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  2. Publication 論文

Publication (2010-)

[Research Article 研究論文]

○Umeda, T., Yamashita, T., Kimura, T., Ohnishi, K., Takuma, H., Ozeki, T., Takashima, A., Tomiyama, T. and Mori, H. Neurodegenerative disorder FTDP-17-related tau intron 10 +16C → T mutation increases tau exon 10 splicing and causes tauopathy in transgenic mice. Am J Pathol. 2013 , 183, p211-225.

○Ono, K., Li, L., Takamura, Y., Yoshiike, Y., Zhu, L., Han, F., Mao, X., Ikeda, T., Takasaki, J., Nishijo, H., Takashima, A., Teplow, D. B., Zagorski, M. G. and Yamada, M. Phenolic Compounds Prevent Amyloid β-Protein Oligomerization and Synaptic Dysfunction by Site-specific Binding. J Biol Chem. 2012, 287, p14631-14643.

○Ferree, A., Guillily, M., Li, H., Smith, K., Takashima, A., Squillace, R., Weigele, M., Collins, J. J. and Wolozin, B. Regulation of Physiologic Actions of LRRK2: Focus on Autophagy. Neurodegener Dis. 2012, 10, p238-241.

○Yoshiike, Y., Yamashita, S., Mizoroki, T., Maeda, S., Murayama, M., Kimura, T., Sahara, N., Soeda, Y. and Takashima, A. Adaptive responses to alloxan-induced mild oxidative stress ameliorate certain tauopathy phenotypes. Aging Cell. 2012, 11, p51-62.

○Mutsuga, M., Chambers, J. K., Uchida, K., Tei, M., Makibuchi, T., Mizorogi, T., Takashima, A. and Nakayama, H. Binding of curcumin to senile plaques and cerebral amyloid angiopathy in the aged brain of various animals and to neurofibrillary tangles in Alzheimer's brain. J Vet Med Sci. 2012, 74, p51-57.

○Takasaki, J., Ono, K., Yoshiike, Y., Hirohata, M., Ikeda, T., Morinaga, A., Takashima, A. and Yamada, M. Vitamin A has anti-oligomerization effects on amyloid-β in vitro. J Alzheimers Dis. 2011, 27, p271-280.

○Sotiropoulos, I., Catania, C., Pinto, L. G., Silva, R., Pollerberg, G. E., Takashima, A, Sousa, N. and Almeida OF. Stress acts cumulatively to precipitate Alzheimer's disease-like tau pathology and cognitive deficits. J Neurosci. 2011, 31, p7840-7847. F1000Prime.com/13355982

○Kambe, T., Motoi, Y., Inoue, R., Kojima, N., Tada, N., Kimura, T., Sahara, N., Yamashita, S., Mizoroki, T., Takashima, A., Shimada, K., Ishiguro, K., Mizuma, H., Onoe, H., Mizuno, Y. and Hattori, N. Differential regional distribution of phosphorylated tau and synapse loss in the nucleus accumbens in tauopathy model mice. Neurobiol Dis. 2011, 42, p404-414.

○Peethumnongsin, E., Yang, L., Kallhoff-Muñoz, V., Hu, L., Takashima, A., Pautler, R. G. and Zheng, H. Convergence of presenilin- and tau-mediated pathways on axonal trafficking and neuronal function. J Neurosci. 2010, 30, p13409-13418.

○Kimura, T., Fukuda, T., Sahara, N., Yamashita, S., Murayama, M., Mizoroki, T., Yoshiike, Y., Lee, B., Sotiropoulos, I., Maeda, S. and Takashima, A. Aggregation of detergent-insoluble tau is involved in neuronal loss but not in synaptic loss. J Biol Chem. 2010, 285, p38692-38699. F1000Prime.com/5657969

○Miyasaka, T., Sato, S., Tatebayashi, Y. and Takashima, A. Microtubule destruction induces tau liberation and its subsequent phosphorylation. FEBS Lett. 2010, 584, p3227-3232. F1000Prime.com/4273956

[Review 総説]

○Takashima, A. GSK-3β and memory formation. Front Mol Neurosci. 2012, 5, 47.

○Takashima, A. Tauopathy and Brain Aging, (Cytoskeleton of the Nervous System. R.A. Nixon and A. Yuan eds) Advances in Neurobiology. 2011, 3, Chapter5, p133-150.

○Takashima, A. Animal Models of Amyloid/PS1 Pathology (Animal Models for Neurodegenerative Disease, J. Avila, J.J. Lucas, and F. Hernandez eds) RSC Drug Discovery, 2011, Chaper 2, p15-38.

○Yoshiike, Y and Takashima, A. Presenilin-Based Transgenic models of Alzheimer’s disease (Animal models of Dementia (P.P. De Deyn and D Van Dam eds) Neuro methods 48, 2011, Part4, Chapter 21, p415-438.

○Takashima, A. Tau aggregation is a therapeutic target for Alzheimer's disease. Curr Alzheimer Res. 2010, 7, p665-669.

[Review 日本語総説]

○高島明彦. タウを指標とする抗アルツハイマー薬の創薬. Human Science. 2013 24, p22-25.

○高島明彦. 顆粒状タウオリゴマー：神経脱落を引き起こすタウ線維中間体. Psychiatry Today. 2012, 31

○吉池裕二, 木村哲也, 高島明彦. 認知症における抑制性シナプス. Clinical Neuroscience. 2012, 30 , p1425-1427.

○高島明彦. アルツハイマー病におけるTauタンパク質の役割. 細胞工学. 2012, 31, p1135-1138.

○高島明彦. βアミロイドとタウ、どちらがアルツハイマー病治療薬の標的としてふさわしいのだろう？ 実験医学増刊. in vivo実験医学によるひと疾患解明の最前線. 2012, p211-217.

○高島明彦. アルツハイマー病. 疾患モデルマウス表現型解析指南. 2011, p58-64.

○高島明彦. タウオパチーモデルマウス.脳、神経疾患—疾患モデルの作成と利用. 2011, p138-144.

○楯林義孝, 高島明彦. 遺伝子改変モデル R406Wモデル. 日本臨床. 2011, 69, p271-275.

○武田雅俊, 高島明彦. アルツハイマー病治療薬の開発. 日本神経精神薬理学雑誌. 2010, 30, p177-180.

○高島明彦. アルツハイマー病発症におけるタウの意義. Brain Nerve. 2010, 62, p701-708.