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バイオバンク

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各種データ

疾患別登録者 13,228人(2023年11月現在)

【疾患別登録者】認知症(AD) 3,353人/認知症(その他)	1,485人/軽度認知障害 1,893人/精神・神経疾患 1,058人/骨関節疾患 2,124人/認知機能健常者 660人/診断待ち・その他 2,166人/合計 12,739人

 

年代別登録者(2023年11月現在)

【年代別登録者数】59歳以下男性356人/60代男性835人/70代男性2,488人/80代男性1695人/90代男性127人/100代男性0人/59歳以下女性294人/60代女性903人/70代女性3,147人/80代女性2637人/90代女性255人/100代女性2人

59歳以下:男性394人・女性343人、60代:男性860人・女性935人、70代:男性2,566人・女性3,263人、
80代:男性1,750人・女性2,717人、90代:男性134人・女性264人、100代:男性0人・女性2人

 

分譲回数(2023年11月現在)

【分譲回数】2018年度迄 112回/2019年度 18回/2020年度 40回/2021年度 57回/2022年度 47回/2023年度 10回/合計 318回

これまでに327回の生物材料・データを配付。配付症例数 延べ204,850件

内訳:DNA 36,006症例、血漿 29,329症例、血清 31,911症例、髄液 229症例、組織 60症例、
便 570症例、データ 106,173症例、その他 572症例

バイオバンク活用研究課題

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バイオバンク活用研究成果

2023年

  1. Zhang S, Otsuka R, Nishita Y, Tange C, Tomida M, Ando F,Shimokata H, Arai H. Twenty-year prospective cohort study of the association between a Japanese dietary pattern and incident dementia: the NILS-LSA project. Eur J Nutr. 2023;62:1719-1729. 
  2. Sala G, Nishita Y, Tange C, Tomida M, Gondo Y, Shimokata H, Otsuka R. No appreciable effect of education on aging-associated declines in cognition: A 20-year follow-up study. Psychol Sci. 2023;34:527-536. 
  3. Guen YL, Luo G, Ambati A, Damotte V, Jansen I, Yu E, et al. Multi-ancestry HLA analysis in Alzheimer's and Parkinson's diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04. Proc Natl Acad Sci U S A. 2023;120:e2302720120.
  4. Koike Y, Takahata M, Nakajima M, Otomo N, Suetsugu H, Liu X, Endo T, Imagama S, Kobayashi K, Kaito T, Kato S, Kawaguchi Y, et al. Genetic insights into ossification of the posterior longitudinal ligament of the spine. Meta-Analysis. Elife. 2023;12:e86514.
  5. Nishito Y, Motoi N, Arai Y, Hiraoka N, Shibata T, Sonobe Y, Kayukawa Y, Hashimoto E, Takahashi M, Fujii E, Nishizawa T, Fukuda H, Ohashi K, Arai K, Mizoguchi Y, Yoshida Y, Watanabe S, Yamashita M, Kitano S, Sakamoto H, Nagata Y, Mitsumori R, Ozaki K, Niida S, Kanai Y, et al. Tumor-infiltrating lymphocyte profiling defines three immune subtypes of NSCLC with distinct signaling pathways and genetic alterations. Cancer Res Commun. 2023;3:1026-1040.
  6. Furutani M, Suganuma M, Akiyama S, Mitsumori R, Takemura M, Matsui Y, Satake S, Nakano Y, Niida S, Ozaki K, Hosoyama T,Shigemizu D. RNA-sequencing analysis identification of potential biomarkers for diagnosis of sarcopenia. J Gerontol A Biol Sci Med Sci. 2023;78:1991-1998.
  7. Shigemizu D, Akiyama S, Suganuma M, Furutani M, Yamakawa A, Ozaki K, Niida S. Classification and deep-learning-based prediction of Alzheimer's disease subtypes by using genomic data. Transl Psychiatry. 2023;13:232.
  8. Saji N, Ishihara Y, Murotani K, Uchiyama A, Takeda A, Sakurai T, Matsushita K. Cross-sectional analysis of periodontal disease and cognitive impairment conducted in a memory clinic: the Pearl study. J Alzheimers Dis. 2023;96:369-380.
  9. Yasuno F, Kimura Y, Ogata A, Ikenuma H, Abe J, Minami H, Nihashi T,Yokoi K, Hattori S, Shimoda N, Watanabe A, Kasuga K, Ikeuchi I, Takeda A,Sakurai T, Ito K, Kato T. Neuroimaging biomarkers of glial activation for predicting the annual cognitive function decline in patients with Alzheimer’s disease. Brain Behav Immun. 2023;114:214-220.
  10. Sugimoto T, Tokuda H, Miura H, Kawashima S, Ando T, Kuroda Y, Matsumoto N, Fujita K, Uchida K, Kishino Y, Sakurai T. Cross-sectional association of metrics derived from continuous glucose monitoring with cognitive performance in older adults with type 2 diabetes. Diabetes Obes Metab. 2023;25:222-228.
  11. Zhang S, Otsuka R, Shimokata H, Nishita Y, Tange C, Takemura M, Satake S. Serum levels of dehydroepiandrosterone sulfate are associated with a lower risk of mobility-subtype frailty in older Japanese community-dwellers. Arch Gerontol Geriatr. 2023;105:104846. 
  12. Nishita Y, Sala G, Shinohara M, Tange C, Ando F, Shimokata H, Sato N, Otsuka R. Effects of APOEɛ4 genotype on age-associated change in cognitive functions among Japanese middle-aged and older adults: A 20-year follow-up study. Exp Gerontol. 2023;171:112036.
  13. Matsuzaki J, Kato K, Oono K, Tsuchiya N, Sudo K, et al. Prediction of tissue-of-origin of early stage cancers using serum miRNomes. JNCI Cancer Spectr. 2023;7:pkac080.
  14. Yasuno F, Kimura Y, Ogata A, Ikenuma H, Abe J, Minami H, Nihashi T, Yokoi K, Hattori S, Shimoda N, Watanabe A, Kasuga K, Ikeuchi T, Takeda A, Sakurai T, Ito K, Kato T. Involvement of inflammation in the medial temporal region in the development of agitation in Alzheimer's disease: an in vivo positron emission tomography study. Psychogeriatrics. 2023;23:126-135.
  15. Fujisawa C, Saji N, Takeda A, Kato T, Nakamura A, Sakurai K, Asanomi Y, Ozaki K, Takada K, Umegaki H, Kuzuya M, Sakurai T. Early-onset Alzheimer’s disease associated with neuromyelitis optica spectrum disorder. Alzheimer Dis Assoc Disord. 2023;37:85-87. 

