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Research Institute


Center for Gerontology and Social Science

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Department of Epidemiology of Aging

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The Department of Epidemiology of Aging conducts the epidemiological study ”National Institute for Longevity Sciences - Longitudinal Study of Aging: NILS-LSA” to promote the mental and physical independence of older adults. We also conduct multi-center collaborative investigations to contribute to geriatric diseases prevention and healthy aging with research institutes inside and outside Japan.


  1.  Long-term longitudinal epidemiological study "National Institute for Longevity Sciences - Longitudinal Study of Aging (NILS-LSA)"

  2. Multi-center collaborative studies with NILS-LSA data

Longitudinal Study : NILS-LSA

National Institute for Longevity Sciences - Longitudinal Study of Aging (NILS-LSA)

The NILS-LSA is a longitudinal study to observe age-related changes among middle-aged and older community dwellers. In this project, the normal aging process has been being assessed using detailed questionnaires and medical checkups, anthropometrical measurements, physical fitness tests, nutritional examinations, and psychological examinations.

The initial survey of NILS-LSA involved 2,267 men and women aged 40 to 79 years, including approximately 300 men and 300 women for each decade. Participants included were gender- and age-stratified random samples living in Obu-shi and Higashiura-Cho, Aichi Prefecture, Japan. They have been followed up every 2 years from the first wave (November 1997 - April 2000), second study (April 2000 - May 2002), third wave (May 2002 - May 2004), fourth wave (June 2004 - July 2006), fifth wave (July 2006 - July 2008), sixth wave (July 2008 - July 2010), seventh wave (July 2010 - July 2012), eighth wave (October 2013 - February 2016), and ninth wave (October 2018 - ongoing). Follow-up postal surveys were also conducted twice in 2013 and 2017. The total length of the first through the eighth waves was 16 years.

When participants could not be followed up (e.g., they moved to another area, dropped out for personal reasons, or died), new age- and sex-matched participants were randomly recruited from the first to the seventh wave. All study waves included nearly 1200 men and 1200 women.

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History of NILS-LSA

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Published Data

Monograph: National Institute for Longevity Sciences - Longitudinal Study of Aging

■NILS-LSA - 1st Wave to 7th Wave -

■NILS-LSA "Brain and Mental Health Survey"

■Postal Survey

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With the cooperation of various specialists, detailed survey data are being collected and analyzed across diverse disciplines related to geriatrics and gerontology including medical science, psychology, body composition, and nutrition.

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