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  1. Mori S, Osawa A, Maeshima S, Sakurai T, Ozaki K, Kondo I, Saitoh E. Possibility of Using Quantitative Assessment with the Cube Copying Test for Evaluation of Visuo-spatial Function in Patients with Alzheimer's Disease. Prog Rehabil Med. 2021 Apr 29;6:20210021.
  2. Omura T, Tamura Y, Sakurai T, Umegaki H, Iimuro S, Ohashi Y, Ito H, Araki A; Japanese Elderly Diabetes Intervention Trial Research Group. Functional categories based on cognition and activities of daily living predict all-cause mortality in older adults with diabetes mellitus: The Japanese Elderly Diabetes Intervention Trial. Geriatr Gerontol Int. 2021 Jun;21(6):512-518.
  3. Seike A, Sumigaki C, Takeuchi S, Hagihara J, Takeda A, Becker C, Toba K, Sakurai T. Efficacy of group-based multi-component psycho-education for caregivers of people with dementia: A randomized controlled study. Geriatr Gerontol Int. 2021 Jul;21(7):561-567.
  4. Yamada Y, Umegaki H, Kinoshita F, Huang CH, Sugimoto T, Fujisawa C, Komiya H, Watanabe K, Nagae M, Kuzuya M, Sakurai T. Cross-Sectional Examination of Homocysteine Levels with Sarcopenia and Its Components in Memory Clinic Outpatients. J Alzheimers Dis. 2021;82(3):975-984.
  5. Watanabe K, Umegaki H, Sugimoto T, Fujisawa C, Komiya H, Nagae M, Yamada Y, Kuzuya M, Sakurai T. Associations Between Polypharmacy and Gait Speed According to Cognitive Impairment Status: Cross-Sectional Study in a Japanese Memory Clinic. J Alzheimers Dis. 2021;82(3):1115-1122.
  6. Sugimoto T, Sakurai T, Akatsu H, Doi T, Fujiwara Y, Hirakawa A, Kinoshita F, Kuzuya M, Lee S, Matsuo K, Michikawa M, Ogawa S, Otsuka R, Sato K, Shimada H, Suzuki H, Suzuki H, Takechi H, Takeda S, Umegaki H, Wakayama S, Arai H. The Japan-Multimodal Intervention Trial for Prevention of Dementia (J-MINT): The Study Protocol for an 18-Month, Multicenter, Randomized, Controlled Trial. J Prev Alzheimers Dis. 2021;8(4):465-476.
  7. Sugimoto T, Araki A, Fujita H, Honda K, Inagaki N, Ishida T, Kato J, Kishi M, Kobayashi K, Kouyama K, Noma H, Ohishi M, Satoh-Asahara N, Shimada H, Sugimoto K, Suzuki S, Takeya Y, Tamura Y, Tokuda H, Umegaki H, Watada H, Yamada Y, Sakurai T. The Multi-Domain Intervention Trial in Older Adults With Diabetes Mellitus for Prevention of Dementia in Japan: Study Protocol for a Multi-Center, Randomized, 18-Month Controlled Trial. Front Aging Neurosci. 2021 Jul 12;13:680341.
  8. Sugimoto T, Arai H, Sakurai T. An update on cognitive frailty: Its definition, impact, associated factors and underlying mechanisms, and interventions. Geriatr Gerontol Int. 2022 Feb;22(2):99-109.
  9. Sugimoto T, Kuroda Y, Matsumoto N, Uchida K, Kishino Y, Saji N, Niida S, Sakurai T. Cross-Sectional Associations of Sarcopenia and Its Components with Neuropsychological Performance among Memory Clinic Patients with Mild Cognitive Impairment and Alzheimer's Disease. J Frailty Aging. 2022;11(2):182-189.
  10. Asanomi Y, Shigemizu D, Akiyama S, Sakurai T, Ozaki K, Ochiya T, Niida S. Dementia subtype prediction models constructed by penalized regression methods for multiclass classification using serum microRNA expression data. Sci Rep. 2021 Oct 22;11(1):20947.
  11. Komiya H, Umegaki H, Ogama N, Sakurai T, Kuzuya M. Relationships between overactive bladder and cerebral white matter hyperintensity in outpatients at a memory clinic. Geriatr Gerontol Int. 2021 Nov;21(11):996-1002.
  12. Umegaki H, Sakurai T, Arai H. Active Life for Brain Health: A Narrative Review of the Mechanism Underlying the Protective Effects of Physical Activity on the Brain. Front Aging Neurosci. 2021 Nov 30;13:761674.
  13. Nihashi T, Sakurai K, Kato T, Iwata K, Kimura Y, Ikenuma H, Yamaoka A, Takeda A, Arahata Y, Washimi Y, Suzuki K, Bundo M, Sakurai T, Okamura N, Yanai K, Ito K, Nakamura A; MULNIAD Study Group. Patterns of Distribution of 18F-THK5351 Positron Emission Tomography in Alzheimer's Disease Continuum. J Alzheimers Dis. 2022;85(1):223-234.
  14. Ogama N, Endo H, Satake S, Niida S, Arai H, Sakurai T. Impact of regional white matter hyperintensities on specific gait function in Alzheimer's disease and mild cognitive impairment. J Cachexia Sarcopenia Muscle. 2021 Dec;12(6):2045-2055.
  15. Ando T, Uchida K, Sugimoto T, Kimura A, Saji N, Niida S, Sakurai T. ApoE4 Is Associated with Lower Body Mass, Particularly Fat Mass, in Older Women with Cognitive Impairment. Nutrients. 2022 Jan 26;14(3):539.
  16. Kuroda Y, Sugimoto T, Matsumoto N, Uchida K, Kishino Y, Suemoto CK, Sakurai T. Prevalence of Behavioral and Psychological Symptoms in Patients With Cognitive Decline Before and During the COVID-19 Pandemic. Front Psychiatry. 2022 Mar 7;13:839683.
  17. Hirashiki A, Shimizu A, Suzuki N, Nomoto K, Kokubo M, Sugimoto T, Hashimoto K, Sato K, Sakurai T, Murohara T, Washimi Y, Arai H. Exercise Capacity and Frailty Are Associated with Cerebral White Matter Hyperintensity in Older Adults with Cardiovascular Disease. Int Heart J. 2022;63(1):77-84.
