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Department of Aging Neurobiology

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We are dedicated to elucidating the pathogenesis of Alzheimer’s disease, with the final goal of developing novel therapeutics. Based on the knowledge and wisdom of our forerunners, we will work with and nurture young researchers who will be responsible for next-generation discoveries. Our cutting-edge research will focus on new areas such as the interactions between Alzheimer’s disease and its genetic and non-genetic risk factors. Ultimately we aim to discover new treatments and provide relief to patients, families, and communities.

Naoyuki Sato
Head of Department of Aging Neurobiology
National Center for Geriatrics and Gerontology


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Department Head of Aging Neurobiology

Sato, Naoyuki M.D., Ph.D.

Section Cheif of Molecular Neuropathology

Akio Fukumori,M.D.,Ph.D.

Section Cheif of Molecular Neuropharmacology

Shinohara, Mitsuru Ph.D.



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Original articles

Shinohara M., Koga S., Konno T., Nix J., Shinohara M., Aoki N., Das P., Parisi J. E., Petersen R. C., Rosenberry T. L., Dickson D. W., Bu G. Distinct spatiotemporal accumulation of N-truncated and full-length amyloid-β42 in Alzheimer’s disease. Brain, 140(12), 3301-3316, 2017

Schlepckow K, Kleinberger G, Fukumori A, Feederle R, Lichtenthaler SF, Steiner H, Haass C. An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function. 
EMBO Mol Med. (10), 1356-1365. Oct 9, 2017

Tagami S, Yanagida K, Kodama TS, Takami M, Mizuta N, Oyama H, Nishitomi K, Chiu YW, Okamoto T, Ikeuchi T, Sakaguchi G, Kudo T, Matsuura Y, Fukumori A, Takeda M, Ihara Y, Okochi M. Semagacestat Is a Pseudo-Inhibitor of γ-Secretase.
Cell Rep.21(1), 259-273 Oct 3, 2017

Trambauer J, Fukumori A, Kretner B, Steiner H. Analyzing Amyloid-β Peptide Modulation Profiles and Binding Sites of γ-Secretase Modulators. Methods Enzymol. 584:157-183. 2017

Wojtas A. M., Kang S. S., Olley B. M., Gatherer M., Shinohara M., Lozano P. A., Liu C. C., Kurti A., Baker K. E., Dickson D. W.,Yue M., Petrucelli L., Bu G., Carare R. O., Fryer J. D. Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways. Proc Natl Acad Sci U S A. 114(33), E6962-E6971, 2017

Zhao J. , Davis M. D., Atagi Y., Shinohara M., Graff-Radford N. R., Younkin S. G., Wszolek Z. K., Kanekiyo T., Bu G. APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes. Human Molecular Genetics, 26(14), 2690-2700, 2017

Rogers J.T., Liu C. C., Zhao N., Wang J., Putzke T., Yang L., Shinohara M., Fryer J. D., Kanekiyo T., Bu G. Subacute ibuprofen treatment rescues the synaptic and cognitive deficits in advanced-aged mice. Neurobiology of Aging, 53, 112-121, 2017

Fukumori A, Steiner H. Substrate recruitment of γ-secretase and mechanism of clinical presenilin mutations revealed by photoaffinity mapping.  EMBO J. 35(15), 1628-43. Aug 1, 2016

Hüttl S, Helfrich F, Mentrup T, Held S, Fukumori A, Steiner H, Saftig P, Fluhrer R, Schröder B. Substrate determinants of signal peptide peptidase-like 2a (SPPL2a)-mediated intramembrane proteolysis of the invariant chain CD74. Biochem J. 473(10), 1405-22. May 15, 2016

Kretner B, Trambauer J, Fukumori A, Mielke J, Kuhn PH, Kremmer E, Giese A, Lichtenthaler SF, Haass C, Arzberger T, Steiner H. Generation and deposition of Aβ43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease. EMBO Mol Med. 8(5), 458-65. May 2, 2016

