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Geroscience Research Center

ホーム > Research > Center > Geroscience Research Center > Division > Metabolic Research

Metabolic Research

2025

BIBLIOGRAPHY

  1. Ikeue K, Kato H, Tanaka M, Yamakage H, Kato S, Iwasa M, Oishi K, Yamamoto Y, Kanasaki M, Masuda I, Ishii K, Satoh-Asahara N. Phase angle is a potential novel early marker for sarcopenia and cognitive impairment in the general population. J Cachexia Sarcopenia Muscle, 2025;16:e13820.
  2. Shimizu H, Miyamoto J, Hisa K, Ohue-Kitano R, Takada H, Yamano M, Nishida A, Sasahara D, Masujima Y, Watanabe K, Nishikawa S, Takahashi S, Ikeda T, Nakajima Y, Yoshida N, Matsuzaki C, Kageyama T, Hayashi I, Matsuki A, Akashi R, Kitahama S, Ueyama M, Murakami T, Inuki S, Irie J, Satoh-Asahara N, Toju H, Mori H, Nakaoka S, Yamashita T, Toyoda A, Yamamoto K, Ohno H, Katayama T, Itoh H, Kimura I. Sucrose-preferring gut microbes prevent host obesity by producing exopolysaccharides. Nat Commun. 2025;16:1145.
  3. Matsushima-Nishiwaki R, Honda Y, Tokuda H, Kozawa O. Gallein, G protein βγ subunits inhibitor, suppresses the TGF-α-induced migration of hepatocellular carcinoma cells via inhibition of the c- Jun N-terminal kinase. Biochem Cell Biol. 2025;103:1-9.
  4. Kamihara T, Kinoshita T, Kawano R, Tanaka S, Omura T, Tanaka K, Hirashiki A, Kokubo M, Arai H, Shimizu A. Unraveling the molecular dissociation between aging and atherosclerosis: A bioinformatics approach. Geriatr Gerontol Int. 2025;25:108-115.
  5. Kamihara T, Kaneko S, Omura T, Motegi K, Hirashiki A, Kokubo M, Shimizu A. Cross-Sectional study demonstrating specificity of iron kinetics in atrial fibrillation. Circ Rep. 2025;7:160-167.
  6. Kamihara T, Omura T, Shimizu A. Deciphering the relationship between sarcopenia and aging: A combined text mining and bioinformatics approach. Geriatr Gerontol Int. doi: 10.1111/ggi.70042. Online ahead of print.
  7. Nakashima H, Omura T, Teng X, Kamihara T, Yokoi K, Kawashima S, Tokuda H. Transient Anti-Glutamic Acid Decarboxylase (GAD) Antibody Positivity and Insulin Secretion Reduction After IVIg in Type 2 Diabetes Mellitu. Cureus. 2025;10;17(4):e82038,
  8. Omura T, Usui C, Matsushima-Nishiwaki R, Kozawa O, Tokuda H. The distinct effect between Amyloid β (1‒40) and Amyloid β (1‒42) on the TRAP-stimulated platelet activation in diabetes mellitus. Biomed Res. 2025;46(3):119-128,
  9. Kamihara T, Kaneko S, Omura T, Hirashiki A, Kokubo M, Shimizu A. Regional Disparities in Atrial Fibrillation Catheter Ablation Based on the Japanese National Survey. Circulation Reports.
  10. Tanaka K, Okazaki H, Nakashima H, Motoki T, Kamihara T, Sugimoto T, Kawashima S, Omura T, Tokuda H. Comparative Analysis of ChatGPT-Based Artificial Intelligence for Diabetes Self-Management Support: Potential of Artificial Intelligence Stratified Implementation and Customization. Diabetes Technology and Obesity Medicine. Published Online．
  11. Kamihara T, Kaneko S, Tanaka K, Omura T, Shimizu A. Role of epicardial adipose tissue in atrial fibrillation as an age-related disease. Archives of Gerontology and Geriatrics Plus. 2025;100159,
  12. Sugimoto T, Crane P, Choi　S, Fujita K, Gallée J, Kuroda Y, Lee M, Matsumoto N, Nakamura A, Noma　H, Omura T, Onoyama A, Scollard P, Uchida　K, Yokoyama Y, Arai H, Sakurai T, J-MINT study group. Multidomain interventions for preventing cognitive decline in older adults with type 2 diabetes and mild cognitive impairment: Secondary analysis of the J-MINT: Multidomain intervention in type 2 diabetes. The Journal of Aging Research & Lifestyle. Volume14, 2025;100016,
  13. Sugimoto T, Omura T, Araki A, Haneda C, Honda K, Kishi M, Takahashi T, Toyoshima K, Tsuume S, Uchida K, Matsumoto N, Noma H, Fujita K, Onoyama A, Yokoyama Y, Kuroda Y, Crane PK, Sakurai T; J‐MIND‐Diabetes Study Group. Differential effects of a multidomain intervention on cognitive decline in older adults with type 2 diabetes according to white matter hyperintensity status: A secondary analysis of the J-MIND-Diabetes. Diabetes Obes Metab.16605. 2025;27(10):5576-5586.
  14. Tanaka K, Okazaki H, Nakashima H, Motoki T, Kamihara T, Sugimoto T, Kawashima S, Omura T, Tokuda H. Comparative Analysis of ChatGPT-Based Artificial Intelligence for Diabetes Self-Management Support: Potential of Artificial Intelligence Stratified Implementation and Customization. Diabetes Technology and Obesity Medicine. Published Online．
  15. Kamihara T, Tanaka K, Kaneko S, Omura T, Shimizu A. Age-independent changes in older patients with obesity: A text-mining, bioinformatics, and cross-sectional study. Geriatr Gerontol Int. 2025;25(9):1260-1270.
  16. Omura T, Sugimoto T, Kamihara T. Global Framework for Comprehensive Geriatric Assessment Implementation Following Frailty Screening. J Am Med Dir Assoc. jamda. 105801. 2025;26(10):105801.
  17. Sugihara K, Kamihara T, Omura T, Shimizu A. Clinical Insights Into Aortitis Following Granulocyte Colony-Stimulating Factor Use in an Older Male Patient. Cureus. 2025;11:17(6):e85801.