  18. Fujisawa C, Umegaki H, Sugimoto T, Huang CH, Fujisawa H, Sugimura Y, Kuzuya M, Toba K, Sakurai T. Older adults with a higher frailty index tend to have electrolyte imbalances. Exp Gerontol. 2022 Jun 15;163:111778.
  19. Yoshimi T, Kato K, Aimoto K, Sato K, Itoh N, Kondo I. Utilization of transfer support equipment for meeting with family members in a nursing home during the COVID-19 pandemic: A case report. Geriatr Gerontol Int. 2021 Aug;21(8):741-742.
  20. Kawamura K, Kondo I, Osawa A, Tanimoto M, Matsui Y, Arai H. Walking speed and short physical performance battery are associated with conversion to long-term care need: A study in outpatients of a locomotive syndrome-frailty clinic. Geriatr Gerontol Int. 2021 Oct;21(10):919-925.
  21. Kawamura K, Kamiya M, Suzumura S, Maki K, Ueda I, Itoh N, Osawa A, Maeshima S, Arai H, Kondo I. Impact of the Coronavirus Disease 2019 Outbreak on Activity and Exercise Levels among Older Patients. J Nutr Health Aging. 2021;25(7):921-925.
  22. Senda M, Ishii K, Ito K, Ikeuchi T, Matsuda H, Iwatsubo T, Iwata A, Ihara R, Suzuki K, Kasuga K, Ikari Y, Niimi Y, Arai H, Tamaoka A, Arahata Y, Itoh Y, Tachibana H, Ichimiya Y, Washizuka S, Odawara T, Ishii K, Ono K, Yokota T, Nakanishi A, Matsubara E, Mori H, Shimada H. A Japanese Multicenter Study on PET and Other Biomarkers for Subjects with Potential Preclinical and Prodromal Alzheimer's Disease. J Prev Alzheimers Dis. 2021;8(4):495-502.
  23. Osawa A, Arai H, Maeshima S. Usefulness of a computerized cognitive assessment and training tool for detecting dementia. Geriatr Gerontol Int. 2021 May;21(5):438-439.
  24. Osawa A, Maeshima S. Unilateral Spatial Neglect Due to Stroke. In: Stroke. Dehkharghani S (Editor).  Exon Publications, Brisbane, Australia. 2021 June 18: 121-131.
  25. Maeshima S, Osawa A. Memory Impairment Due to Stroke. In: Stroke. Dehkharghani S (Editor). Exon Publications, Brisbane, Australia. 2021 June 18: 111-119. 
  26. Maeshima S, Osawa A, Kondo I, Kamiya M, Ueda I, Sakurai T, Arai H. Differences in instrumental activities of daily living between mild cognitive impairment and Alzheimer's disease: A study using a detailed executive function assessment. Geriatr Gerontol Int. 2021 Dec;21(12):1111-1117.
  27. Maeshima S, Osawa A. Community-Based Rehabilitation After Brain Infarction in Japan: From the Acute Phase to Home. In: Cerebral Ischemia. Pluta R (Editor).  Exon Publications, Brisbane, Australia. 2021: 187-200.
  28. Yoshimura T, Osawa A, Maeshima S. Assessment of cube-copying among community-dwelling elderly living in Japan using the vertex criterion and parallelism. Psychogeriatrics. 2021 Sep;21(5):722-729.
  29. Yoshimura T, Osaka M, Osawa A, Maeshima S. The classical backward digit span task detects changes in working memory but is unsuitable for classifying the severity of dementia. Appl Neuropsychol Adult. 2021 Aug 19:1-7.
  30. Kamiya A, Noguchi M, Kibayashi T, Maeshima S, Osawa A, Arai H. Video demonstrating NCGG-HEPOP 2020 exercises for older adults. Geriatr Gerontol Int. 2021 Sep;21(9):871-872.
  31. Suzumura S, Kanada Y, Osawa A, Sugioka J, Maeda N, Nagahama T, Shiramoto K, Kuno K, Kizuka S, Sano Y, Mizuguchi T, Kandori A, Kondo I. Assessment of finger motor function that reflects the severity of cognitive function. Fujita Med J. 2021;7(4):122-129.
  32. Saji N, Tsuduki T, Murotani K, Hisada T, Sugimoto T, Kimura A, Niida S, Toba K, Sakurai T. Relationships between the Japanese-style diet, gut microbiota, and dementia: a cross-sectional study. Nutrition. 2022 Feb;94:111524.
  33. Saji N, Murotani K, Sato N, Tsuduki T, Hisada T, Shinohara M, Sugimoto T, Niida S, Toba K, Sakurai T. Relationship Between Plasma Neurofilament Light Chain, Gut Microbiota, and Dementia: A Cross-Sectional Study. J Alzheimers Dis. 2022;86(3):1323-1335.
  34. Saji N, Saito Y, Yamashita T, Murotani K, Tsuduki T, Hisada T, Sugimoto T, Niida S, Toba K, Sakurai T. Relationship Between Plasma Lipopolysaccharides, Gut Microbiota, and Dementia: A Cross-Sectional Study. J Alzheimers Dis. 2022;86(4):1947-1957.
  35. Nakashima T, Katayama N, Saji N, Teranishi M, Yoshida T, Suzuki H, Sone M, Hamajima N. Dietary habits and medical examination findings in Japanese adults middle-aged or older who live alone. Nutrition. 2021 Sep;89:111268.
  36. Yasuno F, Minami H, Hattori H; Alzheimer's Disease Neuroimaging Initiative. Relationship between neuropsychiatric symptoms and Alzheimer's disease pathology: An in vivo positron emission tomography study. Int J Geriatr Psychiatry. 2021 Apr;36(4):598-605.
  37. Yasuno F, Minami H. Significant effects of cholinesterase inhibitors on tau pathology in the Alzheimer's disease continuum: An in vivo positron emission tomography study. Int J Geriatr Psychiatry. 2021 Aug;36(8):1274-1283.