先頭へ戻る

2022年

  1. Sugimoto T, Noma H, Kuroda Y, Matsumoto N, Uchida K, Kishino Y, Saji N, Niida S, Sakurai T. Time trends (2012-2020) in glycated hemoglobin and adherence to the glycemic targets recommended for elderly patients by the Japan Diabetes Society/Japan Geriatrics Society Joint Committee among memory clinic patients with diabetes mellitus. J Diabetes Investig. 2022;13:2038-2046.
  2. Matsuura T, Kyokane K, Yamada S, Kuno Y. Effective treatments for chronic constipation in elderly patients in view of the differences in intestinal bacteria Clinical Research and Trials. Clin Res Trials, 2022;8:1-2
  3. Sakai Y, Wakao N, Matsui H, Watanabe T, Iida H, Watanabe K. Clinical characteristics of geriatric patients with non-specific chronic low back pain. Sci Rep. 2022;12:1286
  4. Shigemizu D, Akiyama S, Mitsumori R, Niida S, Ozaki K. Identification of potential blood biomarkers for early diagnosis of Alzheimer’s disease through immune landscape analysis. NPJ Aging. 2022;8:15.
  5. Yasuno F, Watanabe A, Kimura Y, Yamauchi Y, Ogata A, Ikenuma H, Abe J, Minami H, Nihashi T, Yokoi K, Hattori S, Shimoda N, Kasuga K, Ikeuchi T, Takeda A, Sakurai T, Ito K, Kato T. Estimation of blood-based biomarkers of glial activation related to neuroinflammation. Brain Behav Immun Health. 2022;26:100549.
  6. Saji N, Saito Y, Yamashita T, Murotani K, Tsuduki T, Hisada T, Sugimoto T, Niida S, Toba K, Sakurai T. Relationship between plasma lipopolysaccharides, gut microbiota, and dementia: a cross-sectional study. J Alzheimers Dis. 2022;86:1947-1957.
  7. Saji N, Murotani K, Sato N, Tsuduki T, Hisada T, Shinohara M, Sugimoto T, Niida S, Toba K, Sakurai T. Relationship between plasma neurofilament light chain, gut Microbiota, and dementia: a cross-sectional study. J Alzheimers Dis. 2022;86:1323-1335.
  8. Kishino Y, Sugimoto T, Kimura A, Kuroda Y, Uchida K, Matsumoto N, Saji N, Niida S, Sakurai T. Longitudinal association between nutritional status and behavioral and psychological symptoms of dementia in older women with mild cognitive impairment and early-stage Alzheimer's disease. Clin Nutr. 2022;41:1906-1912.
  9. Shigemizu D, Asanomi Y, Akiyama S, Higaki S, Sakurai T, Ito K, Niida S, and Ozaki K. Network-based meta-analysis and the candidate gene association studies reveal novel ethnicity-specific variants in MFSD3 and MRPL43 assocated with dementia with Lewy bodies. Am J Med Genet B. 2022;189:139-150.
  10. Shigemizu D, Asanomi Y, Akiyama S, Mitsumori R, Niida S, Ozaki K. Whole-genome sequencing reveals novel ethnicity-specific rare variants associated with Alzheimer's disease. Mol Psychiatry. 2022;27:2554–2562.
  11. Ando T, Uchida K, Sugimoto T, Kimura A, Saji N, Niida S, Sakurai T. ApoE4 Is Associated with Lower Body Mass, Particularly Fat Mass, in Older Women with Cognitive Impairment.Nutrients. 2022;14:539. 
  12. Chen WL, Nishita Y, Nakamura A, Kato T, Nakagawa T, Zhang S, Shimokata H, Otsuka R, Su KP, Arai H. Hemoglobin concentration is associated with the hippocampal volume in community-dwelling adults. Arch Gerontol Geriatr. 2022;101:104668.
  13. Naoki S, Tsuduki T, Murotani K, Hisada T,Sugimoto T , Kimura A , Niida S, Toba K, Sakurai T. Relationship between the Japanese-style diet, gut microbiota, and dementia: A cross-sectional study. Nutrition. 2022;94:111524. 
  14. Asanomi Y, Shigemizu D, Akiyama S, Miyashita A, Mitsumori R, Hara N, Ikeuchi T, Niida S,Ozaki K. A functional variant of SHARPIN confers increased risk of late-onset Alzheimer’s disease. J Hum Genet. 2022;67,203–208.

先頭へ戻る

2021年

  1. Ogiwara Y, Miyado M, Suzuki E, Niida S, Ozaki K, Fukami M. Structural and numerical Y chromosomal variations in elderly men identified through multiplex ligation-dependent probe amplification. J Hum Genet. 2021;66:1181-1184.
  2. Matsuura T, Kyokane K, Yamada S, Kuno Y. The development of the cure of the functional intestinal disorder based on the differences of gut microbiota in aged patients: A randomized clinical trial. Medicine (Baltimore). 2021;100:e27696.
  3. Matsuura T, Kyokane K, Yamada S, Ku Y. Treatment of chronic constipation and dysbiosis in elderly patients. J Clin Trials. 2021;11: No:1000467.
  4. Akiyama S, Higaki S, Ochiya T, Ozaki K, Niida S, Shigemizu D. JAMIR-eQTL: Japanese genome–wide identification of microRNA expression quantitative trait loci across dementia types. Database (Oxford). 2021;2021:baab072. 
  5. Asanomi Y, Shigemizu D, Akiyama S, Sakurai T, Ozaki K, Ochiya T, Niida S. Dementia subtype prediction models constructed by penalized regression methods for multiclass classification using serum microRNA expression data. Sci Rep. 2021;11:20947. 
  6. Yasuno F , Minami H , Hattori H. Interaction effect of Alzheimer's disease pathology and education, occupation, and socioeconomic status as a proxy for cognitive reserve on cognitive performance: in vivo positron emission tomography study. Psychogeriatrics. 2020;20:585-593. 
  7. Ogama N, Endo H, Satake S, Niida S, Arai  H, Sakurai T. Impact of Regional White Matter Hyperintensities on Specific Gait Function in Alzheimer’s Disease and Mild Cognitive Impairment. J Cachexia Sarcopenia Muscle. 2021;12:2045-2055.
  8. Otsuka R, Nishita Y, Nakamura A, Kato T, Iwata K, Tange C, Tomida M, Kinoshita K, Nakagawa T, Ando F, Shimokata H, Arai H. Dietary diversity is associated with longitudinal changes in hippocampal volume among Japanese community dwellers. Eur J Clin Nutr. 2021;75:946-953.
  9. Yasuno F, Nakamura A, Kato T, Iwata K, Sakurai T, Arahata Y, Washimi Y, Hattori H, Ito K. An evaluation of the amyloid cascade model using in vivo positron emission tomographic imaging. Psychogeriatrics. 2021;21:14-23.
  10. Kaneda H, Ida Y,  Kuwahara R, Sato I, Nakano T, Tokuda H, Tsuyoshi S, Murakoshi T, Honke K,  Kotani N. Proximity Proteomics Has Potential for Extracellular Vesicle Identification.  Proteome Res. 2021;2;20:3519-3531.
  11. Kinoshita K, Otsuka R, Tange C, Nishita Y, Tomida M, Ando F, Shimokata H, Arai H. Relationship between serum fatty acids and physical frailty in community-dwelling older Japanese adults. J Frailty Aging. 2021;1:237-240. 
  12. Murata S, Ono R, Sugimoto T, Toba K, Sakurai T. Functional Decline and Body Composition Change in Older Adults With Alzheimer Disease. Alzheimer Dis Assoc Disord. 2021 ;35:36-43.
  13. Shigemizu D, Mitsumori R, Akiyama S, Miyashita A, Morizono T, Higaki S, Asanomi Y, Hara N, Tamiya G, Kinoshita K, Ikeuchi T, Niida S, Ozaki K. Ethnic and trans-ethnic genome-wide association studies identify new loci influencing Japanese Alzheimer’s disease risk. Translational Psychiatry. 2021;11:151.
  14. Saji N, Murotani K, Hisada T, Tsuduki T, Sugimoto T, Kimura A, Niida S, Toba K, Sakurai T. The Association between Cerebral Small Vessel Disease and the Gut Microbiome: A Cross-Sectional Analysis. J Stroke Cerebrovasc Dis. 2021;30:105568. 
  15. Fujisawa C, Umegaki H, Sugimoto T, Samizo S, Huang CH, Fujisawa H, Sugimura Y, Kuzuya M, Toba K, Sakurai T. Mild hyponatremia is associated with low skeletal muscle mass, physical function impairment, and depressive mood in the elderly. BMC Geriatr. 2021 ;21:15.