  18. Omura T, "Older Adult Diabetes": A Conceptual Proposal for a Distinct Clinical Entity. Diabetes Spectr. 2025;38(4):502-505. 

  19. Nakashima H, Kamihara T, Omura T, Shimizu A.　Delayed Severe Heart Failure Despite Successful Graves' Disease Management. Clin Case Rep. 17;13(12):e71693.

  20. Kamihara T, Omura T, Shimizu A. Systemic Hurdles, Not Cardiologist Awareness: The Barriers to CPET Availability in Japan. J Arrhythm. 11;41(6):e70251.

  21. Nakamura J, Sugimoto T, Omura T, Uchida K, Murakami M, Kugimiya Y, Yokoyama Y, Moriya M, Nakano Y, Sato H, Nagai S, Kawashima S, Tokuda H, Sakurai T.    Association Between Oral Frailty and Metrics Derived from Continuous Glucose Monitoring in Older Patients with Type 2 Diabetes. Diabetes Technology and Obesity Medicine. Published Online

  22. Takasaki M, Omura T, Kamihara T, Sugimoto T, Tanaka K, Motegi K, Katsumi A, Tokuda H. Copper Deficiency Anemia in Older Adults    Geriatr Gerontol Int. 25(11):1639-1641.

  23. Kamihara T, Omura T, Shimizu A.　Potential and Limitations of Large Language Models for Medical Literature Analysis: A Preliminary Investigation. Cureus. 17;17(9):e92590.      

  24. Asano Y, Kamihara T, Omura T. Executive Dysfunction After COVID-19 in an Older Adult With Type 1 Diabetes: A Case of Insulin Pump Discontinuation. Cureus. 30;17(9):e93554.

  25. Yu C, Ide M, Sugimoto T, Otsuka R, Takahashi K, Takiwaki M, Tanaka K, Kanouchi H, Takenaka S, Sakurai T, Niida S, Kuwabara A. Association between serum vitamin D metabolite levels and cognitive function in community-dwelling older adults: A cross-sectional study.  Clin Nutr ESPEN.10(69):785-793.

