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血液内科部

血液内科

勝見章

名古屋第一赤十字病院、名古屋大学第一内科、ワシントン大学、スクリプス研究所、名古屋大学血液内科講師、国立長寿医療研究センター輸血管理室医長、浜松医科大学臨床腫瘍学准教授を経て現職。

英文論文

  1. Katsumi A, Abe A, Tamura S, Matsushita T. Anemia in older adults as a geriatric syndrome: A review. Geriatr Gerontol Int. in press (invited review article).
  2. Hayakawa Y, Tamura S, Suzuki N, Odaira K, Tokoro M, Kawashima F, Hayakawa F, Takagi A, Katsumi A, Suzuki A, Okamoto S, Kanematsu T, Matsushita T, Kojima T. Essential role of a carboxyl-terminal α-helix motif in the secretion of coagulation factor XI. J Thromb Haemost 2021 Apr;19(4):920-930.
  3. Kanematsu T, Suzuki N, Tamura S, Suzuki A, Ishikawa Y, Katsumi A, Kiyoi H, Saito H, Kunishima S, Kojima T, Matsushita T. Myh9 R702C is associated with erythroid abnormality with splenomegaly in mice. Nagoya J Med Sci. 2021 Feb;83(1):75-86.
  4. Suzuki A, Suzuki N, Kanematsu T, Okamoto S, Tamura S, Kikuchi R, Katsumi A, Kiyoi H, Kojima T, Matsushita T. Impact of variation in reagent combinations for one-stage clotting assay on assay discrepancy in nonsevere haemophilia A. Int J Lab Hematol. 2021 Feb;43(1):131-138.
  5. Tokoro M, Tamura S, Suzuki N, Kakihara M, Hattori Y, Odaira K, Suzuki S, Takagi A, Katsumi A, Hayakawa F, Okamoto S, Suzuki A, Kanematsu T, Matsushita T, Kojima T. Aberrant X chromosomal rearrangement through multi-step template switching during sister chromatid formation in a patient with severe hemophilia A. Mol Genet Genomic Med. 2020 Sep;8(9):e1390.
  6. Ogawa M, Suzuki N, Takahashi N, Tamura S, Suzuki A, Suzuki S, Hattori Y, Kakihara M, Kanematsu T, Kojima T, Katsumi A, Hayakawa F, Kojima T, Ishiguro N, Kiyoi H, Matsushita T. Higher FVIII:C measured by chromogenic substrate assay than by one-stage assay is associated with silent hemophilic arthropathy. Thromb Res. 2020 Apr;188:103-105.
  7. Abe A, Yamamoto Y, Katsumi A, Yamamoto H, Okamoto A, Inaguma Y, Iriyama C, Tokuda M, Okamoto M, Emi N, Tomita A. Truncated RUNX1 Generated by the Fusion of RUNX1 to Antisense GRIK2 via a Cryptic Chromosome Translocation Enhances Sensitivity to Granulocyte Colony-Stimulating Factor. Cytogenet Genome Res. 2020;160(5):255-263.
  8. Odaira K, Tamura S, Suzuki N, Kakihara M, Hattori Y, Tokoro M, Suzuki S, Takagi A, Katsumi A, Hayakawa F, Okamoto S, Suzuki A, Kanematsu T, Matsushita T, Kojima T. Apparent synonymous mutation F9 c.87A>G causes secretion failure by in-frame mutation with aberrant splicing. Thromb Res. 2019 Jul;179:95-103.
  9. Hashimoto E, Suzuki N, Kakihara M, Odaira K, Hattori Y, Tokoro M, Suzuki S, Takagi A, Katsumi A, Hayakawa F, Suzuki A, Okamoto S, Kanematsu T, Matsushita T, Kojima T. Molecular basis of SERPINC1 mutations in Japanese patients with antithrombin deficiency. Tamura S. Thromb Res. 2019 Jun;178:159-170.