Tsaktanis T, Kremling H, Pavšič M, von Stackelberg R, Mack B, Fukumori A, Steiner H, Vielmuth F, Spindler V, Huang Z, Jakubowski J, Stoecklein NH, Luxenburger E, Lauber K, Lenarčič B, Gires O. Cleavage and cell adhesion properties of human epithelial cell adhesion molecule (HEPCAM). J Biol Chem.291(1), 425. Jan 1, 2016

Fleck D, Voss M, Brankatschk B, Giudici C, Hampel H, Schwenk B, Edbauer D, Fukumori A, Steiner H, Kremmer E, Haug-Kröper M, Rossner MJ, Fluhrer R, Willem M, Haass C. Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases. J Biol Chem.291(1), 318-33. Jan 1, 2016

Tachibana, M., Shinohara, M., Yamazaki, Y., Liu, C. C., Rogers, J., Bu, G., and Kanekiyo, T*. Rescuing effects of RXR agonist bexarotene on aging-related synapse loss depend on neuronal LRP1. Experimental neurology 277, 1-9, 2016.

Shinohara, M., Murray, M. E., Frank, R. D., Shinohara, M., DeTure, M., Yamazaki, Y., Tachibana, M., Atagi, Y., Davis, M. D., Liu, C. C., Zhao, N., Painter, M. M., Petersen, R. C., Fryer, J. D., Crook, J. E., Dickson, D. W., Bu, G., and Kanekiyo, T*. Impact of sex and APOE4 on cerebral amyloid angiopathy in Alzheimer's disease. Acta neuropathologica 132, 225-234, 2016.

Shinohara, M., Kanekiyo, T., Yang, L., Linthicum, D., Shinohara, M., Fu, Y., Price, L., Frisch-Daiello, J. L., Han, X., Fryer, J. D. and Bu, G*. APOE2 eases cognitive decline during Aging: Clinical and preclinical evaluations. Ann Neurol., 79: 758–774, 2016.

Sakae, N., Liu, C. C., Shinohara, M., Frisch-Daiello, J., Ma, L., Yamazaki, Y., Tachibana, M., Younkin, L., Kurti, A., Carrasquillo, M. M., Zou, F., Sevlever, D., Bisceglio, G., Gan, M., Fol, R., Knight, P., Wang, M., Han, X., Fryer, J. D., Fitzgerald, M. L., Ohyagi, Y., Younkin, S. G., Bu, G.*, and Kanekiyo, T*. ABCA7 Deficiency Accelerates Amyloid-beta Generation and Alzheimer's Neuronal Pathology. The Journal of neuroscience : the official journal of the Society for Neuroscience 36, 3848-3859, 2016.

Zhang, Y. J., Gendron, T. F., Grima, J. C., Sasaguri, H., Jansen-West, K., Xu, Y. F., Katzman, R. B., Gass, J., Murray, M. E., Shinohara, M., Lin, W. L., Garrett, A., Stankowski, J. N., Daughrity, L., Tong, J., Perkerson, E. A., Yue, M., Chew, J., Castanedes-Casey, M., Kurti, A., Wang, Z. S., Liesinger, A. M., Baker, J. D., Jiang, J., Lagier-Tourenne, C., Edbauer, D., Cleveland, D. W., Rademakers, R., Boylan, K. B., Bu, G., Link, C. D., Dickey, C. A., Rothstein, J. D., Dickson, D. W., Fryer, J. D., and Petrucelli, L*. C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins. Nature neuroscience 19, 668-677, 2016.

Fu, Y., Zhao, J., Atagi, Y., Nielsen, H. M., Liu, C. C., Zheng, H., Shinohara, M., Kanekiyo, T., and Bu, G. Apolipoprotein E lipoprotein particles inhibit amyloid-beta uptake through cell surface heparan sulphate proteoglycan. Molecular neurodegeneration 11, 37, 2016.