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2024

BIBLIOGRAPHY

 

  1. Tokuda H, Hori T, Mizutani D, Hioki T, Kojima K, Onuma T, Enomoto Y, Doi T, Matsushima-Nishiwaki R, Ogura S, Iida H, Iwama T, Sakurai T, Kozawa O. Inverse relationship between platelet Akt activity and hippocampal atrophy: A pilot case-control study in patients with diabetes mellitus. World J. Clin. Cases. 2024;12:302-313.
  2. Omura T, Inami A, Sugimoto T, Kawashima S, Sakurai T, Tokuda H. Tirzepatide and glycemic control metrics using continuous glucose monitoring in older patients with type 2 diabetes mellitus: An observational pilot study. Geriatrics. 2024;9:27.
  3. Kamihara T, Tabuchi M, Omura T, Suzuki Y, Aritake T, Hirashiki A, Kokubo M, Shimizu A. Evolution of a large language model for preoperative assessment based on the Japanese circulation society 2022 guidelines on perioperative cardiovascular assessment and management for non-cardiac surgery. Circ. Rep. 2024;6:142-148.
  4. Tokuda H, Hori T, Onuma T, Enomoto Y, Doi T, Matsushima-Nishiwaki R, Yamaguchi S, Tanabe K, Omura T, Ogura S, Iwama T, Iida H, Kozawa O. Serotonin reuptake inhibitor suppresses the activation of human platelets by a combination of thrombopoietin and collagen through inhibition of Rac and Rho/Rho-kinase. Biomed. Res. 2024;45:231-241.
  5. Sugimoto T, Sakurai T, Uchida K, Kuroda Y, Tokuda H, Omura T, Noguchi T, Komatsu A, Nakagawa T, Fujita K, Matsumoto N, Ono R, Crane P, Saito T.  Impact of type 2 diabetes mellitus and glycated hemoglobin levels within the recommended target range on mortality in older people with cognitive impairment receiving care at a memory clinic:NCGG-STORIES. Diabetes Care. 2024;47:864-872.
  6. Hioki T, Tachi J, Matsushima-Nishiwaki R, Iida H, Kozawa O, Tokuda H. Oncostatin M suppresses bone morphogenetic protein-4-induced osteoprotegerin synthesis in MC3T3-E1 osteoblast-like cells: p70 S6 kinase attenuation. Cell Biochem. Funct. 2024;42:e4068.
  7. Kamihara T, Tanaka K, Omura T, Kaneko S, Hirashiki A, Kokubo M, Shimizu A. Exploratory bibliometric analysis and text mining to reveal research trends in cardiac aging. Aging Med. 2024;7:301-311.
  8. Kamihara T, Omura T. Does atrial fibrillation occur exclusively in the elderly? Clin Case Rep. 2024;12:e9175.
  9. Kuroyanagi G, Hioki T, Matsushima-Nishiwaki R, Kozawa O, Tokuda H. Gallein increases the fibroblast growth factor 2-elicited osteoprotegerin synthesis in osteoblasts. Biochim. Biophys. Acta. Gen. Subj. 2024;1868:130635.
