ホーム > Research > Center > Geroscience Research Center > Division > Inflammation and Immunosenescence
on November 2020,NCGG,Obu
Last updated on May 9, 2024
Dr. Maruyma acted as the organaiser of the 1st citizen forum of Japan Society for Biomedical Gerontology.
(hold on 7 and 8, November, 2020 at Shinmai media garden, Matsumoto, Nagano)
the 37th annual meeting of JSBMG the 40th annual meeting of JSBMG
the 44th annual meeting of JSBMG the 1st citizen forum of JSBMG
Last updated on May 9, 2024
Professor | Mitsuo Maruyama |
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Associate Professor | |
Research Fellow | Tanenobu Harada |
Yoichiro Kawabe | |
Research Assistant | Keiko Onishi |
Rina Yamamoto | |
Nobuko Saitoh | |
Yuko Ohta | |
Akane Yamada | |
Rie Imura | |
Mai Kondo | |
Kumiko Kanamori | |
Visiting Researcher | Junichi Shimada |
Noboru Motoyama | |
Akinori Tokunaga |
Our department has been in cooperation with the department of Aging Research, Program in Integrated Molecular Medicine, Nagoya University Graduate School of Medicine since 2006.
Actually Dr. Mitsuo Maruyama has charged the course as a visiting professor therefore we can manage not only seminar but also experimental research, whenever new face graduate students join here. If you find any interest or something excited about Aging Research in our web site, please try to contact us I first, and then join our laboratory in Nagoya University to feel cutting edge Aging research.
Nagoya university Graduate School of Medicine |
Program in integrated Molecular Medicine |
Molecular Aging Research,Department of Aging Research |
In our research institute, we had seminars by the famous and popular scientists in the various field of aging from home and abroad. Some of them were introduced as graduate seminars at the Graduate School of Medicine, Nagoya University, and basically all of them were open to the public.
12月2日 |
Promoting health and longevity through diet: metabolic and molecular adaptations(PDF:679KB) |
10月21日 |
Targeting BCL-2 Family-Regulated Cell Death for Cancer Treatment(PDF:207KB) |
Please see also the page in Japanese.
Please see also the page in Japanese.
Please see also the page in Japanese.
Please see also the page in Japanese.
Please see also the page in Japanese.
Please see also the page in Japanese.
Please see also the page in Japanese.
Please see also the page in Japanese.
Please see also the page in Japanese.
Please see also the page in Japanese.
Morita Y, Jounai K, Tomita Y, Maruyama M.
Long-term intake of Lactobacillus paracasei KW3110 prevents age-related circadian locomotor activity and changes in gut metabolism in physiologically aged mice.
Exp Gerontol. 2021 Oct 1;153:111477. Epub 2021 Jul 13.
Kawaguchi K, Komoda K, Mikawa R, Asai A, Sugimoto M.
Cellular senescence promotes cancer metastasis by enhancing soluble E-cadherin production.
iScience. 2021 Aug 24;24(9):103022. eCollection 2021 Sep 24.
Kawaguchi K, Hashimoto M, Mikawa R, Asai A, Sato T, Sugimoto M.
Protocol for assessing senescence-associated lung pathologies in mice.
STAR Protocols.2021 Dec4:2(4):100993
Suda M, Shimizu I, Katsuumi G, Yoshida Y, Hayashi Y, Ikegami R, Matsumoto N, Yoshida Y, Mikawa R, Katayama A, Wada J, Seki M, Suzuki Y, Iwama A, Nakagami H, Nagasawa A, Morishita R, Sugimoto M, Okuda S, Tsuchida M, Ozaki K, Nakanishi-Matsui M, Minamino T.
Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice.
Nature Aging. 10 December 2021. https://doi.org/10.1038/s43587-021-00151-2
Sugiyama Y, Fujiwara M, Sakamoto A, Tsushima H, Nishikimi A, Maruyama M.