  38. Yasuno F, Kimura Y, Ogata A, Ikenuma H, Abe J, Minami H, Nihashi T, Yokoi K, Hattori S, Shimoda N, Ichise M, Sakurai T, Ito K, Kato T. Kinetic modeling and non-invasive approach for translocator protein quantification with 11C-DPA-713. Nucl Med Biol. 2022 Mar 12;108-109:76-84.
  39. Kitamura S, Makinodan M, Matsuoka K, Takahashi M, Yoshikawa H, Ishida R, Kishimoto N, Yasuno F, Yasuda Y, Hashimoto R, Miyasaka T, Kichikawa K, Kishimoto T. Association of adverse childhood experiences and precuneus volume with intrusive reexperiencing in autism spectrum disorder. Autism Res. 2021 Sep;14(9):1886-1895.
  40. Tsujimoto M, Suzuki K, Takeda A, Saji N, Sakurai T, Washimi Y. Differentiating Dementia with Lewy Bodies from Alzheimer's Disease Using the Fall Risk Evaluation Questionnaire. Intern Med. 2021 Oct 26.
  41. Tsujimoto M. Reply to the letter titled, "Dementia with Lewy Bodies and Alzheimer's Disease Sometimes Coexist". Intern Med. 2022 Feb 1.
  42. Yamamoto K, Akasaka H, Yasunobe Y, Shimizu A, Nomoto K, Nagai K, Umegaki H, Akasaki Y, Kojima T, Kozaki K, Kuzuya M, Ohishi M, Akishita M, Takami Y, Rakugi H; Cherry Study Group. Clinical characteristics of older adults with hypertension and unrecognized cognitive impairment. Hypertens Res. 2022 Apr;45(4):612-619.
  43. Komori M, Takemura K, Minoura Y, Uchida A, Iida R, Seike A, and Uchida Y. Revealing structure of social networks through a seven-month survey using wearable device: A case study from a farming community in Japan. Journal of Computational Social Science. 2022 (In press)
  44. Seike A, Sumigaki C, Takeuchi S, Hagihara J, Takeda A, Becker C, Toba K, Sakurai T. Efficacy of group-based multi-component psycho-education for caregivers of people with dementia: A randomized controlled study. Geriatr Gerontol Int. 2021 Jul;21(7):561-567.
  45. Seike A, Takeuchi S. Team work skills. Self-management: For Individual and Organizational Success. Partridge Publishing, 2021. 25-37.
  46. Seike A. Self-awareness. Self-management: For Individual and Organizational Success. Partridge Publishing,2021. 89-100． 

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  1. Kivipelto M, Mangialasche F, Snyder HM, Allegri R, Andrieu S, Arai H, Baker L, Belleville S, Brodaty H, Brucki SM, Calandri I, Caramelli P, Chen C, Chertkow H, Chew E, Choi SH, Chowdhary N, Crivelli L, Torre R, Du Y, Dua T, Espeland M, Feldman HH, Hartmanis M, Hartmann T, Heffernan M, Henry CJ, Hong CH, Håkansson K, Iwatsubo T, Jeong JH, Jimenez-Maggiora G, Koo EH, Launer LJ, Lehtisalo J, Lopera F, Martínez-Lage P, Martins R, Middleton L, Molinuevo JL, Montero-Odasso M, Moon SY, Morales-Pérez K, Nitrini R, Nygaard HB, Park YK, Peltonen M, Qiu C, Quiroz YT, Raman R, Rao N, Ravindranath V, Rosenberg A, Sakurai T, Salinas RM, Scheltens P, Sevlever G, Soininen H, Sosa AL, Suemoto CK, Tainta-Cuezva M, Velilla L, Wang Y, Whitmer R, Xu X, Bain LJ, Solomon A, Ngandu T, Carrillo MC. World-Wide FINGERS Network: A global approach to risk reduction and prevention of dementia. Alzheimers Dement. 2020 Jul;16(7):1078-1094.
  2. Sugimoto T, Ono R, Kimura A, Saji N, Niida S, Sakai T, Rakugi H, Toba K, Sakurai T. Impact of Cognitive Frailty on Activities of Daily Living, Cognitive Function, and Conversion to Dementia Among Memory Clinic Patients with Mild Cognitive Impairment. J Alzheimers Dis. 2020;76(3):895-903.
  3. Wang X, Hu X, Zhang L, Xu X, Sakurai T. Nicotinamide mononucleotide administration after sever hypoglycemia improves neuronal survival and cognitive function in rats. Brain Res Bull. 2020 Jul;160:98-106.
  4. Shimizu A, Sakurai T, Mitsui T, Miyagi M, Nomoto K, Kokubo M, Bando YK, Murohara T, Toba K. Left ventricular diastolic dysfunction is associated with cerebral white matter lesions (leukoaraiosis) in elderly patients without ischemic heart disease and stroke. Geriatr Gerontol Int. 2014 Apr;14 Suppl 2:71-6.
  5. Shigemizu D, Mori T, Akiyama S, Higaki S, Watanabe H, Sakurai T, Niida S, Ozaki K. Identification of potential blood biomarkers for early diagnosis of Alzheimer's disease through RNA sequencing analysis. Alzheimers Res Ther. 2020 Jul 16;12(1):87.
  6. Araki A, Umegaki H, Sakurai T, Mizuno Y, Miyao M, Imori M, Suzuki S, Cambron-Mellott MJ, Yokote K, Onuma T, Yokono K. Determinants and impact of physical impairment in patient-reported outcomes among older patients with type 2 diabetes mellitus in Japan. Curr Med Res Opin. 2021 Mar;37(3):393-402.
  7. Murata S, Ono R, Sugimoto T, Toba K, Sakurai T. Functional Decline and Body Composition Change in Older Adults With Alzheimer Disease: A Retrospective Cohort Study at a Japanese Memory Clinic. Alzheimer Dis Assoc Disord. 2021 Jan-Mar 01;35(1):36-43.
  8. Fujisawa C, Umegaki H, Sugimoto T, Samizo S, Huang CH, Fujisawa H, Sugimura Y, Kuzuya M, Toba K, Sakurai T. Mild hyponatremia is associated with low skeletal muscle mass, physical function impairment, and depressive mood in the elderly. BMC Geriatr. 2021 Jan 6;21(1):15.
