Department of Inflammation and Immunosenescence

Welcome to our DII homepage

Last updated on June 13, 2022

What's new...

• Publication list has been updated to include up to 2021.
• Dr. Maruyma served as a president of the 44th annual meeting of JSBMG. 
  (Joint meeting with the 32nd Japan Gerontological Society held on 11,12and13, June, 2021 at Aichi health Plaza/Simultaneous web delivery) 
• On 1 April 2021, the GSRC was established in the Research Institute and DMA was trans formed  into DII.

• Dr. Maruyma acted as the organaiser of the 1st citizen forum of Japan Society for Biomedical Gerontology.
  (hold on 7 and 8, November, 2020 at Shinmai media garden, Matsumoto, Nagano) 

• Our cover picture was updated to the version 2020. 
• An article on the keynote address of Dr. Maruyama in Presymptomatic disease symposium was published  in the Yomiuri newspaper on Feb. 22, 2020. 
• Dr. Maruyama has been selected as a president of the Japan Society for Biomedical Gerontology on 1 April 2019. 
• Dr. Maruyma served as a president of the 40th annual meeting of JSBMG. 
  (held on 14,15 and 16, June, 2017 at Nagoya Congress Center) 
• Dr. Maruyama has been promoted as a deputy director of our research Institute, NCGG on 1 May 2015. 
• Dr. Maruyma served as a president of the 37th annual meeting of JSBMG. 
  (held on 26 and 27, June, 2014 at Aichi health Plaza) 　

   the 37th annual meeting of JSBMG      the 40th annual meeting of JSBMG

                                          the 44th annual meeting of JSBMG 　  the 1st citizen forum of JSBMG

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Members

Last updated on July 3,2023

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What is DII?

Sorry, this page is currently under construction.

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Notice Board

Let's join our cutting edge research for Mechanism of Aging with us. 

Our department has been in cooperation with the department of Aging Research, Program in Integrated Molecular Medicine, Nagoya University Graduate School of Medicine since 2006. 

Actually Dr. Mitsuo Maruyama has charged the course as a visiting professor therefore we can manage not only seminar but also experimental research, whenever new face graduate students join here. If you find any interest or something excited about Aging Research in our web site, please try to contact us I first, and then join our laboratory in Nagoya University to feel cutting edge Aging research. 

Nagoya university Graduate School of Medicine

Program in integrated Molecular Medicine

Molecular Aging Research,Department of Aging Research

Seminar

In our research institute, we had seminars by the famous and popular scientists in the various field of aging from home and abroad. Some of them were introduced as graduate seminars at the Graduate School of Medicine, Nagoya University, and basically all of them were open to the public.

NCGG seminar（Hosted only by the Department of  Mechanism ofAging）

2019

2018

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Our Pictures

Now, our pictures are being updated.

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Publications

2021 2020 2019 2018

2021

​​Original Papers

• Morita Y, Jounai K, Tomita Y, Maruyama M.
  Long-term intake of Lactobacillus paracasei KW3110 prevents age-related circadian locomotor activity and changes in gut metabolism in physiologically aged mice.
  Exp Gerontol. 2021 Oct 1;153:111477. Epub 2021 Jul 13.

• Kawaguchi K, Komoda K, Mikawa R, Asai A, Sugimoto M.
  Cellular senescence promotes cancer metastasis by enhancing soluble E-cadherin production.
  iScience. 2021 Aug 24;24(9):103022. eCollection 2021 Sep 24.

• Kawaguchi K, Hashimoto M, Mikawa R, Asai A, Sato T, Sugimoto M.
  Protocol for assessing senescence-associated lung pathologies in mice.
  STAR Protocols.2021 Dec4:2(4):100993

• Suda M, Shimizu I, Katsuumi G, Yoshida Y, Hayashi Y, Ikegami R, Matsumoto N, Yoshida Y, Mikawa R, Katayama A, Wada J, Seki M, Suzuki Y, Iwama A, Nakagami H, Nagasawa A, Morishita R, Sugimoto M, Okuda S, Tsuchida M, Ozaki K, Nakanishi-Matsui M, Minamino T.
  Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice.
  Nature Aging. 10 December 2021.  https://doi.org/10.1038/s43587-021-00151-2

• Sugiyama Y, Fujiwara M, Sakamoto A, Tsushima H, Nishikimi A, Maruyama M.
  The immunosenescence-related factor DOCK11 is involved in secondary immune responses of B cells.
  Immunity & Ageing. 2022 Jan 3;19(1):

Review and book

Please see also the page in Japanese.

