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Center for Gerontology and Social Science

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Department of Epidemiology of Aging

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The Department of Epidemiology of Aging conducts the epidemiological study ”National Institute for Longevity Sciences - Longitudinal Study of Aging: NILS-LSA” to promote mental and physical independence of older adults. We also conduct multi-center collaborative investigations to contribute to geriatric disease prevention and healthy aging with research institutes inside and outside Japan.


  1.  Long-term longitudinal epidemiological study "National Institute for Longevity Sciences - Longitudinal Study of Aging (NILS-LSA)"

  2. Multi-center collaborative studies with NILS-LSA data

Longitudinal Study : NILS-LSA

National Institute for Longevity Sciences - Longitudinal Study of Aging (NILS-LSA)

The NILS-LSA is a longitudinal study to observe age-related changes among middle-aged and older community dwellers. This project has assessed the normal aging process using detailed questionnaires and medical checkups, anthropometrical measurements, physical fitness tests, nutritional examinations, and psychological examinations.

The initial survey of NILS-LSA involved 2,267 men and women aged 40 to 79 years, including approximately 300 men and 300 women for each decade of age. Participants included were gender- and age-stratified random samples living in Obu-shi and Higashiura-Cho, Aichi Prefecture, Japan. They have been followed up every 2 years from the first wave (November 1997 - April 2000), second wave (April 2000 - May 2002), third wave (May 2002 - May 2004), fourth wave (June 2004 - July 2006), fifth wave (July 2006 - July 2008), sixth wave (July 2008 - July 2010), seventh wave (July 2010 - July 2012), eighth wave (October 2013 - February 2016), and ninth wave (October 2018 - February 2022). The total length of the first through the ninth waves was 25 years. The tenth wave already started in February 2023. Also, the follow-up postal surveys were conducted in 2013, 2017 and 2022.

When participants could not be followed up (e.g., they moved to another area, dropped out for personal reasons, or died), new age- and sex-matched participants were randomly recruited from the second to the tenth wave. All study waves included nearly 1,200 men and 1,200 women.

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History of NILS-LSA

History of National Institute for Longevity Sciences Longitudinal Study of Aging (NILS-LSA)

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With the cooperation of various specialists, detailed survey data are being collected and analyzed across diverse disciplines related to geriatrics and gerontology including medical science, psychology, body composition, and nutrition.

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