Takasugi, N., Sasaki, T., Shinohara, M., Iwatsubo, T., and Tomita, T. Synthetic ceramide analogues increase amyloid-beta 42 production by modulating gamma-secretase activity. Biochemical and biophysical research communications 457, 194-199, 2015.

Cook, C., Kang, S. S., Carlomagno, Y., Lin, W. L., Yue, M., Kurti, A., Shinohara, M., Jansen-West, K., Perkerson, E., Castanedes-Casey, M., Rousseau, L., Phillips, V., Bu, G., Dickson, D. W., Petrucelli, L., and Fryer, J. D. Tau deposition drives neuropathological, inflammatory and behavioral abnormalities independently of neuronal loss in a novel mouse model. Human molecular genetics 24, 6198-6212, 2015.

Casey, C. S., Atagi, Y., Yamazaki, Y., Shinohara, M., Tachibana, M., Fu, Y., Bu, G., and Kanekiyo, T. Apolipoprotein E Inhibits Cerebrovascular Pericyte Mobility through a RhoA Protein-mediated Pathway. The Journal of biological chemistry 290, 14208-14217, 2015.

Shinohara, M., Fujioka, S., Murray, M. E., Wojtas, A., Baker, M., Rovelet-Lecrux, A., Rademakers, R., Das, P., Parisi, J. E., Graff-Radford, N. R., Petersen, R. C., Dickson, D. W., and Bu, G. Regional distribution of synaptic markers and APP correlate with distinct clinicopathological features in sporadic and familial Alzheimer's disease. Brain : a journal of neurology 137, 1533-1549, 2014.

Zhao, J., Fu, Y., Liu, C. C., Shinohara, M., Nielsen, H. M., Dong, Q., Kanekiyo, T., and Bu, G. Retinoic acid isomers facilitate apolipoprotein E production and lipidation in astrocytes through the retinoid X receptor/retinoic acid receptor pathway. The Journal of biological chemistry 289, 11282-11292, 2014.

Shinohara, M., Petersen, R. C., Dickson, D. W., and Bu, G. Brain regional correlation of amyloid-beta with synapses and apolipoprotein E in non-demented individuals: potential mechanisms underlying regional vulnerability to amyloid-beta accumulation. Acta neuropathologica 125, 535-547, 2013.

Li, J., Kanekiyo, T., Shinohara, M., Zhang, Y., LaDu, M. J., Xu, H., and Bu, G. Differential regulation of amyloid-beta endocytic trafficking and lysosomal degradation by apolipoprotein E isoforms. The Journal of biological chemistry 3, 187-189, 2013.

Kanekiyo, T., Cirrito, J. R., Liu, C. C., Shinohara, M., Li, J., Schuler, D. R., Shinohara, M., Holtzman, D. M., and Bu, G. Neuronal clearance of amyloid-beta by endocytic receptor LRP1. The Journal of neuroscience : the official journal of the Society for Neuroscience 33, 19276-19283, 2013.

Takeda,S., Sato, N.*, Ikimura, K, Nishino, H., Rakugi, H., Morishita R*. Increased Blood-Brain Barrier Vulnerability to Systemic Inflammation in Alzheimer Disease Mouse Model. Neurobiology of Aging, 34(8):2064-70, 2013.

Shimamura, M., Sato, N., Nakagami, H., Osako, M.K., Kyutoku, M., Wakayama, K., Morishita, R. Chronic deposition of Aβ influences microcirculation in the chronic stage of cerebral Ischemia. Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry, 13(1), 77-80, 2013.

Kanekiyo, T., Liu, C. C., Shinohara, M., Li, J., and Bu, G. LRP1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-beta. The Journal of neuroscience : the official journal of the Society for Neuroscience 32, 16458-16465, 2012.