Invited oral presentation(Symposium or keynote speech)

• Sugimoto M. 
  Senolysis: a potential approach against pulmonary aging and diseases.
  Symposium speaker, The 80th Annual Meeting of the Japanese Canser Association,Sep 30th, 2021, Yokohama

• Maruyama M.
  Inflammaging, taking lessons from history
  Workshop Organizer and Closing Remarks, The 44th Annual Meeting of the Molecular Biology Society of Japan, Dec 2nd, 2021, Yokohama

International scientific meeting

• Kawaguchi K, Asai A, Sugimoto M.
  Senescence-dependent ectodomain shedding of E-cadherin promotes cancer metastasis.
  The 6th International Cell Senescence Association Conference, Dec 13th,  2021, Osaka       

Domestic scientific meeting

• Kawaguchi K, Komoda K, Mikawa R , Asai A, Sugimoto M. 
  Senescence-dependent alveolar factor promotes cancer metastasis.
  The 44th Annual Meeting of Japan Society for Biomedical Gerontolosy, Jun 12th, 2021, Obu

•  Sugiyama Y, Nishikimi A, Maruyama M.
  Diversity of p16INK4a-associated chronological senescence in MEF culture.
  The 44th Annual Meeting of Japan Society for Biomedical Gerontolosy, Jun 12th, 2021, Obu

•  Goto A, Hashimoto M, Endo Y, Yokogawa S, Maruyama M, Yamashita H.
  CREG1 enhances muscle function in mice.
  The 44th Annual Meeting of Japan Society for Biomedical Gerontolosy, Jun 12th, 2021, Obu

Lecture and Seminar

Please see also the page in Japanese.

Newspaper, Press release and others

Please see also the page in Japanese.

2020

Original Papers

• Sakamoto A, Maruyama M.
  Contribution of DOCK11 to the Expansion of Antigen-Specific Populations among Germinal Center B Cells.
  Immunohorizons. 2;4(9):520-529, Sep, 2020

• Akatsu H, Manabe T, Kawade Y, Tanaka H, Kanematsu T, Arakawa K, Masaki Y, Hishida C, Kanesaka T, Ogawa N, 　Hashizume Y, Tsuneyama K, Ohara H, Maruyama M, Yamamoto T.
  Iron deposition in autopsided liver specimens from older patients receiving intravenous iron infusion.
  PLoS One. 4;15(8): e0237104, Aug, 2020. 

• Kameyama A, Nishijima R, Yamakoshi K.
  Bmi-1 regulates mucin levels and mucin O-glycosylation in the submandibular gland of mice. 
  PLos One.16(1): e0245607, 2021.

• Kameyama A, Thet Tin WW, Nishijima R, Yamakoshi K.
  Alteration of mucins in the submandibular gland during aging in mice. 
  Arch. Oral Biol., 121:104967, 2021.

• Hashimoto M, Goto A, Endo Y, Sugimoto M, Ueda J, Yamashita H.
  Effects of CREG1 on age-associated metabolic phenotypes and renal senescence in mice. 
  Int. J. Mol. Sci. 22. 1276. 2021.

• Kawaguchi K, Hashimoto M, Sugimoto M.
  An antioxidant suppressed lung cellular senescence and enhanced pulmonary function in aged mice.
  Biochem. Biophys. Res. Commun. 541. 43-49. 2021.

• Johmura Y, Yamanaka T, Omori S, Wang T.W, Sugiura Y, Matsumoto M, Suzuki N, Kumamoto S,Yamaguchi K,Hatakeyama S, Takami T, Yamaguchi R, Shimizu E, Ikeda K, Okahashi N, Mikawa R, Suematsu M, Arita M, Sugimoto M, Nakayama K.I, Furukawa Y, Imoto S, Nakanishi M. 
  Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders. 
  Science 371. 265-270. 2021.