先頭へ戻る

2020年

  1. Yasuno F , Minami H , Hattori H. Interaction effect of Alzheimer's disease pathology and education, occupation, and socioeconomic status as a proxy for cognitive reserve on cognitive performance: in vivo positron emission tomography study. Psychogeriatrics. 2020;205:585-593.
  2. Lim YY, Maruff P, Kaneko N, Doecke J, Fowler C, Villemagne VL, Kato T, Rowe CC, Arahata Y, Iwamoto S, Ito K, Tanaka K, Yanagisawa K, Masters CL, Nakamura A. Plasma Amyloid-β Biomarker Associated with Cognitive Decline in Preclinical Alzheimer's Disease. J Alzheimers Dis
    . 2020;77:1057-1065
  3. Watanabe Y, Hirao Y, Kasuga K, Tokutake T, Kitamura K, Niida S, Ikeuchi T, Nakamura K, Yamamoto T.Urinary Apolipoprotein C3 Is a Potential Biomarker for Alzheimer's Disease. Dement Geriatr Cogn Dis Extra. 2020;10:94-104. 
  4. Shigemizu D, Akiyama S, Higaki S, Sugimoto T, Sakurai T, Boroevich KA, Sharma A, Tsunoda T, Ochiya T, Niida S, Ozaki K. Prognosis prediction model for conversion from mild cognitive impairment to Alzheimer’s disease created by integrative analysis of multi-omics data. Alzheimers Res Ther. 2020;12:145.
  5. Shigemizu D, Mori T, Akiyama S, Higaki S, Watanabe H, Sakurai T, Niida S, and Ozaki K. Identification of potential blood biomarkers for early diagnosis of Alzheimer’s disease through RNA-sequencing analysis. Alzheimer's Research & Therapy. 2020;12:87.
  6. Mitsumori R, Sakaguchi K, Shigemizu D, Mori T, Akiyama S, Ozaki K, Niida S, and Shimoda N.Lower DNA methylation levels in CpG island shores of CR1, CLU, and PICALM in the blood of Japanese Alzheimer’s disease patients. PLoS One. 2020;15:e0239196.
  7. Sugimoto T, Ono R, Kimura A, Saji N, Niida S, Sakai T, Rakugi H, Toba K, Sakurai T. Impact of cognitive frailty on activities of daily living, cognitive function, and conversion to dementia among memory clinic patients with mild cognitive. Journal of Alzheimer's Disease. 2020;76:895-903.
  8. Nakatsu Y, Niida S, Tanaka K, Takenaka S, Kuwabara A. The relationship between serum vitamin E level and risk factors for arteriosclerosis in Japanese postmenopausal women. J Nutr Sci Vitaminol (Tokyo). 2020;66:213-218. 
  9. Ishigaki K, Akiyama M, Kanai M, K Ozaki, S Niida, et al. Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases. Nat Genet. 2020;52:669-679.
  10. Saji N, Murotani K, Hisada T, Kunihiro T, Tsuduki T, Sugimoto T, Kimura A, Niida S,Toba K , Sakurai. Relationship between dementia and gut microbiome-associated metabolites: a cross-sectional study in Japan. Sci Rep. 2020;10:8088. 
  11. Tsukasaki K, Matsui Y, Arai H, Harada A, Tomida M, Takemura M, Otsuka R, Ando F, Shimokata H. Association of muscle strength and gait speed with cross-sectional muscle area determined by mid-thigh computed tomography - A comparison with skeletal muscle mass measured by dual-energy X-ray absorptiometry. J Frailty Aging.2020;9:82-89.
  12. Otsuka R, Tange C, Nishita Y, Kato Y, Tomida M, Imai T, Ando F, Shimokata H. Dietary diversity and all-cause and cause-specific mortality in Japanese community-dwelling older adults. Nutrients. 2020;12:1052.
  13. Otsuka R, Kato Y, Tange C, Nishita Y, Tomida M, Imai T, Ando F, Shimokata H, Arai H. Protein intake per day and at each daily meal and skeletal muscle mass declines among older community dwellers in Japan. Public Health Nutr.2020;23:1090-1097.
  14. Shirai Y, Kuriki K, Otsuka R, Kato Y, Nishita Y, Tange C, Tomida M, Imai T, Ando F, Shimokata H. Green tea and coffee intake and risk of cognitive decline in older adults: the National Institute for Longevity Sciences, Longitudinal Study of Aging. Public Health Nutr.2020;23,1049-1057.
  15. Yamamoto Y, Kondo S, Matsuzaki J, Esaki M, Okusaka T, Shimada K, Murakami Y, Enomoto M, Tamori A, Kato K, Aoki Y, Takizawa S, Sakamoto H, Niida S, Takeshita F, Ochiya T. Highly sensitive circulating microRNA panel for accurate detection of hepatocellular carcinoma in patients with liver disease. Hepatol Commun.2020;4:284-297.