The immunosenescence-related factor DOCK11 is involved in secondary immune responses of B cells.
Immunity & Ageing. 2022 Jan 3;19(1):
Please see also the page in Japanese.
Sugimoto M.
Senolysis: a potential approach against pulmonary aging and diseases.
Symposium speaker, The 80th Annual Meeting of the Japanese Canser Association,Sep 30th, 2021, Yokohama
Maruyama M.
Inflammaging, taking lessons from history
Workshop Organizer and Closing Remarks, The 44th Annual Meeting of the Molecular Biology Society of Japan, Dec 2nd, 2021, Yokohama
Kawaguchi K, Asai A, Sugimoto M.
Senescence-dependent ectodomain shedding of E-cadherin promotes cancer metastasis.
The 6th International Cell Senescence Association Conference, Dec 13th, 2021, Osaka
Kawaguchi K, Komoda K, Mikawa R , Asai A, Sugimoto M.
Senescence-dependent alveolar factor promotes cancer metastasis.
The 44th Annual Meeting of Japan Society for Biomedical Gerontolosy, Jun 12th, 2021, Obu
Sugiyama Y, Nishikimi A, Maruyama M.
Diversity of p16INK4a-associated chronological senescence in MEF culture.
The 44th Annual Meeting of Japan Society for Biomedical Gerontolosy, Jun 12th, 2021, Obu
Goto A, Hashimoto M, Endo Y, Yokogawa S, Maruyama M, Yamashita H.
CREG1 enhances muscle function in mice.
The 44th Annual Meeting of Japan Society for Biomedical Gerontolosy, Jun 12th, 2021, Obu
Please see also the page in Japanese.
Please see also the page in Japanese.
Sakamoto A, Maruyama M.
Contribution of DOCK11 to the Expansion of Antigen-Specific Populations among Germinal Center B Cells.
Immunohorizons. 2;4(9):520-529, Sep, 2020
Akatsu H, Manabe T, Kawade Y, Tanaka H, Kanematsu T, Arakawa K, Masaki Y, Hishida C, Kanesaka T, Ogawa N, Hashizume Y, Tsuneyama K, Ohara H, Maruyama M, Yamamoto T.
Iron deposition in autopsided liver specimens from older patients receiving intravenous iron infusion.
PLoS One. 4;15(8): e0237104, Aug, 2020.
Kameyama A, Nishijima R, Yamakoshi K.
Bmi-1 regulates mucin levels and mucin O-glycosylation in the submandibular gland of mice.
PLos One.16(1): e0245607, 2021.
Kameyama A, Thet Tin WW, Nishijima R, Yamakoshi K.
Alteration of mucins in the submandibular gland during aging in mice.
Arch. Oral Biol., 121:104967, 2021.
Hashimoto M, Goto A, Endo Y, Sugimoto M, Ueda J, Yamashita H.
Effects of CREG1 on age-associated metabolic phenotypes and renal senescence in mice.
Int. J. Mol. Sci. 22. 1276. 2021.
Kawaguchi K, Hashimoto M, Sugimoto M.
An antioxidant suppressed lung cellular senescence and enhanced pulmonary function in aged mice.
Biochem. Biophys. Res. Commun. 541. 43-49. 2021.
Johmura Y, Yamanaka T, Omori S, Wang T.W, Sugiura Y, Matsumoto M, Suzuki N, Kumamoto S,Yamaguchi K,Hatakeyama S, Takami T, Yamaguchi R, Shimizu E, Ikeda K, Okahashi N, Mikawa R, Suematsu M, Arita M, Sugimoto M, Nakayama K.I, Furukawa Y, Imoto S, Nakanishi M.
Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders.
Science 371. 265-270. 2021.
Shimizu T, Yamada K, Suzumura A, Kataoka K, Takayama K, Sugimoto M, Terasaki H, Kaneko H.
