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Department of Clinical and Experimental Neuroimaging

Using brain imaging techniques (i.e. PET, SPECT, MEG, MRI), we investigate pathophysiology of dementia and related diseases to achieve early diagnosis and precise evaluation of treatement effects. We speculate on a wide range of poteintial applications of brain imaging to drug development for the diseases.

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News

Feb 2018, Less than a teaspoon of blood can predict Alzheimer’s disease risk. 

Overview of the research department

Dr_Ito
Director: Kengo Ito, MD, PhD

1. History and Overview

     “National Institute for Longevity Sciences” => “National Center for Geriatrics and Gerontology”   You may wonder what is this.  It shows the name change of our institution since 1995. To be specific, the sequence of names was: "Chubu National Hospital/National Institute for Longevity Sciences (from July 1, 1995 to February 29, 2004)" => "National Center for Geriatrics and Gerontology (from March 1, 2004 to March 31, 2010)" => “National Center for Geriatrics and Gerontology, Independent Administrative Agency (from April 1, 2010 to March 31, 2015)" => "National Center for Geriatrics and Gerontology, National Research and Development Agency (from April 1, 2015 onwards).”  The first “National Institute for Longevity Sciences” is the name of the research center newly established within the long-standing “Chubu National Hospital,” “National Center for Geriatrics and Gerontology” is the name adopted when it became the sixth highly specialized medical center (so-called national center) in March 1, 2004.  “National Center for Geriatrics and Gerontology, Independent Administrative Agency,” with the word “research” in it (Japanese only), is the name that was used when it became an independent administrative agency, and “Independent Administrative Agency” became “National Research and Development Agency.”  This shows how the institute has gone through numerous name changes over the years.  The name of our research department has also changed, along with the reorganization and name changes of the institution: "Department of Biofunctional Research" => "Department of Brain Science and Molecular Imaging" => "Department of Clinical and Experimental Neuroimaging."  After becoming an independent administrative institution, our research department started its operation as a division of the newly established "Center for Development of Advanced Medicine for Dementia" (a center within a center).


     Currently, the Department of Clinical and Experimental Neuroimaging comprises the following four sections: Section of Imaging Molecules, Section of Imaging Diagnosis and Technology, Section of Brain Disease Imaging, and Section of Cognitive Brain Sciences.  Although the name of the research department has changed, its mission remains mostly unchanged since it was established in 1995.  Our main imaging modalities include positron emission tomography (PET-CT) for both human and animals, 3-tesla magnetic resonance imaging (MRI), and whole-head magnetoencephalography (MEG).  Although our main area of research is brain research based on imaging to investigate dementia, age-related neurological disease, and normal aging, in recent years we have specialized in research related to dementia.  Also, we expect to conduct research directly associated with clinical practice and produce results.

multimodal_imaging

     We are involved in several projects including multicenter collaborative research on diagnostic imaging of Alzheimer’s disease in which we are actively engaged and play a central role. Furthermore, in addition to our collaborative efforts with the hospital to establish a network of clinical research and clinical trials of dementia based on the results of these clinical research projects, we aim to expand the network and enhance its functions by conducting clinical drug research.

clinical_trial_network

     The staff of our research department, as of February 2017, comprise the director and four section chiefs that work full-time, one specially-appointed researcher, one research technologist, four researchers, and eight research assistants that work part-time, besides collaborative researchers, visiting researchers and research fellows, etc. We conduct research in collaboration with teams of researchers in the Center and in external institutions such as universities.

2. Collaboration with the hospital unit

     Although the Department of Clinical and Experimental Neuroimaging belongs to the Center for Development of Advanced Medicine for Dementia, which is a research division, it is closely connected to the  Radiology Department of the hospital as it is involved in the handling of diagnostic imaging devices. The Director of the Radiology Department concurrently serves as the Director of the Department of Clinical and Experimental Neuroimaging, while the Chief Physician of the Nuclear Medicine Diagnosis Unit concurrently serves as the Chief of the Section of Imaging Diagnosis and Technology. Also, the Director of the Neurosurgery Department of the hospital concurrently serves as the Chief of Section of Brain Disease Imaging and a diagnostic radiology physician concurrently serves as the Chief of the Section of Imaging Molecules. Regarding imaging, radiological modalities such as PET-CT and single-photon emission computed tomography (SPECT) are performed with the help of diagnostic radiology technicians and nurses, while diagnostic imaging reports for all radiological exams (except a part of nuclear cardiology), are written by the staff of the Department of Clinical and Experimental Neuroimaging.

