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Publications

2024

CRISPR/Cas9-mediated knock-in cells of the late-onset Alzheimer’s disease-risk variant, SHARPIN G186R, reveal reduced NF-κB pathway and accelerated Aβ secretion (Division of Genomic Medicine, Division of Bioinformatics, Molecular Analysis Division, Center for Core Facility Administration)

2022

The list of original papers（PDF：280KB） that Center for Gerontology and Social Science published between July and September 2022
The list of original papers（PDF：316KB） that Center for Gerontology and Social Science published between April and June 2022
Network-based meta-analysis and the candidate gene association studies reveal novel ethnicity-specific variants in MFSD3 and MRPL43 associated with dementia with Lewy bodies (Division of Bioinformatics, Division of Genomic Medicine)
The list of original papers（PDF：285KB） that Center for Gerontology and Social Science published between January and March 2022
Whole-genome sequencing reveals novel ethnicity-specific rare variants associated with Alzheimer’s disease (Division of Bioinformatics, Division of Genomic Medicine)

2021

The list of original papers（PDF：271KB） that Center for Gerontology and Social Science published between October and December 2021
A functional variant of SHARPIN confers increased risk of late-onset Alzheimer’s disease (Division of Genomic Medicine, Division of Bioinformatics)
JAMIR-eQTL: Japanese genome-wide identification of microRNA expression quantitative trait loci across dementia types (Division of Bioinformatics, Division of Genomic Medicine)
The list of original papers（PDF：255KB） that Center for Gerontology and Social Science published between July and September 2021
Dementia subtype prediction models constructed by penalized regression methods for multiclass classification using serum microRNA expression data (Division of Bioinformatics, Division of Genomic Medicine)
Long-term intake of Lactobacillus paracaseiKW3110 prevents age-related circadian locomotor activity and changes in gut metabolism in physiologically aged mice (Department of Inflammation and Immunosenescence)
Cellular enescence promotes cancer metastasis by enhancing soluble E-cadherin production (Department of Inflammation and Immunosenescence)
The list of original papers（PDF：231KB） that Center for Gerontology and Social Science published between April and June 2021
Phenotypic analysis of a transgenic Drosophila model of Alzheimer’s amyloid-β toxicity (Department of Neurogenetics)
PET imaging of colony-stimulating factor 1 receptor: a head-to-head comparison of a novel radioligand, ¹¹C-GW2580, and ¹¹C-CPPC, in mouse models of acute and chronic neuroinflammation and a rhesus monkey (Department of Clinical and Experimental Neuroimaging)
Clinical practice guidelines for high-resolution breast PET, 2019 edition (Department of Clinical and Experimental Neuroimaging)
Quantitative Evaluation of ¹⁸F-Flutemetamol PET in Patients With Cognitive Impairment and Suspected Alzheimer's Disease: A Multicenter Study (Department of Clinical and Experimental Neuroimaging)
A First-in-human Study of¹¹C-MTP38, a Novel PET Ligand for Phosphodiesterase 7 (Department of Clinical and Experimental Neuroimaging)
Biodistribution and radiation dosimetry of the positron emission tomography probe for AMPA receptor, [¹¹C]K-2, in healthy human subjects (Department of Clinical and Experimental Neuroimaging)
Differential associations of dopamine synthesis capacity with the dopamine transporter and D2 receptor availability as assessed by PET in the living human brain (Department of Clinical and Experimental Neuroimaging)
Deletion of B-cell translocation gene 2 (BTG2) alters the responses of glial cells in white matter to chronic cerebral hypoperfusion (Department of Aging Neurobiology)
Upregulated expression of a subset of genes in APP;ob/ob mice: Evidence of an interaction between diabetes‐linked obesity and Alzheimer’s disease (Department of Aging Neurobiology)
Increasing neuronal glucose uptake attenuates brain aging and promotes life span under dietary restriction in Drosophila (Department of Neurogenetics)
Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer's Disease (Department of Neurogenetics)
Ethnic and trans-ethnic genome-wide association studies identify new loci influencing Japanese Alzheimer’s disease risk (Department of Genomic Medicine)

