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バイオバンク登録者数

Enrollment

バイオバンク登録者数

年度別登録者数と累積数(既存試料含む)

 

 

 

バイオバンク分譲回数

Distribution

バイオバンク分譲回数

バイオバンクとして2012年から配布(分譲)開始。これまで134回の配布(分譲)を行った。
配布(分譲)された検体数は、延べ30,386症例となる。(2018年12月末現在)
(配布(分譲)された検体の内訳 : 血清 :11,037症例、血漿 : 3,089症例、DNA : 10,898症例、
組織 : 60症例、便 :129症例、尿:55症例、髄液:6症例、全血:426症例、診療情報のみ : 4,686症例)

 

 

 

バイオバンク活用研究課題

Biobank practical use research task

 

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バイオバンク活用研究成果

Biobank practical use research results

2018年

  1. Tanokashira D, Kurata E, Fukuokaya W, Kawabe K, Kashiwada M,Takeuchi H, Nakazato M, Taguchi A. Metformin treatment ameliorates diabetes‐associated decline in hippocampal neurogenesis and memory via phosphorylation of insulin receptor substrate 1. FEBS Open Bio. 2018;8:1104-1118.
  2. Koide Y, Teranishi M, Sugiura S, Uchida Y, Nishio N, Kato K, Otake H, Yoshida T, Otsuka R, Ando F, Shimokata H, Hasegawa Y, Nakashima T, Sone. Association between Uncoupling Protein 2 Gene Ala55val Polymorphism and Sudden Sensorineural Hearing Loss. J Int Adv Otol. 2018;14:166-169.
  3. Sugimoto T, Ono R, Kimura A, Saji N, Niida S, Toba K, Sakurai T. Physical Frailty Correlates With Behavioral and Psychological Symptoms of Dementia and Caregiver Burden in Alzheimer's Disease. J Clin Psychiatry. 2018;79 pii: 17m11991.
  4. Yokoi A, Matsuzaki J, Yamamoto Y, Yoneoka Y,Takahas k, Shimizu H, Uehara T, Ishikawa M, Ikeda SI, Sonoda T, Kawauchi J, Takizawa S, Aoki Y, Niida S, Sakamoto H, Kato T, Ochiya TIntegrated extracellular microRNA profiling for ovarian cancer screening. Nat Commun. 2018;9:4319. 
  5. Horikawa C, Otsuka R, Kato Y, Nishita Y, Tange C, Rogi T, Kawashima H, Shibata H, Ando F, Shimokata. HLongitudinal Association between n-3 Long-Chain Polyunsaturated Fatty Acid Intake and Depressive Symptoms: A Population-Based Cohort Study in JapanNutrients. Nutrients. 2018;10 pii: E1655.
  6. Nakamoto M, Otsuka R, Nishita Y, Tange C, Tomida M, Kato Y, Imai T, Sakai T, Ando F, Shimokata H. Soy food and isoflavone intake reduces the risk of cognitive impairment in elderly Japanese women. Eur J Clin Nutr. 2018;72:1458-1462. 
  7. Yuki A, Otsuka R, Tange C, Nishita Y, Tomida M, Ando F, Shimokata H. Polypharmacy is associated with frailty in Japanese community-dwelling older adults. Geriatr Gerontol Int. 2018;18:1497-1500. 
  8. Uchida Y, Nishita Y, Kato T, Iwata K, Sugiura S, Suzuki H, Sone M, Tange C, Otsuka R, Ando F, Shimokata H, Nakamura A. Smaller Hippocampal Volume and Degraded Peripheral Hearing Among Japanese Community Dwellers. Front Aging Neurosci. 2018;10:319.