  10. Sugimoto T, Saji N, Omura T, Tokuda H, Miura H, Kawashima S, Ando T, Nakamura A, Uchida K, Matsumoto N, Fujita K, Kuroda Y, Crane PK, Sakurai T. Cross-sectional association of continuous glucose monitoring-derived metrics with cerebral small vessel disease in older adults with type 2 diabetes. Diabetes Obes. Metab. 2024;26:3318-3327.
  11. Kuroyanagi G, Hioki T, Matsushima-Nishiwaki R, Omura T, Kozawa O, Tokuda H. Gallein increases prostaglandin F2α-induced osteoprotegerin and IL-6 secretion in osteoblasts. Biomed. Rep. 2024;21:147.
  12. Tanaka K, Okazaki H, Omura T, Kamihara T, Tokuda H. The potential role of ChatGPT in enhancing diabetes management for older patients. Geriatr. Gerontol. Int. 2024;24:816-817.
  13. Kamihara T, Kawano R, Kinoshita T, Omura T, Kaneko S, Hirashiki A, Kokubo M, Shimizu A. Differences in iron kinetics during cardiac load between patients with atrial fibrillation and those with sinus rhythm. Cardiology. 2024;149:580-689.
  14. Omura T, Inami A, Sugimoto T, Kawashima S, Sakurai T, Tokuda H. Identification of atypical hypoglycemia via continuous glucosemonitoring in a patient presenting with hot flashes. J. Gen. Fam. Med. 2024;25:392-394.
  15. Hioki T, Kuroyanagi G, Matsushima-Nishiwaki R, Omura T, Kozawa O, Tokuda H. Gallein but not fluorescein enhances the PGD2-stimulated synthesis of osteoprotegerin and interleukin-6 in osteoblasts. Geriatr. Gerontol. Int. 2024;203:102639.
  16. Osuka Y, Kojima N, Daimaru K, Ono R, Sugie M, Omura T, Motokawa K, Ueda T, Maruo K, Aoyama T, Inoue S, Sasai H. Effects of Radio-Taiso on health-related quality of life in older adults eith frailty: a randomized controlled trial. J. Epidemiol. 2024;34:467-476.
  17. Ono T, Watanabe N, Hayakawa K, Kainuma S, Yamada H, Waseda Y, Kanda Y, Fukuoka M, Tokuda H, Murakami H, Kuroyanagi G. Comparative outcomes of cemented versus cementless stems in bipolar hemiarthroplasty for femoral neck fractures. Medicine. 2024;103:e39946.
  18. Sugimoto T, Araki A, Fujita H, Fujita K, Honda K, Inagaki N, Ishida T, Kato J, Kishi M, Kishino Y, Kobayashi K, Kouyama K, Kuroda Y, Kuwahata S, Matsumoto N, Murakami T, Noma H, Ogino J, Ogura M, Ohishi M, Shimada H, Sugimoto K, Kakenaka T, Tamura Y, Tokuda H, Uchida K, Umegaki H, Sakurai T. Multidomain intervention trial for preventing cognitive decline among older adults with type 2 diabetes: J-MIND-Diabetes. J. Prev. Alz. Dis. 2024;11:1604-1614. 