  10. Abe A, Yamamoto Y, Katsumi A, Okamoto A, Tokuda M, Inaguma Y, Yamamoto K, Yanada M, Kanie T, Tomita A, Akatsuka Y, Okamoto M, Kameyama T, Maeda A, Emi N. Rearrangement of VPS13B, a causative gene of Cohen syndrome, in a case of RUNX1-RUNX1T1 leukemia with t(8;12;21)  Int J Hematol. 2018 Aug;108(2):208-212
  11. Abe A, Yamamoto Y, Katsumi A, Okamoto A, Tokuda M, Inaguma Y, Yamamoto K, Yanada M, Kanie T, Tomita A, Akatsuka Y, Okamoto M, Kameyama T, Mayeda A, Emi N. Rearrangement of VPS13B, a causative gene of Cohen syndrome, in a case of RUNX1-RUNX1T1 leukemia with t(8;12;21). Int J Hematol. 2017 Dec 20. doi: 10.1007/s12185-017-2387-x. [Epub ahead of print]
  12. Tamura S, Murata-Kawakami M, Takagi Y, Suzuki S, Katsumi A, Takagi A, Kojima T. In vitro exploration of latent prothrombin mutants conveying antithrombin resistance. Thromb Res. 2017 Nov;159:33-38. doi: 10.1016/j.thromres.2017.09.020. Epub 2017 Sep 20.
  13. Kishimoto M, Matsuda T, Yanase S, Katsumi A*, Suzuki N, Ikejiri M, Takagi A, Ikawa M, Kojima T, Kunishima S, Kiyoi H, Naoe T, Matsushita T, Maruyama M*  RhoF promotes murine marginal zone B cell development. Nagoya J Med Sci. 2014 Aug;76(3,4):293-305 (*corresponding author). 
  14. Chihara D, Ito H, Matsuda T, Shibata A, Katsumi A, Nakamura S, Tomotaka S, Morton LM, Weisenburger DD, Matsuo K.  Differences in incidence and trends of haematological malignancies in Japan and the United States. Br J Haematol. 2014 Feb;164(4):536-45. doi: 10.1111/bjh.12659.
  15. Abe A, Katsumi A, Kobayashi M, Okamoto A, Tokuda M, Kanie T, Yamamoto Y, Naoe T, Emi N.  A novel RUNX1-C11orf41 fusion gene in a case of acute myeloid leukemia with a t(11;21)(p14;q22). Cancer Genet. 2012 Nov;205(11):608-11. doi: 10.1016/j.cancergen.2012.10.001. Epub 2012 Oct 24.
  16. Wang S, Watanabe T, Matsuzawa K, Katsumi A, Kakeno M, Matsui T, Ye F, Sato K, Murase K, Sugiyama I, Kimura K, Mizoguchi A, Ginsberg MH, Collard JG, Kaibuchi K. Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration. J Cell Biol. 2012 Oct 15;199(2):331-45. 
  17. Kajiguchi T, Katsumi A, Tanizaki R, Kiyoi H, Naoe T.  Y654 of β-catenin is essential for FLT3/ITD-related tyrosine phosphorylation and nuclear localization of β-catenin. Eur J Haematol. 2012 Apr;88(4):314-20. Epub 2012 Jan 4.
  18. Katsumi A, Nishida T, Murata M, Terakura S, Shimada K, Saito S, Kobayashi M, Kodaira A, Shibata M, Oda I, Yagi T, Kiyoi H, Matsushita T, Kojima T, Naoe T. Virus-Associated Hemophagocytic Syndrome Caused by Pandemic Swine-Origin Influenza A (H1N1) in a Patient After Unrelated Bone Marrow Transplantation. J Clin Exp Hematop. 2011 May;51(1):63-5.
  19. Katsumi A, Kiyoi H, Abe A, Tanizaki R, Iwasaki T, Kobayashi M, Matsushita T, Senga T, Kohno T, Kojima T, Kaibuchi K, Hamaguchi M, Naoe T.  FLT3/ITD regulates leukaemia cell adhesion through α4β1 integrin and Pyk2 signaling. Eur J Haematol. 2011 Mar;86(3):191-8.