2020

Effects of p-Cresol on Senescence, Survival, Inflammation, and Odontoblast Differentiation in Canine Dental Pulp Stem Cells (Department of Stem Cell Biology and Regenerative Medicine)
Imaging of muscle activity-induced morphometric changes in fibril network of myofascia by two-photon microscopy (Department of Oral Disease Research)
Alteration of mucins in the submandibular gland during aging in mice (Department of Mechanism of Aging)
From population to neuron: exploring common mediators for metabolic problems and mental illnesses (Department of Integrated Neuroscience)
SOD2 deficiency in cardiomyocytes defines defective mitochondrial bioenergetics as a cause of lethal dilated cardiomyopathy (Aging Stress Response Research Project Team)
High-contrast in vivo imaging of tau pathologies in Alzheimer’s and non-Alzheimer’s disease tauopathies (Department of Clinical and Experimental Neuroimaging)
Dietary diversity is associated with longitudinal changes in hippocampal volume among Japanese community dwellers (Department of Epidemiology of Aging, Section of NILS-LSA, Department of Clinical and Experimental Neuroimaging)
Plasma Amyloid-β Biomarker Associated with Cognitive Decline in Preclinical Alzheimer's Disease (Department of Clinical and Experimental Neuroimaging, Department of Biomarker Research, Center for Development of Advanced Medicine for Dementia)
An evaluation of the amyloid cascade model using in vivo positron emission tomographic imaging (Department of Clinical and Experimental Neuroimaging)
Brain pharmacokinetics and biodistribution of ¹¹C-labeled isoproterenol in rodents (Department of Clinical and Experimental Neuroimaging)
APOE2 is associated with longevity independent of Alzheimer's disease (Department of Aging Neurobiology)
Interaction between APOE genotype and diabetes in cognitive decline (Department of Aging Neurobiology)
Increased levels of Aβ42 decrease the lifespan of ob/ob mice with dysregulation of microglia and astrocytes (Department of Aging Neurobiology)
APOE2: protective mechanism and therapeutic implications for Alzheimer’s disease (Department of Aging Neurobiology)
The Emerging role of the apolipoproteins APOE and APOJ in the interaction between diabetes and Alzheimer’s disease (Department of Aging Neurobiology)
Microtubule affinity-regulating kinase 4 with an Alzheimer's disease-related mutation promotes tau accumulation and exacerbates neurodegeneration (Department of Alzheimer's disease)
Disruption of a RAC1-centred network is associated with Alzheimer's disease pathology and causes age-dependent neurodegeneration (Department of Alzheimer's disease)
Increase of verbal communication by long-term use of transfer-support robots in nursing facilities (Laboratory for Clinical Evaluation with Robotics)
Prognosis prediction model for conversion from mild cognitive impairment to Alzheimer’s disease created by integrative analysis of multi-omics data (Department of Genomic Medicine)
Musashi expression in intestinal stem cells attenuates radiation-induced decline in intestinal permeability and survival in Drosophila A4 (Aging Research Homeostasis Research Project Team)
Artificial cortico-muscular connection via neural interface to regain volitional control of limb movements (Laboratory for Clinical Evaluation with Robotics)
Effects of a Balance Exercise Assist Robot on Older Patients with Hip Fracture: A Preliminary Study (Laboratory for Practical Technology in Community)
Lower DNA methylation levels in CpG island shores of CR1, CLU, and PICALM in the blood of Japanese Alzheimer’s disease patients (Department of Regenerative Medicine, Department of Genomic Medicine)
Synthetic cell-permeable caveolin-1 scaffolding domain peptide activates phagocytosis of Escherichia coli by regulating Rab5 activity (Department of Oral Disease Research)
Contribution of DOCK11 to the Expansion of Antigen-Specific Populations among Germinal Center B Cells (Department of Mechanism of Aging)
Pulp Regeneration: Current Approaches, Challenges, and Novel Rejuvenating Strategies for an Aging Population (Department of Stem Cell Biology and Regenerative Medicine)
Nanobubble-Enhanced Antimicrobial Agents: A Promising Approach for Regenerative Endodontics (Department of Stem Cell Biology and Regenerative Medicine)
Caveolin-1 Promotes Cellular Senescence in Exchange for Blocking Subretinal Fibrosis in Age-Related Macular Degeneration (Department of Mechanism of Aging)
Oral hypofunction and its association with frailty in community‐dwelling older people (Department of Oral Disease Research)
DOK7 Gene Therapy Enhances Neuromuscular Junction Innervation and Motor Function in Aged Mice (Laboratory of Experimental Animals)
Iron deposition in autopsied liver specimens from older patients receiving intravenous iron infusion (Department of Mechanism of Aging)
Identification of potential blood biomarkers for early diagnosis of Alzheimer’s disease through RNA sequencing analysis (Department of Genomic Medicine)
UGGT1 retains proinsulin in the endoplasmic reticulum in an arginine dependent manner (Department of Aging Intervention)
Vitamin D Inhibits Myogenic Cell Fusion and Expression of Fusogenic Genes (Department of Musculoskeletal Disease, Department of Regenerative Medicine)
A recurrent PJA1 variant in trigonocephaly and neurodevelopmental disorders (Department of Musculoskeletal Disease)
Lamivudine Inhibits Alu RNA-induced Retinal Pigment Epithelium Degeneration via Anti-inflammatory and Anti-senescence Activities (Department of Mechanism of Aging)
Application of Robot and Artificial Intelligence to Patients with Dementia [Japanese] (Center of Assistive Robotics and Rehabilitation for Longevity and Good Health (CARRL))
High concentration of glucose induces filaggrin-1 expression through AP-1 in skin keratinocytes (Department of Oral Disease Research)
CCR3 antagonist protects against induced cellular senescence and promotes rejuvenation in periodontal ligament cells for stimulating pulp regeneration in the aged dog (Department of Stem Cell Biology and Regenerative Medicine)

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