  9. Nakamura A, Kaneko N, Villemagne VL, Kato T, Doecke J, Doré V, Fowler C, Li QX, Martins R, Rowe C, Tomita T, Matsuzaki K, Ishii K, Ishii K, Arahata Y, Iwamoto S, Ito K, Tanaka K, Masters CL, Yanagisawa K. High performance plasma amyloid-β biomarkers for Alzheimer's disease. Nature. 2018;554:249-254. 
  10. Ogama N, Sakurai T, Kawashima S, Tanikawa T, Tokuda H, Satake S, Miura H, Shimizu A, Kokubo M, Niida S, Toda K, Umegaki H, Kuzuya M. Postprandia hyperglycemia is associated with white matter hyperintensity and brain atrophy in older patients with type 2 diabetes mellitus. Frontiers in Aging Neuroscience. 2018;10:273.
  11. Yuki A, Otsuka R, Tange C, Nishita Y, Tomida M, Ando F, Shimokata H. Physical frailty and mortality risk in Japanese older adults. Geriatr Gerontol Int. 2018;18:1085-1092.
  12. Sugimoto T, Toba K, Sakurai . Status of glycemic control in elderly patients with cognitive impairment treated by general practitioners relative to the glycemic targets recommended for elderly patients by the Japan Diabetes Society/Japan Geriatrics Society Joint Committee: A retrospective analysis. J Diabetes Investig. 2018;9:1230-1232.
  13. Koda M, Kitamura I, Okura T, Otsuka R, Ando F, Shimokata H. Men who were thin during early adulthood exhibited greater weight gain-associated visceral fat accumulation in a study of middle-aged Japanese men. Obes Sci Pract. 2018;4:289-295.
  14. Sugiura S, Yasue M, Uchida Y, Teranish M, Sone M, Suzuki H, Nakashima T, Otsuka R, Ando F, Shimokata H. Prevalence and risk factors of MRI abnormality which was suspected as sinusitis in Japanese middle-aged and elderly community dwellers. BioMed Res Int. 2018, Article ID 4096845, 6pages.
  15. Otsuka R, Nishita Y, Tange C, Tomida M, Kato Y, Imai T, Ando F, Shimokata H. Age-related 12-year changes in dietary diversity and food intakes among community-dwelling Japanese aged 40 to 79 years. J Nutr Health Aging. 2018;22:594-600.
  16. Tanisawa K, Hirose N, Arai Y, Shimokata H, Yamada Y, Kawai H, Kojima M, Obuchi S, Hirano H, Suzuki H, Fujiwara Y, Taniguchi Y, Shinkai S, Ihara K, Sugaya M, Higuchi M, Arai T, Mori S, Sawabe M, Sato N, Muramatsu M, Tanaka M. Inverse association between height-increasing alleles and extreme longevity in Japanese women. J Gerontol A Biol Sci Med Sci. 2018;73:588-595.
  17. Nagata Y, Hirayama A, Ikeda S, Shirahata A, Shoji F, Maruyama M, Kayano M, Bundo M, Hattori K, Yoshida S, Goto Y, Urakami K, Soga T, Ozaki K, Niida S. Comparative analysis of cerebrospinal fluid metabolites in Alzheimer's disease and idiopathic normal pressure hydrocephalus in a Japanese cohort. Biomarker Res. 2018;6:5.
  18. Otsuka R, Matsui Y, Tange C, Nishita Y, Tomida M, Ando F, Shimokata H, Arai H. What is the best adjustment of appendicular lean mass for predicting mortality or disability among Japanese community dwellers? BMC geriatrics. 2018;18:8.

