ホーム > Research > Center > Center for Development of Advanced Medicine for Dementia > Department > Neurogenetics
Our goal is to understand the pathogenesis of Alzheimer's disease through the analyses of the various cellular and animal models of the disease, leading to the development of novel diagnostic, preventive and therapeutic measures.
The goals of our reserch are to elucidate molecular mechanisms underlying the pathogenesis of Alzheimer's disease (AD) and to identify novel risk factors and therapeutic targets for AD.
Koichi M. Iijima, Ph.D.
Michiko Sekiya, Ph.D.
Yasufumi Sakakibara, Ph.D.
Yu Hirota, Ph.D.
Kyoko Ibaraki, Ph.D.
Jingwei Shang, Ph.D.
Kimi Takei, B.S.
Sachie Chikamatsu, M.S.
Yoko Tsubokawa, M.S.
Risa Nishijima, M.S.
Naoko Muraki, B.S.
Risa Yamashiro, M.S.
Sachie Chikamatsu, M.S.
Takashi Saitoh, Ph.D.
Tetsuya Kimura, Ph.D.
Xiuming Quan, Ph.D.
Corporate reserchers (2)
Shingo Koinuma, Ph.D.
Shohei Shibamoto, M.S.
Ken Okada, Ph.D.
Nobuyuki Kimura, Ph.D.
Sayuri Asai
Yukako Tsuchiya, M.S
The goals of our research are to elucidate mechanisms underlying the pathogenesis of Alzheimer's disease and develop disease modifying therapies.
48. Sakakibara, Y., Hirota, Y., Ibaraki, K., Takei, K., Chikamatsu, S., Tsubokawa, Y., Saito, T., Saido, T.C., Sekiya, M., Iijima, K.M. (2021) Widespread Reduced Density of Noradrenergic Locus Coeruleus Axons in the App Knock-In Mouse Model of Amyloid-β Amyloidosis. J Alzheimers Dis, doi: 10.3233.
47. Sekiya, M., Iijima, KM. (2021) Phenotypic Analysis of a Transgenic Drosophila Model of Alzheimer’s Amyloid-β Toxicity. STAR Protocols, 2(2), 100501.
46. Oka, M., Suzuki, E., Asada, A., Saito, T., Iijima, KM., Ando, K. (2021) Increasing neuronal glucose uptake attenuates brain aging and promotes lifespan in Drosophila. iScience, Volume 24, Issue 1, 22 January 2021, 101979
45. Wang, M.*, Li, A.*, Sekiya, M.*, Beckmann, ND.*, Quan, X.*, Schrode, N., Fernando, MB., Yu, A., Zhu, L., Cao, J., Lyu, L., Horgusluoglu, E., Wang, Q., Guo, L., Wang, YS., Neff, R., Song, WM., Wang E., Shen, Q., Zhou, X., Ming, C., Ho, SM., Vatansever, S., Kaniskan, H.Ü, Jin, J., Zhou, MM., Ando, K., Ho, L., Slesinger, PA., Yue, Z., Zhu, J., Katsel, P., Gandy, S., Ehrlich, ME., Fossati, V., Noggle S., Cai D., Haroutunian, V., Iijima, KM.#, Schadt, E.#, Brennand, KJ.# and Zhang, B.# (2021) Transformative Network Modeling of Multi-Omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer's Disease. Neuron, Volume 109, Issue 2, 20 January 2021, Pages 257-272.e14, *First author, #Senior author.
44. Oba, T, Saito, T, Asada, A, Shimizu, S, Iijima, KM, Ando, K. (2020) Microtubule Affinity Regulating Kinase 4 with an Alzheimer disease-related mutation promotes tau accumulation and exacerbates neurodegeneration
J Biol Chem. Dec 11;295(50):17138-17147. doi: 10.1074/jbc.RA120.014420. Epub 2020 Oct 5. PMID: 33020179
43. Kikuchi, M., Sekiya, M., Hara, N., Miyashita, A., Kuwano, R., Ikeuchi, T., Iijima, K.M., Nakaya, A. (2020) Disruption of a RAC1-centred network is associated with Alzheimer’s disease pathology and causes age-dependent neurodegeneration Hum. Mol. Genet., 2020 Mar 27;29(5):817-833. doi: 10.1093/hmg/ddz320.
