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研究業績
2013
Yasuyo Suzuki, Chenghua Jin, Ikuru Yazawa
Increased aggregation of polyleucine compared with that of polyglutamine in dentatorubral-pallidoluysian atrophy protein.
Neuroscience Letters, 552, 156-161, 2013.

2012
Nakayama K, Suzuki Y, and Yazawa I

Binding of neuronal α-synuclein to β-III tubulin and accumulation in a model of multiple system atrophy.

Biochemical and biophysical research communications, 417, 1170-1175, 2012.

Ito　H, Nakayama K, Jin C, Suzuki Y, and Yazawa I
α-Synuclein accumulation reduces GABAergic inhibitory transmission in a model of multiple system atrophy.
Biochemical and biophysical research communications, 428, 348-353, 2012.

2011
Suzuki Y and Yazawa I

Pathological accumulation of atrophin-1 in dentatorubralpallidoluysian atrophy.

International Journal of Clinical and Experimental Pathology, 4, 378-384, 2011

2010
Suzuki Y, Nakayama K, Hashimoto N, and Yazawa I
Proteolytic processing regulates pathological accumulation in dentatorubral-pallidoluysian atrophy.
FEBS Journal, 277, 4873-4887, 2010.

2009
Hazeki-Taylor N, Yazawa I, and Kanazawa I
Perspectives on the therapeutic targets for Huntington's disease in view of the structural and biochemical properties of polyglutamine aggregates.
International Journal of Medical and Biological Frontiers, 15, 337-355, 2009

Nakayama K, Suzuki Y, and Yazawa I
Microtubule depolymerization supresses alpha-synuclein accumulation in a mouse of multiple system atrophy.
The American Journal of Pathology, 174, 1471-1480, 2009


主な過去の論文

2006
Uryu K, Richter-Landberg C, Welch W, Sun E, Goldbaum O, Norris EH, Pham CT, Yazawa I, Hilburger K, Giasson BI, Bonini N, Lee VMY and Trojanowski JQ.
Convergence of Hsp90 with ubiquitin in filamentous alpha-synuclein inclusions of alpha-synucleinopathy. Am J Pathol 168, 947-961, 2006

2005
Yazawa I, Giasson BI, Sasaki R, Zhang B, Joyce S, Uryu K, Trojanowski JQ and Lee VMY. Mouse model of multiple system atrophy: alpha-synuclein expression in oligodendrocytes causes glial and neuronal degeneration. Neuron 45, 847-859

2000
Yazawa I. Aberrant phosphorylation of dentatorubral-pallidoluysian atrophy (DRPLA) protein complex in brain tissue. Biochem J 351, 587-591

1995
Yazawa I, Nukina N, Hashida H, Goto J, Yamada M and Kanazawa I. Abnormal gene product identified in hereditary dentatorubral-pallidoluysian atrophy (DRPLA) brain. Nat Genet 10, 99-103, 1995.

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