4. 主な研究成果とその参考文献 (最近発表のもの) Nakamura H, Kawagishi H, Watanabe A, Sugimoto K, Maruyama M, Mizutani S, and Sugimoto M "Cooperative role of the RNA-binding proteins Hzf and HuR in p53 activation." Molecular Cellular Biology, 10, 1997-2009, 2011 Ito T, Takii T, Maruyama M, Hayashi D, Wako T, Asai A, Horita Y, Taniguchi K, Yano I, Yamamoto S, Onozaki K "Effectiveness of BCG vaccination to aged mice." Immun Ageing, 7:12-12,2010 Kawagishi H, Nakamura H, Maruyama M, Mizutani S, Sugimoto K, Takagi M, and Sugimoto M "ARF suppresses tumor angiogenesis through translational control of VEGFA mRNA." Cancer Research, 70(11): 4749-4758, 2010 Jia YJ, Asai A, Sakabe I, and Maruyama M "Rat Monoclonal Antibodies against New Guanine Nucleotide Exchange Factor (GEF), mouse Zizimin2. " Hybridoma, 29(3): 205-209. 2010 Maruyama M "214I9 against mouse Zizimin2 C-terminal-half fragment." Hybridoma, 29(3): 273-273, 2010 Nakamura H, Asai A, Maruyama M and Sugimoto M "Production of Rat Monoclonal Antibodies Against RNA-binding Protein, Hzf." Hybridoma, 29(1):7-11, 2010 Maruyama M, Wakoh T, Terauchi K, Sugimoto M, and Jun-ichi Shimada "Putative role of a novel p53-dependent cellular senescence related gene, TARSH in tumor suppression". The Journal of Nutrition, Health and Aging, 13(suppl.1), S553, 2009 Wakoh T, Uekawa N, Terauchi K, Sugimoto M, Ishigami A, Shimada J, and Maruyama M: "Implication of p53-dependent cellular senescence related gene, TARSH in tumor suppression." Biochemical and Biophysical Research Communications, 380, 807-812. 2009 Wakoh T, Sugimoto M, Terauchi K, Shimada J,and Maruyama M: "A novel p53-dependent apoptosis function of TARSH in tumor development." Nagoya J Med Sci. 71(3-4), 109-114. 2009 Kawagishi H, Wakoh T, Uno H, Maruyama M, Moriya A, Morikawa S, Okano H, Sherr C.J., Takagi M, and Sugimoto M. "Hzf regulates adipogenesis through translational control of C/EBPα.." The EMBO Journal , 27(10), 1481-1490, 2008 Uekawa N, Nishioka T, Terauchi K, Ohta S, Sugimoto M, Shimada J, and Maruyama M "Generation and Characterization of Novel Monoclonal Antibodies Against Murine and Human TARSH Proteins " Hybridoma. 26(6): 381-386, 2007 Maruyama M "M38, MS6, and MS13 Against Murine TARSH C Terminal-Half Fragment " Hybridoma. 26(6): pp441-442, 2007 Maruyama M "H165, H56, and H69 Against Murine and Human TARSH C Terminal-Half Fragment " Hybridoma. 26(6): pp443-444, 2007 Ujike-Asai A，Okada A，Du Y，Maruyama M，Yuan X，Ishikawa F，Motoo Y，Isobe K and Nakajima H "Large defects of type I allergic response in telomerase reverse transcriptase knockout mice" J Leukoc Biol. 82:429-435, 2007 Mitsuda N, Yamagata HD, Zhong W, Aoto M, Akatsu H, Uekawa N, Kamino K, Taguchi K, Yamamoto T, Maruyama M, Kosaka K, Takeda M, Kondo I,and Miki T. "A novel alternative splice variant of nicastrin and its implication in Alzheimer disease." Life Sci. 78, 2444-2448, 2006 Murata Y*, Wakoh T*, Uekawa N, Sugimoto M, Asai A, Miyazaki T and Maruyama M. "Death-associated protein 3 regulates cellular senescence through oxidative stress response" FEBS Lett 580, 6093-6099, 2006 (*equal contribution) Terauchi K, Shimada J, Uekawa N, Yaoi T, Maruyama M and Fushiki S
"Cancer-associated loss of TARSH gene expression in human primary lung cancer.”
J Cancer Res Clin Oncol. 132, 28-34, 2006 Uekawa N,Terauchi,K Nishikimi A, Shimada J, and Maruyama M
"Expression of TARSH gene in MEFs senescence and its potential implication in human lung cancer.” Biochem Biophys res Commun 329, 1031-1038, 2005 Novobrantseva T, Xu S, Tan J, Maruyama M, Schwers S, Pelanda R, and Lam KP
"Stochastic Pairing of Immunoglobulin Heavy and Light Chains Frequently Generates B Cell Antigen Receptors That Are Subject to Editing in Vivo.” Int Immunol. 17, 343-350, 2005 Nishikimi A*, Meller N*, Uekawa N, Isobe K, Schwartz MA and Maruyama M
"Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes .” FEBS Lett 579, 1039-1046, 2005 (*equal contribution) Uekawa N, Nishikimi, A Isobe K, Iwakura Y, and Maruyama M.