42. Saito, T., Oba, T., Shimizu, S., Asada, A., Iijima, K.M. & Ando, K. (2019) Cdk5 increases MARK4 activity and augments pathological tau accumulation and toxicity through tau phosphorylation at Ser262. Hum. Mol. Genet., 28(18):3062-3071. doi: 10.1093/hmg/ddz120.
41. 飯島浩一 (2019) アルツハイマー病の治療法確立に向けた基礎研究の展望, 日本医事新報・特集・医療の近未来予想図, No.4958 p.18
40. Sakakibara, Y., Sekiya, M., Saito, T., Saido, T.C. & Iijima, K.M. (2019) Amyloid-β plaque formation and reactive gliosis are required for induction of cognitive deficits in App knock-in mouse models of Alzheimer's disease. BMC Neurosci., 2019 Mar 20;20(1):13. doi: 10.1186/s12868-019-0496-6.
39. Chiku, T., Hayashishita, M., Saito, T., Oka, M., Shinno, K., Ohtake, Y., Shimizu, S., Asada, A., Hisanaga, S., Iijima, K.M., & Ando, K. (2018) S6K/p70S6K1 protects against tau-mediated neurodegeneration by decreasing the level of tau phosphorylated at Ser262 in a Drosophila model of tauopathy. Neurobiol Aging., 2018 Nov;71:255-264. doi: 10.1016/j.neurobiolaging.2018.07.021. Epub 2018 Aug 3.
38. Sakakibara, Y., Sekiya, M., Saito, T., Saido, T.C. & Iijima, K.M. (2018) Cognitive and emotional alterations in App knock-in mouse models of Aβ amyloidosis. BMC Neurosci., 2018 Jul 28;19(1):46. doi: 10.1186/s12868-018-0446-8.
37. 飯島浩一，関谷倫子 (2018) アルツハイマー病の発症機序研究〜TREM2/TYROBPから見えてきたアルツハイマー病発症機序〜 Animus 2018 No.96 p.13-17
36. Sekiya, M.*, Wang, M.*, Fujisaki, N., Sakakibara, Y., Quan, X., Ehrlich, M.E., De Jager, P.L., Bennett, D.A., Schadt, E.E., Gandy, S., Ando, K., Zhang, B., & Iijima, K.M. (2018) Integrated biology approach reveals molecular and pahological interactions among Alzheimer's Aβ42, Tau, TREM2, and TYROBP in Drosophilamodels. Genome Med., 2018 Mar29;10(1):26., *Co-first authors
35. Sakakibara, Y.*, Sekiya, M.*, Fujisaki, N., Quan, X., & Iijima, K.M. (2018) Knockdown of wfs1, a fly homolog of Wolfram syndrome 1, in the nervous system increases susceptibility to age- and stress-induced neuronal dysfunction and degeneration in Drosophila. PLOS Genetics, 14(1): e1007196., *Co-first authors
34. Satoh, A. & Iijima, K.M. (2018) Roles of tau pathology in the locus coeruleus (LC) in age-associated pathophysiology and Alzheimer’s disease pathogenesis. (Review) Brain Research, 2017 Dec 21. pii: S0006-8993(17)30562-0. doi: 10.1016/j.brainres.2017.12.027
33. Sekiya, M., Maruko-Otake, A., Hearn, S., Fujisaki, N., Sakakibara, Y., Suzuki, E., Ando, K. & Iijima, K.M. (2017) EDEM function in ERAD protects against chronic ER proteinopathy and age-related physiological decline in Drosophila. Developmental Cell, 41 (6) 652-664. e5, 19 June 2017
32. Oka, M., Fujisaki, N.,Maruko-Otake, A., Ohtake, Y., Shimizu, S., Saitoh T., Hisanaga, S., Iijima, K.M. & Ando, K. (2017) Ca2+/calmodulin-dependent protein kinase II promotes neurodegeneration caused by tau phosphorylated at Ser262/356 in a transgenic Drosophila model of tauopathy. J. Biochem., DOI: https://doi.org/10.1093/jb/mvx038
31. 岡未来子, 飯島浩一, 安藤香奈絵 (2017) 神経細胞内のミトコンドリア局在異常と認知症, 実験医学, 認知症: 発症前治療のために解明すべき分子病態は何か？, Vol. 35, No.12, p182-p185
30. Ando, K., Oka, M., Ohtake, M., Hayashishita, M., Shimizu,S., Hisanaga, S. & Iijima, K.M. (2016) Tau phosphorylation at Alzheimer's disease-related Ser356 contributes to tau stabilization when PAR-1/MARK activity is elevated. Biochem Biophys Res Commun, 478(2):929-34. doi:10.1016/j.bbrc.2016.08.053. Epub 2016 Aug 9
29. 関谷倫子，飯島浩一 (2016) 統合生物学的手法によるアルツハイマー型神経細胞死の機序解明とその抑止法, Dementia Japan, 30巻, 2号, 246-256