Sato, N.*, Okochi, M., Shinohara, M., Thinakaran, G., Takeda, S., Fukumori, A., Shinohara-Noma, M., Mori-Ueda, M., Hamada, H., Takeda, M., Rakugi, H., Morishita, R. Differential Regulation of Amyloid Precursor Protein /Presenilin 1 Interaction during Aβ40/42 Production Detected Using Fusion Constructs. PLoS ONE 7(11): e48551, 2012.

Takeda, S., Sato, N.*, Uchio-Yamada, K., Yu, H., Moriguchi, A., Rakugi, H., Morishita, R. Oral Glucose Loading Modulates Plasma Aβ Level in Alzheimer Disease Patients: Potential Diagnostic Method for Alzheimer Disease. Dementia and Geriatric Cognitive Disorders, 34(1):25-30, 2012.

Hayashi H, Nakagami H, Takeichi M, Shimamura M, Koibuchi N, Oiki E, Sato N, Koriyama H, Mori M, Gerardo Araujo R, Maeda A, Morishita R, Tamai K, Kaneda Y*. HIG1, a novel regulator of mitochondrial γ-secretase, maintains normal mitochondrial function. FASEB J. 26(6):2306-17, 2012.

Shimamura M, Taniyama Y, Katsuragi N, Koibuchi N, Kyutoku M, Sato N, Allahtavakoli M, Wakayama K, Nakagami H, and Morishita R*. Role of Central Nervous System Periostin in Cerebral Ischemia. Stroke, 43(4):1108-14, 2012.

Takeda, S., Sato, N.*, Ikimura, K., Nishino, H., Rakugi, R., Morishita, R*. Novel microdialysis method to assess neuropeptides and large molecules in free-moving mouse. Neuroscience, 186:110-9, 2011.

Shinohara, M, Sato, N, Kurinami, H., Takeuchi, D., Takeda, S, Shimamura, M., Yamashita, T., Uchiyama, Y., Rakugi, H., Morishita, R*. Reduction of brain Aβ by fluvastatin, an HMG-CoA reductase inhibitor, through increase in degradation of APP-CTFs and Aβ clearance. The Journal of Biological Chemistry 285, 22091-22102, 2010.

Takeda, S., Sato, N., Uchio-Yamada, K, Sawada, K., Kunieda, T., Takeuchi, D., Kurinami, H., Shinohara, M., Rakugi, H., Morishita, R*. Diabetes accelerated memory dysfunction via cerebrovascular inflammation and Aβ deposition in an Alzheimer mouse model with diabetes. Proc Natl Acad Sci U S A, 13, 107, 7036-41, 2010.

Takeda, S., Sato, N., Takeuchi, D., Kurinami, H., Shinohara, M., Niisato, K., Kano, M., Ogihara, T., Rakugi, H., Morishita, R*. Angiotensin Receptor Blocker Prevented β-Amyloid-Induced Cognitive Impairment Associated with Recovery of Neurovascular Coupling. Hypertension, 54, 1345-52, 2009.

Hayashi S*, Sato N, Yamamoto A, Ikegame Y, Nakashima S, Ogihara T, Morishita R. Alzheimer disease-associated peptide, amyloid beta40, inhibits vascular regeneration with induction of endothelial autophagy. Arterioscler Thromb Vasc Biol. 29, 1909-15, 2009.

Takeda, S., Sato, N., Niisato, K., Takeuchi, D., Kurinami, H., Shinohara, M., Rakugi, H., Kano, M., Morishita, R*. Validation of Aβ1-40 Administration into Mouse Cerebroventricles as an Animal Model for Alzheimer Disease. Brain Research, 1280, pp137-147, 2009

Takeda, S., Sato, N., Uchio-Yamada, K., Sawada, K., Kunieda, T., Takeuchi, D., Kurinami, H., Shinohara, M., Rakugi, H., Morishita, R*. Elevation of Plasma β-amyloid Level by Glucose Loading in Alzheimer Mouse Models. Biochemical and Biophysical Research Communications, 385, 193-197, 2009.

