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Research Institute

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Geroscience Research Center

ホーム > Research > Center > Geroscience Research Center > Division > Chemical Biology

Department of Chemical Biology

  1. Identification of longevity regulated protein
  2. Identification of longevity regulated protein degrader
  3. Development of anti-aging chemicals

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  1. Bioactive small molecule signaling
    Arginine target protein → UGGT1, glucokinase, cereblon
  2. Glycolysis regulating chemical
    Glucose metabolism deficiency for elderly people and diabetes patients Cancer
  3. Liver regeneration accelerator
    Estrogen-ESR1
    Chorionic gonadotropin

 

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Takeshi Imai

  • Total citation 2673
  • H-index 23
  • Editorial Board Member of International Journal of Chemistry (2012-)
  • Editorial Board Member of Pharmacologia (2014-) 
  • Guest editor of Letters in Applied NanoBioScience (2017)
  • Marquis Who's Who publication (2012-)
  • 2000 Outstanding Intellectuals of the 21st Century 2013
  • Leading Health Professionals of the World 2013

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  1. UGGT1 retains proinsulin in the endoplasmic reticulum in an arginine dependent manner. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7863631/This link will open in a new window
  2. Chorionic gonadotropin stimulates maternal hepatocyte proliferation during pregnancy
    https://en.x-mol.com/paper/article/1441522209404022784This link will open in a new window
  3. L-Arginine prevents cereblon-mediated ubiquitination of glucokinase and stimulates glucose-6-phosphate production in pancreatic β-cells.
    https://www.x-mol.com/paper/1303505643892871168This link will open in a new window
  4. L-Arginine prevents cereblon-mediated ubiquitination of glucokinase and stimulates glucose-6-phosphate production in pancreatic β-cells. https://medicine.uiowa.edu/internalmedicine/research/recent-research-articlesThis link will open in a new window
  5. L-Arginine prevents cereblon-mediated ubiquitination of glucokinase and stimulates glucose-6-phosphate production in pancreatic β-cells.  https://www.stemcellsciencenews.com/news_archive/pancreatic-cell-news-volume-11-34-sep-8-2020/This link will open in a new window
  6. 新しいインスリン分泌促進機構の発見～若年性糖尿病・日本人の健康寿命延伸法開発に期待～
    https://medibio.tiisys.com/75709/This link will open in a new window
  7. L-Arginine prevents cereblon-mediated ubiquitination of glucokinase and stimulates glucose-6-phosphate production in pancreatic β-cells https://www.semanticscholar.org/paper/L-Arginine-prevents-cereblon-mediated-of-and-in-Cho-Horikawa/9f3d8f06281bf88fb1841b8aa07e78b4a158a5bfThis link will open in a new window
  8. L-Arginine prevents cereblon-mediated ubiquitination of glucokinase and stimulates glucose-6-phosphate production in pancreatic β-cells https://www.newsbreak.com/news/2056921698682/l-arginine-prevents-cereblon-mediated-ubiquitination-of-glucokinase-and-stimulates-glucose-6-phosphate-production-in-pancreatic-cellsThis link will open in a new window
  9. 東京医科大学ケミカルバイオロジー講座の半田宏特任教授が参画する共同研究グループが、新しいインスリン分泌促進機構を発見 －若年性糖尿病・日本人の健康寿命延伸法開発に期待－ https://www.tokyo-med.ac.jp/news/2020/0909_121642002477.htmlThis link will open in a new window https://www.tokyo-med.ac.jp/news/20200909pressrelease.pdfThis link will open in a new window

 