先頭へ戻る

2019年

  1. Kawaharada R, Sugimoto T, Matsuda N, Tsuboi Y, Sakurai T, Ono R. Impact of loss of independence in basic activities of daily living on caregiver burden in patients with Alzheimer’s disease: a retrospective cohort study. Geriatr Gerontol Int. 2019;19:1243-1247.
  2. Kimura A, Sugimoto T, Kitamori K, Saji N, Niida S, Toba K, Sakurai T. Malnutrition is Associated with Behavioral and Psychiatric Symptoms of Dementia in Older Women with Mild Cognitive Impairment and Early-Stage Alzheimer's Disease. Nutrients. 2019;11:1951.
  3. Fujisawa C, Umegaki H, Nakashima H, Kuzuya M, Toba K, Sakurai T. Complaint of poor night sleep Is correlated with physical function Impairment in mild Alzheimer's disease patients. Geriatr Gerontol Int. 2019;19:171-172.
  4. Ogama N, Sakurai T, Kawashima S,Tanikawa T, Tokuda H, Satake S, Miura H, Shimizu A, Kokubo M, Niida S, Toba K, Umegaki H, Kuzuya M. Association of Glucose Fluctuations with Sarcopenia in Older Adults with Type 2 Diabetes Mellitus. Journal of Clinical Medicine. 2019, 8.319.
  5. Sonoda T,Matsuzaki J,Yamamot Y,Sakurai T, Yoshiaki Aoki Y, Takizawa S, Shumpei Niida S, Ochiya T. Serum MicroRNA-Based Risk Prediction for Stroke. Stroke. 2019;50:1510-1518.
  6. Sugimoto T, Ono R, Kimura A, Saji N, Niida S, Toba K, Sakurai T. Cross-Sectional Association Between Cognitive Frailty and White Matter Hyperintensity Among Memory Clinic Patients. J Alzheimers Dis. 2019;72:605-612.
  7. Nishita Y, Nakamura A, Kato T, Otsuka R, Iwata K, Tange C, Ando F, Ito K, Shimokata H, Arai H. Links Between Physical Frailty and Regional Gray Matter Volumes in Older Adults: A Voxel-Based Morphometry Study. J Am Med Dir Assoc. 2019;20:1587-1592.e7. 
  8. Saji N,Murotani K, Hisada T, Tsuduki T, Sugimoto T, Kimura A, Niida S, Toba K, Sakurai  T. The relationship between the gut microbiome and mild cognitive impairment in patients without dementia: a cross-sectional study conducted in Japan. Sci Rep. 2019;9:19227. 
  9. Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Sakurai T, Ozaki K, Ochiya T, Niida S. A comparison of machine learning classifiers for dementia with Lewy bodies using miRNA expression data. BMC Med Genomics. 2019;12:150.
  10. Liu S, Ando F, Fujita Y, Liu J, Maeda T, Shen X, Kikuchi K, Matsumoto A, Yokomori M, Tanabe-Fujimura C, Shimokata H, Michikawa M, Komano H, Zou K. A clinical dose of angiotensin-converting enzyme (ACE) inhibitor and heterozygous ACE deletion exacerbate Alzheimer's disease pathology in mice. J Biol Chem. 2019;294:9760-9770.
  11. Chou MY, Nishita Y, Nakagawa T, Tange C, Tomida M, Shimokata H, Otsuka R, Chen LK, Arai H. Role of gait speed and grip strength in predicting 10-year cognitive decline among community-dwelling older people. BMC Geriatr. 2019;19:186.
  12. Zhang S, Otsuka R, Tomata Y, Shimokata H, Tange C, Tomida M, Nishita Y, Matsuyama S, Tsuji I. A cross-sectional study of the associations between the traditional Japanese diet and nutrient intakes: the NILS-LSA project. Nutr J. 2019;18:43.
  13. Yuki A, Otsuka R, Tange C, Nishita Y, Tomida M, Ando F, Shimokata H, Arai H. Daily Physical Activity Predicts Frailty Development Among Community-Dwelling Older Japanese Adults. Am Med Dir Assoc. 2019;20:1032-1036.
  14. Sudo K, Kato K, Matsuzaki J, Boku N, Abe S, Saito Y, Daiko H, Takizawa S, Aoki Y, Sakamoto H, Niida S, Takeshita F, Fukuda T, Ochiya T. Development and Validation of an Esophageal Squamous Cell Carcinoma Detection Model by Large-Scale MicroRNA Profiling. JAMA Netw Open. 2019;2:e194573.
  15. Nishita Y, Tange C, Tomida M, Otsuka R, Ando F, Shimokata H. Positive Effects of Openness on Cognitive Aging in Middle-Aged and Older Adults: A 13-Year Longitudinal Study. Int J Environ Res Public Health. 2019;16.pii: E2072. 
  16. Ogawa T, Uchida Y, Nishita Y, Tange C, Sugiura S, Ueda H, Nakada T, Suzuki H, Otsuka R, Ando F, Shimokata H. Hearing-impaired elderly people have smaller social networks: A population-based aging study. Arch Gerontol Geriatr. 2019;83:75-80. 
  17. Otsuka R, Tange C, Nishita Y, Tomida M, Kato Y, Imai T, Ando F, Shimokata H. Fish and meat intake, serum eicosapentaenoic acid and docosahexaenoic acid levels, and mortality in community-dwelling Japanese older persons. Int J Environ Res Public Health. 2019;16. pii: E1806.
  18. Otsuka R, Nishita Y, Tange C, Tomida M, Ando F, Shimokata H. Hemoglobin A1c and 10-year information processing speed in Japanese community dwellers. Environ Health Prev Med. 2019;24:24. 
  19. Asanomi Y, Shigemizu D, Miyashita A, Mitsumori R, Mori T, Hara N, Ito K, Niida S, Ikeuchi T, Ozaki K. A rare functional variant of SHARPIN attenuates theinflammatory response and associates with increased risk of late-onset Alzheimer's disease. Mol Med. 2019;25:20.
  20. Sugimoto T, Ono R, Kimura A, Saji N, Niida S, Toba K, Sakurai T. Impact of Glycemic Control on Daily Living Activities Over 1-Year Follow-up in Memory Clinic Patients With Diabetes.  J Am Med Dir Assoc. 2019;20:792-794.
  21. Saji N, Hisada T,Tsuduki T,Niida S,Toba k, Sakurai T. Proportional changes in the gut microbiome: a risk factor for cardiovascular disease and dementia? Hypertens Res. 2019;42:1090-1091.
  22. Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S. Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data. Commun Biol. 2019;2:77.
  23. Otsuka R, Tange C, Tomida M, Nishita Y, Kato Y, Yuki A, Ando F, Shimokata H, Arai H. Dietary factors associated with the development of physical frailty in community-dwelling older adults. J Nutr Health Aging. 2019;23:89-95
  24. Saji N, Niida S, Murotani K, Hisada T, Tsuduki T, Sugimoto T, Kimura A, Toba K, Sakurai. Analysis of the relationship between the gut microbiome and dementia: a cross-sectional study conducted in Japan. Sci Rep. 2019;9:1008
  25. Usuba W, Urabe F, Yamamoto Y, Matsuzaki J, Sasaki H, Ichikawa M, Takizawa S, Aoki Y, Niida S, Kato K, Egawa S, Chikaraishi T, Fujimoto H, Ochiya T. Circulating miRNA panels for specific and early detection in bladder cancer. Cancer Sci. 2019;110:408-419