  9. Ishihara M, Saito T, Sakurai T, Arai H. Sustained mood improvement by the positive photo appreciation program in older adults. Int J Geriatr Psychiatry. 2021 Jan 18.
  10. Röhr S, Arai H, Mangialasche F, Matsumoto N, Peltonen M, Raman R, Riedel-Heller SG, Sakurai T, Snyder HM, Sugimoto T, Carrillo M, Kivipelto M, Espeland MA; World‐Wide FINGERS Study Group. Impact of the COVID-19 pandemic on statistical design and analysis plans for multidomain intervention clinical trials: Experience from World-Wide FINGERS. Alzheimers Dement (N Y). 2021 Mar 11;7(1):e12143.
  11. Hattori M, Tsuboi T, Yokoi K, Tanaka Y, Sato M, Suzuki K, Arahata Y, Hori A, Kawashima M, Hirakawa A, Washimi Y, Watanabe H, Katsuno M. Subjects at risk of Parkinson's disease in health checkup examinees: cross-sectional analysis of baseline data of the NaT-PROBE study. J Neurol. 2020 May;267(5):1516-1526.
  12. Takano E, Maltais M, Kondo I, Rolland Y; MAPT/DSA group. Bidirectional relationship between depressive symptoms and physical performance in community-dwelling older people with subjective memory complaints. Eur Geriatr Med. 2021 Mar 5.
  13. Sugioka J, Suzumura S, Kawahara Y, Osawa A, Maeda N, Ito M, Nagahama T, Kuno K, Shiramoto K, Kizuka S, Mizuguchi T, Sano Y, Kandori A, Kondo I. Assessment of finger movement characteristics in dementia patients using a magnetic sensing finger-tap device. Japanese Journal of Comprehensive Rehabilitation Science 11, 91-97, doi.org/10.11336/jjcrs.11.91,2020.
  14. Yasuno F, Makinodan M, Takahashi M, Matsuoka K, Yoshikawa H, Kitamura S, Ishida R, Kishimoto N, Miyasaka T, Kichikawa K, Kishimoto T. Microstructural Anomalies Evaluated by Neurite Orientation Dispersion and Density Imaging Are Related to Deficits in Facial Emotional Recognition via Perceptual-Binding Difficulties in Autism Spectrum Disorder. Autism Res. 2020 May;13(5):729-740.
  15. Yasuno F, Minami H, Hattori H; Alzheimer's Disease Neuroimaging Initiative. Relationship between neuropsychiatric symptoms and Alzheimer's disease pathology: An in vivo positron emission tomography study. Int J Geriatr Psychiatry. 2021 Apr;36(4):598-605.
  16. Yasuno F, Nakamura A, Kato T, Iwata K, Sakurai T, Arahata Y, Washimi Y, Hattori H, Ito K. An evaluation of the amyloid cascade model using in vivo positron emission tomographic imaging. Psychogeriatrics. 2021 Jan;21(1):14-23.
  17. Yasuno F, Minami H, Hattori H; Alzheimer's Disease Neuroimaging Initiative. Interaction effect of Alzheimer's disease pathology and education, occupation, and socioeconomic status as a proxy for cognitive reserve on cognitive performance: in vivo positron emission tomography study. Psychogeriatrics. 2020 Sep;20(5):585-593.
  18. Takahashi M, Kitamura S, Matsuoka K, Yoshikawa H, Yasuno F, Makinodan M, Kimoto S, Miyasaka T, Kichikawa K, Kishimoto T. Uncinate fasciculus disruption relates to poor recognition of negative facial emotions in Alzheimer's disease: a cross-sectional diffusion tensor imaging study. Psychogeriatrics. 2020 May;20(3):296-303.
  19. Ando D, Yokota C, Koshino K, Yasuno F, Sato T, Yamamoto A, Odani H, Nakajima T, Higuchi T, Tatsumi E. Microstructural white matter changes following gait training with Hybrid Assistive Limb initiated within 1 week of stroke onset. J Neurol Sci. 2020 Aug 15;415:116939.
  20. Matsuoka K, Makinodan M, Kitamura S, Takahashi M, Yoshikawa H, Yasuno F, Ishida R, Kishimoto N, Yasuda Y, Hashimoto R, Taoka T, Miyasaka T, Kichikawa K, Kishimoto T. Increased Dendritic Orientation Dispersion in the Left Occipital Gyrus is Associated with Atypical Visual Processing in Adults with Autism Spectrum Disorder. Cereb Cortex. 2020 Oct 1;30(11):5617-5625.
  21. Osawa A, Maeshima S, Kondo I, Arai H. Balancing infection control and frailty prevention during and after the COVID-19 pandemic: Introduction of the National Center for Geriatrics and Gerontology Home Exercise Program for Older People Home Exercise Program for Older People 2020. Geriatr Gerontol Int. 2020 Sep;20(9):846-848.
  22. Osawa A, Maeshima S, Arai H, Kondo I. Dementia with aphasia and mirror phenomenon: examination of the mechanism using neuroimaging and neuropsychological findings: a case report. BMC Neurol. 2020 Nov 24;20(1):425.
  23. Saji N, Murotani K, Hisada T, Tsuduki T, Sugimoto T, Kimura A, Niida S, Toba K, Sakurai T. The Association between Cerebral Small Vessel Disease and the Gut Microbiome: A Cross-Sectional Analysis. J Stroke Cerebrovasc Dis. 2021 Mar;30(3):105568.
  24. Saji N, Murotani K, Hisada T, Kunihiro T, Tsuduki T, Sugimoto T, Kimura A, Niida S, Toba K, Sakurai T. Relationship between dementia and gut microbiome-associated metabolites: a cross-sectional study in Japan. Sci Rep. 2020 May 18;10(1):8088.
  25. Saji N, Makizako H, Suzuki H, Nakai Y, Tabira T, Obuchi S, Kawai H, Murotani K, Katayama N, Toba K, Uchida Y, Nakashima T. Hearing impairment is associated with cognitive function in community-dwelling older adults: A cross-sectional study. Arch Gerontol Geriatr. 2021 Mar-Apr;93:104302.
