認知症予防を目指した多因子介入によるランダム化比較研究

Japan-multimodal intervention trial for prevention of dementia

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論文

2025年度

Takashi N, Ohtera S, Kuroda Y, Arai H, Sakurai T; J-MINT investigators. Cost-effectiveness of multimodal intervention for the prevention of dementia in Japan. J Prev Alzheimers Dis. 1: 100460, 2026. doi: 10.1016/j.tjpad.2025.100460このリンクは別ウィンドウで開きます

Uchida K, Sugimoto T, Inatomi T, Matsumoto N, Yokoyama Y, Fujita K, Kuroda Y, Sakurai T, Arai H; J-MINT investigators. Association of Visual Acuity and Self-Reported Vision Status With Physical, Social, and Cognitive/Psychological Components of Frailty in Older Adults With Mild Cognitive Impairment. Geriatr Gerontol Int. 26 (1) : e70293, 2026. doi: 10.1111/ggi.70293このリンクは別ウィンドウで開きます

Sugimoto T, Uchida K, Yokoyama Y, Onoyama A, Noma H, Arai H, Sakurai T, J-MINT study group. Efficacy of a multidomain intervention in older adults with vascular risks: The Japan-Multimodal Intervention Trial for the Prevention of Dementia (J-MINT) . Alzheimers Dement. 21 (11) : e70822, 2025. doi: 10.1002/alz.70822このリンクは別ウィンドウで開きます

Sakurai R, Suzuki H, Fujiwara Y, Uchida K, Fujita K, Nakamura A, Sakurai T, Arai H. Elevated plasma GFAP levels in MCI link APOE ε4 allele with impaired gait speed. Geroscience. Online ahead of print, 2025. doi: 10.1007/s11357-025-01955-5このリンクは別ウィンドウで開きます

Fujita K, Kinoshita F, Kuroda Y, Sugimoto T, Yamashita M, Sakurai H, Yamashiro D, Shimizu K, Matsumoto N, Uchida K, Yokoyama Y, Onoyama A, Kobayashi Y, Suzuki H, Fujiwara Y, Arai H, Sakurai T. Feasibility and effectiveness of a handbook-based multidomain lifestyle intervention for older adults with mild cognitive impairment: A quasi-experimental design with propensity score matching. J Alzheimers Dis. 107 (4) : 1768-1779, 2025. doi: 10.1177/13872877251372957このリンクは別ウィンドウで開きます

Sugimoto T, Crane PK, Choi SE, Fujita K, Gallée J, Kuroda Y, Lee M, Matsumoto N, Nakamura A, Noma H, Omura T, Onoyama A, Scollard P, Uchida K, Yokoyama Y, Arai H, Sakurai T, J-MINT study group. Multidomain interventions for preventing cognitive decline in older adults with type 2 diabetes and mild cognitive impairment: Secondary analysis of the J-MINT: Multidomain intervention in type 2 diabetes. JAR Life. 14: 100016, 2025. doi: 10.1016/j.jarlif.2025.100016このリンクは別ウィンドウで開きます

Fujita K, Kimura T, Yamakawa A, Niida S, Ozaki K, Sakurai T, Arai H, Shigemizu D; J-MINT study group. Genetic background and multidomain interventions in mild cognitive impairment. Alzheimers Res Ther. 17 (1) : 130, 2025. doi: 10.1186/s13195-025-01764-0このリンクは別ウィンドウで開きます

2024年度

Sugimoto T, Uchida K, Sato K, Yokoyama Y, Onoyama A, Fujita K, Kuroda Y, Wakayama S, Arai H, Sakurai T; J-MINT study group. Factors associated with adherence to tablet-based cognitive training: J-MINT study. Alzheimers Dement (N Y). 11 (1) : e70062, 2025. doi: 10.1002/trc2.70062このリンクは別ウィンドウで開きます

Matsumoto N, Sugimoto T, Yamashita F, Mori F, Kuroda Y, Fujita K, Uchida K, Kishino Y, Sasaki M, Arai H, Sakurai T. A diffusion kurtosis imaging study of the relationship between whole brain microstructure and cognitive function in older adults with mild cognitive impairment. Acta Radiol. 66 (1): 107-114, 2025. doi: 10.1177/02841851241295394このリンクは別ウィンドウで開きます

Sugimoto T, Uchida K, Yokoyama Y, Onoyama A, Fujita K, Kuroda Y, Hinakura K, Ogawa S, Suzuki H, Fujiwara Y, Crane PK, Arai H, Sakurai T; J-MINT study group. Adherence and aerobic exercise intensity in live online exercise sessions for older adults with mild cognitive impairment: Insights from the Japan-Multimodal Intervention Trial for the Prevention of Dementia. JAR Life. 14: 100003, 2025. doi: 10.1016/j.jarlif.2025.100003このリンクは別ウィンドウで開きます

Sakurai T, Sugimoto T, Akatsu H, Doi T, Fujiwara Y, Hirakawa A, Kinoshita F, Kuzuya M, Lee S, Matsumoto N, Matsuo K, Michikawa M, Nakamura A, Ogawa S, Otsuka R, Sato K, Shimada H, Suzuki H, Suzuki H, Takechi H, Takeda S, Uchida K, Umegaki H, Wakayama S, Arai H; J-MINT study group. Japan-Multimodal Intervention Trial for the Prevention of Dementia: A randomized controlled trial. Alzheimers Dement. 20 (6) : 3918-3930, 2024. doi: 10.1002/alz.13838このリンクは別ウィンドウで開きます

2023年度

Matsumoto N, Kuroda Y, Sugimoto T, Fujita K, Uchida K, Kishino Y, Arai H, Sakurai T. Factors associated with changes in psychological resilience of older adults with mild cognitive impairment during the COVID-19 pandemic. Front Aging Neurosci. 11: 15: 1169891, 2023. doi: 10.3389/fnagi.2023.1169891このリンクは別ウィンドウで開きます

Shigemizu D, Akiyama S, Suganuma M, Furutani M, Yamakawa A, Nakano Y, Ozaki K, Niida S. Classification and deep-learning-based prediction of Alzheimer disease subtypes by using genomic data. Transl Psychiatry.  13 (1) : 232, 2023. doi: 10.1038/s41398-023-02531-1このリンクは別ウィンドウで開きます

2021年度

Sugimoto T, Sakurai T, Akatsu H, Doi T, Fujiwara Y, Hirakawa A, Kinoshita F, Kuzuya M, Lee S, Matsuo K, Michikawa M, Ogawa S, Otsuka R, Sato K, Shimada H, Suzuki H, Suzuki H, Takechi H, Takeda S, Umegaki H, Wakayama S, Arai H. The Japan-Multimodal Intervention Trial for Prevention of Dementia (J-MINT): The Study Protocol for an 18-Month, Multicenter, Randomized, Controlled Trial. J Prev Alzheimers Dis. 8 (4) : 465-476, 2021. doi: 10.14283/jpad.2021.29このリンクは別ウィンドウで開きます