2017年

  1. Nishita Y, Tange C, Tomida M, Otsuka R, Ando F, Shimokata H. Cognitive abilities predict death during the next 15 years in older Japanese adults.  Geriatr Gerontol Int. 2017;17:1654-1660. 
  2. Yuki A, Ando F, Otsuka R, Shimokata H. Sarcopenia based on the Asian Working Group for Sarcopenia criteria and all-cause mortality risk in older Japanese adults. Geriatr Gerontol Int. 2017;17:1642-1647.
  3. Sugimoto T, Ono R, Murata S, Saji N, Matsui Y, Niida S, Toba K, Sakurai T. Sarcopenia is associated with impairment of activities of daily living in Japanese patients with early-stage Alzheimer disease. Alzheimer Dis Assoc Disord. 2017;31:256-258.
  4. Sugimoto T, Nakamura A, Kato K, Iwata K, Saji N, Arahata Y, Hattori H, Bundo M, Ito K, Niida S, Sakurai T; MULNIAD study group.
    Decreased glucose metabolism in medial prefrontal areas is associated with nutritional status in patients with prodromal and early Alzheimer's disease. J Alzheimers Dis. 2017;60:225-233.
  5. Nagata Y, Bundo M, Sugiura S, Kamita M, Ono M, Hattori K, Yoshida S, Goto Y, Urakami K, Niida S. PTPRQ as a potential biomarker for idiopathic normal pressure hydrocephalus. Mol Med Rep. 2017;16:3034-3040.
  6. Satake S, Shimokata H, Senda K, Kondo I, Toba K. Validity of total Kihon checklist score for predicting the incidence of 3-year dependency and mortality in a community-dwelling older population. J Am Med Dir Assoc. 2017;18:552.e1-552.e6.
  7. Otsuka R, Nishita Y, Tange C, Tomida M, Kato Y, Nakamoto M, Imai T, Ando F, Shimokata H. Dietary diversity decreases the risk of cognitive decline among Japanese older adults. Geriatr Gerontol Int. 2017;17:937-944
  8. Fukuoka H, Tange C, Otsuka R, Ando F, Shimokata H. The impact of anthropometric and ocular parameters on optic cup-to-disc ratio. BMJ Open Ophthalmology. 2017;1:e000012.
  9. Tanisawa K, Arai Y, Hirose N, Shimokata H, Yamada Y, Kawai H, Kojima M, Obuchi S, Hirano H, Yoshida H, Suzuki H, Fujiwara Y, Ihara K, Sugaya M, Arai T, Mori S, Sawabe M, Sato N, Muramatsu M, Higuchi M, Liu YW, Kong QP, Tanaka M. Exome-wide association study identifies CLEC3B missense variant p.S106G as being associated with extreme longevity in east Asian populations. J Gerontol A Biol Sci Med Sci. 2017;72:309-318.
  10. Ogama N, Sakurai T, Nakai T, Niida S, Saji N, Toba K, Umegaki H, Kuzuya M. Impact of frontal white matter hyperintensity on instrumental activities of daily living in elderly women with Alzheimer disease and amnestic mild cognitive impairment. PLOS One. 2017;12:e0172484. 
  11. Otsuka R, Nishita Y, Tange C, Tomida M, Kato Y, Nakamoto M, Ando F, Shimokata H, Suzuki T. The effect of modifiable healthy practices on higher-level functional capacity decline among Japanese community dwellers. Prev Med Rep. 2017;5:205-209.
  12. Sugimoto T, Yoshida M, Ono R, Murata S, Saji N, Niida S, Toba K, Sakurai T. Frontal Lobe Function Correlates with One-Year Incidence of Urinary Incontinence in Elderly with Alzheimer Disease. J Alzheimers Dis. 2017;56:567-574.