  1. Cho J, Horikawa Y, Oiwa Y, Hoshomichi K, Yabe D, Imai T. Glucokinase Variant Proteins Are Resistant to Fasting-Induced Uridine Diphosphate Glucose-Dependent Degradation in Maturity-Onset Diabetes of the Young Type 2 Patients. Int. J. Mol. Sci. 2023, 24,15842; IF=6.208 https://doi.org/10.3390/ijms242115842このリンクは別ウィンドウで開きます
  2. Cho J, Miyagawa A, Yamaguchi K, Abe W, Tsugawa Y, Yamamura H & Imai T. UDP-glucose, cereblon-dependent proinsulin degrader. Scientific Reports IF=4.996, vol 12, Article number: 14568 (2022). https://www.nature.com/articles/s41598-022-18902-5このリンクは別ウィンドウで開きます
  3. Cho J, Miyagawa A, Yamaguchi K, Abe W, Tsugawa Y, Yamamura H, and Imai T*. UDP-Glucose: A Cereblon-Dependent Glucokinase Protein Degrader. Int. J. Mol. Sci. 2022, 23(16), 9094; IF=6.208, DOI: https://doi.org/10.3390/ijms23169094, https://www.mdpi.com/1422-0067/23/16/9094このリンクは別ウィンドウで開きます
  4. Cho J, Tsugawa Y, and Imai T*.
    R1526 residue in arginine/proinsulin binding domain of UGGT1 is involved in proinsulin binding. Biochemical and Biophysical Research Communications, 615: 131-135, IF3.575 (2022). PMID: 32423812, PMCID: PMC7863631, NIHMSID: NIHMS1661560, DOI: 10.1016/j.bbrc.2022.05.060, https://www.sciencedirect.com/science/article/abs/pii/S0006291X22007653This link will open in a new window
  5. Cho J, Tsugawa Y, Imai Y, and Imai T*. Chorionic gonadotropin stimulates maternal hepatocyte proliferation during pregnancy. Biochemical and Biophysical Research Communications, 579: 110-115, IF3.575 (2021)., PMID: 34597993, PMCID: PMC8568302 DOI:10.1016/j.bbrc.2021.09.039, https://doi.org/10.1016/j.bbrc.2021.09.039This link will open in a new window
  6. Cho J, Horikawa Y, Enya M, Takeda J, Imai Y, Imai Y, Handa H, Imai T*.
    L-Arginine prevents cereblon-mediated ubiquitination of glucokinase and stimulates glucose-6-phosphate production in pancreatic β-cells
    Communications Biology volume 3, Article number: 497 (2020), https://doi.org/10.1038/s42003-020-01226-3, IF=6.548 (2021)
    ​https://www.nature.com/articles/s42003-020-01226-3This link will open in a new window
  7. Cho J, Hiramoto M, Masaike Y, Sakamoto S, Imai Y, ImaiY, Handa H, Imai T*.
    UGGT1 retains proinsulin in the endoplasmic reticulum in an arginine dependent manner 
    Biochem Biophys Res Commun 527(3):668-675, 2020
    doi: 10.1016/j.bbrc.2020.04.158
  8. Tsugawa Y, Natori M, Handa H, and Imai T*.
    Estradiol accelerates liver regeneration through estrogen receptor α
    Clinical and Experimental Gastroenterology Volume12, 331-336, 2019
    https://doi.org/10.2147/CEG.S214196This link will open in a new window
  9. Tsugawa Y, Handa H, and Imai T*.
    Arginine induces IGF-1 secretion from the endoplasmic reticulum 
    Biochem Biophys Res Commun Volume 514 (4), 1128-1132 2019
    https://doi.org/10.1016/j.bbrc.2019.05.044This link will open in a new window
  10. Ando H, Sato T, Ito T, Yamamoto J, Sakamoto S, Nitta N, Asatsuma T, Shimizu N, Mizushima R, Aoki I, Imai T, Yamaguchi Y, Berk AJ, Handa H
    Cereblon control of zebrafish brain size by regulation of neural stem cell proliferation
    iScience 15, 95-108, 2019,
    PMID: 31055217 
    DOI: 10.1016/j.isci.2019.04.007
  11. Tsugawa Y, Hiramoto M, Imai T*.
    Estrogen induces Estrogen Receptor α expression and hepatocyte proliferation in the late pregnancy.
    Biochem Biophys Res Commun 511 (3), 592-596, 2019.