28. Ando, K., Maruko-Otake, A., Otake, Y., Sekiya, M. & Iijima, K.M. (2016) Stabilization of microtubule-unbound tau via tau phosphorylation at Ser262/356 by Par-1/MARK contributes to augmentation of AD-related phosphorylation and Aβ42-induced tau toxicity. PLOS Genetics, 12(3): e1005917
27. 関谷倫子, 飯島浩一 (2016) システム生物学を用いてアルツハイマー病を遺伝子ネットワークから読み解く(総説), ファルマシア, Vol. 52 No. 2, p121-126
26. Ando, K., Suzuki E. Hearn, A., Sekiya, M., Maruko-Otake, A. & Iijima, K.M. (2015) Electron microscopy of the brains of Drosophila models of Alzheimer's disease, Neuromethods, Transmission Electron Microscopy Methods for Understanding the Brain, Springer, DOI 10.1007/7657_2015_75
25. Mendoza, J., Sekiya, M., Taniguchi, T., Iijima, M.K., Wang, R., and Ando, K. (2013) Global Analysis of Phosphorylation of Tau by the Checkpoint Kinases Chk1 and Chk2 in vitro, Journal of Proteome Research, 12(6):2654-65
24. Iijima-Ando, K., Sekiya, M., Maruko-Otake, A., Ohtake, Y., Suzuki, E., Lu, B., and Iijima, K.M. (2012) Loss of axonal mitochondria promotes tau-mediated neurodegeneration and Alzheimer's disease-related tau phosphorylation via PAR-1, PLOS Genetics, 8(8): e1002918
23. Iijima, K. and Iijima-Ando, K. (2011) Transgenic Drosophila models of Alzheimer's amyloid-beta 42 toxicity, Handbook of Animal Models in Alzheimer's Disease: G. Casadesus (Ed.), IOS Press., 89-106
22. Iijima, K., Gatt, A. and Iijima-Ando, K. (2010) Tau Ser262 phosphorylation is critical for Abeta42-induced tau toxicity in a transgenic Drosophila model of Alzheimer's disease, Hum. Mol. Genet., 19:2947-57. Epub 2010 May 12
21. Iijima-Ando, K., Zhao, L., Gatt, A., Shenton, C., and Iijima, K. (2010) A DNA damage-activated checkpoint kinase phosphorylates tau and enhances tau-induced neurodegeneration, Hum. Mol. Genet., 19: 1930-1938
20. Iijima, K., Zhao, L., Shenton, C., and Iijima-Ando, K. (2009) Regulation of energy stores and feeding by neuronal and peripheral CREB activity in Drosophila, PLOS ONE, 4(12): e8498
19. Iijima-Ando, K. and Iijima, K. (2009) Transgenic Drosophila models of Alzheimer's disease and tauopathies, (review article), Brain Struct. Funct., 214(2-3):245-62, Epub 2009 Dec 5
18. Iijima-Ando, K., Hearn, S.A., Shenton, C., Gatt, A., Zhao, L. and Iijima, K. (2009) Mitochondrial mislocalization underlies Abeta42-induced neuronal dysfunction in a Drosophila model of Alzheimer's disease, PLOS ONE, 4(12): e8310
17. Lee, K-S., Iijima-Ando, K., Iijima, K., Lee, W-J., Lee, J.H., Yu, K., and Lee, D-S. (2009) JNK/FOXO-mediated neuronal expression of fly homologue of Peroxiredoxin II reduces oxidative stress and extends lifespan in Drosophila, J. Biol. Chem., 284, 29454-61
16. Iijima, K., Iijima-Ando, K., and Zhong, Y. (2009) Drosophila model of Alzheimer's amyloidosis, Chapter 14, Handbook of Behavior Genetics, Springer
15. Chiang, H., Iijima, K., Hakker, I., and Zhong, Y. (2009) Distinctive roles of different beta-amyloid 42 aggregates in modulation of synaptic functions. FASEB J, 23(6):1969-77
14. Iijima, K., and Iijima-Ando, K. (2008) Drosophila models of Alzheimer amyloidosis; the challenge of dissecting the complex mechanisms of toxicity of amyloid-beta 42. (Review article) Journal of Alzheimer Disease, 15(4):523-40
