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Mission: It is well known that prevalence of the metabolic syndrome such as type 2 diabetes increases with advancement of age. However, molecular mechanisms linking metabolic syndrome and aging remain largely unclear. Since malfunction of adult tissue stem cells are known to be involved in age-associated decline of tissue homeostasis, it is conceivable that failure of stem cell maintenance plays a key role in the development of age-associated metabolic syndrome. In our laboratory, we are aiming to understand how stem cell functionality changes with age. We believed that elucidating the molecular pathways underlying stem cell dysfunction with age will provide valuable new insight into the development of age-associated metabolic disease and open up new possibilities for its control. | ||
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Contact： Kimi Yamakoshi, Ph.D. Section Chief, Laboratory of Biochemistry Department of Mechanism of Aging, Research Institute, National Center for Geriatrics and Gerontology
35 Gengo, Morioka-machi, Obu, Aichi 474-8511 JAPAN Tel : +81-562-44-5651 ext.5059(office)/5114(lab.) Fax : +81-562-46-8461 E-mail : kyama＠ncgg.go.jp | ||
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Publications Original articles Takeuchi, S., Takahashi, A., Motoi, N., Yoshimoto, S., Tajima, T., Yamakoshi, K, Hirao, A., Yanagi, S., Fukami, K., Ishikawa, Y., Sone, S., Hara, E., Ohtani, N. Intrinsic cooperation between p16INK4a and p21Waf1/Cip1 in the onset of cellular senescence and tumor suppression in vivo. Cancer Res., 70, 9381-9390 (2010)
Yamakoshi K., Takahashi A., Hirota F., Nakayama R., Ishimaru N., Kubo Y., Mann DJ.,Ohmura M., Hirao A., Saya H., Arase S., Hayashi Y., Nakao K., Matsumoto M., Ohtani N., Hara E. Real-time in vivo imaging of p16INK4a reveals cross talk with p53. J. Cell Biol., 186, 393-407 (2009)
Ohtani N., Imamura Y., Yamakoshi K., Hirota F., Nakayama R., Kubo Y., Takahashi A., Hirao A., Saya H., Hayashi Y., Arase S., Matsumoto M., Nakao K., Hara E. Visualizing the dynamics of p21Waf1/Cip1 cyclin-dependent kinase inhibitor expression in living animals. Proc. Natl. Acad. Sci. USA, 104, 15034-15039 (2007)
Takahashi A., Ohtani N., Yamakoshi K., Iida S., Tahara H.,Nakayama K., Nakayama K.I., Ide T., Saya H., Hara E. Mitogenic signalling and the p16INK4a/Rb pathway co-operate to enforce irreversible cellular senescence. Nature Cell Biol., 8, 1291-1297 (2006)
Maehara K., Yamakoshi K., Ohtani N., Kubo Y., Takahashi A., Arase S., Jones N., Hara E. Reduction of total E2F/DP activity induces senescence-like cell cycle arrest in cancer cells lacking functional pRB and p53. J. Cell Biol., 168, 553-560 (2005)
Shimoda N., Yamakoshi K., Miyake A., Takeda H. Identification of a gene required for de novo DNA methylation of the zebrafish no tail gene. Dev. Dyn., 233, 1509-1516 (2005)
Yamakoshi K., Shishido Y., Shimoda N. Generation of aberrant transcripts of and free DNA ends in zebrafish no tail gene. Mar. Biotechnol (NY)., 7, 163-172 (2005)
Yamakoshi K., Shimoda N. De novo DNA methylation at the CpG island of the zebrafish no tail gene. Genesis, 37, 195-202 (2003)
Yamakoshi K., Shimoda N. PCR-based cloning of an intronless zebrafish no tail gene. Biochem. Biophys. Res. Commun., 306, 598-602 (2003)
Review articles
Ohtani N., Yamakoshi K., Takahashi A. & Hara E. Real-time in vivo imaging of p16 gene expression: a new approach to study senescence stress signaling in living animals. Cell. Div., 5, 1. (2010)
Ohtani N., Yamakoshi K., Takahashi A. & Hara E. The p16INK4a-RB pathway: molecular link between cellular senescence and tumor suppression. J. Med. Invest., 51, 146-153 (2004) | ||
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