先頭へ戻る

2018年

  1. Fujisawa C, Umegaki H, Kato T, Nakashima H, Kuzuya M, Ito K, Toba K, Sakurai T.  Correlation between regional cerebral blood flow and body composition in healthy older women: A single-photon emission computed tomography study. Geriatr Gerontol Int. 2018;18:1303-1304.
  2. Koide Y, Teranishi M, Sugiura S, Uchida Y, Nishio N, Kato K, Otake H, Yoshida T, Otsuka R, Ando F, Shimokata H, Hasegawa Y, Nakashima T, Sone. Association between Uncoupling Protein 2 Gene Ala55val Polymorphism and Sudden Sensorineural Hearing Loss. J Int Adv Otol. 2018;14:166-169.
  3. Sugimoto T, Ono R, Kimura A, Saji N, Niida S, Toba K, Sakurai T. Physical Frailty Correlates With Behavioral and Psychological Symptoms of Dementia and Caregiver Burden in Alzheimer's Disease. J Clin Psychiatry. 2018;79 pii: 17m11991.
  4. Yokoi A, Matsuzaki J, Yamamoto Y, Yoneoka Y,Takahas k, Shimizu H, Uehara T, Ishikawa M, Ikeda SI, Sonoda T, Kawauchi J, Takizawa S, Aoki Y, Niida S, Sakamoto H, Kato T, Ochiya T. Integrated extracellular microRNA profiling for ovarian cancer screening. Nat Commun. 2018;9:4319. 
  5. Horikawa C, Otsuka R, Kato Y, Nishita Y, Tange C, Rogi T, Kawashima H, Shibata H, Ando F, Shimokata H. Longitudinal Association between n-3 Long-Chain Polyunsaturated Fatty Acid Intake and Depressive Symptoms: A Population-Based Cohort Study in JapanNutrients. Nutrients. 2018;10 pii: E1655.
  6. Nakamoto M, Otsuka R, Nishita Y, Tange C, Tomida M, Kato Y, Imai T, Sakai T, Ando F, Shimokata H. Soy food and isoflavone intake reduces the risk of cognitive impairment in elderly Japanese women. Eur J Clin Nutr. 2018;72:1458-1462. 
  7. Yuki A, Otsuka R, Tange C, Nishita Y, Tomida M, Ando F, Shimokata H. Polypharmacy is associated with frailty in Japanese community-dwelling older adults. Geriatr Gerontol Int. 2018;18:1497-1500. 
  8. Uchida Y, Nishita Y, Kato T, Iwata K, Sugiura S, Suzuki H, Sone M, Tange C, Otsuka R, Ando F, Shimokata H, Nakamura A. Smaller Hippocampal Volume and Degraded Peripheral Hearing Among Japanese Community Dwellers. Front Aging Neurosci. 2018;10:319.
  9. Nakamura A, Kaneko N, Villemagne VL, Kato T, Doecke J, Doré V, Fowler C, Li QX, Martins R, Rowe C, Tomita T, Matsuzaki K, Ishii K, Ishii K, Arahata Y, Iwamoto S, Ito K, Tanaka K, Masters CL, Yanagisawa K. High performance plasma amyloid-β biomarkers for Alzheimer's disease. Nature. 2018;554:249-254. 
  10. Ogama N, Sakurai T, Kawashima S, Tanikawa T, Tokuda H, Satake S, Miura H, Shimizu A, Kokubo M, Niida S, Toda K, Umegaki H, Kuzuya M. Postprandia hyperglycemia is associated with white matter hyperintensity and brain atrophy in older patients with type 2 diabetes mellitus. Frontiers in Aging Neuroscience. 2018;10:273.
  11. Yuki A, Otsuka R, Tange C, Nishita Y, Tomida M, Ando F, Shimokata H. Physical frailty and mortality risk in Japanese older adults. Geriatr Gerontol Int. 2018;18:1085-1092.
  12. Sugimoto T, Toba K, Sakurai . Status of glycemic control in elderly patients with cognitive impairment treated by general practitioners relative to the glycemic targets recommended for elderly patients by the Japan Diabetes Society/Japan Geriatrics Society Joint Committee: A retrospective analysis. J Diabetes Investig. 2018;9:1230-1232.
  13. Koda M, Kitamura I, Okura T, Otsuka R, Ando F, Shimokata H. Men who were thin during early adulthood exhibited greater weight gain-associated visceral fat accumulation in a study of middle-aged Japanese men. Obes Sci Pract. 2018;4:289-295.
  14. Sugiura S, Yasue M, Uchida Y, Teranish M, Sone M, Suzuki H, Nakashima T, Otsuka R, Ando F, Shimokata H. Prevalence and risk factors of MRI abnormality which was suspected as sinusitis in Japanese middle-aged and elderly community dwellers. BioMed Res Int. 2018, Article ID 4096845, 6pages.
  15. Otsuka R, Nishita Y, Tange C, Tomida M, Kato Y, Imai T, Ando F, Shimokata H. Age-related 12-year changes in dietary diversity and food intakes among community-dwelling Japanese aged 40 to 79 years. J Nutr Health Aging. 2018;22:594-600.
  16. Tanisawa K, Hirose N, Arai Y, Shimokata H, Yamada Y, Kawai H, Kojima M, Obuchi S, Hirano H, Suzuki H, Fujiwara Y, Taniguchi Y, Shinkai S, Ihara K, Sugaya M, Higuchi M, Arai T, Mori S, Sawabe M, Sato N, Muramatsu M, Tanaka M. Inverse association between height-increasing alleles and extreme longevity in Japanese women. J Gerontol A Biol Sci Med Sci. 2018;73:588-595.
  17. Nagata Y, Hirayama A, Ikeda S, Shirahata A, Shoji F, Maruyama M, Kayano M, Bundo M, Hattori K, Yoshida S, Goto Y, Urakami K, Soga T, Ozaki K, Niida S. Comparative analysis of cerebrospinal fluid metabolites in Alzheimer's disease and idiopathic normal pressure hydrocephalus in a Japanese cohort. Biomarker Res. 2018;6:5.
  18. Otsuka R, Matsui Y, Tange C, Nishita Y, Tomida M, Ando F, Shimokata H, Arai H. What is the best adjustment of appendicular lean mass for predicting mortality or disability among Japanese community dwellers? BMC geriatrics. 2018;18:8.