2016年

  1. Nishita Y, Tange C, Tomida M, Ostuka R, Ando F, Shimokata H. Personality and global cognitive decline in Japanese community-dwelling elderly people: A 10-year longitudinal study. J Psychosom Res. 2016;91:20-25.
  2. Hida T, Shimokata H, Sakai Y, Ito S, Matsui Y, Takemura M, Kasai T, Ishiguro N, Harada A. Sarcopenia and sarcopenic leg as potential risk factors for acute osteoporotic vertebral among older women. Eur Spine J. 2016;25:3424-3431.
  3. Kayano M, Higaki S, Satoh J, Matsumoto K, Matsubara E, Takikawa O, Niida S. Plasma microRNA biomarker detection for mild cognitive pairment using differential correlation analysis. Biomarker Res. 2016;4:22. 
  4. Uchida Y, Nishita Y, Tange C, Sugiura S, Otsuka R, Ueda H, Nakashima T, Ando F, Shimokata H. The longitudinal impact of hearing impairment on cognition differs according to cognitive domain. Front Aging Neurosci. 2016;8:1-9.
  5. Koda M, Kitamura I, Okura T, Otsuka R, Ando F, Shimokata H. The associations between smoking habits and serum triglyceride or hemoglobin A1c levels differ according to visceral fat accumlation. J Epidemiol. 2016;26:208-215.
  6. Otsuka R, Kato Y, Nishita Y, Tange C, Nakamoto M, Tomida M, Imai T, Ando F, Shimokata H, Suzuki T. Dietary diversity and 14-year decline in higher-level functional capacity among middle-aged and elderly Japanese. Nutrition. 2016;32:784-789.
  7. Horikawa C, Otsuka R, Kato Y, Nishita Y, Tange C, Kakutani S, Rogi T, Kawashima H, Shibata H, Ando F, Shimokata H. Cross-sectional association between serum concentrations of n-3 long-chain PUFA and depressive symptoms: results in Japanese community dwellers. Br J Nutr. 2016;115:672-680.
  8. Kozakai R, Ando F, Kim HY, Yuki A, Otsuka R, Shimokata H. Sex-differences in age-related grip strength decline: a 10-year longitudinal study of community-living middle-aged and older Japanese. J Phys Fitness Sports Med. 2016;5:87-94.
  9. Otsuka R, Kato Y, Nishita Y, Tange C, Tomida M, Nakamoto M, Imai T, Ando F, Shimokata H. Age-related changes in energy intake and weight in community-dwelling middle-aged and elderly Japanese. J Nutr Health Aging. 2016;20:383-390.
  10. Sugimoto T, Ono R, Murata S, Saji N, Matsui Y, Niida S, Toba K, Sakurai T. Prevalence and associated factors of sarcopenia in elderly subjects with amnestic mild cognitive impairment or Alzheimer disease. Current Alzheimer Research. 2016;13:718-726.
  11. Shimomura A, Shiino S, Kawauchi J, Takizawa S, Sakamoto H, Matsuzaki J, Ono M, Takeshita F, Niida S, Shimizu C, Fujiwara Y, Kinoshita T, Tamura K, Ochiya T. A novel combination of serum microRNAs for detecting breast cancer in the early stage. Cancer Sci. 2016;107:326–334.
  12. Ogama N, Yoshida M, Nakai T, Niida S, Toba K, Sakurai T. Frontal white matter hyperintensity predicts lower urinary tract dysfunction in older adults with amnestic mild cognitive impairment and Alzheimer‘s disease. Geriatr Gerontol Int. 2016;16:167-174.