  12. Umeda M, Hiramoto M, Watanabe A, Tsunoda N, Imai T*.
    Arginine-induced insulin secretion in endoplasmic reticulum.
    Biochem Biophys Res Commun 466(4):717-722, 2015.
  13. Umeda M, Hiramoto M & Imai T*.
    Partial hepatectomy induces delayed hepatocyte proliferation and normal liver regeneration in ovariectomized mice.
    Clinical and Experimental Gastroenterology 2015 (8):175-182, 2015, 
    PMCID: PMC4494181
  14. Uebi T, Umeda M & Imai T*.
    Estrogen induces Estrogen Receptor alpha expression and hepatocyte proliferation in the livers of the male mice.
    Genes to Cells 20(3):217-223, 2015
    DOI: 10.1111/gtc.12214
  15. Umeda M, Uebi T, Maekawa N, Handa H & Imai T*.
    PGJIFs, new mitochondrial PGJ2 target proteins, regulate cell proliferation.
    J Biosciences & Medicines 1 (3):11-15, 2013.
    DOI: 10.4236/jbm.2013.13003
  16. Umeda M, Uebi T, Maekawa N, Isaki M, Miyama Y, Masaike Y, Handa H & Imai T*.
    Effective Cofactor Complex Purification using Nanobeads
    J Biosciences & Medicines 1 (3):5-10, 2013.
    DOI: 10.4236/jbm.2013.13002
  17. Uebi T, Umeda M, Maekawa N, Karasawa S, Handa H & Imai T*.
    Prohibitins, novel vitamin K2 target factors in osteoblast
    J Biosciences & Medicines, 1 (3):1-4, 2013.
    DOI: 10.4236/jbm.2013.13001
  18. Enomoto T, Kawano M, Fukuda H, Sawada W, Inoue T, Haw K, Kita Y, Sakamoto S, Yamaguchi Y, Imai T, Hatakeyama M, Saito S, Sandhu A, Matsui M, Aoki I, Handa H.
    Viral Protein-Coated Magnetic Nanoparticles for in vivo Tumor-Targeting MR Imaging.
    J Biotechnol 167 (1):8-15, 2013.
    https://doi.org/10.1016/j.jbiotec.2013.06.005This link will open in a new window
  19. Imai T*.
    Adipogenesis and osteoblastgenesis in aging
    Adipocyte: signaling pathways, molecular regulation and impact on human disease. pp95-108. Nova Science Publishers Inc, New York.
  20. Tange S, Zhou Y, Nagakui-Noguchi Y, Imai T & Nakanishi A.
    Initiation of human astrovirus type 1 infection was blocked by inhibitors of phosphoinositide 3-kinase
    Virol J 10:153-166, 2013
  21. Hotta K, Nashimoto A, Yasumura E, Suzuki M, Azuma M, Shima D, Nabeshima R, Hiramoto M, Okada A, Sakata-Sogawa K, Tokunaga M, Ito T, Sakamoto S, Kabe Y, Aizawa S, Imai T, Yamaguchi Y, Watanabe H & Handa H.
    Vesnarinone suppresses TNFa mRNA expression by inhibiting valosin-containing proteins.
    Mol Pharm 83(5):930-938, 2013.
    PMID: 23393163 DOI: 10.1124/mol.112.081935
  22. Karasawa S, Azuma M, Kasama T, Sakamoto S, Kabe Y, Imai T, Yamaguchi Y, Miyazawa K & Handa H.
    Vitamin K2 covalently binds to Bak and induces Bak-mediated apoptosis.
    Mol Pharm 83 (3):613-620, 2013.
    PMID: 23229512 DOI: 10.1124/mol.112.082602
  23. Tange S, Imai T, Nakanishi A.
    An SV40 mutant defective in VP4 expression exhibits a temperature-sensitive growth defect.
    Virus Res 157 (1):116-120, 2011.
    https://doi.org/10.1016/j.virusres.2011.02.001This link will open in a new window
  24. Maekawa N, Hiramoto M, Sakamoto S, Ikeda M, Naitou M, Acharya HP, Kobayashi Y, Suematsu M, Handa H & Imai T*.
    High performance affinity chromatography method for identification of 15-deoxy-12,14-prostaglandin J2 interacting factors using magnetic nanobeads.
    Biomed Chromatogr 25 (4):466-471, 2011.
    http://dx.doi.org/10.1002/bmc.1469This link will open in a new window
  25. 高齢者住民における保有歯数と認知機能
    Association with the lipid and sugar metabolism parameters, the number of teeth and cognitive function in elderly population.