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2017年

  1. Mori T,Sakai Y,Mitsunori K,Matsuda A,Oboki K,Matsumoto K,Harada A,Niida S,Watanabe K. MicroRNA transcriptome analysis on hypertrophy of ligamentum flavum in patients with lumbar spinal stenosis. Spine Surg Relat Res. 2017;1:211–217.
  2. Harada K, Lee S, Shimada H, Lee S, Bae S, Anan Y, Harada K, Suzuki T. Psychological predictors of participation in screening for cognitive impairment among community-dwelling older adults. Geriatr Gerontol Int. 2017;17:1197-1204.
  3. Harada K, Lee S, Lee S, Bae S, Harada K, Suzuki T, Shimada H. Objectively-measured outdoor time and physical and psychological function among older adults. Geriatr Gerontol Int. 2017;17:1455-1462.
  4. Doi T, Verghese J, Makizako H, Tsutsumimoto K, Hotta R, Nakakubo S, Suzuki T, Shimada H. Effects of Cognitive Leisure Activity on Cognition in Mild Cognitive Impairment: Results of a Randomized Controlled Trial. J Am Med Dir Assoc. 2017;18:686-691.
  5. Nishita Y, Tange C, Tomida M, Otsuka R, Ando F, Shimokata H. Cognitive abilities predict death during the next 15 years in older Japanese adults.  Geriatr Gerontol Int. 2017;17:1654-1660. 
  6. Yuki A, Ando F, Otsuka R, Shimokata H. Sarcopenia based on the Asian Working Group for Sarcopenia criteria and all-cause mortality risk in older Japanese adults. Geriatr Gerontol Int. 2017;17:1642-1647.
  7. Sugimoto T, Ono R, Murata S, Saji N, Matsui Y, Niida S, Toba K, Sakurai T. Sarcopenia is associated with impairment of activities of daily living in Japanese patients with early-stage Alzheimer disease. Alzheimer Dis Assoc Disord. 2017;31:256-258.
  8. Sugimoto T, Nakamura A, Kato K, Iwata K, Saji N, Arahata Y, Hattori H, Bundo M, Ito K, Niida S, Sakurai T; MULNIAD study group.
    Decreased glucose metabolism in medial prefrontal areas is associated with nutritional status in patients with prodromal and early Alzheimer's disease. J Alzheimers Dis. 2017;60:225-233.
  9. Nagata Y, Bundo M, Sugiura S, Kamita M, Ono M, Hattori K, Yoshida S, Goto Y, Urakami K, Niida S. PTPRQ as a potential biomarker for idiopathic normal pressure hydrocephalus. Mol Med Rep. 2017;16:3034-3040.
  10. Satake S, Shimokata H, Senda K, Kondo I, Toba K. Validity of total Kihon checklist score for predicting the incidence of 3-year dependency and mortality in a community-dwelling older population. J Am Med Dir Assoc. 2017;18:552.e1-552.e6.
  11. Otsuka R, Nishita Y, Tange C, Tomida M, Kato Y, Nakamoto M, Imai T, Ando F, Shimokata H. Dietary diversity decreases the risk of cognitive decline among Japanese older adults. Geriatr Gerontol Int. 2017;17:937-944
  12. Fukuoka H, Tange C, Otsuka R, Ando F, Shimokata H. The impact of anthropometric and ocular parameters on optic cup-to-disc ratio. BMJ Open Ophthalmology. 2017;1:e000012.
  13. Tanisawa K, Arai Y, Hirose N, Shimokata H, Yamada Y, Kawai H, Kojima M, Obuchi S, Hirano H, Yoshida H, Suzuki H, Fujiwara Y, Ihara K, Sugaya M, Arai T, Mori S, Sawabe M, Sato N, Muramatsu M, Higuchi M, Liu YW, Kong QP, Tanaka M. Exome-wide association study identifies CLEC3B missense variant p.S106G as being associated with extreme longevity in east Asian populations. J Gerontol A Biol Sci Med Sci. 2017;72:309-318.
  14. Ogama N, Sakurai T, Nakai T, Niida S, Saji N, Toba K, Umegaki H, Kuzuya M. Impact of frontal white matter hyperintensity on instrumental activities of daily living in elderly women with Alzheimer disease and amnestic mild cognitive impairment. PLOS One. 2017;12:e0172484. 
  15. Otsuka R, Nishita Y, Tange C, Tomida M, Kato Y, Nakamoto M, Ando F, Shimokata H, Suzuki T. The effect of modifiable healthy practices on higher-level functional capacity decline among Japanese community dwellers. Prev Med Rep. 2017;5:205-209.
  16. Sugimoto T, Yoshida M, Ono R, Murata S, Saji N, Niida S, Toba K, Sakurai T. Frontal Lobe Function Correlates with One-Year Incidence of Urinary Incontinence in Elderly with Alzheimer Disease. J Alzheimers Dis. 2017;56:567-574.

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2016年

  1. Nishita Y, Tange C, Tomida M, Ostuka R, Ando F, Shimokata H. Personality and global cognitive decline in Japanese community-dwelling elderly people: A 10-year longitudinal study. J Psychosom Res. 2016;91:20-25.
  2. Hida T, Shimokata H, Sakai Y, Ito S, Matsui Y, Takemura M, Kasai T, Ishiguro N, Harada A. Sarcopenia and sarcopenic leg as potential risk factors for acute osteoporotic vertebral among older women. Eur Spine J. 2016;25:3424-3431.
  3. Kayano M, Higaki S, Satoh J, Matsumoto K, Matsubara E, Takikawa O, Niida S. Plasma microRNA biomarker detection for mild cognitive pairment using differential correlation analysis. Biomarker Res. 2016;4:22. 
  4. Uchida Y, Nishita Y, Tange C, Sugiura S, Otsuka R, Ueda H, Nakashima T, Ando F, Shimokata H. The longitudinal impact of hearing impairment on cognition differs according to cognitive domain. Front Aging Neurosci. 2016;8:1-9.
  5. Koda M, Kitamura I, Okura T, Otsuka R, Ando F, Shimokata H. The associations between smoking habits and serum triglyceride or hemoglobin A1c levels differ according to visceral fat accumlation. J Epidemiol. 2016;26:208-215.
  6. Otsuka R, Kato Y, Nishita Y, Tange C, Nakamoto M, Tomida M, Imai T, Ando F, Shimokata H, Suzuki T. Dietary diversity and 14-year decline in higher-level functional capacity among middle-aged and elderly Japanese. Nutrition. 2016;32:784-789.
  7. Horikawa C, Otsuka R, Kato Y, Nishita Y, Tange C, Kakutani S, Rogi T, Kawashima H, Shibata H, Ando F, Shimokata H. Cross-sectional association between serum concentrations of n-3 long-chain PUFA and depressive symptoms: results in Japanese community dwellers. Br J Nutr. 2016;115:672-680.
  8. Kozakai R, Ando F, Kim HY, Yuki A, Otsuka R, Shimokata H. Sex-differences in age-related grip strength decline: a 10-year longitudinal study of community-living middle-aged and older Japanese. J Phys Fitness Sports Med. 2016;5:87-94.
  9. Otsuka R, Kato Y, Nishita Y, Tange C, Tomida M, Nakamoto M, Imai T, Ando F, Shimokata H. Age-related changes in energy intake and weight in community-dwelling middle-aged and elderly Japanese. J Nutr Health Aging. 2016;20:383-390.
  10. Sugimoto T, Ono R, Murata S, Saji N, Matsui Y, Niida S, Toba K, Sakurai T. Prevalence and associated factors of sarcopenia in elderly subjects with amnestic mild cognitive impairment or Alzheimer disease. Current Alzheimer Research. 2016;13:718-726.
  11. Shimomura A, Shiino S, Kawauchi J, Takizawa S, Sakamoto H, Matsuzaki J, Ono M, Takeshita F, Niida S, Shimizu C, Fujiwara Y, Kinoshita T, Tamura K, Ochiya T. A novel combination of serum microRNAs for detecting breast cancer in the early stage. Cancer Sci. 2016;107:326–334.
  12. Ogama N, Yoshida M, Nakai T, Niida S, Toba K, Sakurai T. Frontal white matter hyperintensity predicts lower urinary tract dysfunction in older adults with amnestic mild cognitive impairment and Alzheimer‘s disease. Geriatr Gerontol Int. 2016;16:167-174.