Caveolin-1 Promotes Cellular Senescence in Exchange for Blocking Subretinal Fibrosis in Age-Related Macular Degeneration.
Invest. Ophthalmol. Vis. Sci. 61. 21. 2020
Yamada K, Kaneko H, Shimizu H, Suzumura A, Namba R, Takayama K, Ito S, Sugimoto M, Terasaki H.
Lamivudine Inhibits Alu RNA-induced Retinal Pigment Epithelium Degeneration via Anti-inflammatory and Anti- senescence Activities.
Transl. Vis. Sci. Technol. 9. 1. 2020.
Please see also the page in Japanese.
Please see also the page in Japanese.
Kawaguchi K, Sugimoto M.
Senescence-dependent alveolar factor promotes metastatic lung cancer. Mechanism of Aging, Cold Spring Harbor Laboratory Meeting,September 22-25, 2020, USA(Web)
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Please see also the page in Japanese.
Please see also the page in Japanese.
Kawaguchi K, Kim SE, Sugiyama D, Sugimoto M, Maruyama M.
Age-associated alterations in murine dermis through inflammatory response with mitochondrial DNA deletions.
Geriatrics & Gerontology International, 19: 451–457, 2019
Kim SE, Kawaguchi K, Hayashi H, Furusho K, Maruyama M.
Remissive effects of dietary soybean isoflavones on DSS-induced murine colitis and LPS-induced macrophage cell line.
Nutrients, 11, 1746, 2019
Mikawa R, Sato T, Suzuki Y, Baskoro H, Kawaguchi K, Sugimoto M.
p19Arf exacerbates cigarette smoke-induced lung dysfunction.
Biomolecules, 10: E462, 2020.
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Maruyama M.
Infrastructure and Platform Building for Geroscience in Japan.
Asian Geroscience Conferences, May 25, 2019, Shenzhen China.
Maruyama M.
Current Aging Research and Society in Japan
The 2nd International Conference on Biomedical Health in Beijing
UNESCO, Dec 16 2019, Beijing, Chin
Akatsu H, Kawabe Y, Arakawa K, Masaki Y, Tanaka H, Kanematsu T, Hashizume Y, Tuneyama K, Manabe T, Ohohara T, Maruyama M, Fukushimura NST team
How Risky Of Intravenous Iron Administration? (Analysis Of Iron Deposition By 157 Pathological Liver Tissues).
41st ESPEN Congress on Clinical Nutrition & Metabolism.
September 2, 2019, Krakow, Poland
Kawaguchi K, Kim SE, Sugiyama D, Sugimoto M, Maruyama M.
Age-associated alterations in murine skin involving inflammatory response with mitochondrial DNA deletions.
ICSA 2019 in Conference. September 11, 2019, Athens, Greece
Hayakawa T, Morimoto R, Kimura Y, Nagasaki M, Nagata M, Motoyama N.
SIRT1-p21 pathway negatively regulates senescence-associated secretory phenotype. (SASP)
ICSA 2019 in Conference. September 11, 2019, Athens, Greece
Kawaguchi K, Kim SE, Sugiyama D, Sugimoto M, Maruyama M.
Age-associated alterations in murine dermis through inflammatory response with mitochondrial DNA deletions.
11th IAGG AOR congress, Oct 26 2019, Taipei, Taiwa
Motoyama N.
The nutritional interventions on the basic mechanisms of aging and age-related diseases. Introduction
The 42nd Annual Meeting of the MBSJ, workshop, Dec 4 2019, Fukuoka
Kim SE, Morita Y, Sakamoto A, Maruyama M.
Inflammation and trophic control on immunosenescence.
The 42nd Annual Meeting of the MBSJ, workshop, Dec 4 2019, Fukuoka
Maruyama M.
The nutritional interventions on the basic mechanisms of aging and age-related diseases. ConclutionThe 42nd Annual Meeting of the MBSJ, workshop, Dec 4 2019, Fukuoka
Sakamoto A, Maruyama M.