  20. Urakawa H, Nishida Y, Tsukushi S, Katsumi A, Ishiguro N. Glanzmann thrombasthenia detected because of knee hemarthrosis: a case report.  J Pediatr Orthop B. 2010 Nov;19(6):521-3.
  21. Miyawaki Y, Suzuki A, Fujimori Y, Takagi A, Murate T, Suzuki N, Katsumi A, Naoe T, Yamamoto K, Matsushita T, Takamatsu J, Kojima T.  Severe hemophilia A in a Japanese female caused by an F8-intron 22 inversion associated with skewed X chromosome inactivation. Int J Hematol. 2010 Sep;92(2):405-8.  
  22. Suzuki M, Abe A, Imagama S, Nomura Y, Tanizaki R, Minami Y, Hayakawa F, Ito Y, Katsumi A, Yamamoto K, Emi N, Kiyoi H, Naoe T. BCR-ABL-Independent and RAS/MAPK Pathway-Dependent Form of Imatinib Resistance in Ph-Positive Acute Lymphoblastic Leukemia Cell line with Activation of EphB4. Eur J Haematol. 2010 Mar;84(3):229-38.
  23. Takefuji M, Asano H, Mori K, Amano M, Kato K, Watanabe T, Morita Y, Katsumi A, Itoh T, Takenawa T, Hirashiki A, Izawa H, Nagata K, Hirayama H, Takatsu F, Naoe T, Yokota M, Kaibuchi K. Mutation of ARHGAP9 in patients with coronary spastic angina. J Hum Genet. 2010 Jan;55(1):42-9.
  24. Tanaka R, Nakashima D, Suzuki A, Miyawaki Y, Fujimori Y, Yamada T, Takagi A, Murate T, Yamamoto K, Katsumi A, Matsushita T, Naoe T, Kojima T. Impaired secretion of carboxyl-terminal truncated factor VII due to an F7 nonsense mutation associated with FVII deficiency. Thromb Res. 2010 Mar;125(3):262-6.
  25. Inamoto Y, Murata M, Katsumi A*, Kuwatsuka Y, Tsujimura A, Ishikawa Y, Sugimoto K, Onizuka M, Terakura S, Nishida T, Kanie T, Taji H, Iida H, Suzuki R, Abe A, Kiyoi H, Matsushita T, Miyamura K, Kodera Y, Naoe T. Donor single nucleotide polymorphism in the CCR9 gene affects the incidence of skin GVHD. Bone Marrow Transplant. 2010 Feb;45(2):363-9(*corresponding author).
  26. Takagi A, Tanaka R, Nakashima D, Fujimori Y, Yamada T, Okumura K, Murate T, Yamada M, Horikoshi Y, Yamamoto K, Katsumi A, Matsushita T, Naoe T, Kojima T. Definite diagnosis in Japanese patients with protein C deficiency by identification of causative PROC mutations. Int J Hematol. 2009 May;89(4):555-7.
  27. Abe A, Minami Y, Hayakawa F, Kitamura K, Nomura Y, Murata M, Katsumi A, Kiyoi H, Jamieson H.M.C., Wang Y.J.J., Naoe T. Retention But Significant Reduction of BCR-ABL Transcript in Hematopoietic Stem Cells in Chronic Myelogenous Leukemia After Imatinib Therapy. Int J Hematol. 2008 Dec;88(5):471-5.
  28. Tanizaki R, Katsumi A*, Kiyoi H, Kunishima S, Iwasaki T, Ishikawa Y, Kobayashi M, Abe A, Matsushita T, Watanabe T, Kojima T, Kaibuchi K, Kojima S, Naoe T. Mutational analysis of SOS1 in acute myeloid leukemia.  Int J Hematol. 2008 Nov;88(4):460-2. (*corresponding author)
  29. Iwasaki T, Katsumi A*, Kiyoi H, Tanizaki R, Ishikawa Y, Ozeki K, Kobayashi M, Abe A, Matsushita T, Watanabe T, Amano M, Kojima T, Kaibuchi K, Naoe T. Prognostic implication and biological roles of RhoH in acute myeloid leukaemia. Eur J Haematol. 2008 Dec;81(6):454-60. (*corresponding author)
  30. Okumura K, Fujimori Y, Takagi A, Murate T, Ozeki M, Yamamoto K, Katsumi A, Matsushita T, Naoe T, Kojima T. Skewed X chromosome inactivation in fraternal female twins results in moderately severe and mild haemophilia B. Haemophilia. 2008 Sep;14(5):1088-93.
