Male and female mice:
C57BL/6NCrSlc
C57BL/6J
Male and female rats:
RccHan:Wistar
F344/NSlc
Slc:SD
National Center for Geriatrics and Gerontology (NCGG) provides male and female mice C57BL/6J and C57BL/6NCrSlc, and rats RccHan:WIST, F344/NSlc, and SLc:SD.
Rush orders can be completed in as little as 48 hours. The mice and rats are available from 18 to 24 months. Other ages are available if young control animals breed in the same conditions are necessary; please contact us for more information.
The animal preparation includes:
The NCGG aging farm program also provides physiological, behavioral, biochemical, and serological data on our animals. It is possible to breed the animals in the NCGG facilities and conduct experiments in the center through an inter-center collaboration program. For more details, please contact us.
Thanks to the NCGG aging farm program, we can supply animals kept in our facilities, saving researchers time and money and thus facilitating research. Physiological and anatomical changes similar to humans were observed in aged mice and rats from 18 months of age. Therefore, keeping the animals for about two years is necessary for geriatrics and gerontological experiments. NCGG breeds naturally aged mice and rats for gerontology and geriatrics research. The center has been providing research animals for researchers of our center for about 30 years, and from the end of 2022, for external research. Researchers reduce breeding costs, with animals of all ages available, healthy, and ready for research.
The NCGG saves valuable time and resources. The NCGG, under its Aging Farm program, not only provides mice (C57BL/6N and C57B/6J) and aged rats F344/NSlc, RccHan:Wistar, and Slc:SD. But also provides useful phenotypic information about the various strains before supplementing animals:
Animals are individually checked daily, with changes in behavior, stereotypes, and feeding disorders. Our team of researchers studies the optimal conditions to reduce stress in our animals through different breeding strategies. Other types of enrichment, larger cage sizes, and reduction of group size are some strategies that our researchers use in animals with high stress levels or aggressiveness.
A veterinarian observes, monitors, and analyses the health status of the animals. The stress and pathology produced by fights or stereotypes negatively influence the state of health of aging animals, increasing the incidence of specific pathologies (renal amyloidosis, pituitary disorders, etc.). For this reason, our team specializes in maintaining a high health state for young animals.
Changes in body temperature of two strains of mice with aging (Mean ± SD) (C57BL/6J (B6J) and C57BL/6NCrSlc (B6N)).
Changes in food (A) and water (B) intakes by two strains of mice with aging (Mean ± SD)(C57BL/6J (B6J) and C57BL/6NCrSlc (B6N)).
Body weights and survival rates of three rat strains. The body weight of rats at the indicated ages was measured (Mean ± SD) (n=30/age). Kaplan-Meier survival curves estimated over the lifespan by strain. (n=100-150/age).
Food and water consumption of the three strains was calculated by measuring the consumption per cage for one week. (Mean ± SD) (n=30/age).
Red Blood Cell counts of three rat strains (Mean ± SD) (n=10-15/age). Different letters indicate significant differences between ages (P ≤0.05) (Steel’s test). All age groups were compared for age-related changes.
White blood cell counts of three rat strains (Mean ± SD) (n=10-15/age). Different letters indicate significant differences between ages (P ≤0.05) (Steel’s test). All age groups were compared for age-related changes.
Percentage of lymphocytes and other leukocytes in three rat strains (Mean ± SD) (n=10-15/age). Different letters indicate significant differences between ages (P ≤0.05) (Steel’s test). All age groups were compared for age-related changes.
National Center for Geriatrics and Gerontology
Laboratory of Experimental Animals
474-8511 Prefecture of Aichi Obu City Morioka-cho 7-430 Japan