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Brain-Skeletal Muscle Connection in Aging Project Team

Welcome to our Brain-Skeletal Muscle Connection in Aging Project Team homepage

​News

  • April 22th, 2024 Updated the Members, Publications and Contact.
  • March 1st, 2023 Dr. Takahiro Eguchi has joined our team.
  • September 1st, 2022 Dr. Kiyoshi Yoshioka, Keiko Kabetani and Kazuko Otsuka has joined our team.
  • July 26th, 2022 Research on a new molecular mechanisms of frailty and sarocopenia has been published in Cell Reports.
  • July 1st, 2022 Brain-Skeletal Muscle Connection in Aging Project Team was launched.

 

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Our Research

Focusing on the functional linkage between the brain and skeletal muscle, we are engaged in research that will lead to the development of preventive and therapeutic interventions for sarcopenia. In particular, we are focusing on the NAD+ metabolism in the hypothalamus and skeletal muscle, and on its relationship to sarcopenia.

 

We will update soon.

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Members

Project leader Naoki Ito
Researcher Takahiro Eguchi
Visiting researcher Kiyoshi Yoshioka
Research assistant Keiko Kabetani
Research assistant Kazuko Otsuka

 

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Publications

2023

  1. Takumi Sugimoto, Chihiro Sakamaki, Tokushi Kimura, Takahiro Eguchi, Shinji Miura & Yasutomi Kamei Peroxisome Proliferator-activated receptor g coactivator 1a regulates downstream of tyrosine kinase-7 (Dok-7) expression important for neuromuscular junction formation. Scientific Reports. 14(1): 1780, 2024.

  2. Takahiro Eguchi, Tohru Tezuka, Yuji Watanabe, Akane Inoue-Yamauchi, Hiroshi Sagara, Manabu Ozawa, Yuji Yamanashi. Calcium-binding protein 7 expressed in muscle negatively regulates age-related degeneration of neuromuscular junctions in mice. iScience. 27(2): 108997, 2024.

 

2022

  1. Naoki Ito, Ai Takatsu, Hiromi Ito, Yuka Koike, Kiyoshi Yoshioka, Yasutomi Kamei & *Shin-ichiro Imai. Slc12a8 in the lateral hypothalamus maintains energy metabolisms and skeletal muscle functions during aging. Cell Reports. 40(4). 111131. 2022.

 

2021

  1. *Haruko Watanabe-Takano, Hiroki Ochi, Ayano Chiba, Ayaka Matsuo, Yugo Kanai, Shigetomo Fukuhara, Naoki Ito, Keisuke Sako, Takahiro Miyazaki, Kazuki Tainaka, Ichiro Harada, Shingo Sato, Yasuhiro Sawada, Naoto Minamino, Shu Takeda, Hiroki R. Ueda, Akihiro Yasoda & *Naoki Mochizuki. Mechanical load regulates bone growth via periosteal Osteocrin. Cell Reports. 36(2). 109380. 2021.

  2. Risa Okada, Shin‑ichiro Fujita, Riku Suzuki, Takuto Hayashi, Hirona Tsubouchi, Chihiro Kato, Shunya Sadaki, Maho Kanai, Sayaka Fuseya, Yuri Inoue, Hyojung Jeon, Michito Hamada, Akihiro Kuno, Akiko Ishii, Akira Tamaoka, Jun Tanihata, Naoki Ito, Dai Shiba, Masaki Shirakawa, Masafumi Muratani, *Takashi Kudo & *Satoru Takahashi. Transcriptome analysis of gravitational effects on mouse skeletal muscles under microgravity and artificial 1 g onboard environment. Scientific reports. 11(1). Article number: 9168. 2021.

  3. Naoki Ito, Yuko Miyagoe-Suzuki, *Shin’ichi Takeda, *Akira Kudo. Periostin Is Required for the Maintenance of Muscle Fibers during Muscle Regeneration. International Journal of Molecular Sciences. 22(7). 3627. 2021.

 

2018

  1. *Naoki Ito, Shinobu Seki, Fumitaka Ueda. Effects of Composite Supplement Containing Collagen Peptide and Ornithine on Skin Conditions and Plasma IGF-1 Levels—A Randomized, Double-Blind, Placebo-Controlled Trial. Marine Drugs. 16(12). 482. 2018.

  2. *Naoki Ito, Urs T. Ruegg, *Shin’ichi Takeda. ATP-induced increase in intracellular calcium levels and subsequent activation of mTOR as regulators of skeletal muscle hypertrophy. International Journal of Molecular Sciences. 19(9). 2804. 2018.