13. Iijima-Ando, K., Hearn, S.A., Granger, L., Shenton, C., Gatt, A., Chiang, H.C., Hakker, I., Zhong, Y., and Iijima, K. (2008). Overexpression of Neprilysin Reduces Alzheimer Amyloid beta-42 (Abeta42)-induced Neuron Loss and Intraneuronal Abeta42 Deposits but Causes a Reduction in cAMP-responsive Element-binding Protein-mediated Transcription, Age-dependent Axon Pathology, and Premature Death in Drosophila. J. Biol. Chem. 283, 19066-19076
12. Iijima, K., Chiang, H. C., Hearn, S. A., Hakker, I., Gatt, A., Shenton, C., Granger, L., Leung, A., Iijima-Ando, K., and Zhong, Y. (2008) Abeta42 mutants with different aggregation profiles induce distinct pathologies in Drosophila. PLOS ONE 3, e1703
11. Sano, Y., Nakaya, T., Pedrini, S., Furukori, K., Iijima-Ando, K., Iijima, K., Mathews, P.M., Itohara, S., Gandy, S, and Suzuki, T. (2006) Physiological mouse brain amyloid-beta levels are not related to the phosphorylation state of threonine-668 of Alzheimer APP. PLOS ONE, 1, e51
10. Iijima-Ando, K., Wu, P., Drier, A., Iijima, K. & Yin, J.C.P. (2005) CREB and HSP70 additively suppress polyglutamine-induced toxicity in Drosophila. Proc. Natl. Acad. Sci. 102, 10261-6
9. Asaumi, M., Iijima, K., Sumioka, A.,Iijima-Ando, K., Kirino, Y., Nakaya, T. & Suzuki, T. (2005) Interaction of N-terminal acetyltransferase with the cytoplasmic domain of beta-amyloid precursor protein and its effect on Abeta secretion. J. Biochem. (Tokyo). 137(2):147-55
8. Iijima, K., Liu, H-P., Chiang, A-S., Hearn, S. A., Konsolaki, M. & Zhong, Y. (2004) Dissecting the pathological effects of human Abeta40 and Abeta42 in Drosophila: A potential model for Alzheimer disease. Proc. Natl. Acad. Sci. 101, 6623-6628
7. Taru, H., Iijima, K., Hase, M., Kirino, Y., Yagi, Y., & Suzuki, T. (2002) Interaction of Alzheimer beta-Amyloid Precursor Family Proteins with Scaffold Proteins of the JNK Signaling Cascade. J. Biol. Chem. 277, 20070-78
6. Ando, K., Iijima, K., Elliott, J.L., Kirino, Y., & Suzuki, T. (2001) Phosphorylation-dependent regulation on the interaction of amyloid precursor protein with Fe65 and the production of beta-amyloid. J. Biol. Chem. 276, 40353-61
5. Iijima, K., Ando, K., Takeda, S., Satoh, Y., Seki, T., Itohara, S., Greengard, P., Narin, A.C., Kirino, Y. & Suzuki, T. (2000). Neuron-specific phosphorylation of Alzheimer amyloid precursor protein by Cdk5. J. Neurochem. 75, 1085-91
4. Suzuki, T., Ando, K., Iijima, K., Oguchi, S., Takeda, S. (1999). Phosphorylation of Amyloid Precursor Protein (APP) Family Proteins. Alzheimer's Disease Methods and Protocols, Methods in Molecular Medicine, Vol 32, 271-282
3. Ando, K., Oishi, M., Takeda, S., Iijima, K., Isohara, T., Narin, A.C., Kirino, Y., Greengard, P., & Suzuki, T. (1999). Role of phosphorylation of Alzheimer amyloid precursor protein during neuronal differentiation. J Neurosci. 19, 4421-7
2. Watanabe,T., Sukegawa, J., Sukegawa, I., Tomita, S., Iijima, K., Oguchi, S., Suzuki, T., Nairn, A.C., & Greengard, P. (1999). A 127-kDa protein (UV-DDB) binds to the cytoplasmic domain of the Alzheimer amyloid precursor protein. J. Neurochem. 72, 549-56
1. Iijima, K, Lee, D.S., Okutsu, J., Tomita, S., Hirashima, N., Kirino, Y., & Suzuki, T. (1998) cDNA isolation of Alzheimer amyloid precursor protein from cholinergic nerve terminals of the electric organ of the electric ray. Biochem. J. 330, 29-33
34. Sakakibara, Y., Hirota, Y., Ibaraki, K., Takei, K., Chikamatsu, S., Tsubokawa, Y., Saito, T., Saido, T.C., Sekiya, M., Iijima, K.M. (2021) Widespread Reduced Density of Noradrenergic Locus Coeruleus Axons in the App Knock-In Mouse Model of Amyloid-β Amyloidosis. J Alzheimers Dis, doi: 10.3233.