• Shimizu T, Yamada K, Suzumura A, Kataoka K, Takayama K, Sugimoto M, Terasaki H, Kaneko H.
  Caveolin-1 Promotes Cellular Senescence in Exchange for Blocking Subretinal Fibrosis in Age-Related Macular 　Degeneration. 
  Invest. Ophthalmol. Vis. Sci. 61. 21. 2020

• Yamada K, Kaneko H, Shimizu H, Suzumura A, Namba R, Takayama K, Ito S, Sugimoto M, Terasaki H.
  Lamivudine Inhibits Alu RNA-induced Retinal Pigment Epithelium Degeneration via Anti-inflammatory and Anti-　senescence Activities. 
  Transl. Vis. Sci. Technol. 9. 1. 2020.

Review and book

Please see also the page in Japanese.

Invited oral presentation(Symposium or keynote speech)

Please see also the page in Japanese.

International Meeting

• Kawaguchi K, Sugimoto M.
  Senescence-dependent alveolar factor promotes metastatic lung cancer. Mechanism of Aging, Cold Spring Harbor Laboratory Meeting,September 22-25, 2020, USA（Web）

Domestic scientific meeting

Please see also the page in Japanese.

Lecture and Seminar

Please see also the page in Japanese.

Newspaper, Press release and others

Please see also the page in Japanese.

2019

​​Original Papers

• Kawaguchi K, Kim SE, Sugiyama D, Sugimoto M, Maruyama M.
  Age-associated alterations in murine dermis through inflammatory response with mitochondrial DNA deletions.
  Geriatrics & Gerontology International, 19: 451–457, 2019

• Kim SE, Kawaguchi K, Hayashi H, Furusho K, Maruyama M.
  Remissive effects of dietary soybean isoflavones on DSS-induced murine colitis and LPS-induced macrophage cell line.
  Nutrients, 11, 1746, 2019

• Mikawa R, Sato T, Suzuki Y, Baskoro H, Kawaguchi K, Sugimoto M.
  p19Arf exacerbates cigarette smoke-induced lung dysfunction. 
  Biomolecules, 10: E462, 2020.

Review and book

Please see also the page in Japanese.

Invited oral presentation (Symposium or keynote speech)

• Maruyama M.
  Infrastructure and Platform Building for Geroscience in Japan.
  Asian Geroscience Conferences, May 25, 2019, Shenzhen China.

• Maruyama M.
  Current Aging Research and Society in Japan
  The 2nd International Conference on Biomedical Health in Beijing
  UNESCO, Dec 16 2019, Beijing, Chin

International scientific meeting

• Akatsu H, Kawabe Y, Arakawa K, Masaki Y, Tanaka H, Kanematsu T, Hashizume Y, Tuneyama  K, Manabe T, Ohohara T, Maruyama M, Fukushimura NST team 
  How Risky Of Intravenous Iron Administration? (Analysis Of Iron Deposition By 157 Pathological Liver Tissues).
  41st ESPEN Congress on Clinical Nutrition & Metabolism. 
  September 2, 2019, Krakow, Poland

• Kawaguchi K, Kim SE, Sugiyama D, Sugimoto M,  Maruyama M.
  Age-associated alterations in murine skin involving inflammatory response with mitochondrial DNA deletions.
  ICSA 2019 in Conference. September 11, 2019, Athenｓ, Greece

• Hayakawa T, Morimoto R, Kimura Y, Nagasaki M, Nagata M, Motoyama N.
  SIRT1-p21 pathway negatively regulates senescence-associated secretory phenotype. (SASP)
  ICSA 2019 in Conference. September 11, 2019, Athenｓ, Greece

• Kawaguchi K, Kim SE, Sugiyama D, Sugimoto M, Maruyama M.
  Age-associated alterations in murine dermis through inflammatory response with mitochondrial DNA deletions.
  11th IAGG AOR congress, Oct 26 2019, Taipei, Taiwa

Domestic scientific meeting

• Motoyama N.
  The nutritional interventions on the basic mechanisms of aging and age-related diseases. Introduction
  The 42nd Annual Meeting of the MBSJ, workshop, Dec 4 2019, Fukuoka

• Kim SE, Morita Y, Sakamoto A, Maruyama M.
  Inflammation and trophic control on immunosenescence.
  The 42nd Annual Meeting of the MBSJ, workshop, Dec 4 2019, Fukuoka

• Maruyama M.
  The nutritional interventions on the basic mechanisms of aging and age-related diseases. ConclutionThe 42nd Annual Meeting of the MBSJ, workshop, Dec 4 2019, Fukuoka

• Sakamoto A, Maruyama M.
  Contribution of DOCK11 to the expansion of antigen-specific B-cell populations.
  The 48th Annual Meeting of the JSI, Dec 12 2019, Hamamatsu

Lecture and Seminar

Please see also the page in Japanese.