Wakayama K, Shimamura M, Sata M, Koibuchi N, Sato N, Ogihara T, Morishita R*. A model of cerebrovascular injury in rats. . 175, 187-95, 2008.

Kurinami H, Sato N, Shinohara M, Takeuchi D, Takeda S, Shimamura M, Ogihara T and Morishita R*.. Prevention of amyloid β-induced memory impairment by fluvastatin, associated with the decrease in amyloid β accumulation and oxidative stress in amyloid βinjection mouse model. International Journal of Molecular Medicine 21, 531-7, 2008.

Takeuchi D, Sato N, Shimamura M, Kurinami H, Takeda S , Shinohara M , Suzuki S , Kojima M, Ogihara T and Morishita R*. Alleviation of Aβ-induced cognitive impairment by ultrasound-mediated gene transfer of HGF in a mouse model. Gene Therapy, 15, 561-71, 2008.

Hayashi H, Nakagami H*, Takami Y, Sato N, Saitoh Y, Nishikawa T, Mori M, Koriyama H, Tamai K, Morishita R, Kaneda Y*. Involvement of gamma-secretase in postnatal angiogenesis. Biochem. Biophys. Res. Commun. 363, 584-90, 2007.

Shimamura M, Sato N, Sata, M, Kurinami, H, Takeuchi, D, Wakayama, K, Hayashi, T, Iida, H, Morishita R*. Delayed Post-ischemic Treatment with Fluvastatin Improved Learning and Memory Deficit After Stroke in Rats. Stroke 38, 3251-8, 2007.

Shimamura M, Sato N, Sata M, Wakayama K, Ogihara T, Morishita R*. Expression of hepatocyte growth factor and c-Met after spinal cord injury in rats. Brain Res. 1151, 188-94, 2007.

Wakayama K, Shimamura M, Sata M, Sato N, Kawakami K, Fukuda H, Tomimatsu T, Ogihara T, Morishita R*. Quantitative measurement of neurological deficit after mild (30 min) transient middle cerebral artery occlusion in rats. Brain Res. 1130, 181-7, 2007.

Shimamura M, Sato N, Waguri S, Uchiyama Y, Hayashi T, Iida H, Nakamura T, Ogihara T, Kaneda Y, Morishita R*. Gene Transfer of Hepatocyte Growth Factor Gene Improves Learning and Memory in the Chronic Stage of Cerebral Infarction. Hypertension. 47, 742-51, 2006.

Sato N, Okochi M, Taniyama Y, Kurinami H, Shimamura M, Takeuchi D, Hamada H, Fukumori A, Kiyosue K, Taguchi T, Tanaka T, Miyasaka M, Takeda M, Ogihara T, Morishita R*. Development of new screening system for Alzheimer Disease, in vitro Aβ sink assay, to identify the dissociation of soluble Aβ from fibrils. Neuobiology of Disease 22, 487-495, 2006.

Shimamura, M., Sato, N, Taniyama, Y., Kurinami, H., Tanaka, H., Takami, T., Ogihara, T., Tohyama, M., Kaneda, Y. & Morishita, R*. Gene transfer into adult rat spinal cord using naked plasmid DNA and ultrasound microbubbles. J. Gene Med. 7, 1468-74, 2005.

Shimamura M, Sato N, Taniyama Y, Yamamoto S, Endoh M, Kurinami H, Aoki M, Ogihara T, Kaneda Y, Morishita R*. Development of efficient plasmid DNA transfer into adult rat central nervous system using microbubble-enhanced ultrasound. Gene Ther. 11:1532-9, 2004.

Shimamura M, Sato N, Oshima K, Aoki M, Kurinami H, Waguri S, Uchiyama Y, Ogihara T, Kaneda Y, Morishita R*. A novel therapeutic strategy to treat brain ischemia: Over-expression of hepatocyte growth factor gene reduced ischemic injury without cerebral edema in rat model. Circulation, 109:424-31, 2004.