  31. Kashiwagi T, Matsushita T, Ito Y, Hirashima K, Sanda N, Fujimori Y, Yamada T, Okumura K, Takagi A, Murate T, Katsumi A, Takamatsu J, Yamamoto K, Naoe T, Kojima T. L1503R is a member of group I mutation and has dominant-negative effect on secretion of full-length VWF multimers: an analysis of two patients with type 2A von Willebrand disease. Haemophilia. 2008 May;14(3):556-63. 
  32. Nakayama T, Matsushita T, Yamamoto K, Mutsuga N, Kojima T, Katsumi A, Nakao N, Sadler JE, Naoe T, Saito H. Identification of amino acid residues responsible for von Willebrand factor binding to sulfatide by charged-to-alanine-scanning mutagenesis. Int J Hematol. 2008 May;87(4):363-70.
  33. Imagama S, Abe A, Suzuki M, Hayakawa F, Katsumi A, Emi N, Kiyoi H, Naoe T.  LRP16 is fused to RUNX1 in monocytic leukemia cell line with t(11;21)(q13;q22). Eur J Haematol. 2007 Jul;79(1):25-31.
  34. Hiraga J, Katsumi A*, Iwasaki T, Abe A, Kiyoi H, Matsushita T, Kinoshita T, Naoe T. Prognostic analysis of aberrant somatic hypermutation of RhoH gene in diffuse large B cell lymphoma. Leukemia. 2007 Aug;21(8):1846-7. (*corresponding author)
  35. Abe A, Kiyoi H, Ninomiya M, Yamazaki T, Murase T, Ozeki K, Suzuki M, Hayakawa F, Katsumi A, Emi N, Naoe T. Establishment of a stroma-dependent human acute myelomonocytic leukemia cell line, NAMO-2, with FLT3 tandem duplication. Int J Hematol. 2006 Nov;84(4):328-36.
  36. Ninomiya M, Abe A, Katsumi A, Xu J, Ito M, Arai F, Suda T, Ito M, Kiyoi H, Kinoshita T, Naoe T. Homing, proliferation and survival sites of human leukemia cells in vivo in immunodeficient mice.  Leukemia. 2007 Jan;21(1):136-42. 
  37. Katsumi A*, Matsushita T, Hirashima K, Iwasaki T, Adachi T, Yamamoto K, Kojima T, Takamatsu J, Saito H, Naoe T.  Recurrent intramural hematoma of small intestine in a severe hemophilia A patient with high titer of factor VIII inhibitor.  A case report and a review of the literatures.  Int J. Hematol. 2006 Aug;84(2):166-9. (*corresponding author)
  38. Adachi T, Matsushita T, Ichihashi R, Hirashima K, Ito M, Inukai A, Yokozawa T, Nishida T, Murata M, Hayashi M, Katsumi A, Kojima T, Saito H, Naoe T. High Titer of ADAMTS13 Inhibitor Associated with Thrombotic Microangiopathy of the Gut and Skeletal Muscle after Allogeneic Hematopoietic Stem Cell Transplantation. Int J Hematol. 2006 Jun;83(5):415-9.
  39. Hayashi M, Matsushita T, Mackman N, Ito M, Adachi T, Katsumi A, Yamamoto K, Takeshita K, Kojima T, Saito H, Murohara T, Naoe T. Fatal thrombosis of antithrombin-deficient mice is rescued differently in the heart and liver by intercrossing with low tissue factor mice. J Thromb Haemost. 2006 Jan;4(1):177-85. 
  40. Adachi T, Matsushita T, Dong Z, Katsumi A, Nakayama T, Kojima T, Saito H, Sadler JE, Naoe T. Identification of amino acid residues essential for heparin binding by the A1 domain of human von Willebrand factor. Biochem Biophys Res Commun. 2006 Jan 27;339(4):1178-83. 