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2015年

  1. Kusudo T, Hashida Y, Ando F, Shimokata H, Yamashita H. Asp3Gly polymorphism affects fatty acid-binding protein 3 intracellular stability and subcellular localization. FEBS Lett. 2015;589:2382-2387.
  2. Harada A, Ito S, Matsui Y, Sakai Y, Takemura M, Tokuda H, Hida T, Shimokata H. Effect of alendronate on muscle mass: Investigation in patients with osteoporosis. Osteop Sarcopenia. 2015;1:53-58.
  3. Yasue M, Sugiura S, Uchida Y, Otake H, Teranishi M, Sakurai T, Toba K, Shimokata H, Ando F, Otsuka R, Nakashima T. Prevalence of sinusitis detected by magnetic resonance imaging in subjects with dementia or Alzheimer's disease. Curr Alzheimer Res. 2015;12:1006-1011.
  4. Ogama N, Saji N, Niida S, Toba K, Sakurai T. Validation of a simple and reliable visual rating scale of white matter hyperintensity comparable with computer-based volumetric analysis. Geriatr Gerontol Int. 2015;15:83-85.
  5. Nakamoto M, Otsuka R, Yuki A, Nishita Y, Tange C, Tomida M, Kato Y, Ando F, Shimokata H, Suzuki T. Higher gait speed and smaller sway area decrease the risk for decline in higher-level functional capacity among middle-aged and elderly women. Arch Gerontol Geriatr. 2015;61:429-436.
  6. Kasai T, Ishiguro N, Matsui Y, Harada A, Takemura M, Yuki A, Kato Y, Otsuka R, Ando F, Shimokata H. Sex- and age-related differences in mid-thigh composition and muscle quality determined by computed tomography in middle-aged and elderly Japanese. Geriatr Gerontol Int. 2015;15:700-706.
  7. Otsuka R, Kato Y, Imai T, Ando F, Shimokata H. Secular trend of serum docosahexaenoic acid, eicosapentaenoic acid, and arachidonic acid concentrations among Japanese-A 4- and 13-year descriptive epidemiologic study. Prostaglandins Leukot Essent Fatty Acids. 2015;94:35-42.
  8. Yoshimura N, Akune T, Fujiwara S, Shimizu Y, Yoshida H, Nishiwaki Y, Sudo A, Omori G, Yoshida M, Shimokata H, Suzuki T, Muraki S, Oka H, Nakamura K. Incidence of disability and its associated factors in Japanese men and women: the Longitudinal Cohorts of Motor System Organ (LOCOMO) study. J Bone Miner Metab. 2015;33:186-191.
  9. Yuki A, Ando F, Otsuka R, Shimokata H. Low free testosterone is associated with loss of appendicular muscle mass in Japanese community-dwelling women. Geriatr Gerontol Int. 2015;15:326-333.
  10. Kamita M, Mori T, Sakai Y, Ito S, Gomi M, Miyamoto Y, Harada A, Niida S, Yamada T, Watanabe K, Ono M. Proteomic analysis of ligamentum flavum from patients with lumbar spinal stenosis. Proteomics. 2015;15:1622-1630.
  11. 大塚礼, 加藤友紀, 西田裕紀子, 丹下智香子, 今井具子, 安藤富士子, 下方浩史. 地域在住高齢者における短鎖および中鎖脂肪酸摂取が8年間の認知機能得点低下に及ぼす影響. 日本栄養・食糧学会誌. 2015;68:101-111.
  12. 野坂咲耶, 光岡佑奈, 高井なつみ, 今井具子, 加藤友紀, 大塚礼, 安藤富士子, 下方浩史. 料理ベースの写真付きiPhone・iPad対応食事診断アプリケーションの有用性. 日本未病システム学会雑誌. 2015;21:7-20.
  13. 丹下智香子, 西田裕紀子, 富田真紀子, 大塚礼, 安藤富士子, 下方浩史, 鈴木隆雄. 中高年期における14年後の日常生活活動能力への心的発達要因の影響. 日本未病システム学会雑誌. 2015;21:106-110.

2014年

  1. Otsuka R, Tange C, Nishita Y, Kato Y, Imai T, Ando F, Shimokata H. Serum docosahexaenoic and eicosapentaenoic acid and risk of cognitive decline over 10 years among elderly Japanese. Eur J Clin Nutr. 2014;68:503-509.
  2. Kitamura I, Koda M, Otsuka R, Ando F, Shimokata H. Six-year longitudinal changes in body composition of middle-aged and elderly Japanese: Age and sex differences in appendicular skeletal muscle mass. Geriatr Gerontol Int. 2014;14:354-361.
  3. Yoshimura N, Akune T, ujiwara S, Shimizu Y, Yoshida H, Omori G, Sudo A, Nishiwaki Y, Yoshida M, Shimokata H, Suzuki T, Muraki S, Oka H, Nakamura K. Prevalence of knee pain, lumbar pain and its coexistence in Japanese men and women: The Longitudinal Cohorts of Motor System Organ (LOCOMO) study. J Bone Miner Metab. 2014;32:524-532.
  4. Matsui Y, Takemura M, Harada A, Ando F, Shimokata H. Effects of knee extensor muscle strength on the incidence of osteopenia and osteoporosis after 6 years. J Bone Miner Metab. 2014;32:550-555. 
  5. Otsuka R, Kato Y, Nishita Y, Tange C, Nakamoto M, Tomida M, Imai T, Ando F, Shimokata H. Cereal intake increases and dairy products decrease risk of cognitive decline among elderly female Japanese. J Prev Alz Dis. 2014;1:160-167.
  6. Uchida Y, Sugiura S, Ueda H, Nakashima T, Ando F, Shimokata H. The association between hearing impairment and polymorphisms of genes encoding inflammatory mediators in Japanese aged population. Immun Ageing. 2014;11:18.
  7. Kaneko N, Nakamura A, Washimi Y, Kato T, Sakurai T, Arahata Y, Bundo M, Takeda A, Niida S, Ito K, Toba K, Tanaka K, Yanagisawa K. Novel plasma biomarker surrogating cerebral amyloid deposition. Proc Jpn Acad Ser B Phys Biol Sci. 2014;90:353-364.
  8. Ogama N, Sakurai T, Shimizu A, Toba K. Regional white matter lesions predict falls in patients with amnestic mild cognitive impairment and Alzheimer's disease. J Am Med Dir Assoc. 2014;15:36-41.
  9. Seike A, Sumigaki C, Takeda A, Endo H, Sakurai T, Toba K. Developing an interdisciplinary program of educational support for early-stage dementia patients and their family members: an investigation based on learning needs and attitude changes. Geriatr Gerontol Int. 2014;14:28-34.
  10. Kamiya M, Sakurai T, Ogama N, Maki Y, Toba K. Factors associated with increased caregivers’ burden in several cognitive stages of Alzheimer disease. Geriatr Gerontol Int. 2014;14:45-55. 
  11. Sugiura S, Yasue M, Sakurai T, Sumigaki C, Uchida Y, Nakashima T, Toba K. The Effect of Cerumen Impaction on Hearing and Cognitive Functions in Japanese Elderly with Cognitive Impairment. Geriatr Gerontol Int. 2014;14:56-61. 
  12. Sakurai T, Kawashima S, Satake S, Miura H, Tokuda H, Toba K. Differential subtypes of diabetic elderly diagnosed with Alzheimer's disease. Geriatr Gerontol Int. 2014;14:62-70. 
  13. Shimizu A, Sakurai T, Mitsui T, Miyagi M, Nomoto K, Kokubo M, Bando K, Murohara T, Toba K. Left ventricular diastolic dysfunction is associated with cerebral white matter lesion (leukoaraiosis) in elderly patients without ischemic heart disease and stroke. Geriatr Gerontol Int. 2014;14:71-76.
  14. Matsui Y, Fujita R, Harada, A, Sakurai T,Nemoto T, Noda N, Toba K. The association of grip strength and related indices with independence of ADL in the elderly, investigated by a newly-developed grip strength measuring device. Geriatr Gerontol Int. 2014;14:77-86.
  15. Matsui Y, Fujita R, Harada A, Sakurai T, Nemoto T, Noda N, Toba K. A New grip-strength measuring device for detailed evaluation of muscle contraction Among the elderly. J Frailty Aging. 2014;3:142-7.
  16. 加藤友紀, 大塚礼, 西田裕紀子, 丹下智香子, 今井具子, 安藤富士子, 下方浩史. 地域在住中高年者のプロリン摂取量が知能に及ぼす影響に関する縦断的研究. 日本未病システム学会雑誌. 2014;20:99-104.
  17. 松井康素, 村真里枝, 原田敦, 幸篤武, 加藤友紀, 大塚礼, 安藤富士子, 下方浩史. 膝関節の変形および痛みと身体組成の関連. Osteoporosis Jpn. 2014;22:507-510.

