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研究成果

研究推進基盤センターの支援を受けた研究の成果を紹介します。

2023年

  1. Ogata, A., Ikenuma, H., Abe, J.Yamada T, Hattori S, Ichise M, Suzuki M, Kato T, Kimura Y. . Radiosynthesis of [11C]MNS for PET imaging of NLRP3 inflammasome with [11C]nitromethane in one-pot and its evaluation in rat brains. J Radioanal Nucl Chem. (2023) 332: 4591–4595.

  2. Ikenuma H, Ogata A, Koyama H, Ji B, Ishii H, Yamada T, Abe J, Seki C, Nagai Y, Ichise M, Minamimoto T, Higuchi M, Zhang MR, Kato T, Ito K, Suzuki M, Kimura Y. Synthesis and evaluation of a novel PET ligand, a GSK’963 analog, aiming at autoradiography and imaging of the receptor interacting protein kinase 1 in the brain. EJNMMI Radiopharm Chem. (2023) 8: 31.

  3. Yamamori-Morita T, Yu J, Kashima Y, Kamata R, Yamamoto G, Minamide T, Mashima C, Yoshiya M, Sakae Y, Yamauchi T, Hakozaki Y, Kageyama SI, Nakamura A, Lightcap E, Tanaka K, Niu H, Kannan K, Ohashi A. CDC7 inhibition induces replication stress-mediated aneuploid cells with an inflammatory phenotype. Nat Commun. (2023) 14: 7490.

  4. Ogata A, Yamada T, Hattori S, Ikenuma H, Abe J, Tada M, Ichise M, Suzuki M, Ito K, Kato T, Amaike K, Hirota T, Kakita A, Itami K, Kimura Y. Development of a novel PET ligand, [11C]GO289 targeting CK2 expressed in the brain. Bioorg Med Chem Lett. (2023) 90:129327.

  5. Yasuno F, Kimura Y, Ogata A, Ikenuma H, Abe J, Minami H, Nihashi T, Yokoi K, Hattori S, Shimoda N, Watanabe A, Kasuga K, Ikeuchi T, Takeda A, Sakurai T, Ito K, Kato T. Involvement of inflammation in the medial temporal region in the development of agitation in Alzheimer's disease: an in vivo positron emission tomography study. Psychogeriatrics (2023) 23:126-1353.

  6. Nishikimi A, Nakagawa T, Fujiwara M, Watanabe K, Watanabe A, Komatsu A, Yasuoka M, Watanabe R, Naya M, Oshima H, Kitagawa Y, Tokuda H, Kondo I, Niida S, Sakurai T, Kojima M, Arai H. Humoral and cellular responses to the third COVID-19 BNT162b2 vaccine dose in research institute workers in Japan. J Infect (2023) 86: e33-e35.

  7. Sugiyama Y, Harada T, Kamei Y, Yasuda T, Mashimo T, Nishikimi A, Maruyama M. A senolytic immunotoxin eliminates p16INK4a-positive T cells and ameliorates age-associated phenotypes of CD4+ T cells in a surface marker knock-in mouse. Exp Gerontol (2023) 174: 112130.

  8. Yasuno F, Kimura Y, Ogata A, Ikenuma H, Abe J, Minami H, Nihashi T, Yokoi K, Hattori S, Shimoda N, Watanabe A, Kasuga K, Ikeuchi T, Takeda A, Sakurai T, Ito K, Kato T. Involvement of inflammation in the medial temporal region in the development of agitation in Alzheimer's disease: an in vivo positron emission tomography study. Psychogeriatrics (2023) 23: 126-135. 

  9. Tsuji S, Brace C, Yao R, Tanie Y, Tada H, Rensing N, Mizuno S, Almunia J, Kong Y, Nakamura K, Furukawa T, Ogiso N, Toyokuni S, Takahashi S, Wong M, Imai S, Satoh A. Sleep-wake patterns are altered with age, Prdm13 signaling in the DMH, and diet restriction in mice. Life science alliance (2023) 6: e202301992.

  10. Kawaguchi K, Asai A, Mikawa R, Ogiso N, Sugimoto M. Age-related changes in lung function in National Center for Geriatrics and Gerontology Aging Farm C57Bl/6N mice. Exp Anim. (2023) 72: 173-182.

  11. Shirai, M., Shimoda, N., Takahashi, H., Takayama, K., Kikuchi, Y. Microarray Transcriptome datasets of maternal-zygotic DNA methyltransferase 3aa−/− zebrafish during early developmental stages. Data in Brief  (2023) 47: 108967.

  12. Sakamoto S, Nagasaki A, Shrestha M, Shintani T, Watanabe A, Furusho H, Chayama K, Takata T, Miyauchi M. Porphyromonas gingivalis-odontogenic infection is the potential risk for progression of nonalcoholic steatohepatitis-related neoplastic nodule formation. Sci Rep. (2023) 13: 9350.