    今井剛、西永正典、中村知子、奥宮清人，松林公蔵、土居義典、松下健二
    愛知学院大学歯学会誌　第48巻59-66ページ2010年
  26. Hiramoto M, Maekawa N, Masaike Y, Kuge T, Ayabe F, Watanabe A, Masaike Y, Hatakeyama M, Handa H & Imai T*.
    High-performance affinity chromatography method for identification of L-arginine interacting factors using magnetic nanobeads.
    Biomed Chromatogr 24 (6):606-612, 2010.
    PMID 19810004
  27. 高齢者の残存歯数と認知機能との関連性
    今井剛、西永正典、松下健二
    鹿児島大学医学雑誌　第61巻47-51ページ2010年
  28. Chapellier B, Maekawa N, Hiramoto M, Imai T & Nakanishi A.
    Cell-type restricted gene delivery using polyomaviral vectors.
    J Gene Med 11:1156, 2009.
  29. Nakanishi A, Chapellier B, Maekawa N, Hiramoto M, Kuge T, Takahashi RU, Handa H & Imai T.
    SV40 vectors carrying minimal sequence of the viral origin with exchangeable capsid.
    Virology 379:110-117, 2008. 
    PMID 18667220
  30. Takahashi RU, Kanesashi SN, Inoue T, Enomoto T, Kawano MA, Tsukamoto H, Takeshita F, Imai T, Ochiya T, Kataoka K, Yamaguchi Y & Handa H.
    Presentation of functional foreign peptides on the surface of SV40 virus-like particles.
    J Biotechnol 135:385-392, 2008. 
    PMID 18588926
  31. Inoue T, Kawano MA, Takahashi RU, Tsukamoto H, Enomoto T, Imai T, Kataoka K & Handa H.
    Engineering of SV40-based nano-capsules for delivery of heterologous protein as fusions with the minor capsid proteins VP2/3.
    J Biotechnol 134:181-192, 2008. 
    PMID 18243389
  32. Tsukamoto H, Kawano M, Inoue T, Enomoto T, Takahashi R, Yokoyama N, Yamamoto N, Imai T, Kataoka K, Yamaguchi Y & Handa H.
    Evidence that SV40 VP1-DNA interactions contribute to the assembly of 40-nm spherical viral particles.
    Genes to Cell 12:1267-1279, 2007. (IF 3.299)
    PMID 17986010
  33. Yokoyama N, Kawano MA, Tsukamoto H, Enomoto T, Inoue T, Takahashi R, Nakanishi A, Imai T, Wada T & Handa H
    Mutational analysis of the carboxyl-terminal region of the SV40 major capsid protein VP1.
    J Biochem 141:279-286, 2007. 
    PMID 17283011
  34. 今井　剛
    健康寿命の延伸
    慶應医学、84、149−155、2007
  35. Kawano MA, Inoue T, Tsukamoto H, Takaya T, Enomoto T, Takahashi R, Yokoyama N, Yamamoto N, Nakanishi A, Imai T, Wada T, Kataoka K & Handa H.
    The VP2/VP3 minor capsid protein of SV40 promotes the in vitro assembly of the major capsid protein VP1 into particles.
    J Biol Chem 281:10164-10173, 2006. 
    PMID 16478732
  36. 今井　剛
    老化制御
    医療、60、29—32、2006

 

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  1. 日本人に多い2型糖尿病予防に効果 https://agaricus-med.jp/agarikusu/agarikusukatuyou2.phpこのリンクは別ウィンドウで開きます
  2. 新しいインスリン分泌促進機構を発見、若年性糖尿病の治療開発に期待－長寿研ほか Sept10/2020 @ QlifePro http://www.qlifepro.com/news/20200910/mody2.htmlこのリンクは別ウィンドウで開きます 
  3. Arginine-stimulated insulin secretion @ Pancreatic Cell News Volume 11.34 | Sep 8 2020. https://www.stemcellsciencenews.com/news_archive/pancreatic-cell-news-volume-11-34-sep-8-2020/このリンクは別ウィンドウで開きます
  4. June 30/2022 @ NIH National library. R1526 residue in arginine/proinsulin binding domain of UGGT1 is involved in proinsulin binding. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7863631/このリンクは別ウィンドウで開きます
  5. Nov 19/2022 @ NIH National library. Chorionic gonadotropin stimulates maternal hepatocyte proliferation during pregnancy. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568302/このリンクは別ウィンドウで開きます

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