Suzuki T, Fukuo K*, Suhara T, Yasuda O, Sato N, Takemura Y, Tsubakimoto M, Ogihara T. Eicosapentaenoic acid protects endothelial cells against anoikis through restoration of cFLIP. Hypertension. 42, 342-8, 2003.

Fukuo K*, Yang J, Suzuki T, Kaimoto T, Takemura Y, Yasuda O, Suhara T, Sato N, Ogihara T. Nifedipine upregulates manganese superoxide dismutase expression in vascular smooth muscle cells via endothelial cell-dependent pathways. Hypertens Res. 26, 503-8, 2003.

Fukuo K*, Yang J, Yasuda O, Mogi M, Suhara T, Sato N, Suzuki T, Morimoto S, Ogihara T. Nifedipine Indirectly Upregulates Superoxide Dismutase Expression in Endothelial Cells via Vascular Smooth Muscle Cell–Dependent Pathways. Circulation. 106, 356-61, 2002.

Mori M, Nakagami H, Morishita R, Mitsuda N, Yamamoto K, Yoshimura S, Ohkubo N, Sato N, Ogihara T, Kaneda Y*. N141I mutant presenilin-2 gene enhances neuronal cell death and decreases bcl-2 expression. Life Sci. 70:2567-80, 2002.

Sato N, Urano F, Yoon Leem J, Kim SH, Li M, Donoviel D, Bernstein A, Lee AS, Ron D, Veselits ML, Sisodia SS, Thinakaran G*. Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression. Nat Cell Biol. 2, 863-70, 2000.

Hatanaka Y, Kamino K, Fukuo K*, Mitsuda N, Nishiwaki-Ueda Y, Sato N, Satoh T, Yamamoto H, Yoneda H, Imagawa M, Miki T, Ohta S, Ogihara T. Low density lipoprotein receptor-related protein gene polymorphisms and risk for late-onset Alzheimer's disease in a Japanese population. Clin Genet. 58:319-23, 2000.

Mitsuda N*, Ohkubo N, Tamatani M, Lee YD, Taniguchi M, Namikawa K, Kiyama H, Yamaguchi A, Sato N, Sakata K, Ogihara T, Vitek MP, Tohyama M. Activated cyclic AMP- response element-binding protein regulates neuronal expression of presenilin-1. J Biol Chem. 276:9688-98, 2001.

Sato N, Kamino K*, Tateishi K, Satoh T, Nishiwaki Y, Yoshiiwa A, Miki T, Ogihara T. Elevated Amyloid β Protein (1-40) Level Induces CREB Phosphorylation  at serine-133 via p44/p42 MAP Kinase(ERK1/2)-dependent Pathway in Rat Pheochromocytoma PC12 Cells. Biochem. Biophys. Res. Commun. 232, 637-642, 1997.

Nishiwaki Y, Kamino K*, Yoshiiwa A, Sato N, Tateishi K, Takeda M, Kobayashi T, Yamamoto H, Nonomura Y, Yoneda H, Sakai T, Imagawa M, Miki T, Ogihara T. T/G polymorphism at intron 9 of presenilin 1 gene is associated with, but not responsible for sporadic late-onset Alzheimer's disease in Japanese population. Neurosci Lett., 227, 123-6, 1997.

Yoshiiwa A, Kamino K*, Yamamoto H, Kobayashi T, Imagawa M,Nonomura Y, Yoneda H, Sakai T, Nishiwaki Y, Sato N,Rakugi H, Miki T, Ogihara T. a1-Antichymotrypsin as a risk modifier for late-onset Alzheimer’s disease in Japanese Apolipoprotein E e4 allele carriers. Annals of Neurology, 42, 115-117, 1997.

