ホーム > Research > Center > Geroscience Research Center > Division > Metabolic Research > About the department
We perform the research in Metabolism especially about the regulatory mechanism of bone remodeling to the pathogenesis of bone metabolic diseases including osteoporosis, which is closely related to The Frailty in aging. Based on the cell biological findings, we will scientifically support the effective and efficient prevention for The Frailty, one of the main targets of NCGG.
We investigate the action of bioactive substances including hormones, growth factors, cytokines etc. and the underlying mechanism such as intracellular signal transduction with biochemical, pharmacological and molecular biological analyses, using cultured cells and clinical samples. We have aggressively elucidated how the bioactive substances like prostaglandin (PG)E2, PGE1, PGF2alfa, PGD2, platelet-derived growth factor (PDGF), insulin-like growth factor-I (IGF-I), basic fibroblast growth factor (bFGF), interleukin (IL)-1, 1-25 (OH) vitamin D3, triiodothyronine and bone morphogenic protein (BMP-4) affect osteoblast functions such as IL-6 synthesis, vascular endothelial growth factor (VEGF) synthesis, osteoprotegerin synthesis, heat shock protein (HSP)27 induction, alkaline phosphatase (ALP) activity and migration, and published more than 200 articles in these three decades.
| Professor | Haruhiko Tokuda |
|---|---|
| Associate Professor | Takuya Omura |
| Visiting Researcher | Osamu Kozawa |
| Tomoaki Doi | |
| Gen Kuroyanagi | |
| Rie Matsushima-Nishiwaki | |
| Takamitsu Hori | |
| Tomoyuki Hioki | |
| Research Assistant | Chika Usui |
| Akemi Inami |
It is prohibited to reprint the content of this homepage without permission.
© National Center for Geriatrics and Gerontology. All Rights Reserved.