  26. Saji N, Suzuki H, Katayama N, Makizako H, Uchida Y, Nakashima T. Sensory impairment: A preventable risk factor in older adults. Arch Gerontol Geriatr. 2021 Mar-Apr;93:104300.
  27. Seike A, Takeuchi S. Teamwork skills. Self-management: For Individual and Organizational Success. Partridge, 25-37, 2021．

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  1. Sonoda T, Matsuzaki J, Yamamoto Y, Sakurai T, Aoki Y, Takizawa S, Niida S, Ochiya T. Serum miRNA-based risk predication for stroke. Stroke. 2019 Jun;50(6):1510-1518.
  2. Kawashima K, Hirashiki K, Nomoto K, Kokubo M, Shimizu A, Sakurai T, Washimi Y, Arai H, Toba K, Murohara T. Peak work rate during exercise could detect frailty status in elderly patients with stable heart failure. Int Heart J. 2019 Nov 30;60(6):1366-1372.
  3. Ishihara M, Saito T, Sakurai T, Osawa A Ueda I, Kamiya M, Arai H. Development of the Positive Photo Appreciation for Dementia program for people with mild cognitive impairment and early‐stage Alzheimer's disease: A feasibility study. Geriatr. Gerontol. Int. 2019 Oct; 19(10):1064–1066.
  4. Kawaharada R, Sugimoto T, Matsuda N, Tsuboi Y, Sakurai T, Ono R. Impact of loss of independence in basic activities of daily living on caregiver burden in patients with Alzheimer’s disease: a retrospective cohort study. Geriatr Gerontol Int. 2019 Dec;19(12):1243-1247.      
  5. Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S. A comparison of machine learning classifiers for dementia with Lewy bodies using miRNA expression data. BMC Med Genomics volume 2019 Oct 30;12(1):150.
  6. Takeda S, Banno Y, Sugimoto T, Fujii F, Kimura A, Sakurai T. The Effectiveness of Training Programs on the Fidelity of Neuropsychological Tests. Yonago Acta Med 2019 Oct 25;62(4):278-284.
  7. Omura T, Tamura Y, Yamaoka T, Yoshimura Y, Sakurai T, Umegaki H, Kamada C, Iimuro S, Ohashi Y, Ito H, Araki A. Assessing the Association Between Optimal Energy Intake and All-Cause Mortality in Older Patients With Diabetes Mellitus Using the Japanese Elderly Diabetes Intervention Trial. Geriatr Gerontol Int. 2020 Jan;20 (1):59-65.
  8. Kawaharada R, Sugimoto T, Matsuda N, Tsuboi Y, Sakurai T, Ono R. Delving into the caregiver burden associated basic activity of daily living disability among caregivers of patients with mild to moderate Alzheimer’s disease. Geriatr Gerontol Int. 2020 Mar;20(3):263-265.
  9. Yasuno F, Ando D, Yamamoto A, Koshino K, Yokota C. Dendrite complexity of the posterior cingulate cortex as a substrate for recovery from post-stroke depression: A pilot study. Psychiatry Res Neuroimaging. 2019 May;30;287:49-55.
  10. Yasuno F, Kajimoto K, Ihara M, Taguchi A, Yamamoto A, Fukuda T, Kazui H, Iida H, Nagatsuka K. Amyloid β deposition in subcortical stroke patients and effects of educational achievement: A pilot study. Int J Geriatr Psychiatry 2019 Nov;34(11):1651-1657.
  11. Takahashi M, Yasuno F, Yamamuro K, Matsuoka K, Kitamura S, Yoshikawa H, Yamamoto A, Iida H, Fukuda T, Ihara M, Nagatsuka K, Kishimoto T. Detection of brain amyloid-β deposits due to the repetitive head trauma in a former karate player. Psychogeriatrics 2019 May;19(3):276-281.
  12. Saji N, Hisada T, Tsuduki T, Niida S, Toba K, Sakurai T. Proportional changes in the gut microbiome: a risk factor for cardiovascular disease and dementia? Hypertens Res. 2019 Jul;42(7):1090-1091.
  13. Sugimoto T, Ono R, Kimura A, Saji N, Niida S, Toba K, Sakurai T. Cross-sectional association between cognitive frailty and white matter hyperintensity among memory clinic patients. J Alzheimers Dis. 2019;72(2):605-612.
  14. Sugimoto T, Ono R, Kimura A, Saji N, Niida S, Toba K, Sakurai T. Impact of Glycemic Control on Daily Living Activities Over 1-Year Follow-up in Memory Clinic Patients With Diabetes. J Am Med Dir Assoc. 2019 Jun;20(6):792-794.
  15. Kimura A, Sugimoto T, Kitamori K, Saji N, Niida S, Toba K, Sakurai T. Malnutrition is Associated with Behavioral and Psychiatric Symptoms of Dementia in Older Women with Mild Cognitive Impairment and Early-Stage Alzheimer's Disease. Nutrients. 2019 Aug 20;11(8): 1951.
  16. Isa T, Sugimoto T, Murata S, Tsuboi Y, Ebina A, Kondo Y, Torizawa K, Okumura M, Shigemoto C, Matsuda N, Misu S, Ono R. Lower physical activity is associated with daytime sleepiness in children aged 9-12 years. J Child Health Care. 2019 Sep;23(3):415-424.
  17. Misu S, Asai T, Doi T, Sawa R, Ueda Y, Murata S, Saito T, Sugimoto T, Isa T, Tsuboi Y, Yamada M, Ono R. Development and validation of Comprehensive Gait Assessment using InerTial Sensor score (C-GAITS score) derived from acceleration and angular velocity data at heel and lower trunk among community-dwelling older adults. J Neuroeng Rehabil. 2019 May 28;16(1):62.

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  1. Ogama N, Sakurai T, Kawashima S, Tanikawa T, Tokuda H, Satake S, Miura H, Kokubo M, Shimizu A, Niida S, Toba K, Umegaki H, Kuzuya M. Association of Glucose Fluctuations with Sarcopenia in Older Adults with Type 2 Diabetes Mellitus. J Clin Med. 2019 Mar 6;8(3). 
