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Aging Homeostasis Research Project Team

Aging Homeostasis Research PT

Lab News

February 2017

  • Akagi PL and Trindade attended “the 9th NAGOYA global retreat” and Akagi PL presented our work as an invited speaker.

November 2016

  • Akagi PL attended “the 39th Annual Meeting of the Molecular Biology Society of Japan” in Yokohama.
  • Akagi PL attended “Frontiers in aging research toward healthy longevity” in Tokyo.

October 2016

  • Lucas Trindade, Ph.D. has joined the lab as a postdoc.

September 2016

  • Akagi PL presented our work at “the 12th Japanese Drosophila Research Conference” in Tokyo.

June 2016

  • Akagi PL presented our work at “the 1st MORPHOMEOSTASIS meeting” in Shizuoka.
  • Mrs. Taguchi and Honda have joined the lab as a lab technician.

May 2016

  • Akagi PL has joined the National Center for Geriatrics and Gerontology as a project leader.

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Research

    We aim for understanding how nutrients influence tissue homeostasis and organismal survival in molecular level using fruit fly, Drosophila melanogaster. Dietary restriction (DR) has been shown to extend lifespan in diverse organisms including mammals. However, tissue-specific effects of DR on aging have not fully understood. We are mainly focusing on how DR impacts on intestinal homeostasis including gut permeability, intestinal stem cell activity and inflammation which are known to be affected by age. We are also interested in understanding how different tissues or cells communicate each other upon different nutrient conditions and age to maintain tissue homeostasis. 

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Publications

  • Akagi K., Sarhan M., Sultan A., Nishida H., Nakayama T., Koie A, Ueda H. (2016) A biological timer in the fat body comprising Blimp-1, βFtz-f1 and Shade regulates pupation timing in Drosophila melanogaster. Development, 143, 2410-2416
  • Katewa S.D., Akagi K., Rakshit K., Bose N., Camarella T., Zheng X., Nelson C., Brem R., Sehgal A., Giebultowicz J.M., Kapahi P. (2016) Peripheral circadian clocks modulate nutrient dependent changes in lifespan and fat metabolism. Cell Metabolism, 12;23(1):143-54
  • Ohhara Y., Shimada-Niwa Y., Niwa R., Kayashima Y., Hayashi Y., Akagi K., Ueda H., Yamakawa-Kobayashi K., Kobayashi S. (2015) Autocrine regulation of ecdysone synthesis by β3-octopamine receptor in the prothoracic gland is essential for Drosophila metamorphosis. Proc Natl Acad Sci U S A, 112(5): 1452-1457
  • Akagi K., Kageyama Y., Kayashima Y., Takakura Y., Hirose S., Ueda H. (2013) The Binding of Multiple Nuclear Receptors to a Single Regulatory Region Is Important for the Proper Expression of EDG84A in Drosophila melanogaster. Journal of Molecular Biology, 425(1): 71-81
  • Akagi K. and Ueda H. (2011) Regulatory mechanisms of ecdysone-inducible Blimp-1 encoding a transcriptional repressor that is important for the prepupal development in Drosophila. Development Growth and Differentiation, 53(5): 697-703
  • Agawa Y., Sarhan M., Kageyama Y., Akagi K., Takai M., Hashiyama K., Wada T., Handa H., Iwamatsu A., Hirose S., Ueda H. (2007) Drosophila Blimp-1 is a transient transcriptional repressor that controls timing of the ecdysone-induced developmental pathway. Molecular and Cellular Biology, 27(24): 8739-8747

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Members

Project Leader:  Kazutaka Akagi, Ph.D.

Postdoctoral Fellow: Lucas Siqueira Trindade, Ph.D.

Lab Technician: Mayumi Taguchi

Lab Technician: Misao Honda

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Photos

December 2016

December 2016

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NCGG

  • National Center for Geriatrics and Gerontology
  • National Hospital for Geriatric Medicine, NCGG
  • Center for Gerontology and Social Science

National Center for Geriatrics and Gerontology

7-430 Morioka-cho, Obu City, Aichi Prefecture, Japan