  41. Katsumi A, Naoe T, Matsushita T, Kaibuchi K, Schwartz MA.  Integrin activation and matrix binding mediate cellular responses to mechanical stretch. J Biol Chem. 2005 Apr 29;280(17):16546-9.
  42. Nakayama M, Amano M, Katsumi A, Kaneko T, Kawabata S, Takefuji M, Kaibuchi K. Rho-kinase and myosin II activities are required for cell type and environment specific migration. Genes to Cells 2005 Feb;10(2):107-17.
  43. Matsushita T, Hayashi H, Kunishima S, Hayashi M, Ikejiri M, Takeshita K, Yuzawa Y, Adachi T, Hirashima K, Sone M, Yamamoto K, Takagi A, Katsumi A, Kawai K, Nezu T, Takahashi M, Nakashima T, Naoe T, Kojima T, Saito H.  Targeted disruption of mouse ortholog of the human MYH9 responsible for macrothrombocytopenia with different organ involvement: hematological, nephrological, and otological studies of heterozygous KO mice.  Biochem Biophys Res Commun. 2004 Dec 24;325(4):1163-71
  44. Katsumi A, Orr AW, Tzima E, Schwartz MA.  Integrins in mechanotransduction.  J. Biol. Chem. 2004 March 26;279(13):12001-4
  45. Katsumi A, Milanini J, Kiosses WB, del Pozo MA, Kaunas R, Chien S, Hahn KM, Schwartz MA.  Effects of cell tension on the small GTPase Rac.  J. Cell Biol.2002 Jul 8;158(1):153-64.
  46. Bodo I, Katsumi A, Tuley EA, Eikenboom JC, Dong Z, Sadler JE.  Type 1 von Willebrand disease mutation Cys1149Arg causes intracellular retention and degradation of heterodimers: a possible general mechanism for dominant mutations of oligomeric proteins. Blood. 2001 Nov 15;98(10):2973-9.
  47. Katsumi A, Tuley EA, Bodo I, Sadler JE.  Localization of Disulfide Bonds in the Cystine Knot Domain of Human von Willebrand Factor. J Biol Chem. 2000 Aug 18;275(33):25585-94.
  48. Katsumi A*, Matsushita T, Yamazaki T, Sugiura I, Kojima T, Saito H.  Severe factor VII deficiency caused by a novel mutation His348 to Gln in the catalytic domain. Thromb Haemost. 2000 Feb;83(2):239-43. (*corresponding author)
  49. Miyata T, Sakata T, Yasumuro Y, Okamura T, Katsumi A, Saito H, Abe T, Shirahata A, Sakai M, Kato H.  Genetic analysis of protein C deficiency in nineteen Japanese families: five recurrent defects can explain half of the deficiencies. Thromb Res. 1998 Nov 15;92(4):181-7.
  50. Katsumi A*, Kojima T, Senda T, Yamazaki T, Tsukamoto H, Sugiura I, Kobayashi S, Miyata T, Umeyama H, Saito H.  The carboxyl-terminal region of protein C is essential for its secretion. Blood. 1998 May 15;91(10):3784-91. (*corresponding author)
  51. Tsuzuki S, Kojima T, Katsumi A, Yamazaki T, Sugiura I, Saito H.  Molecular cloning, genomic organization, promoter activity, and tissue-specific expression of the mouse ryudocan gene. J Biochem (Tokyo). 1997 Jul;122(1):17-24.
  52. Yamazaki T, Katsumi A, Okamoto Y, Takafuta T, Tsuzuki S, Kagami K, Sugiura I, Kojima T, Fujimura K, Saito H.  Two distinct novel splice site mutations in a compound heterozygous patient with protein S deficiency. Thromb Haemost. 1997 Jan;77(1):14-20.
  53. Yamazaki T, Hamaguchi M, Takamatsu J, Okamoto Y, Katsumi A, Kagami K, Sugiura I, Kojima T, Saito H.  Analysis for heterozygosity of protein S mRNA: application to genetic screening and family studies in hereditary protein S deficiency.  Int J Hematol. 1996 Aug;64(2):119-25.