  3. Jun Tanihata, Tetsuya Nagata, Naoki Ito, Takashi Saito, Akinori Nakamura, Susumu Minamisawa, Yoshitsugu Aoki, Urs Ruegg, *Shin’ichi Takeda. Truncated dystrophin ameliorates the dystrophic phenotype of mdx mice by reducing sarcolipin-mediated SERCA inhibition. Biochemical and Biophysical Research Communications. 505(1). 51-59. 2018.

  4. *Naoki Ito, Shinobu Seki, Fumitaka Ueda. The Protective Role of Astaxanthin for UV-Induced Skin Deterioration in Healthy People—A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 10(7). 817. 2018.

  5. *Naoki Ito, Hitomi Saito, Shinobu Seki, Fumitaka Ueda, Takashi Asada. Effects of composite supplement containing astaxanthin and sesamin on cognitive function in people with mild cognitive impairment: A randomized, double-blind, placebo-controlled trial. Journal of Alzheimer’s Diseases. 62(4). 1767-1775. 2018.

  6. *Ayano Imai, Yuriko Oda, Naoki Ito, Shinobu Seki, Kiyotaka Nakagawa, Teruo Miyazawa, Fumitaka Ueda. Effects of Dietary Supplementation of Astaxanthin and Sesamin on Daily Fatigue: A Randomized, Double-Blind, Placebo-Controlled, Two-Way Crossover Study. Nutrients. 10(3). 281. 2018.

 

2017

  1. Naoki Ito, Isao Kii, Noriaki Shimizu, Hirotoshi Tanaka, *Shin’ichi Takeda. Direct reprogramming of fibroblasts into skeletal muscle progenitor cells by transcription factors enriched in undifferentiated subpopulation of satellite cells. Scientific reports. 7(1). Article number: 8097. 2017.

  2. *Yoshitsugu Aoki, Raquel Manzano, Yi Lee, Ruxandra Dafinca, Misako Aoki, Andrew G. L. Douglas, Miguel A. Varela, Chaitra Sathyaprakash, Jakub Scaber, Paola Barbagallo, Pieter Vader, Imre Mäger, Kariem Ezzat, Martin R. Turner, Naoki Ito, Samanta Gasco, Norihiko Ohbayashi, Samir El Andaloussi, Shin’ichi Takeda, Mitsunori Fukuda, Kevin Talbot, *Matthew J. A. Wood. C9orf72 and RAB7L1 regulate vesicle trafficking in amyotrophic lateral sclerosis and frontotemporal dementia. Brain. 140(4). 887-897. 2017.

 

2016

  1. Naoki Ito, Shimizu Noriaki, Hirotoshi Tanaka, *Shin’ichi Takeda. Enhancement of satellite cell transplantation efficiency by leukemia inhibitory factor. Journal of Neuromuscular Diseases. 3(2). 201-207. 2016.

  2. Miki Shimbo, *Takashi Kudo, Michito Hamada, Hyojung Jeon, Yuki Imamura, Keigo Asano, Risa Okada, Yuki Tsunakawa, Seiya Mizuno, Ken-ichi Yagami, Chihiro Ishikawa, Haiyan Li, Takashi Shiga, Junji Ishida, Juri Hamada, Kazuya Murata, Tomohiro Ishimaru, Misuzu Hashimoto, Akiyoshi Fukamizu, Mutsumi Yamane, Masahito Ikawa, Hironobu Morita, Masahiro Shinohara, Hiroshi Asahara, Taishin Akiyama, Nobuko Akiyama, Hiroki Sasanuma, Nobuaki Yoshida, Rui Zhou, Ying-Ying Wang, Taito Ito, Yuko Kokubu, Taka-aki K. Noguchi, Hisako Ishimine, Akira Kurisaki, Dai Shiba, Hiroyasu Mizuno, Masaki Shirakawa, Naoki Ito, Shin’ichi Takeda, *Satoru Takahashi. Ground-based assessment of JAXA mouse habitat cage unit by mouse phenotypic studies. Experimental Animals. 65(2). 175-187. 2016.

 

2015

  1. Kana Ishii, Nobuharu Suzuki, Yo Mabuchi, Naoki Ito, So-ichiro Fukada, Hideyuki Okano, Shin’ichi Takeda, *Chihiro Akazawa. Muscle Satellite Cell Protein Teneurin-4 Regulates Differentiation during Muscle Regeneration. Stem Cells. 33(10). 3017-3027. 2015.

