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Aging is closely related to abnormalities in adaptation to various environmental stresses such as DNA damage response, redox response to oxidative stress, inflammatory stress response to tissue damage, endoplasmic reticulum stress response, mitochondrial stress response, etc. In order to understand the aging mechanism, it is extremely important to elucidate changes of these various response mechanisms during aging process. It is also significant in aging research to understand how these aging stress response mechanisms protect or damage cells and tissues at the molecular level. The research project team especially focuses on mitochondria, which are the core organelles of energy metabolism and reactive oxygen species, and aims to elucidate the mechanism of mitochondrial stress response based on mitochondrial dysfunction. We are also studying the molecular mechanism that leads to signal transmission from mitochondria to the nucleus and epigenetics regulation during aging and age-related diseases.
Project Leader | Takahiko Shimizu |
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Research Fellow | Shuichi Shibuya |
Kenji Watanabe | |
Research Assistant | Masahiro Kamijyo |
Rina Yamamoto | |
Visiting Researcher | Akira Shimamoto |
Hidetoshi Nojiri | |
Sunao Takeshita | |
Kazuma Murakami |