 

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2023

BIBLIOGRAPHY

  1. Iida H, Onuma T, Nakashima D, Mizutani D, Hori T, Ueda K, Hioki T, Kim W, Enomoto Y, Doi T, Matsushima-Nishiwaki R, Yamaguchi S, Tachi J, Tanabe K, Ogura S, Iwama T, Kozawa O, Tokuda H. Tramadol regulates the activation of human platelets via Rac but not Rho/Rho-kinase. PLoS One. 2023;18:e0279011.
  2. Sugimoto T, Tokuda H, Miura H, Kawashima S, Ando T, Kuroda Y, Matsumoto N, Fujita K, Uchida K, Kishino Y, Sakurai T. Cross-sectional association of metrics derived from continuous glucose monitoring with cognitive performance in older adults with type 2 diabetes. Diabetes Obes. Metab. 2023;25:222-228.
  3. Nishikimi A, Nakagawa T, Fujiwara M, Watanabe K, Watanabe A, Komatsu A, Yasuoka M, Watanabe R, Naya M, Oshima H, Kitagawa Y, Tokuda H, Kondo I, Niida S, Sakurai T, Kojima M, Arai H. Humoral and cellular responses to the third COVID-19 BNT162b2 vaccine dose in research institute workers in Japan. J. Infect. 2023;86:e33-e35.
  4. Kuroyanagi G, Hioki T, Tachi J, Matsushima-Nishiwaki R, Iida H, Kozawa O, Tokuda H. Oncostatin M stimulates prostaglandin D2-induced osteoprotegerin and interleukin-6 synthesis in osteoblasts. Prostaglandins Leukot. Essent. Fatty Acids. 2023;192:102575.
  5. Hioki T, Kuroyanagi G, Matsushima-Nishiwaki R, Kozawa O, Tokuda H. Oncostatin M attenuates tumor necrosis factor-alfa-induced synthesis of macrophage-colony stimulating factor via suppression of Akt in osteoblasts. Connect. Tissue Res. 2023;64:139-147.
  6. Li J, Nakagawa T, Kojima M, Nishikimi A, Tokuda H, Nishimura K, Umezawa J, Tanaka S, Inoue M, Ohmagari N, Yamaguchi K, Takeda K, Yamamoto S, Konishi M, Miyo K, Mizoue T. Underlying medical conditions and anti-SARS-CoV-2 spike IgG antibody titers after two doses of BNT162b2 vaccination: A cross-sectional study. PLoS One. 2023;18:e0283658.
  7. Enomoto Y, Onuma T, Hori T, Tanabe K, Ueda K, Mizutani D, Doi T, Matsushima-Nishiwaki R, Ogura S, Iida H, Iwama T, Kozawa O, Tokuda H. Synergy by ristocetin and CXCL12 in human platelet activation: Divergent regulation by Rho/Rho kinase and Rac. Int. J. Mol. Sci. 2023;24:9716.
  8. Kuroyanagi G, Hioki T, Tachi J, Matsushima-Nishiwaki R, Iida H, Tokuda H, Kozawa O. Resveratrol inhibits basic fibroblast growth factor-induced macrophage colony-stimulating factor synthesis via the PI3-kinase/Akt pathway in osteoblasts. Biosci. Biotechnol. Biochem. 2023;87:1462-1469. 
  9. Sugimoto T, Tokuda H, Miura H, Kawashima S, Omura T, Ando T, Kuroda Y, Matsumoto N, Fujita K, Uchida K, Kishino Y, Sakurai T. Longitudinal association of continuous glucose monitoring-derived metrics with cognitive decline in older adults with type 2 diabetes: A 1-year prospective observational study. Diabetes Obes. Metab. 2023;25:3831-3836.
  10. Kuroyanagi G, Hioki T, Matsushima-Nishiwaki R, Kozawa O, Tokuda H. HSP70 inhibitor amplifies the bFGF‑induced release of IL‑6 in osteoblasts. Mol. Med. Rep. 2023;28:230. 
  11. Hioki T, Tachi J, Ueda K, Matsushima-Nishiwaki R, Iida H, Kozawa O, Tokuda H. Oncostatin M enhances osteoprotegerin synthesis but reduces macrophage colony‑stimulating factor synthesis in bFGF‑stimulated osteoblast‑like cells. Exp. Ther. Med. 2023;27:34.
  12. Kawai Y, Watanabe Y, Omae Y, Miyahara R, Khor SS, Noiri E, Kitajima K, Shimanuki H, Gatanaga H, Hata K, Hattori K, Iida A, Ishibashi-Ueda H, Kaname T, Kanto T, Matsumura R, Miyo K, Noguchi M, Ozaki K, Sugiyama M, Takahashi A, Tokuda H, Tomita T, Umezawa A, Watanabe H, Yoshida S, Goto Y, Maruoka Y, Matsubara Y, Niida S, Mizokami M, Tokunaga K. Exploring the genetic diversity of the Japanese population: Insights from a large-scale whole genome sequencing analysis. PLoS Genet. 2023;19:e1010625.
  13. Omura T, Katsumi A, Kawashima S, Naya M, Tokuda H. Prolonged COVID-19 infection in a patient with complete remission from follicular lymphoma with hyperosmolar hyperglycemic syndrome. Geriatrics. 2023;8:110.