  13. Panahi M, Hase Y, Gallart-Palau X, Mitra S, Watanabe A, Low RC, Yamamoto Y, Sepulveda-Falla D, Hainsworth AH, Ihara M, Sze SK, Viitanen M, Behbahani H, Kalaria RN. ER stress induced immunopathology involving complement in CADASIL: implications for therapeutics.Acta. Neuropathol. Commun. (2023) 11: 76.

2022年

  1. Nishikimi A, Watanabe K, Watanabe A, Yasuoka M, Watanabe R, Oshima H, Kitagawa Y, Tokuda H, Niida S, Kojima M. Prevalence of SARS-CoV-2 antibodies after one-year follow up among workers in a research institute in Japan. J Infect (2022) 84: e23-e25.

  2. Sugiyama Y, Fujiwara M, Sakamoto A, Tsushima H, Nishikimi A, Maruyama M. The immunosenescence-related factor DOCK11 is involved in secondary immune responses of B cells. Immun Aging (2022) 19: 2.

  3. Nishikimi A, Watanabe K, Watanabe A, Yasuoka M, Watanabe R, Fujiwara M, Oshima H, Nakagawa T, Kitagawa Y, Tokuda H, Washimi Y, Niida S, Kojima M. Immune responses to COVID-19 vaccine BNT162b2 in workers at a research institute in Japan: 6-month follow-up survey. J Infect (2022) 85: 174-176.

  4. Shirai M,  Takayama K, Takahashi H,  Hirose Y, Fujii M, Awazu A, Shimoda N, Kikuchi Y. Methylome data derived from maternal-zygotic DNA methyltransferase 3aa-/-. Data in Brief. (2022) 44: 108514.

  5. Shirai M, Nara T, Takahashi H, Takayama K, Chen Y, Hirose Y, Fujii M, Awazu A, Shimoda N, Kikuchi Y. Identification of aberrant transcription termination at specific gene loci with DNA hypomethylated transcription termination sites caused by DNA methyltransferase deficiency. Genes & Genetic Systems. (2022) 97:139-152.

  6. Yasuno F, Kimura Y, Ogata A, Ikenuma H, Abe J, Minami H, Nihashi T, Yokoi K, Hattori S, Shimoda N, Ichise M, Sakurai T, Ito K, Kato T. Kinetic modeling and non-invasive approach for translocator protein quantification with 11C-DPA-713. Nuclear Medicine and Biology (2022) 108-109, 76-84.

  7. Zhou C, Jung CG, Kim MJ, Watanabe A, Abdelhamid M, Taslima F, Michikawa M. Insulin deficiency increases Sirt2 Level in Streptozotocin-treated Alzheimer's disease-like mouse model: Increased Sirt2 induces Tau phosphorylation through ERK activation. Mol Neurobiol (2022) 59: 5408-54252.

  8. Yasuno F, Watanabe A, Kimura Y, Yamauchi Y, Ogata A, Ikenuma H, Abe J, Minami H, Nihashi T, Yokoi K, Hattori S, Shimoda N, Kasuga K, Ikeuchi T, Takeda A, Sakurai T, Ito K, Kato T. Estimation of blood-based biomarkers of glial activation related to neuroinflammation. Brain Behav Immun Health (2022) 26: 100549.

  9. Furukawa M, Tada H, Wang J, Yamada M, Kurosawa M, Satoh A, Ogiso N,  Shikama Y, Matsushita K. Molar loss induces hypothalamic and hippocampal astrogliosis in aged mice. Sci Rep. (2022) 12: 6409.

  10. Wang W, Tanokashira D, Shibayama Y, Tsuji R, Maruyama M, Kuroiwa C, Saito T, Saido TC, Taguchi A. Effects of high-fat diet on nutrient metabolism and cognitive functions in young APPKINL-G-F/NL-G-F mice.
    Neuropsychopharmacol Rep. (2022) 42: 272-2802.

  11. Ogata A, Ji B, Yamada T, Hattori S, Abe J, Ikenuma H, Ichise M, Koyama H, Suzuki M, Kato T, Ito K, Kimura Y. [11C]NCGG401, a novel PET ligand for imaging of colony stimulating factor 1 receptors. Bioorg Med Chem Lett. (2022) 65: 1287042.

  12. Shirai, M., Nara, T., Takahashi, H., Takayama, K., Chen, Y., Hirose, Y., Fujii, M., Awazu, A., Shimoda, N., Kikuchi, Y. Identification of aberrant transcription termination at specific gene loci with DNA hypomethylated transcription termination sites caused by DNA methyltransferase deficiency. Genes & Genetic Systems (2022) 97: 139-152.