  2. Fujisawa C, Umegaki H, Sakurai T, Toba K, Umegaki H, Kuzuya M. Correlation between regional cerebral blood flow and body composition in healthy older women: A single-photon emission computed tomography study. Geriatr Gerontol Int. 2018 Aug;18(8):1303-1304.
  3. Tsujimoto M, Yamaoka A, Horibe K, Takeda A, Arahata Y, Sakurai T, Washimi Y. The Validation of the NCGG-4D (National Center for Geriatrics and Gerontology differential diagnostic tool For degenerative Dementia): -a simple and effective tool for diagnosis and longitudinal evaluation. Journal of Clinical Gerontology & Geriatrics 9:18-24, 2018.　 
  4. Ogama N, Sakurai T, Saji N, Nakai T, Niida S, Toba K, Umegaki H, Kuzuya M. Frontal White Matter Hyperintensity is Associated with Verbal Aggressiveness in Elderly Women with Alzheimer’s Disease and Amnestic Mild Cognitive Impairment. Dementia and Geriatric Cognitive Disorders EXTRA. 2018 Apr 11;8(1):138-150.   
  5. Nakamura A, Cuesta P, Fernándezc A, Arahata Y, Iwata K, Kuratsubo I, Bundo M, Hattori H, Sakurai T, Fukuda K, Washimi Y, Endo H, Takeda A, Diers K, Bajo R, Maestúc F, Ito K, Kato T. Electromagnetic signatures of the preclinical and prodromal stages of Alzheimer’s disease. Brain. 2018 May 1;141(5):1470-1485.
  6. Sugimoto T, Sakurai T, Ono R, Kimura A, Saji N, Niida S, Toba K, Chen LK, Arai H. Epidemiological and Clinical Significance of Cognitive Frailty: a Mini Review. Ageing Res Rev. 2018 Jul;44:1-7.
  7. Umegaki H, Makino T, Yanagawa M, Nakashima H, Kuzuya M, Sakurai T, Toba K. Maximum gait speed is associated with a wide range of cognitive functions in subjects with a clinical dementia rating of 0.5. Geriatr Gerontol Int 2018 Sep;18(9):1323–1329. 
  8. Arai Y, Kajiwara K, Toba K, Sakurai T, Mori D, Ookubo N, Fujisaki A. A prompt and practical on-site support programme for family caregivers of persons with dementia: a preliminary uncontrolled interventional study. Psychogeriatrics. 2018 Nov;18(6):476-478.
  9. Ishihara M, Saito M, Sakurai T, Shimada H, Arai H. Effect of a Positive Photo Appreciation Program on Depressive Mood in Older Adults: A Pilot Randomized Controlled Trial. Int J Environ Res Public Health. 2018 Jul 12;15(7):1472.  
  10. Toyoshima K, Araki A, Tamura Y, Iritani O, Ogawa S, Kozaki K, Ebihara S, Hanyu H, Arai H, Kuzuya M, Iijima K, Sakurai T, Suzuki T, Toba K, Arai H, Akishita M, Rakugi H, Yokote K, Ito H, Awata S. Development of the Dementia Assessment Sheet for Community-based Integrated Care System 8-items, a short version of the Dementia Assessment Sheet for Community-based Integrated Care System 21-items, for the assessment of cognitive and daily functions. Geriatr Gerontol Int. 2018 Oct;18(10):1458-1462.  
  11. Maki Y, Sakurai T, Okochi J, Yamaguchi H, Toba K. Rehabilitation to live better with dementia. Geriatr Gerontol Int. 2018 Nov;18(11):1529-1536.  
  12. Ogama N, Sakurai T, Kawashima S, Tanikawa T, Tokuda H, Satake S, Miura H, Kokubo M, Shimizu A, Niida S, Toba K, Umegaki H, Kuzuya M. Postprandial Hyperglycemia is Associated with White Matter Hyperintensity and Brain Atrophy in Older Person with Type 2 Diabetes Mellitus Front Aging Neurosci. 2018 Sep 12;10:273.
  13. Saji N, Sakurai T, Ito K, Tomimoto H, Kitagawa K, Miwa K, Tanaka Y, Kozaki K, Kario K, Eto M, Suzuki K, Shimizu A, Niida S, Hirakawa A, Toba K, on behalf of the Strawberry study investigators. Protective effects of oral anticoagulants on cerebrovascular diseases and cognitive impairment in patients with atrial fibrillation: protocol of a multicenter, prospective, observational, longitudinal cohort study (Strawberry study). BMJ Open 2018 Nov;25;8(11):e021759. doi:10.1136/ bmjopen-2018-021759.
  14. Saji N, Tone S, Murotani K, Yagiya Y, Kimura K, Sakurai T. Cilostazol may decrease plasma inflammatory biomarkers in patients with recent small subcortical infarcts: a pilot study. J Stroke Cerebrovasc Dis. 2018 Jun;27(6):1639-1645.
  15. Saji N, Niida S, Murotani K, Hisada T, Tsuduki T, Sugimoto T, Kimura A, Toba K, Sakurai T. Analysis of the relationship between the gut microbiome and dementia: a cross-sectional study conducted in Japan. Sci Rep. 2019 Jan 30;9(1):1008.
  16. Sugimoto T, Ono R, Kimura A, Saji N, Niida S, Toba K, Sakurai T. Physical Frailty Correlates With Behavioral and Psychological Symptoms of Dementia and Caregiver Burden in Alzheimer's Disease. J Clin Psychiatry. 2018 Nov 13;79(6).
  17. Sugimoto T, Toba K, Sakurai T. Status of glycemic control in elderly patients with cognitive impairment treated by general practitioners relative to the glycemic targets recommended for elderly patients by the Japan Diabetes Society/Japan Geriatrics Society Joint Committee: A retrospective analysis. J Diabetes Investig. 2018 Sep;9(5):1230-1232.
  18. Sugimoto T, Sakurai T, Ono R, Kimura A, Saji N, Niida S, Toba K, Chen LK, Arai H. Epidemiological and clinical significance of cognitive frailty: A mini review. Ageing Res Rev. 2018 Jul;44:1-7.