  2. Nozomi Hayashiji, *Shinsuke Yuasa, Yuko Miyagoe-Suzuki, Mie Hara, Naoki Ito, Hisayuki Hashimoto, Dai Kusumoto, Tomohisa Seki, Shugo Tohyama, Masaki Kodaira, Akira Kunitomi, Shin Kashimura, Makoto Takei, Yuki Saito, Shinichiro Okata, Toru Egashira, Jin Endo, Toshikuni Sasaoka, Shin’ichi Takeda, Keiichi Fukuda. G-CSF supports long-term muscle regeneration in mouse models of muscular dystrophy. Nature Communications. 6. 6745. 2015.

  3. Noriaki Shimizu, Takako Maruyama, Noritada Yoshikawa, Ryo Matsumiya, Yanxia Ma, Naoki Ito, Yuki Tasaka, Akiko Kuribara-Souta, Keishi Miyata, Yuichi Oike, Stefan Berger, Gunther Schutz, Shin’ichi Takeda, *Hirotoshi Tanaka. A muscle-liver-fat signalling axis is essential for central control of adaptive adipose remodelling. Nature Communications. 6. 6693. 2015.

  4. Janek Hyzewicz, Jun Tanihata, Mutsuki Kuraoka, Naoki Ito, Yuko Miyagoe-Suzuki, *Shin’ichi Takeda. Low intensity training of mdx mice reduces carbonylation and increases expression levels of proteins involved in energy metabolism and muscle contraction. Free Radical Biology & Medicine. 82. 122-136. 2015.

 

2013

  1. Naoki Ito, Urs T. Ruegg, Akira Kudo, Yuko Miyagoe-Suzuki, *Shin’ichi Takeda. Capsaicin mimics mechanical load-induced intracellular signaling events: Involvement of TRPV1-mediated calcium signaling in induction of skeletal muscle hypertrophy. Channels. 7(3). 221-224. 2013.

  2. Naoki Ito, Urs T. Ruegg, Akira Kudo, Yuko Miyagoe-Suzuki, *Shin’ichi Takeda. Activation of calcium signaling through Trpv1 by nNOS and peroxynitrite as a key trigger of skeletal muscle hypertrophy. Nature Medicine. 19(1). 101-106. 2013.

 

2011

  1. Bo Wang, Yuko Miyagoe-Suzuki, Erica Yada, Naoki Ito, Takashi Nishiyama, Miho Nakamura, Yusuke Ono, Norio Motohashi, Makoto Segawa, Satoru Masuda, *Shin’ichi Takeda. Reprogramming efficiency and quality of induced Pluripotent Stem Cells (iPSCs) generated from muscle-derived fibroblasts of mdx mice at different ages. PLoS Currents. 3. RRN1274. 2011.

  2. Hideya Mizuno, Akinori Nakamura, Yoshitsugu Aoki, Naoki Ito, Soichiro Kishi, Kazuhiro Yamamoto, Masayuki Sekiguchi, Shin’ichi Takeda, *Kazuo Hashido. Identification of Muscle-Specific MicroRNAs in Serum of Muscular Dystrophy Animal Models Promising Novel Blood-Based Markers for Muscular Dystrophy. PLoS One. 6(3). e18388. 2011.

  3. Noriaki Shimizu, Noritada Yoshikawa, Naoki Ito, Takako Maruyama, Yuko Suzuki, Sin-ichi Takeda, Jun Nakae, Yusuke Tagata, Shinobu Nishitani, Kenji Takehana, Motoaki Sano, Keiichi Fukuda, Makoto Suematsu, Chikao Morimoto, *Hirotoshi Tanaka. Crosstalk between glucocorticoid receptor and nutritional sensor mTOR in skeletal muscle. Cell Metabolism. 13(2). 170-182. 2011.

  4. Masahiro Fukaya, Akifumi Kamata, Yoshinobu Hara, Hideaki Tamaki, Osamu Katsumata, Naoki Ito, Shin’ichi Takeda, Yutaka Hata, Tatsuo Suzuki, Masahiko Watanabe, Robert J. Harvey, *Hiroyuki Sakagami. SynArfGEF is a guanine nucleotide exchange factor for Arf6 and localizes preferentially at post-synaptic specializations of inhibitory synapses. Journal of Neurochemistry. 116(6). 1122-1137. 2011.

 

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Recruitment

Update soon.

 

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Contact

Naoki Ito Ph.D

National Center for Geriatrics and Gerontology, Geroscience research center

Brain-Skeletal Muscle Connection in Aging Project Team

Project leader

〒474-8511 7-430, Morioka-cho, Obu-si, Aichi-ken, Japan

Tel: 0562-44-5651 Ext: 7594 (Phone), 6508 (Lab)

E-mail: naoki.ito at ncgg.go.jp

 

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