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Department of Mechanism of Aging

on June 2018, NCGG, Obu

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Welcome to our DMA homepage

Last updated on October 1, 2018

What's new.......

  • Members of our department and contents were partially updated.
  • Our cover picture was updated to the version 2018.
  • Our cover picture was updated to the version 2017.
  • Dr. Maruyma served as a president of the 40th annual meeting of JSBMG 
     (held on 14,15 and 16, June, 2017 at Nagoya Congress Center)
  • Dr. Maruyama has been promoted as a deputy director of our research Institute,
    NCGG on 1 May 2015.
  • Dr. Maruyma served as a president of the 37th annual meeting of JSBMG 
     (held on 26 and 27, June, 2014 at Aichi health Plaza)

The 40th annual meeting of JSBMG

The 37th annual meeting of JSBMG


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Groups and Members

Last updated on October 1, 2018

Department of Mechanism of Aging

Department head

Deputy Director

Mitsuo Maruyama


Kouichiro Kawaguchi

Sangeun Kim

Yuka Kamei

Akihiko Sakamoto


Satoshi Arai

Naohiro Hashimoto

Yuji Morita

Mitsutoshi Ota

Research Assistant

Eri Arata

Mai Kondo

Naomi Matsui

Keiko Onishi

Yuko Ota

Akane Yamada

Rumiko Watanabe
















The Section of Immunology

Section Chief

Kimi Yamakoshi

Research Assistant

Risa Nishijima

The Section of Biochemistry

Section Chief

Masataka Sugimoto


Ryuta Mikawa


Kaori Komoda

Research Assistant

Yuko Tottori

Visiting Scientist

Kyoto Prefectural University of Medicine

Junichi Shimada

Tokyo Metropolitan Institute of Gerontology

Akihito Ishigami

Sugiyama Jogakuen


Noboru Motoyama

Kyusyu University

Tomoharu Yasuda

Senior Scientist

Nagoya City University

Hiroyasu Akatsu

Hokkaido University

Daisuke Kamimura



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What is DMA

 Up and down in our history

Our group, so called Michan group, was originally established in April 2001 as a laboratory of Pathology, Department of Basic Gerontology, NILS. In the first year, although it was difficult to recognize our minimum research unit consisting of a section chief and a research fellow as a laboratory, we have started our research on the mechanism of Aging from the viewpoints of molecular biology and immunology. Our group was transferred to the laboratory of experimental animal model research (LEAR) that was newly established with the reorganization of National Center for Geriatrics and Gerontology in March 2004. We then focused a couple of aging projects on cellular senescence, especially, with Mouse Embryonic Fibroblasts, (MEF) and on individual aging for immunological memory in a few members like the individual store, besides the maintenance and control of the rodents in experimental animal facilities. In this dawn period, we had set up the laboratory with the flexicibility and passion for the research in addition to novelty. Finally, we returned to the manager group in refreshed Department of Mechanism of Aging (DMA), (Department of Basic Gerontology as the former title) again in July 2005. Other three section chiefs were all invited from the top laboratories inside or outside of Japan. Our group also hopes that the individual interests or curiosity extracted from daily discussion or even chattering bear fruit as a result. 

We really welcome to you who have a fine ambition for making a historical milestone in a crosstalk of cellular senescence and human aging or in a prevention of marked decline of immune responses in the aged, or who have an interest to join the developing laboratory to leave your name in the history of laboratory. We are looking forward to your contacts from anyplace in the world.

Research purpose and our sprits

It should be really important mission that we concerned with aging research help to grow old soundly in the aged society coming at a record-breaking speed, in other words, to maintain healthy aged persons. Along with aging, we are faced with the weakness of daily immune response decreasing by 10% of young people and we have realized this decline involves the major cause of various diseases which the aged is suffered consequently. Especially, it is said that the weakness of aged people's resistance to the infectious disease is caused by the decline of host defense function including the immunological memory lasting for a long time. In other words, it is obviously important subject for our facing aged society that we challenge to analyze a molecular mechanism of the establishment or maintenance of immunological memory in which memory B cells and the effecter cells play a central role. We are also interested in the molecular mechanism of aging through a little more fundamental aging research in addition to the research on immune response with aging described above. This strategy is based on a differential screening of gene expression in murine or even human aging and our aim and goal is to search and reveal one of master genes regulate normal aging exhaustively.We have isolated several novel or known cellular senescence related genes from mouse embryonic fibroblasts (MEF) and analyzed their function reaching to throw a new light on mechanism of human aging. We also generate the gene targeted mutant mice to analyze its biological significances on functional disorder, morbid growth or apoptosis. Ultimately our goal is to clarify the relation of cause and effect between its functional disruption and diseases and find the best treatment to be recovered.

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Notice Board

Let's join our cutting edge research for Mechanism of Aging with us.

Our department has been in cooperation with the department of Aging Research, Program in Integrated Molecular Medicine, Nagoya University Graduate School of Medicine since 2006.

Actually both Dr. Mitsuo Maruyama and Dr. Masataka Sugimoto have charged the course as a visiting professor and associate professor, respectively, therefore we can manage not only seminar but also experimental research, whenever new face graduate students join here. If you find any interest or something excited about Aging Research in our web site, please try to contact us first, and then join our laboratory in Nagoya University to feel cutting edge Aging research.


NCGG seminar

In our research institute, we have NCGG seminars by the famous and popular scientists in the various field of aging from home and abroad.

We also introduce the detail of each seminar in another page linked below. We are very happy to come the seminar for everybody.


DMA seminar

We have also “Journal seminar (Journal Club)” and “Research Seminar (Progress Report)” every other Friday Morning from 10:30 to around noon as Department of Mechanism of Aging (DMA) meeting. “Seeing is Believing”, we always welcome to join us for whoever is interested in our project and strategy. Seminar schedule is sometime alternative, therefore let us know your visit to our office in advance .



National Center for Geriatrics and Gerontology, Research Institute
Deputy Director
Department Head of Mechanism of Aging


Tel: +81-562-46-2311 (ext 5002)
Email: michan (at) ncgg.go.jp


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Our Pictures

Last updated on July 20, 2017


Chulalongkorn Univ Bangkok, Thailand
on 3 June 2016


ICOBM in Phuket, Thailand 
on 31 May 2016 ~ 2 June 2016


The 2nd ICAH-NCGG Meeting in Taiwan
on 14~17 April 2016


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Tab6 Title

Tab6 Contents

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  • National Center for Geriatrics and Gerontology
  • National Hospital for Geriatric Medicine, NCGG
  • Center for Development of Advanced Medicine for Dementia
  • Center for Gerontology and Social Science

National Center for Geriatrics and Gerontology

7-430 Morioka-cho, Obu City, Aichi Prefecture, Japan