Contribution of DOCK11 to the expansion of antigen-specific B-cell populations.
The 48th Annual Meeting of the JSI, Dec 12 2019, Hamamatsu
Please see also the page in Japanese.
Please see also the page in Japanese.
Iida M, Matsuno YK, Watanabe A, Maruyama M, Kameyama A, Yamakoshi K.
A sialo-oligosaccharide-rich mucin-like molecule specifically detected in the submandibular glands of aged mice.
Arch. Oral Biol., 12(97), 52-58, 2018.
Morita Y, Jounai K, Sakamoto A, Tomita Y, Sugihara Y, Suzuki H, Ohshio K, Otake M, Fujiwara D, Kanauchi O, Maruyama M.
Long-term intake of Lactobacillus paracasei KW3110 prevents age-related chronic inflammation and retinal cell loss in physiologically aged mice.
Aging., 10(10)2723-2740, 2018.
Kameyama A, Yamakoshi K, Watanabe A.
A rapid separation and characterization of mucins from mouse submandibular glands by supported molecular matrix electrophoresis.
Biochim. Biophys. Acta Proteins Proteom., 1867(1), 76-81, 2019.
Mikawa R, Okuno A, Yoshimi T, Watanabe A, Maruyama M, Takikawa O.
Partial Identification of Amyloid-β Degrading Activity in Human Serum
Nagoya J Med Sci. 81(1): 55-64,2019
Sakamoto A, Kunou S, Shimada K, Tsunoda M, Aoki T, Iriyama C, Tomita A, Nakamura S, Hayakawa F, Kiyoi H.
Pyruvate secreted from patient-derived cancer-associated fibroblasts supports survival of primary lymphoma cells.
Cancer Sci., 110:269–78, 2019.
Kawaguchi K, Kim SE, Sugiyama D, Sugimoto M, Maruyama M.
Age-associated alterations in murine dermis through inflammatory response with mitochondrial DNA deletions.
Geriatr Gerontol Int. 19(5):451-457, 2019
Mikawa R, Suzuki Y, Baskoro Y, Kanayama K, Sugimoto K, Sato T.
Elimination of p19ARF-expressing cells protects against pulmonary emphysema in mice.
Aging Cell 30., e12827. 2018.
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Sakamoto A, Matsui N, Takaoka A, Maruyama M.
Natural antibody immunity and immunosenescence
Asian Society for Aging Research Symposium, Apr 19, 2018, Jeju, South Korea
Kim S, Kawaguchi K, Maruyama M.
Potential anti-inflammation effect of water-soluble soybean isoflavones on a murine macrophage cell line and DSS-induced murine colitis model
Asian Society for Aging Research Symposium, Apr 19, 2018, Jeju, South Korea
Miyamoto J, Nakatani A, Sutou A, Kamei Y, Maruyama M, Kimura I.
Short-chain fatty acid receptors and aging-related energy metabolism regulation.
Asian Society for Aging Research Symposium, Apr 19, 2018, Jeju, South Korea
Maruyama M.
Summary Report in Aging Biology.
ICAH-NCGG symposium, May 11, 2018, Taipei.
Sugimoto M.
Pathophysiological roles of cellular senescence in pulmonary diseases.
ICAH-NCGG symposium, May 10, 2018, Taipei.
Hayakawa T, Morimoto R, Kimura Y, Nagasaki M, Nagata M, Maruyama M, Motoyama N.
SIRT1 regulates the expression of p21 during cellular senescence.
Metabolism and Aging Cell Symposia, Sep 23-25, 2018, Sitges, Spain.
Sugimoto M.
Cellular senescence in pulmonary aging and disease.
The 77th Annual Meeting of the Japanese Cancer Association, Sep 28, Osaka.
Please see also the page in Japanese.
Plese see also the page in Japanese.
Please see also the page in Japanese.