先頭へ戻る

2014年

  1. Otsuka R, Tange C, Nishita Y, Kato Y, Imai T, Ando F, Shimokata H. Serum docosahexaenoic and eicosapentaenoic acid and risk of cognitive decline over 10 years among elderly Japanese. Eur J Clin Nutr. 2014;68:503-509.
  2. Kitamura I, Koda M, Otsuka R, Ando F, Shimokata H. Six-year longitudinal changes in body composition of middle-aged and elderly Japanese: Age and sex differences in appendicular skeletal muscle mass. Geriatr Gerontol Int. 2014;14:354-361.
  3. Yoshimura N, Akune T, ujiwara S, Shimizu Y, Yoshida H, Omori G, Sudo A, Nishiwaki Y, Yoshida M, Shimokata H, Suzuki T, Muraki S, Oka H, Nakamura K. Prevalence of knee pain, lumbar pain and its coexistence in Japanese men and women: The Longitudinal Cohorts of Motor System Organ (LOCOMO) study. J Bone Miner Metab. 2014;32:524-532.
  4. Matsui Y, Takemura M, Harada A, Ando F, Shimokata H. Effects of knee extensor muscle strength on the incidence of osteopenia and osteoporosis after 6 years. J Bone Miner Metab. 2014;32:550-555. 
  5. Otsuka R, Kato Y, Nishita Y, Tange C, Nakamoto M, Tomida M, Imai T, Ando F, Shimokata H. Cereal intake increases and dairy products decrease risk of cognitive decline among elderly female Japanese. J Prev Alz Dis. 2014;1:160-167.
  6. Uchida Y, Sugiura S, Ueda H, Nakashima T, Ando F, Shimokata H. The association between hearing impairment and polymorphisms of genes encoding inflammatory mediators in Japanese aged population. Immun Ageing. 2014;11:18.
  7. Kaneko N, Nakamura A, Washimi Y, Kato T, Sakurai T, Arahata Y, Bundo M, Takeda A, Niida S, Ito K, Toba K, Tanaka K, Yanagisawa K. Novel plasma biomarker surrogating cerebral amyloid deposition. Proc Jpn Acad Ser B Phys Biol Sci. 2014;90:353-364.
  8. Ogama N, Sakurai T, Shimizu A, Toba K. Regional white matter lesions predict falls in patients with amnestic mild cognitive impairment and Alzheimer's disease. J Am Med Dir Assoc. 2014;15:36-41.
  9. Seike A, Sumigaki C, Takeda A, Endo H, Sakurai T, Toba K. Developing an interdisciplinary program of educational support for early-stage dementia patients and their family members: an investigation based on learning needs and attitude changes. Geriatr Gerontol Int. 2014;14:28-34.
  10. Kamiya M, Sakurai T, Ogama N, Maki Y, Toba K. Factors associated with increased caregivers’ burden in several cognitive stages of Alzheimer disease. Geriatr Gerontol Int. 2014;14:45-55. 
  11. Sugiura S, Yasue M, Sakurai T, Sumigaki C, Uchida Y, Nakashima T, Toba K. The Effect of Cerumen Impaction on Hearing and Cognitive Functions in Japanese Elderly with Cognitive Impairment. Geriatr Gerontol Int. 2014;14:56-61. 
  12. Sakurai T, Kawashima S, Satake S, Miura H, Tokuda H, Toba K. Differential subtypes of diabetic elderly diagnosed with Alzheimer's disease. Geriatr Gerontol Int. 2014;14:62-70. 
  13. Shimizu A, Sakurai T, Mitsui T, Miyagi M, Nomoto K, Kokubo M, Bando K, Murohara T, Toba K. Left ventricular diastolic dysfunction is associated with cerebral white matter lesion (leukoaraiosis) in elderly patients without ischemic heart disease and stroke. Geriatr Gerontol Int. 2014;14:71-76.
  14. Matsui Y, Fujita R, Harada, A, Sakurai T,Nemoto T, Noda N, Toba K. The association of grip strength and related indices with independence of ADL in the elderly, investigated by a newly-developed grip strength measuring device. Geriatr Gerontol Int. 2014;14:77-86.
  15. Matsui Y, Fujita R, Harada A, Sakurai T, Nemoto T, Noda N, Toba K. A New grip-strength measuring device for detailed evaluation of muscle contraction Among the elderly. J Frailty Aging. 2014;3:142-7.
  16. 加藤友紀, 大塚礼, 西田裕紀子, 丹下智香子, 今井具子, 安藤富士子, 下方浩史. 地域在住中高年者のプロリン摂取量が知能に及ぼす影響に関する縦断的研究. 日本未病システム学会雑誌. 2014;20:99-104.
  17. 松井康素, 村真里枝, 原田敦, 幸篤武, 加藤友紀, 大塚礼, 安藤富士子, 下方浩史. 膝関節の変形および痛みと身体組成の関連. Osteoporosis Jpn. 2014;22:507-510.

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