E-Mail

kmatsu30@ncgg.go.jp

Telephone

+81-562-46-2311（Ext. 5401）

Fax

+81-562-46-8479

Degree

DDS, PhD

Fields of Expertise

Vascular Biology, Conservative Dentistry, Periodontology, Oral Immunology, Oral Bacteriology, Gerodontology

Subjects of Research

Control of Oral Infectious Diseases, Control of Vascular Inflammation, Oral Health Promotion for Aging Well

Keyword

Periodontitis, P. gingivalis, Atherosclerosis, Thrombosis, Endothelial cells, Exocytosis, Endocytosis, NSF, Nitric Oxide, Reactive Oxygen Species, Epidemiological Survey

Collateral Offices

Visiting Professor: Collaborative Department of Longevity Oral Science, Graduate School of Dentistry, Tohoku University; Collaborative Department of Longevity Oral Science, Graduate School of Dental Medicine, Hokkaido University; School of Dentistry, Health Sciences University of Hokkaido; School of Dentistry, Aichi Gakuin University; Collaborative Department of Longevity Oral Science, Kagoshima University Graduate School of Medical and Dental Sciences Visiting Lecture: Kyusyu University School of Dentistry, Hiroshima University School of Dentistry, Chubu University

Board of Academic Society

Japanese Society of Periodontology, Japanese Society of Anti-Aging Medicine, Oral Medicine Frontier

Awards & Honors

Young Investigator Award, Japanese Society of Conservative Dentistry (1995)
Young Investigator Prize in Thrombosis, 4th Annual Conference on Arteriosclerosis, Thrombosis and Vascular Biology (2003)
Young Investigator Award, The 3rd International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide (2004)

Selected Publications

• Matsushita K, Morrell CN, Cambien B, Yang SX, Yamakuchi M, Bao C, Hara MR, Quick RA, Cao W, O'Rourke B, Lowenstein JM, Pevsner J, Wagner DD, Lowenstein CJ: Nitric oxide regulates exocytosis by S-nitrosylation of N-ethylmaleimide-sensitive factor. Cell 115:139-150, 2003.
• Matsushita K, Morrell CN, and Lowenstein CJ: Sphingosine 1-phosphate activates Weibel-Palade body exocytosis. Proc Natl Acad Sci USA 101:11483-11487, 2004.
• §Bhatia R, §Matsushita K, Yamakuchi M, Morrell CN, Cao W, and Lowenstein CJ: Ceramide triggers Weibel-Palade body exocytosis. Circ Res 95:319-324, 2004.
• Matsushita K, Morrell CN, and Lowenstein CJ: A novel class of fusion polypeptides inhibits exocytosis. Mol Pharmacol 67:1137-1144, 2005.
• Matsushita K, Yamakuchi M, Morrell CN, Ozaki M, O'Rourke B, Irani K, and Lowenstein CJ: Vascular endothelial growth factor regulation of Weibel-Palade-body exocytosis. Blood 105:207-214, 2005.
• Matsushita K, Morrell CN, Mason RJA, Yamakuchi M, Khanday FA, Irani K, and Lowenstein CJ: Hydrogen Peroxide Regulation of Endothelial Exocytosis by Inhibition of N-Ethylmaleimide Sensitive Factor. J Cell Biol 170:73-79, 2005.
• Into T, Kanno Y, Dohkan JI, Nakashima M, Inomata M, Shibata KI, Lowenstein CJ, Matsushita K. Pathogen recognition by Toll-like receptor 2 activates Weibel-Palade body exocytosis in human aortic endothelial cells. J Biol Chem 282:8134-8141, 2007.
• Into T, Inomata M, Nakashima M, Shibata K, Hacker H, Matsushita K: Regulation of MyD88-dependent signaling events by S nitrosylation retards toll-like receptor signal transduction and initiation of acute-phase immune responses. Mol Cell Biol 28:1338-1347, 2008.
• Kanno Y, Into T, Lowenstein CJ, Matsushita K: Nitric oxide regulates vascular calcification by interfering with TGF- signaling. Cardiovasc Res 77:221-730, 2008.
• §Jeong Y, Chaupin DF, §Matsushita K, Yamakuchi M, Cameron S, Morell CN, Lowenstein CJ: Aldosterone activates endothelial exocytosis. Proc Natl Acad Sci USA 106:3782-3787, 2009.

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