Newspaper, Press release and others

Please see also the page in Japanese.

2018

​​Original Papers

• Iida M, Matsuno YK, Watanabe A, Maruyama M, Kameyama A, Yamakoshi K.
  A sialo-oligosaccharide-rich mucin-like molecule specifically detected in the submandibular glands of aged mice.
  Arch. Oral Biol., 12(97), 52-58, 2018.

• Morita Y, Jounai K, Sakamoto A, Tomita Y, Sugihara Y, Suzuki H, Ohshio K, Otake M, Fujiwara D, Kanauchi O, Maruyama M.
  Long-term intake of Lactobacillus paracasei KW3110 prevents age-related chronic inflammation and retinal cell loss in physiologically aged mice. 
  Aging., 10(10)2723-2740, 2018.

• Kameyama A, Yamakoshi K, Watanabe A.
  A rapid separation and characterization of mucins from mouse submandibular glands by supported molecular matrix electrophoresis.
  Biochim. Biophys. Acta Proteins Proteom., 1867(1), 76-81, 2019.

• Mikawa R, Okuno A, Yoshimi T, Watanabe A, Maruyama M, Takikawa O.
  Partial Identification of Amyloid-β Degrading Activity in Human Serum 
  Nagoya J Med Sci.  81(1): 55-64,2019

• Sakamoto A, Kunou S, Shimada K, Tsunoda M, Aoki T, Iriyama C, Tomita A, Nakamura S, Hayakawa F, Kiyoi H.
  Pyruvate secreted from patient-derived cancer-associated fibroblasts supports survival of primary lymphoma cells. 
  Cancer Sci., 110:269–78, 2019.

• Kawaguchi K, Kim SE, Sugiyama D, Sugimoto M, Maruyama M.
  Age-associated alterations in murine dermis through inflammatory response with mitochondrial DNA deletions.
  Geriatr Gerontol Int. 19(5):451-457, 2019 

• Mikawa R, Suzuki Y, Baskoro Y, Kanayama K, Sugimoto K, Sato T.
  Elimination of p19ARF-expressing cells protects against pulmonary emphysema in mice.
  Aging Cell 30., e12827. 2018.

Review and book

Please see also the page in Japanese.

Invited oral presentation(Symposium or keynote speech)

• Sakamoto A, Matsui N, Takaoka A, Maruyama M.
  Natural antibody immunity and immunosenescence
  Asian Society for Aging Research Symposium, Apr 19, 2018, Jeju, South Korea

• Kim S, Kawaguchi K, Maruyama M.
  Potential anti-inflammation effect of water-soluble soybean isoflavones on a murine macrophage cell line and DSS-induced murine colitis model
  Asian Society for Aging Research Symposium, Apr 19, 2018, Jeju, South Korea

• Miyamoto J, Nakatani A, Sutou A, Kamei Y, Maruyama M, Kimura I. 
  Short-chain fatty acid receptors and aging-related energy metabolism regulation. 
  Asian Society for Aging Research Symposium, Apr 19, 2018, Jeju, South Korea 

• Maruyama M.
  Summary Report in Aging Biology.
  ICAH-NCGG symposium, May 11, 2018, Taipei.

• Sugimoto M.
  Pathophysiological roles of cellular senescence in pulmonary diseases.
  ICAH-NCGG symposium, May 10, 2018, Taipei.

• Hayakawa T, Morimoto R, Kimura Y, Nagasaki M, Nagata M, Maruyama M, Motoyama N.
  SIRT1 regulates the expression of p21 during cellular senescence.
  Metabolism and Aging Cell Symposia, Sep 23-25, 2018, Sitges, Spain．

• Sugimoto M. 
  Cellular senescence in pulmonary aging and disease. 
  The 77th Annual Meeting of the Japanese Cancer Association, Sep 28, Osaka.

Domestic scientific meeting

Please see also the page in Japanese.

Lecture and Seminar

Plese see also the page in Japanese.

Newspaper, Press release and others

Please see also the page in Japanese.

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