  19. Kimura A, Sugimoto T, Niida S, Toba K, Sakurai T. Association Between Appetite and Sarcopenia in Patients With Mild Cognitive Impairment and Early-Stage Alzheimer's Disease: A Case-Control Study. Front Nutr. 2018 Dec 18;5:128.
  20. Fujisawa C, Umegaki H, Nakashima H, Kuzuya M, Toba K, Sakurai T. Complaint of poor night sleep Is correlated with physical function Impairment in mild Alzheimer's disease patients. Geriatr Gerontol Int. 2019 Feb 19(2):171-172, 2019.
  21. Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Takizawa S, Sakurai T, Ozaki K, Niida S. Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data. Commun Biol. 2019 Feb 25;2:77.  
  22. Matsuoka K, Yasuno F, Hashimoto A, Miyasaka T, Takahashi M, Kiuchi K, Iida J, Kichikawa K, Kishimoto T. Left dorsolateral prefrontal cortex atrophy is associated with frontal lobe function in Alzheimer's disease and contributes to caregiver burden. Int J Geriatr Psychiatry. 2018 May;33(5):703-709.doi:10.1002/gps.4843.
  23. Suma S, Watanabe Y, Hirano H, Kimura A, Edahiro A, Awata S, Yamashita Y, Matsushita K, Arai H, Sakurai T. Factors affecting the appetites of persons with Alzheimer's disease and mild cognitive impairment. Geriatr Gerontol Int. 2018 Aug;18(8):1236-1243.
  24. Takenoshita S, Terada S, Yokota O, Kutoku Y, Wakutani Y, Nakashima M, Maki Y, Hattori H, Yamada N. Sally-Anne Test in Patients with Alzheimer's Disease Dementia. J Alzheimers Dis. 2018;61(3):1029-1036. 
  25. Yasuno F, Matsuoka K, Miyasaka T, Takahashi M, Kitamura S, Yoshikawa H, Hattori H, Kichikawa K, Kishimoto T. Decreased perfusion of the posterior cingulate gyri as a possible marker of the onset of behavioural and psychological symptoms of Alzheimer’s disease. Psychogeriatrics. 2019 Mar;19(2):165-170.

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  1. Tamura Y, Kimbara Y, Yamaoka T, Sato K, Tsuboi Y, Kodera Y, Chiba Y, Mori S, Fujiwara Y, Tokumaru AM, Ito H, Sakurai T, Araki A. White matter hyperintensity in elderly patients with diabetes mellitus is sssociated with cognitive impairment, functional disability, and a high glycoalbumin/glycohemoglobin ratio. Front Aging Neurosci, 9,2017 doi: 10.3389/fnagi.2017.00220. eCollection 2017.
  2. Kamiya M, Osawa A, Kondo I, Sakurai T. Factors associated with cognitive function that affect decline in activities of daily living level in Alzheimer’s disease. Geriatr Gerontol Int. 2018 Jan;18(1):50-56.
  3. Araki A, Yoshimura Y, Sakurai T, Umegaki H, Kamada C, Iimuro S, Ohashi Y, Ito H, and the Japanese Elderly Diabetes Intervention Trial Research Group. Low intake of carotene, vitamin B2, and calcium predicts cognitive decline in elderly patients with diabetes mellitus: the Japanese Elderly Diabetes Intervention Trial. Geriatr Gerontol Int.2017 Aug;17(8):1168-1175.
  4. Fujisawa C, Umegaki H, Nakashima H, Okamoto K, Kuzuya M, Toba K, Sakurai T. Physical Function Differences Between the Stages From Normal Cognition to Moderate Alzheimer Disease. J Am Med Dir Assoc. 2017 Apr 1;18(4):368.e9-e368.e15.
  5. Sakurai T. Committee Report: Glycemic targets for elderly patients with diabetes. Japan Diabetes Society (JDS)/Japan Geriatrics Society (JGS) Joint Committee on Improving Care for Elderly Patients with Diabetes. J Diabetes Investig. 2017 Jan;8(1):126-128.
  6. Saji N, Sakurai T. Is gait speed a risk factor for dementia? Geriatr Gerontol Int. 2017 Apr;17 Suppl 1:75-76.
  7. Saji N, Murotani K, Shimizu H, Uehara T, Kita Y, Toba K, Sakurai T. Increased pulse wave velocity in patients with acute lacunar infarction doubled a risk of future ischemic stroke. Hypertens Res. 2017 Apr;40(4):371-375.
  8. Tsuboi Y, Ueda Y, Sugimoto T, Naruse F, Ono R. Association between metabolic syndrome and disability due to low back pain among care workers. Int J Occup Med Environ Health. 2018 Jan 7;31(2):165-172.
  9. Sugimoto T, Nakamura A, Kato T, Iwata K, Saji N, Arahata Y, Hattori H, Bundo M, Ito K, Niida S, Sakurai T; MULNIAD study group. Decreased Glucose Metabolism in Medial Prefrontal Areas is Associated with Nutritional Status in Patients with Prodromal and Early Alzheimer's Disease. J Alzheimers Dis. 2017;60(1):225-233.
  10. Sugimoto T, Yoshida M, Ono R, Murata S, Saji N, Niida S, Toba K, Sakurai T. Frontal Lobe Function Correlates with One-Year Incidence of Urinary Incontinence in Elderly with Alzheimer Disease. J Alzheimers Dis. 2017;56(2):567-574.
  11. Sugimoto T, Ono R, Murata S, Saji N, Matsui Y, Niida S, Toba K, Sakurai T. Sarcopenia is Associated With Impairment of Activities of Daily Living in Japanese Patients With Early-Stage Alzheimer Disease. Alzheimer Dis Assoc Disord. 2017 Jul-Sep 2017;31(3):256-258.
  12. Sawa R, Doi T, Misu S, Saito T, Sugimoto T, Murata S, Asai T, Yamada M, Ono R. The severity and number of musculoskeletal pain associated with gait in community-dwelling elderly individuals. Gait Posture. 2017 May;54:242-247.
