabe R, Fujiwara M, Oshima H, Nakagawa T, Kitagawa Y, Tokuda H, Washimi Y, Niida S, Kojima M. Immune responses to COVID-19 vaccine BNT162b2 in workers at a research institute in Japan: 6-month follow-up survey. J. Infect. 2022;85:174-211.
  9. Yamamoto S, Tanaka A, Ohmagari N, Yamaguchi K, Ishitsuka K, Morisaki N, Kojima M, Nishikimi A, Tokuda H, Inoue M, Tanaka S, Umezawa J, Okubo R, Nishimura K, Konishi M, Miyo K, Mizoue T. Use of heated tobacco products, moderate alcohol drinking, and anti-SARS-CoV-2 IgG antibody titers after BNT162b2 vaccination among Japanese healthcare workers. Prev. Med. 2022 ;161:107123.             
  10. Nishikimi A, Nakagawa T, Fujiwara M, Watanabe K, Watanabe A, Komatsu A, Yasuoka M, Watanabe R, Naya M, Oshima H, Kitagawa Y, Tokuda H, Kondo I, Niida S, Sakurai T, Kojima M, Arai H. Humoral and cellular responses to the third COVID-19 BNT162b2 vaccine dose in research institute workers in Japan. J. Infect. 2022;S0163-4453(22)00621-1.
  11. Hioki T, Matsushima-Nishiwaki R, Tokuda H, Kozawa O. Selective estrogen receptor modulators, acting as agonists of estrogen receptor α in osteoblasts, reduce the TGF-beta-induced synthesis of macrophage colony-stimulating factor via inhibition of JNK signaling pathway. Biomed. Res. 2022;43:211-221.
  12. Hori T, Mizutani D, Onuma T, Okada Y, Kojima K, Doi T, Enomoto Y, Iida H, Ogura S, Sakurai T, Iwama T, Kozawa O, Tokuda H. Relationship between the responsiveness of amyloid beta protein to platelet activation by TRAP stimulation and brain atrophy in patients with diabetes mellitus. Int. J. Mol. Sci. 2022;23:14100.
  13. Kuroyanagi G, Tachi J, Fujita K, Kawabata T, Sakai G, Nakashima D, Kim W, Tanabe K, Matsushima-Nishiwaki R, Otsuka T, Iida H, Kozawa O, Tokuda H. HSP70 inhibitors upregulate prostaglandin E1-induced synthesis of interleukin-6 in osteoblasts. PLoS One. 2022;17:e0279134.

 

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2021年

欧文原著

  1. Hioki T, Tokuda H, Nakashima D, Fujita K, Kawabata T, Sakai G, Kim W, Tachi J, Tanabe K, Matsushima-Nishiwaki R, Otsuka T, Iida H, Kozawa O. HSP90 inhibitors strengthen extracellular ATP-stimulated synthesis of interleukin-6 in osteoblasts: Amplification of p38 MAP kinase. Cell Biochem. Funct. 2021;39:88-97.
  2. Kuroyanagi G, Sakai G, Otsuka T, Yamamoto N, Fujita K, Kawabata T, Matsushima-Nishiwaki R, Kozawa O, Tokuda H. HSP22 (HSPB8) positively regulates PGF2alfa-induced synthesis of interleukin-6 and vascular endothelial growth factor in osteoblasts. J. Orthop. Surg. Res. 2021;16:72.
  3. Kim W, Tokuda H, Tanabe K, Yamaguchi S, Hioki T, Tachi J, Matsushima-Nishiwaki R, Kozawa O, Iida H. Acetaminophen reduces osteoprotegerin synthesis stimulated by PGE2 and PGF2alfa in osteoblasts: Attenuation of SAPK/JNK but not p38 MAPK or p44/p42 MAPK. Biomed. Res. 2021;42:77-84.
  4. Sable-Morita S, Tanikawa T, Satake S, Okura M, Tokuda H, Arai H. Microvascular complications and frailty can predict adverse outcomes in older patients with diabetes. Geriatr. Gerontol. Int. 2021;21:359-363.
  5. Tachi J, Onuma T, Yamaguchi S, Kim W, Hioki T, Matsushima-Nishiwaki R, Tanabe K, Tokuda H, Kozawa O, Iida H. Duloxetine suppresses BMP-4-induced release of osteoprotegerin via inhibition of the SMAD signaling pathway in osteoblasts. Biochem. Cell. Biol. 2021;99:578-586.
  6. Sable-Morita S, Okura M, Tanikawa T, Kawashima S, Tokuda H, Arai H. Associations between diabetes-related foot disease, diabetes, and age-related complications in older patients. Eur. Geriatr. Med. 2021;12:1003-1009.
  7. Sugimoto T, Arai A, Fujita H, Honda K, Inagaki N, Ishida T, Kato J, Kishi M, Kobayashi K, Kouyama K,　Noma H, Ohishi M, Satoh-Asahara N, Shimada H, Sugimoto K, Suzuki S, Takeya Y, Tamura Y, Tokuda H, Umegaki H, Watada H, Yamada Y, Sakurai T. The multi-domain intervention trial in older adults with diabetes mellitus for prevention of dementia in Japan: Study protocol for a multi-center, randomized, 18-month controlled rial. Front. Aging Neurosci. 2021;13:680341.
  8. Hioki T, Tokuda H, Kuroyanagi G, Kim W, Tachi J, Matsushima-Nishiwaki R,  Iida H, Kozawa O. Olive polyphenols attenuate TNF-alfa-stimulated M-CSF and IL-6 synthesis in osteoblasts: Suppression of Akt and p44/p42 MAP kinase signaling pathways. Biomed. Pharmacother. 2021;141:111816.
  9. Hioki T, Tokuda H, Tanabe K, Kim W, Tachi J, Yamaguchi S, Matsushima-Nishiwaki R, Kozawa O, Iida H. Amplification by tramadol of PGD2-induced osteoprotegerin synthesis in osteoblasts: Involvement of mu-opioid receptor and 5-HT transporter. Prostaglandins Leukot Essent. Fatty Acids. 2021;172:102323.
  10. Sable-Morita S, Arai Y, Takanashi S, Aimoto K, Okura M, Tanikawa T, Maeda K, Tokuda H, Arai H. Development and testing of the foot care scale for older Japanese diabetic patients. Int. J. Low. Extrem. Wounds. 2021;15347346211045033. Online ahead of print.
  11. Kaneda H, Ida Y, Kuwahara R, Sato I, Nakano T, Tokuda H, Sato T, Murakoshi T, Honke K, Kotani N. Proximity proteomics has potential for extracellular vesicle identification. J. Proteome. Res. 2021;20:3519-3531.
  12. Nishikimi A, Kojima M, Watanabe K, Watanabe A, Yasuoka M, Oshima H, T Okuda H, Niida S. Seroprevalence of antibodies against SARS-CoV-2 among workers in a national research institute and hospital in central Japan. GHM Open. 2021;1:40-42.

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