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2022

BIBLIOGRAPHY

  1. Hioki T, Kuroyanagi G, Fujita K, Sakai G, Kawabata T, Kim W, Tachi J, Matsushima-Nishiwaki R, Iida H, Kozawa O, Tokuda H. Incretins enhance PGF2alfa-induced synthesis of IL-6 and osteoprotegerin in osteoblasts. Horm. Metab. Res. 2022;54:42-49.
  2. Nishikimi A, Watanabe K, Watanabe A, Yasuoka M, Watanabe R, Oshima H, Kitagawa Y, Tokuda H, Niida S, Kojima M. Prevalence of SARS-CoV-2 antibodies after one-year follow up among workers in a research institute in Japan. J. Infect. 2022;84:e23-e25.
  3. Mizutani D, Tokuda H, Onuma T, Uematsu K, Nakashima D, Ueda K, Doi T, Enomoto Y, Matsushima-Nishiwaki R, Ogura S, Iida H, Kozawa O, Iwama T. Amyloid-beta protein negatively regulates human platelet activation induced by thrombin receptor-activating protein. Biosci. Biotechnol. Biochem. 2022;86:185-198.
  4. Doi T, Hioki T, Tachi J, Ueda K, Matsushima-Nishiwaki R, Iida H, Ogura S, Kozawa O, Tokuda H. Oncostatin M reduces the synthesis of macrophage-colony stimulating factor stimulated by TGF-beta via suppression of p44/p42 MAP kinase and JNK in osteoblasts. Biomed. Res. 2022;43:41-51.
  5. Kuroyanagi G, Tokuda H, Fujita K, Kawabata T, Sakai G, Kim W, Hioki T, Tachi J, Matsushima-Nishiwaki R, Otsuka T, Iida H, Kozawa O. Upregulation of TGF-beta-induced HSP27 by HSP90 inhibitors in osteoblasts. BMC Musculoskelet Disord. 2022;23:495.
  6. Doi T, Hori T, Onuma T, Mizutani D, Ueda K, Enomoto Y, Matsushima-Nishiwaki R, Tanabe K, Hioki T, Tokuda H, Iwama T, Iida H, Kozawa O, Ogura S. Thrombopoietin and collagen in low doses cooperatively induce human platelet activation. Acute. Med. Surg. 2022;9:e769.
  7. Kuroyanagi G, Kawabata T, Tokuda H, Fujita K, Matsushima-Nishiwaki R,  Sakai G, Tachi J, Hioki T, Kim W, Iida H, Otsuka T, Kozawa O. Attenuation by HSP90 inhibitors of EGF-elicited migration of osteoblasts: Involvement of p44/p42 MAP kinase. Connect. Tissue Res. 2022;63:359-369.
  8. Nishikimi A, Watanabe K, Watanabe A, Yasuoka M, Watanabe R, Fujiwara M, Oshima H, Nakagawa T, Kitagawa Y, Tokuda H, Washimi Y, Niida S, Kojima M. Immune responses to COVID-19 vaccine BNT162b2 in workers at a research institute in Japan: 6-month follow-up survey. J. Infect. 2022;85:174-211.
  9. Yamamoto S, Tanaka A, Ohmagari N, Yamaguchi K, Ishitsuka K, Morisaki N, Kojima M, Nishikimi A, Tokuda H, Inoue M, Tanaka S, Umezawa J, Okubo R, Nishimura K, Konishi M, Miyo K, Mizoue T. Use of heated tobacco products, moderate alcohol drinking, and anti-SARS-CoV-2 IgG antibody titers after BNT162b2 vaccination among Japanese healthcare workers. Prev. Med. 2022 ;161:107123.
  10. Nishikimi A, Nakagawa T, Fujiwara M, Watanabe K, Watanabe A, Komatsu A, Yasuoka M, Watanabe R, Naya M, Oshima H, Kitagawa Y, Tokuda H, Kondo I, Niida S, Sakurai T, Kojima M, Arai H. Humoral and cellular responses to the third COVID-19 BNT162b2 vaccine dose in research institute workers in Japan. J. Infect. 2022;S0163-4453(22)00621-1.
  11. Hioki T, Matsushima-Nishiwaki R, Tokuda H, Kozawa O. Selective estrogen receptor modulators, acting as agonists of estrogen receptor α in osteoblasts, reduce the TGF-beta-induced synthesis of macrophage colony-stimulating factor via inhibition of JNK signaling pathway. Biomed. Res. 2022;43:211-221.
  12. Hori T, Mizutani D, Onuma T, Okada Y, Kojima K, Doi T, Enomoto Y, Iida H, Ogura S, Sakurai T, Iwama T, Kozawa O, Tokuda H. Relationship between the responsiveness of amyloid beta protein to platelet activation by TRAP stimulation and brain atrophy in patients with diabetes mellitus. Int. J. Mol. Sci. 2022;23:14100.
  13. Kuroyanagi G, Tachi J, Fujita K, Kawabata T, Sakai G, Nakashima D, Kim W, Tanabe K, Matsushima-Nishiwaki R, Otsuka T, Iida H, Kozawa O, Tokuda H. HSP70 inhibitors upregulate prostaglandin E1-induced synthesis of interleukin-6 in osteoblasts. PLoS One. 2022;17:e0279134.