33. Sekiya, M., Iijima, KM. (2021) Phenotypic Analysis of a Transgenic Drosophila Model of Alzheimer’s Amyloid-β Toxicity. STAR Protocols, 2(2), 100501.
32. Wang, M.*, Li, A.*, Sekiya, M.*, Beckmann, ND.*, Quan, X.*, Schrode, N., Fernando, MB., Yu, A., Zhu, L., Cao, J., Lyu, L., Horgusluoglu, E., Wang, Q., Guo, L., Wang, YS., Neff, R., Song, WM., Wang E., Shen, Q., Zhou, X., Ming, C., Ho, SM., Vatansever, S., Kaniskan, H.Ü, Jin, J., Zhou, MM., Ando, K., Ho, L., Slesinger, PA., Yue, Z., Zhu, J., Katsel, P., Gandy, S., Ehrlich, ME., Fossati, V., Noggle S., Cai D., Haroutunian, V., Iijima, KM.#, Schadt, E.#, Brennand, KJ.# and Zhang, B.# (2021) Transformative Network Modeling of Multi-Omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer's Disease. Neuron, Volume 109, Issue 2, 20 January 2021, Pages 257-272.e14, *First author, #Senior author.
31. Kikuchi, M., Sekiya, M., Hara, N., Miyashita, A., Kuwano, R., Ikeuchi, T., Iijima, K.M., Nakaya, A. (2020) Disruption of a RAC1-centred network is associated with Alzheimer’s disease pathology and causes age-dependent neurodegeneration Hum. Mol. Genet., 2020 Mar 27;29(5):817-833. doi: 10.1093/hmg/ddz320.
30. Sakakibara, Y., Sekiya, M., Saito, T., Saido, T.C. & Iijima, K.M. (2019) Amyloid-β plaque formation and reactive gliosis are required for induction of cognitive deficits in App knock-in mouse models of Alzheimer's disease. BMC Neurosci., 2019 Mar 20;20(1):13. doi: 10.1186/s12868-019-0496-6.
29. Sakakibara, Y., Sekiya, M., Saito, T., Saido, T.C. & Iijima, K.M. (2018) Cognitive and emotional alterations in App knock-in mouse models of Aβ amyloidosis. BMC Neurosci., 2018 Jul 28;19(1):46. doi: 10.1186/s12868-018-0446-8.