Sato N, Fujio Y*, Yamada-Honda Y, Funai H, Wada A, Kawashima S, Awata N, Shibata N. Elevated calcium level induces calcium-dependent proteolysis of A-CAM (N-cadherin) in heart - analysis by detergent-treated model. Biochem. Biophys. Res. Commun.,217, 649-653, 1995.

Fujio Y*, Yamada-Honda Y, Sato N, Funai H, Wada A, Awata N, Shibata N. Disruption of cell-cell adhesion in an inbred strain of hereditary cardiomyopathic hamster (Bio 14.6). Cardiovascular Research, 30, 899-904, 1995.


Review articles

Sato, N.*, Morishita, R. The Roles of Lipid and Glucose Metabolism in Modulation of b-Amyloid, Tau, and Neurodegeneration in the Pathogenesis of Alzheimer disease. Front. Aging Neurosci. | doi: 10.3389/fnagi.2015.00199, 2015.

Sato, N.*, Morishita, R. Brain alterations and clinical symptoms of dementia in diabetes: Aβ/tau-dependent and independent mechanisms. Frontiers in Endocrinology. Front. Endocrinol. | doi: 10.3389/fendo.2014.00143, 2014.

Takeda, S., Sato, N.*, Morishita, R.* Systemic inflammation, blood-brain barrier vulnerability and cognitive / non-cognitive symptoms in Alzheimer disease: Relevance to pathogenesis and therapy. Front. Aging Neurosci. doi: 10.3389/fnagi.2014.00171, 2014.

Shinohara, M., Sato, N.*, Kurinami, H., Shimamura, M., Hamasaki, T., Chatterjee, A., Rakugi, H., Morishita, R. Possible modification of Alzheimer's disease by statins in midlife: interactions with genetic and non-genetic risk factors. Front. Aging Neurosci. doi: 10.3389/fnagi.2014.00071, 2014

Sato N* and Morishita R*. Roles of Vascular and Metabolic Components in Cognitive Dysfunction of Alzheimer disease: Short- and Long-term Modification by Non-genetic Risk Factors. Front. Aging Neurosci. 5:64. doi: 10.3389/fnagi.2013.00064, 2013.

Shinohara, M.*, Bu, G. What can we learn from regional vulnerability to Aβ accumulation in non-demented individuals? Neurodegenerative disease management, 3(3): 187-189, 2013.

Sato, N.*, Morishita, R.* Plasma Abeta: A Possible Missing Link Between Alzheimer Disease and Diabetes. Diabetes, 62, 1005-1006, 2013.

Kurnami H, Shimamura M, Sato N, Nakagami H, Morishita R*. Do angiotensin receptor blockers protect against Alzheimer's disease? Drugs&Aging.  30:367-72, 2013. 

Sato, N.*, Shinohara, M., Rakugi, H., Morishita, R. Dual effects of statins on Abeta metabolism: Up-regulation of degradation of APP-CTF and Abeta clearance. Neurodegenerative diseases, 10(1-4):305-8, 2012.

Shimamura M, Sato N, Nakagami H, Taniyama Y, Morishita R*. Development of nucleic acid drugs for neurological disorders. Curr Top Med Chem. 12(15):1621-9, 2012. 

Shimamura M, Sato N, Morishita R*. Experimental and clinical application of plasmid DNA in the field of central nervous diseases. Curr Gene Ther., 11(6), 491-500, 2011.

Takeda S, Sato N*, Rakugi H, Morishita R*. Molecular mechanisms linking diabetes mellitus and Alzheimer disease: beta-amyloid peptide, insulin signaling, and neuronal function. Mol Biosyst. 7(6):1822-7, 2011.

Sato, N.*, Takeda, S., Uchio-Yamada, K., Ueda, H., Fujisawa, T., Rakugi, H., Morishita, R. Role of insulin signaling in the interaction between Alzheimer disease and diabetes mellitus: a missing link to therapeutic potential. Current Aging Science, 4, 118-127, 2011.