“Involvement of IL-1 family proteins in p38 linked cellular senescence of mouse embryonic fibroblasts.”
FEBS Lett 575, 30-34, 2004 Oberdoerffer P, Otipoby K, Maruyama M, and Rajewsky K
“Unidirectional Cre-mediated genetic inversion in mice using the mutant loxP pair lox66/lox71.” Nucleic Acids Res. 31, e140, 2003 Maruyama M, Lam KP, and Rajewsky K
"Memory B-cell persistence is independent of persisting immunizing antigen. Nature 407, 636-642, 2000 杉本昌隆、丸山光生 細胞老化の分子機構と生体内における役割
基礎老化研究 30（3）pp5-10, 2006 丸山光生 知の歴史/ネイチャー特別編集 Laura Garwin, Tim Lincoln編集
徳間書店 分担訳者 東京 pp158-167, 2002 丸山光生 「記憶B細胞の維持と免疫抗原の関係」
羊土社 実験医学 vol.17, 380 -383, 2001 丸山光生 「記憶B細胞の生体内での維持における免疫抗原の役割」
中山書店「免疫'01 - '02」vol.38, 160-170, 2001 丸山光生 ザ・プロトコールシリーズ「遺伝子機能破壊実験法」
羊土社 p38-44, 羊土社, 2001 丸山光生 ﾒ Hope 登場ﾓ 「素人であり続けたい免疫学」, 2006 (その参考文献) *Stephan Martin and Chris Goodnow
"Memory needs no reminders" (N & V) Nature, 407, 576-577, (2000) *Garnett Kelsoe " Remembrance of things past" (N & V)
Nature immunology, 1, 375-376, (2000) *週刊 科学新聞 「問題の問題点」2001年4月27日号 (これまでの主な発表) * Maruyama M., Shibuya H., Harada H., Hatakeyama M., Seiki M., Fujita T., Inoue J.I., Yoshida M. and Taniguchi T. "Evidence for Aberrant Activation of the Interleukin-2 Autocrine Loop by HTLV-1-Encoded p40x and T3/Ti Complex Triggering" Cell, vol.48, 343 - 350, (1987) * Miyamoto M., Fujita T., Kimura Y., Maruyama M., Harada H., Sudo Y., Miyata T. and Taniguchi T "Regulated Expression of a Gene Encoding a Nuclear Factor, IRF-1, That Specifically Binds to IFN-γ Gene Regulatory Element" Cell, Vol.54, 903 - 913, (1988) * Maruyama M., Fujita T. and Taniguchi T. "Sequence of a cDNA coding for Human IRF-1"
Nucleic Acids Research, Vol.17, 8, 3292 (1989) * Harada H., Fujita F., Miyamoto M., Kimura Y., Maruyama M., Furia A., Miyata T., and Taniguchi T. "Structurally Similar but Functionally Distinct Factors, IRF-1 and IRF-2, Bind to the Same Regulatory Elements of IFN and IFN-Induced Genes" Cell, Vol.58, 729 - 739, (1989) * Miyazaki T., Maruyama M., Yamada G., Hatakeyama M. and Taniguchi T. "The integrity of the conserved "WS-motif" common to IL-2 and other cytokine receptors is essential for ligand binding and signal transduction"
EMBO J. Vol.10, 3191 - 3197, (1991) * Ogawa E., Maruyama M., Kagoshima H., Inuzuka M., Lu J., Satake M., Shigesada K. and Ito. Y. " PEBP2/PEA2 represents α new family of transcription factor homologous to the products of the Drosophila runt and the human AML1." Proc. Natl. Acad. Sci USA 90, 6859 - 6863, (1993) * Bae S.C., Ogawa E., Maruyama M., Oka H., Satake M., Shigesada K., Jenkins N.A., Gilbert D.J., Copeland N.G. and Ito. Y. "PEBP2αB/Mouse AML1 consists of multiple isoforms that possess differential transactivation potentials." Mol. Cell. Biol., 14, 3242 - 3252, (1994) * Lu J., Maruyama M., Satake M., Bae S.C., Ogawa E., Kagoshima H., Shigesada K. and Ito Y. " Subcellular Localization of the α and β Subunits of Acute Myeloid Leukemia-linked Transcription Factor PEBP2/CBF."
Mol Cell Biol, 15, 1651-1661, (1995) * Ahn M.Y., Bae S.C., Maruyama M. and Ito Y . "Comparison of the human genomic structure of the Runt domain-encoding PEBP2/CBFα gene family." Gene, 68(2): 279-280, (1996) | 