28. 飯島浩一，関谷倫子 (2018) アルツハイマー病の発症機序研究〜TREM2/TYROBPから見えてきたアルツハイマー病発症機序〜 Animus 2018 No.96 p.13-17
27. Sekiya, M.*, Wang, M.*, Fujisaki, N., Sakakibara, Y., Quan, X., Ehrlich, M.E., De Jager, P.L., Bennett, D.A., Schadt, E.E., Gandy, S., Ando, K., Zhang, B., & Iijima, K.M. (2018) Integrated biology approach reveals molecular and pahological interactions among Alzheimer's Aβ42, Tau, TREM2, and TYROBP in Drosophilamodels. Genome Med., 2018 Mar29;10(1):26., *Co-first authors
26. Sakakibara, Y.*, Sekiya, M.*, Fujisaki, N., Quan, X., & Iijima, K.M. (2018) Knockdown of wfs1, a fly homolog of Wolfram syndrome 1, in the nervous system increases susceptibility to age- and stress-induced neuronal dysfunction and degeneration in Drosophila. PLOS Genetics, 14(1): e1007196., *Co-first authors
25. Sekiya, M., Maruko-Otake, A., Hearn, S., Fujisaki, N., Sakakibara, Y., Suzuki, E., Ando, K. & Iijima, K.M. (2017) EDEM function in ERAD protects against chronic ER proteinopathy and age-related physiological decline in Drosophila. Developmental Cell, 41 (6) 652-664. e5, 19 June 2017
24. 関谷倫子，飯島浩一 (2016) 統合生物学的手法によるアルツハイマー型神経細胞死の機序解明とその抑止法, Dementia Japan, 30巻, 2号, 246-256
23. Ando, K., Maruko-Otake, A., Otake, Y., Sekiya, M. & Iijima, K.M. (2016) Stabilization of microtubule-unbound tau via tau phosphorylation at Ser262/356 by Par-1/MARK contributes to augmentation of AD-related phosphorylation and Aβ42-induced tau toxicity. PLOS Genetics, 12(3): e1005917
22. 関谷倫子, 飯島浩一 (2016) システム生物学を用いてアルツハイマー病を遺伝子ネットワークから読み解く(総説), ファルマシア, Vol. 52 No. 2, p121-126
21. Ando, K., Suzuki E. Hearn, A., Sekiya, M., Maruko-Otake, A. & Iijima, K.M. (2015) Electron microscopy of the brains of Drosophila models of Alzheimer's disease, Neuromethods, Transmission Electron Microscopy Methods for Understanding the Brain, Springer, DOI 10.1007/7657_2015_75
20. Mendoza, J., Sekiya, M., Taniguchi, T., Iijima, M.K., Wang, R., and Ando, K. (2013) Global Analysis of Phosphorylation of Tau by the Checkpoint Kinases Chk1 and Chk2 in vitro, Journal of Proteome Research, 12(6):2654-65
19. Ichiyanagi, T., Kashiwada, Y., Shida, Y., Sekiya, M., Hatano, Y., Takaishi, Y., and Ikeshiro, Y. (2013). Structural elucidation and biological fate of two glucuronyl metabolites of pelargonidin 3-O-beta-D-glucopyranoside in rats. Journal of agricultural and food chemistry 61, 569-578.
18. Iijima-Ando, K., Sekiya, M., Maruko-Otake, A., Ohtake, Y., Suzuki, E., Lu, B., and Iijima, K.M. (2012) Loss of axonal mitochondria promotes tau-mediated neurodegeneration and Alzheimer's disease-related tau phosphorylation via PAR-1, PLOS Genetics, 8(8): e1002918
17. Xiong, J., Taniguchi, M., Kashiwada, Y., Sekiya, M., Yamagishi, T., and Takaishi, Y. (2010). Papyriferic acid derivatives as reversal agents of multidrug resistance in cancer cells. Bioorganic & medicinal chemistry 18, 2964-2975.
16. Tanaka, N., Kashiwada, Y., Nakano, T., Shibata, H., Higuchi, T., Sekiya, M., Ikeshiro, Y., and Takaishi, Y. (2009). Chromone and chromanone glucosides from Hypericum sikokumontanum and their anti-Helicobacter pylori activities. Phytochemistry 70, 141-146.
15. Tanaka, N., Kashiwada, Y., Kim, S.Y., Sekiya, M., Ikeshiro, Y., and Takaishi, Y. (2009). Xanthones from Hypericum chinense and their cytotoxicity evaluation. Phytochemistry 70, 1456-1461.
14. Tanaka, N., Kashiwada, Y., Kim, S.Y., Hashida, W., Sekiya, M., Ikeshiro, Y., and Takaishi, Y. (2009). Acylphloroglucinol, biyouyanagiol, biyouyanagin B, and related spiro-lactones from Hypericum chinense. Journal of natural products 72, 1447-1452.
13. Sekiya, M., Ichiyanagi, T., Ikeshiro, Y., and Yokozawa, T. (2009). The Chinese prescription Wen-Pi-Tang extract delays disease onset in amyotrophic lateral sclerosis model mice while attenuating the activation of glial cells in the spinal cord. Biological & pharmaceutical bulletin 32, 382-388.