2015年

  1. Kusudo T, Hashida Y, Ando F, Shimokata H, Yamashita H. Asp3Gly polymorphism affects fatty acid-binding protein 3 intracellular stability and subcellular localization. FEBS Lett. 2015;589:2382-2387.
  2. Harada A, Ito S, Matsui Y, Sakai Y, Takemura M, Tokuda H, Hida T, Shimokata H. Effect of alendronate on muscle mass: Investigation in patients with osteoporosis. Osteop Sarcopenia. 2015;1:53-58.
  3. Yasue M, Sugiura S, Uchida Y, Otake H, Teranishi M, Sakurai T, Toba K, Shimokata H, Ando F, Otsuka R, Nakashima T. Prevalence of sinusitis detected by magnetic resonance imaging in subjects with dementia or Alzheimer's disease. Curr Alzheimer Res. 2015;12:1006-1011.
  4. Ogama N, Saji N, Niida S, Toba K, Sakurai T. Validation of a simple and reliable visual rating scale of white matter hyperintensity comparable with computer-based volumetric analysis. Geriatr Gerontol Int. 2015;15:83-85.
  5. Nakamoto M, Otsuka R, Yuki A, Nishita Y, Tange C, Tomida M, Kato Y, Ando F, Shimokata H, Suzuki T. Higher gait speed and smaller sway area decrease the risk for decline in higher-level functional capacity among middle-aged and elderly women. Arch Gerontol Geriatr. 2015;61:429-436.
  6. Kasai T, Ishiguro N, Matsui Y, Harada A, Takemura M, Yuki A, Kato Y, Otsuka R, Ando F, Shimokata H. Sex- and age-related differences in mid-thigh composition and muscle quality determined by computed tomography in middle-aged and elderly Japanese. Geriatr Gerontol Int. 2015;15:700-706.
  7. Otsuka R, Kato Y, Imai T, Ando F, Shimokata H. Secular trend of serum docosahexaenoic acid, eicosapentaenoic acid, and arachidonic acid concentrations among Japanese-A 4- and 13-year descriptive epidemiologic study. Prostaglandins Leukot Essent Fatty Acids. 2015;94:35-42.
  8. Yoshimura N, Akune T, Fujiwara S, Shimizu Y, Yoshida H, Nishiwaki Y, Sudo A, Omori G, Yoshida M, Shimokata H, Suzuki T, Muraki S, Oka H, Nakamura K. Incidence of disability and its associated factors in Japanese men and women: the Longitudinal Cohorts of Motor System Organ (LOCOMO) study. J Bone Miner Metab. 2015;33:186-191.
  9. Yuki A, Ando F, Otsuka R, Shimokata H. Low free testosterone is associated with loss of appendicular muscle mass in Japanese community-dwelling women. Geriatr Gerontol Int. 2015;15:326-333.
  10. Kamita M, Mori T, Sakai Y, Ito S, Gomi M, Miyamoto Y, Harada A, Niida S, Yamada T, Watanabe K, Ono M. Proteomic analysis of ligamentum flavum from patients with lumbar spinal stenosis. Proteomics. 2015;15:1622-1630.
  11. 大塚礼, 加藤友紀, 西田裕紀子, 丹下智香子, 今井具子, 安藤富士子, 下方浩史. 地域在住高齢者における短鎖および中鎖脂肪酸摂取が8年間の認知機能得点低下に及ぼす影響. 日本栄養・食糧学会誌. 2015;68:101-111.
  12. 野坂咲耶, 光岡佑奈, 高井なつみ, 今井具子, 加藤友紀, 大塚礼, 安藤富士子, 下方浩史. 料理ベースの写真付きiPhone・iPad対応食事診断アプリケーションの有用性. 日本未病システム学会雑誌. 2015;21:7-20.
  13. 丹下智香子, 西田裕紀子, 富田真紀子, 大塚礼, 安藤富士子, 下方浩史, 鈴木隆雄. 中高年期における14年後の日常生活活動能力への心的発達要因の影響. 日本未病システム学会雑誌. 2015;21:106-110.