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2021

BIBLIOGRAPHY

  1. Hioki T, Tokuda H, Nakashima D, Fujita K, Kawabata T, Sakai G, Kim W,   Tachi J, Tanabe K, Matsushima-Nishiwaki R, Otsuka T, Iida H, Kozawa O. HSP90 inhibitors strengthen extracellular ATP-stimulated synthesis of interleukin-6 in osteoblasts: Amplification of p38 MAP kinase. Cell Biochem. Funct. 2021;39:88-97.
  2. Kuroyanagi G, Sakai G, Otsuka T, Yamamoto N, Fujita K, Kawabata T, Matsushima-Nishiwaki R, Kozawa O, Tokuda H. HSP22 (HSPB8) positively regulates PGF2alfa-induced synthesis of interleukin-6 and vascular endothelial growth factor in osteoblasts. J. Orthop. Surg. Res. 2021;16:72.
  3. Kim W, Tokuda H, Tanabe K, Yamaguchi S, Hioki T, Tachi J, Matsushima-Nishiwaki R, Kozawa O, Iida H. Acetaminophen reduces osteoprotegerin synthesis stimulated by PGE2 and PGF2alfa in osteoblasts: Attenuation of SAPK/JNK but not p38 MAPK or p44/p42 MAPK. Biomed. Res. 2021;42:77-84.
  4. Sable-Morita S, Tanikawa T, Satake S, Okura M, Tokuda H, Arai H. Microvascular complications and frailty can predict adverse outcomes in older patients with diabetes. Geriatr. Gerontol. Int. 2021;21:359-363.
  5. Tachi J, Onuma T, Yamaguchi S, Kim W, Hioki T, Matsushima-Nishiwaki R, Tanabe K, Tokuda H, Kozawa O, Iida H. Duloxetine suppresses BMP-4-induced release of osteoprotegerin via inhibition of the SMAD signaling pathway in osteoblasts. Biochem. Cell. Biol. 2021;99:578-586.
  6. Sable-Morita S, Okura M, Tanikawa T, Kawashima S, Tokuda H, Arai H. Associations between diabetes-related foot disease, diabetes, and age-related complications in older patients. Eur. Geriatr. Med. 2021;12:1003-1009.
  7. Sugimoto T, Arai A, Fujita H, Honda K, Inagaki N, Ishida T, Kato J, Kishi M, Kobayashi K, Kouyama K,　Noma H, Ohishi M, Satoh-Asahara N, Shimada H, Sugimoto K, Suzuki S, Takeya Y, Tamura Y, Tokuda H, Umegaki H, Watada H, Yamada Y, Sakurai T. The multi-domain intervention trial in older adults with diabetes mellitus for prevention of dementia in Japan: Study protocol for a multi-center, randomized, 18-month controlled rial. Front. Aging Neurosci. 2021;13:680341.
  8. Hioki T, Tokuda H, Kuroyanagi G, Kim W, Tachi J, Matsushima-Nishiwaki R,  Iida H, Kozawa O. Olive polyphenols attenuate TNF-alfa-stimulated M-CSF and IL-6 synthesis in osteoblasts: Suppression of Akt and p44/p42 MAP kinase signaling pathways. Biomed. Pharmacother. 2021;141:111816.
  9. Hioki T, Tokuda H, Tanabe K, Kim W, Tachi J, Yamaguchi S, Matsushima-Nishiwaki R, Kozawa O, Iida H. Amplification by tramadol of PGD2-induced osteoprotegerin synthesis in osteoblasts: Involvement of mu-opioid receptor and 5-HT transporter. Prostaglandins Leukot Essent. Fatty Acids. 2021;172:102323.
  10. Sable-Morita S, Arai Y, Takanashi S, Aimoto K, Okura M, Tanikawa T, Maeda K, Tokuda H, Arai H. Development and testing of the foot care scale for older Japanese diabetic patients. Int. J. Low. Extrem. Wounds. 2021;15347346211045033. Online ahead of print.
  11. Kaneda H, Ida Y, Kuwahara R, Sato I, Nakano T, Tokuda H, Sato T, Murakoshi T, Honke K, Kotani N. Proximity proteomics has potential for extracellular vesicle identification. J. Proteome. Res. 2021;20:3519-3531.
  12. Nishikimi A, Kojima M, Watanabe K, Watanabe A, Yasuoka M, Oshima H, T Okuda H, Niida S. Seroprevalence of antibodies against SARS-CoV-2 among workers in a national research institute and hospital in central Japan. GHM Open. 2021;1:40-42.

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