12. Tanaka, N., Kashiwada, Y., Sekiya, M., Ikeshiro, Y., and Takaishi, Y. (2008). Takaneones A–C, prenylated butylphloroglucinol derivatives from Hypericum sikokumontanum. Tetrahedron Letters 49, 2799-2803.
11. Rhyu, D.Y., Kang, K.S., Sekiya, M., Tanaka, T., Park, J.C., and Yokozawa, T. (2008). Active compounds isolated from traditional Chinese prescription Wen-Pi-Tang protecting against peroxynitrite-induced LLC-PK1 cell damage. The American journal of Chinese medicine 36, 761-770.
10. Ichiyanagi, T., Shida, Y., Rahman, M.M., Sekiya, M., Hatano, Y., Matsumoto, H., Hirayama, M., Konishi, T., and Ikeshiro, Y. (2008). Effect on both aglycone and sugar moiety towards Phase II metabolism of anthocyanins. Food chemistry 110, 493-500.
9. Hashida, W., Tanaka, N., Kashiwada, Y., Sekiya, M., Ikeshiro, Y., and Takaishi, Y. (2008). Tomoeones A-H, cytotoxic phloroglucinol derivatives from Hypericum ascyron. Phytochemistry 69, 2225-2230.
8. Suzuki, K., Okasaka, M., Kashiwada, Y., Takaishi, Y., Honda, G., Ito, M., Takeda, Y., Kodzhimatov, O.K., Ashurmetov, O., Sekiya, M., et al. (2007). Sesquiterpene lactones from the roots of Ferula varia and their cytotoxic activity. Journal of natural products 70, 1915-1918.
7. Sekiya, M., Kashiwada, Y., Nabekura, T., Kitagawa, S., Yamagishi, T., Yokozawa, T., Ichiyanagi, T., Ikeshiro, Y., and Takaishi, Y. (2007). Effect of triterpenoids isolated from the floral spikes of Betula platyphylla var. japonicaon P-glycoprotein function. Planta medica 73, 1558-1562.
6. Rhyu, D.Y., Kang, K.S., Sekiya, M., and Yokozawa, T. (2007). Antioxidant effect of Wen-Pi-Tang and its component crude drugs on oxidative stress. The American journal of Chinese medicine 35, 127-137.
5. Kashiwada, Y., Sekiya, M., Yamazaki, K., Ikeshiro, Y., Fujioka, T., Yamagishi, T., Kitagawa, S., and Takaishi, Y. (2007). Triterpenoids from the floral spikes of Betula platyphylla var. japonica and their reversing activity against multidrug-resistant cancer cells. Journal of natural products 70, 623-627.
4. Yokozawa, T., Sekiya, M., Cho, E.J., Kurokawa, M., and Shiraki, K. (2004). Effect of Wen-Pi-Tang extract on lung damage by influenza virus infection. Phytomedicine : international journal of phytotherapy and phytopharmacology 11, 625-632.
3. Kashiwada, Y., Sekiya, M., Ikeshiro, Y., Fujioka, T., Kilgore, N.R., Wild, C.T., Allaway, G.P., and Lee, K.H. (2004). 3-O-Glutaryl-dihydrobetulin and related monoacyl derivatives as potent anti-HIV agents. Bioorganic & medicinal chemistry letters 14, 5851-5853.
2. Chen, C., Yokozawa, T., Sekiya, M., Hattori, M., and Tanaka, T. (2001). Protective effect of Sanguisorbae Radix against peroxynitrite-mediated renal injury. Journal of Traditional Medicines 18, 1-7.
1. Yokozawa, T., Sekiya, M., Rhyu, D., Hattori, M., and Chung, H. (2000). Radical-scavenging activity of Wen-Pi-Tang and its component crude drugs: with special reference to the effects on nitric oxide, superoxide and peroxynitrite. Journal of Traditional Medicines 17, 41-47.
Graduate students can enter our lab via Nagoya city University, Guraduate School of Pharmaceutical Science program (Experimental Gerontology)
.
If you are interested in working on our projects as a postdoctoral fellow, please contact us.
Tel: 0562-46-2311 (ext. 6401/7505/6408)
E-mail: iijimakm (at) ncgg.go.jp
7-430, Morioka-machi, Obu City, Aichi 474-8511, Japan
About 30 minutes by car from the Chubu International Airport (Centrair)
Access to NCGG (Link)
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