  54. Okamoto Y, Yamazaki T, Katsumi A, Kojima T, Takamatsu J, Nishida M, Saito H.  A novel associated with an exon skipping in a patient with hereditary protein S deficiency type I. Thromb Haemost. 1996 Jun;75(6):877-82.
  55. Yamazaki T, Katsumi A, Kagami K, Okamoto Y, Sugiura I, Hamaguchi M, Kojima T, Takamatsu J, Saito H.  Molecular basis of a hereditary type I protein S deficiency caused by a substitution of Cys for Arg474. Blood. 1996 Jun 1;87(11):4643-50.
  56. Katsumi A*, Senda T, Yamashita Y, Yamazaki T, Hamaguchi M, Kojima T, Kobayashi S, Saito H.  Protein C Nagoya, an elongated mutant of protein C, is retained within the endoplasmic reticulum and is associated with GRP78 and GRP94. Blood. 1996 May 15;87(10):4164-75. (*corresponding author)
  57. Takagi A, Kojima T, Tsuzuki S, Katsumi A, Yamazaki T, Sugiura I, Hamaguchi M, Saito H.  Structural organization and promoter activity of the human ryudocan gene. J Biochem (Tokyo). 1996 May;119(5):979-84.
  58. Yamazaki T, Katsumi A, Tsuzuki S, Sugiura I, Kojima T, Takamatsu J, Saito H.  Analysis for antithrombin gene polymorphisms in Japanese subjects and cosegregation studies in families with hereditary antithrombin deficiency. Thromb Res. 1996 May 1;82(3):275-80.
  59. Kojima T, Katsumi A, Yamazaki T, Muramatsu T, Nagasaka T, Ohsumi K, Saito H.  Human ryudocan from endothelium-like cells binds basic fibroblast growth factor, midkine, and tissue factor pathway inhibitor. J Biol Chem. 1996 Mar 8;271(10):5914-20.
  60. Yamazaki T, Hamaguchi M, Katsumi A, Kagami K, Kojima T, Takamatsu J, Saito H.  A quantitative protein S deficiency associated with a novel nonsense mutation and markedly reduced levels of mutated mRNA. Thromb Haemost. 1995 Aug;74(2):590-5.
  61. Katsumi A, Emi N, Abe A, Hasegawa Y, Ito M, Saito H.  Humoral and cellular immunity to an encoded protein induced by direct DNA injection. Hum Gene Ther. 1994 Nov;5(11):1335-9.

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  1. Suzuki M, Abe A, Imagama S, Nomura Y, Tanizaki R, Minami Y, Hayakawa F, Ito Y, Katsumi A, Yamamoto K, Emi N, Kiyoi H, Naoe T. BCR-ABL-independent and RAS/MAPK pathway-dependent form of imatinib resistance in Ph-positive acute lymphoblastic leukemia cell line with activation of EphB4. Eur J Haematol. 2010; 84: 229-238.
  2. Imagama S, Abe A, Suzuki M, Hayakawa F, Katsumi A, Emi N, Kiyoi H, Naoe T. LRP16 is fused to RUNX1 in monocytic leukemia cell line with t（11;21）（q13;q22）. Eur J Haematol. 2007; 79: 25-31.
  3. Abe A, Emi N, Kanie T, Imagama S, Kuno Y, Takahashi M, Saito H, Naoe T. Expression cloning of oligomerization-activated genes with cell-proliferating potency by pseudotype retrovirus vector. Biochem Biophys Res Commun. 2004; 320; 920-926.
  4. Nishida T, Hamaguchi M, Hirabayashi N, Haneda M, Terakura S, Astuta Y, Imagama S, Kanie T, Murata M, Taji H, Suzuki R, Morishita Y, Kodera Y. Intestinal thrombotic microangiopathy after allogeneic bone marrow transplantation: a clinical imitator of acute enteric graft-versus-host disease. Bone Marrow Transplant. 2004; 33; 1143-1150.

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