  13. Misu S, Asai T, Doi T, Sawa R, Ueda Y, Saito T, Nakamura R, Murata S, Sugimoto T, Yamada M, Ono R. Association between gait abnormality and malnutrition in a community-dwelling elderly population. Geriatr Gerontol Int. 2017 Aug;17(8):1155-1160.

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  1. Maki Y, Sakurai T, Toba K. A new model of care for patients with dementia-Japanese Initiative for Dementia Care. Oxford Textbook Geriatric Medicine. P1027-1032, 2016. Third Edition, Edited by Jean-Pierre Michel, B. Lynn Beattie, Finbarr C. Martin, and Jeremy D. Walston, Oxford University Press
  2. Sakurai T, Arai H, Toba K. Japan’s challenge of early detection of persons with cognitive decline. J Am Med Dir Assoc.2016 May 1;17(5):451-2.
  3. Ogama N, Sakurai T, Nakai T, Niida S, Saji N, Toba K, Umegaki H, Kuzuya M.Impact of Frontal White Matter Hyperintensity on Instrumental Activities of Daily Living in Elderly Women with Alzheimer Disease and Amnestic Mild Cognitive Impairment. PLoS One. 2017 Mar 2;12(3):e0172484.
  4. Wang XN, Hu X, YangY, Takata T, Sakurai T. Nicotinamide mononucleotide protects against β-amyloid oligomer-induced cognitive impairment and neuronaldeath. Brain Res.2016 Jul 15;1643:1–9.
  5. Glycemic Targets for Elderly Patients with Diabetes. Japan Diabetes Society (JDS)/Japan Geriatrics Society (JGS) Joint Committee on Improving Care for Elderly Patients with Diabetes. Geriatr Gerontol Int. 2016 Dec;16(12):1243-1245.
  6. Saji N, Sakurai T, Toba K. Cerebral small vessel disease and arterial stiffness: Tsunami effect in the brain? Pulse (Basel).2016 Apr;3(3-4):182-9.
  7. Saji N, Sakurai T, Suzuki K, Mizusawa H, Toba K, on behalf of the ORANGE investigators. ORANGE’s challenge: developing wide-ranging dementia research in Japan. Lancet Neurol. 2016 Jun;15(7):661-662.
  8. Saji N, Kimura K, Tateishi Y, Fujimoto S, Kaneko N, Urabe T, Tsujino A, Iguchi Y, daVinci study group. Safety and efficacy of non-vitamin K oral anticoagulant treatment compared with warfarin in patients with non-valvular atrial fibrillation who develop acute ischemic stroke or transient ischemic attack: a multicenter prospective cohort study (daVinci study). J Thromb Thrombolysis. 2016 Nov;42(4):453-62.
  9. Sugimoto T, Misu S, Sawa R, Nakakubo S, Ueda Y, Nakatsu N, Saito T, Nakamura R, Murata S, Ono R. Association between the Cardio-Ankle Vascular Index and Executive Function in Community-Dwelling Elderly People. J Atheroscler Thromb. 2016 Jul 1;23(7):857-64.
  10. Sugimoto T, Ono R, Murata S, Saji N, Matsui Y, Niida S, Toba K, Sakurai T. Prevalence and associated factors of sarcopenia in elderly subjects with amnestic mild cognitive impairment or Alzheimer disease. Curr Alzheimer Res. 2016;13(6):718-26.
  11. Sugimoto T, Tsutsumimoto K, Nakakubo S, Murata S, Doi T, Ono R. Abdominal obesity mediates the association between a low physical activity and a decline in gait speed in community-dwelling elderly people: A cross-sectional study. Nihon Ronen Igakkai Zasshi. 2016;53(1):54-61.

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  1. Nakashima T, Sugiura S, Naganawa S, Yasue M, Inui Y, Sakurai T, Uchida Y, Sone M, Teranishi M, Yoshida T, Ito K, Toba K. Cerumen Impaction Revealed by Brain Magnetic Resonance Imaging in Patients with Cognitive Impairment. Geriatr Gerontol Int.2016 Mar;16(3):392-5.
  2. Ogama N, Yoshida M, Nakai T, Niida S, Toba K, Sakurai T. Frontal white matter hyperintensity predicts lower urinary tract dysfunction in older adults with amnestic mild cognitive impairment and Alzheimer's disease. Geriatr Gerontol Int. 2016 Feb;16(2):167-74.
  3. Satake S, Senda K, Hong Y-J, Miura H, Endo H, Sakurai T, Kondo I, Toba K. Validity of the Kihon checklist for assessing frailty status. Geriatr Gerontol Int.2016 Jun;16(6):709-15.
  4. Seike A, Sakurai T, Sumigaki C, Takeda A, Endo H, Toba K. Verification of Educational Support Intervention for Family Caregivers of Persons with Dementia. J Am Geriatr Soc.2016 Mar;64(3):661-3.
  5. Saji N, Ogama N, Toba K, Sakurai T. White matter hyperintensities and the geriatric syndrome: an important role of arterial stiffness. Geriatr Gerontol Int. 2015 Dec;15 Suppl 1:17-25.
  6. Saji N, Kimura K, Yagita Y, Uemura J, Aoki J, Sato T, Sakurai T. Deep cerebral microbleeds and renal dysfunction in patients with acute lacunar infarcts. J Stroke Cerebrovasc Dis. 2015 Nov;24(11):2572-9.
  7. Saji N, Kawarai T, Miyamoto R, Sato T, Morino H, Orlacchio A, Oki R, Kimura K, Kaji R. Exome sequencing identifies a novel intronic mutation in ENG that cause recurrence of pulmonary arteriovenous malformations. J Neurol Sci. 2015;352(1-2):29-33.
  8. Saji N, Kimura K, Aoki J, Uemura J, Sakamoto Y. Intracranial hemorrhage caused by non-vitamin K antagonist oral anticoagulants (NOACs): a multicenter retrospective cohort study in Japan. Circ J. 2015;79(5):1018-23.
  9. Saji N, Kimura K, Yagita Y, Kawarai T, Shimizu H, Kita Y. Comparison of arteriosclerotic indicators in patients with ischemic stroke: ankle-brachial index, brachial-ankle pulse wave velocity, and cardio-ankle vascular index. Hypertens Res. 2015 May;38(5):323-8.

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