2014年

  1. Otsuka R, Tange C, Nishita Y, Kato Y, Imai T, Ando F, Shimokata H. Serum docosahexaenoic and eicosapentaenoic acid and risk of cognitive decline over 10 years among elderly Japanese. Eur J Clin Nutr. 2014;68:503-509.
  2. Kitamura I, Koda M, Otsuka R, Ando F, Shimokata H. Six-year longitudinal changes in body composition of middle-aged and elderly Japanese: Age and sex differences in appendicular skeletal muscle mass. Geriatr Gerontol Int. 2014;14:354-361.
  3. Yoshimura N, Akune T, ujiwara S, Shimizu Y, Yoshida H, Omori G, Sudo A, Nishiwaki Y, Yoshida M, Shimokata H, Suzuki T, Muraki S, Oka H, Nakamura K. Prevalence of knee pain, lumbar pain and its coexistence in Japanese men and women: The Longitudinal Cohorts of Motor System Organ (LOCOMO) study. J Bone Miner Metab. 2014;32:524-532.
  4. Matsui Y, Takemura M, Harada A, Ando F, Shimokata H. Effects of knee extensor muscle strength on the incidence of osteopenia and osteoporosis after 6 years. J Bone Miner Metab. 2014;32:550-555. 
  5. Otsuka R, Kato Y, Nishita Y, Tange C, Nakamoto M, Tomida M, Imai T, Ando F, Shimokata H. Cereal intake increases and dairy products decrease risk of cognitive decline among elderly female Japanese. J Prev Alz Dis. 2014;1:160-167.
  6. Uchida Y, Sugiura S, Ueda H, Nakashima T, Ando F, Shimokata H. The association between hearing impairment and polymorphisms of genes encoding inflammatory mediators in Japanese aged population. Immun Ageing. 2014;11:18.
  7. Kaneko N, Nakamura A, Washimi Y, Kato T, Sakurai T, Arahata Y, Bundo M, Takeda A, Niida S, Ito K, Toba K, Tanaka K, Yanagisawa K. Novel plasma biomarker surrogating cerebral amyloid deposition. Proc Jpn Acad Ser B Phys Biol Sci. 2014;90:353-364.
  8. Ogama N, Sakurai T, Shimizu A, Toba K. Regional white matter lesions predict falls in patients with amnestic mild cognitive impairment and Alzheimer's disease. J Am Med Dir Assoc. 2014;15:36-41.
  9. Seike A, Sumigaki C, Takeda A, Endo H, Sakurai T, Toba K. Developing an interdisciplinary program of educational support for early-stage dementia patients and their family members: an investigation based on learning needs and attitude changes. Geriatr Gerontol Int. 2014;14:28-34.
  10. Kamiya M, Sakurai T, Ogama N, Maki Y, Toba K. Factors associated with increased caregivers’ burden in several cognitive stages of Alzheimer disease. Geriatr Gerontol Int. 2014;14:45-55. 
  11. Sugiura S, Yasue M, Sakurai T, Sumigaki C, Uchida Y, Nakashima T, Toba K. The Effect of Cerumen Impaction on Hearing and Cognitive Functions in Japanese Elderly with Cognitive Impairment. Geriatr Gerontol Int. 2014;14:56-61. 
  12. Sakurai T, Kawashima S, Satake S, Miura H, Tokuda H, Toba K. Differential subtypes of diabetic elderly diagnosed with Alzheimer's disease. Geriatr Gerontol Int. 2014;14:62-70. 
  13. Shimizu A, Sakurai T, Mitsui T, Miyagi M, Nomoto K, Kokubo M, Bando K, Murohara T, Toba K. Left ventricular diastolic dysfunction is associated with cerebral white matter lesion (leukoaraiosis) in elderly patients without ischemic heart disease and stroke. Geriatr Gerontol Int. 2014;14:71-76.
  14. Matsui Y, Fujita R, Harada, A, Sakurai T,Nemoto T, Noda N, Toba K. The association of grip strength and related indices with independence of ADL in the elderly, investigated by a newly-developed grip strength measuring device. Geriatr Gerontol Int. 2014;14:77-86.
  15. Matsui Y, Fujita R, Harada A, Sakurai T, Nemoto T, Noda N, Toba K. A New grip-strength measuring device for detailed evaluation of muscle contraction Among the elderly. J Frailty Aging. 2014;3:142-7.
  16. 加藤友紀, 大塚礼, 西田裕紀子, 丹下智香子, 今井具子, 安藤富士子, 下方浩史. 地域在住中高年者のプロリン摂取量が知能に及ぼす影響に関する縦断的研究. 日本未病システム学会雑誌. 2014;20:99-104.
  17. 松井康素, 村真里枝, 原田敦, 幸篤武, 加藤友紀, 大塚礼, 安藤富士子, 下方浩史. 膝関節の変形および痛みと身体組成の関連. Osteoporosis Jpn. 2014;22:507-510.

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