Takeda, S., Sato, N., Rakugi, H., Morishita, R*. Plasma Beta-Amyloid as Potential Biomarker of Alzheimer Disease: Possibility of Diagnostic Tool of Alzheimer Disease. Molecular BioSystems, 6, 1760-1766, 2010.

Fournier A*, Oprisiu-Fournier R, Serot JM, Godefroy O, Achard JM, Faure S, Mazouz H, Temmar M, Albu A, Bordet R, Hanon O, Gueyffier F, Wang J, Black S, Sato N. Prevention of dementia by antihypertensive drugs: how AT1-receptor-blockers and dihydropyridines better prevent dementia in hypertensive patients than thiazides and ACE-inhibitors. Expert Rev Neurother. 9(9):1413-31, 2009.

Takeda S, Sato N, Ogihara T, Morishita R*. The Renin-Angiotensin System, Hypertension and cognitive dysfunction in Alzheimer's Disease: New Therapeutic Potential. Frontiers in Bioscience. , 2008.

Sato N, Shimamura M, Takeuchi D, Kurinami H, Ogihara T, Morishita R*. Gene Therapy for Ischemic Brain Disease with special reference to Vascular Dementia. Geriatrics and Gerontology International. 2006.

Shimamura, M., Sato, N, Yoshimura S, Kaneda, Y., Morishita, R*. HVJ-based non-viral gene transfer method: successful gene therapy using HGF and VEGF genes in experimental ischemia Frontiers in Bioscience. 11, 753-759, 2006.

Sato N, Shimamura M, Morishita R*. Recent Progress in Cerebrovascular Gene Therapy. Current Neurovascular Research. 2, 235-247, 2005.

Thinakaran G*, Bowen JW, Ito D, Leem JY, Veselits ML, Sato N. Investigation of unfolded-protein response in cells expressing familial Alzheimer's disease-linked presenilin variants. Methods Mol Biol. 232, 203-16, 2003.

Miki T*, Nakura J, Ye L, Mitsuda N, Morishima A, Sato N, Kamino K, Ogihara T. Molecular and epidemiological studies of Werner syndrome in the Japanese population. Mech Ageing Dev. 98, 255-65, 1997.



Sato, N.*, Morishita, R. Aβ Deposition, Insulin Signaling, and Tau Phosphorylation in Animal Models of Alzheimer Disease and Diabetes. Metabolic Syndrome and Neurological Disorders. Eds: Akhlaq A. Farooqui, Tahira Farooqui. John Wiley & Sons, Inc.383-394, 2013.

Takeda, S., Sato, N., Rakugi, H., Morishita, R*. Animal Models of Alzheimer Disease for Translational Research: Current and Future Concepts. Horizons in Neuroscience Research. Volume 4 (Hardcover), Nova Science Publishers, Inc. 2010.

Sato, N., Thinakaran, G*. The Unfolded Protein Response-mediated Upregulation of BiP and CHOP Is not Affected by Presenilin Expression. Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics. Eds: Khalid Iqbal, Sangram S. Sisodia and Bengt Winblad. John Wiley & Sons Ltd. 559-568, 2001.

Kamino K*, Yoshiiwa A, Nishiwaki Y, Sato N, Tateishi K, Kudo T, Nishimura T, Takeda M, Miki T and Ogihara T. Integration of genetic factors into pathogenesis of Alzheimer's disease.
Research and Practice in Alzheimer's disease. Eds: Vellas B. et al. Springer Publishing Company, Paris. 51-70, 1998.

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  • National Center for Geriatrics and Gerontology
  • National Hospital for Geriatric Medicine, NCGG
  • Research Institute, NCGG
  • Center for Gerontology and Social Science

National Center for Geriatrics and Gerontology

7-430 Morioka-cho, Obu City, Aichi Prefecture, Japan