 

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People in DCEN(2017–2018)

Director

Kengo Ito

Section chiefs

Section of Imaging Molecules: Yasuyuki Kimura

Section of Imaging Diagnosis and Technology: Takashi Kato

Section of Brain Disease Imaging: Masahiko Bundo

Section of Cognitivr Brain Sciences: Akinori Nakamura

Postdoctoral researcher

Aya Ogata

Specially-appointed researchers

Masaaki Suzuki

Michiyo Sugawara

Researchers

Research Technologist: Hiroshi Ikenuma

Researcher: Yoshitaka Inui

Researcher: Nozomi Yamawaki

Researcher: Takashi Yamada

Research Assistants

Yoko Arai, Michiko Shiroyama

Miyuki Yamauchi, Mayumi Oguri

Chiharu Kitamura, Chihomi Sawado

Kyoko Shinoda, Yukari Suganuma

Collaborative researchers

Ryuichi Takahashi, Hiroko Koyama

Suguru Miyaji, Susumu Inoue

Chie Seki

Research fellows

Toshihisa Tashima, Miho Shidahara

Ikuko Tanaka, Yoshino Ueki

Shiho Kato, Keita Matsumoto

Chiaki Saito, Kaori Iwata

Yoshiteru Horie, Natsumi Shimada

Masaki Hirano, Akiko Ishikawa

Naoya Kajino, Shota Shimizu

Visiting Researchers

Hiroshi Toyama, Shoji Kawazu

Nobuhisa Maeno, Kentaro Hatano

Yuichi Kimura, Hideki Ishii

Hiroshi Yamaguchi, Atsushi Natsume

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Publications in English

2016  2015  2014  2013  2012  2011

2016

Original Papers

Ota K, Oishi N, Ito K, Fukuyama H, SEAD-J Study Group: Alzheimer’s Disease Neuroimaging Initiative. Prediction of Alzheimer's Disease in Amnestic Mild Cognitive Impairment Subtypes: Stratification Based on Imaging Biomarkers. J Alzheimers Dis. 2016 Apr 12; 52(4):1385-4012

Kato K., Nakamura A., Kato T., Kuratsubo I., Yamagishi M., Iwata K, Ito K: Age-related changes in attentional control using an n-back working memory paradigm. Experimental Aging Research, 2016, 42 (4), 390-402.

Matsumoto K, Sugiyama T, Saito C, Kato S, Kuriyama K, Kanemoto K, Nakamura A: Behavioral study on emotional voice perception in children with autism spectrum disorder. Journal of Pediatric Neuropsychology, 2016 13 Oct . [Epub ahead of print]           

Kimura Y, Maeda J, Yamada M, Takahata K, Yokokawa K, Ikoma Y, Seki C, Ito H, Higuchi M, Suhara T: Measurement of psychological state changes at low dopamine transporter occupancy following a clinical dose of mazindol. Psychopharmacology, 234(3): 323–328, 2017.

Doi H, Sato K, Koyama H, Hosoya T, Watanabe Y, Shimizu T, Tsukada H, Nakanishi K, Suzuki M: Blood-Brain-Barrir Permeability of Gonkgolide: Comparison of the Behavior of PET Probes, 7a-[18F]Fluoro- and 10-O-p-[11C]Methylbenzyl Ginkgolide B in Monkey and Rat Brains, Bioorg. Med. 2016, Nov 1; 24(21):5148-5157

Ikari Y, Akamatsu G, Nishio T, Ishii K, Ito K, Iwatsubo T, Senda M: Phantom criteria for qualification of brain FDG and amyloid PET across different cameras. EJNMMI Phys, 2016 Dec; 3(1):23. Epub 2016 Oct 6.

Moriguchi S, Kimura Y, Ichise M, ArakawaR, Takano T, Seki C, Ikoma Y, Takahata K, Nagashima T, Yamada M, Mimura M, Suhara T: PET.quantification of the norepinephrine transporter in human brain with (S,S)-18F-FMeNER-D2. J Nucl Med 2016 Dec 15. [Epub ahead of print]

Yamane T, Ishii K, Sakata M, Ikari Y, Nishio T, Ishii K, Kato T, Ito K, Senda M, J-ADNI Study Group: Inter-rater variability of visual interpretation and comparison with quantitative evaluation of 11C-PiB PET amyloid images of the Japanese Alzheimer's Disease Neuroimaging Initiative (J-ADNI) multicenter study. Eur J Nucl Med Mol Imaging, 2017 May; 44(5):850-857. 

Koyama H, Ikenuma H, Toda H, Kondo G, Hirano M, Kato M, Abe J, Yamada T, Wakabayashi T, Ito K, Natsume A, Suzuki M: Synthesis of PET probe O6-[(3-[11C]methyl)benzyl]guanine by Pd0-mediated      rapid C-[11C]methylation toward imaging DNA repair protein O6-methylguanine-DNA methyltransferase in glioblastoma, Bioorg. Med. Chem. Lett., 27, 2017, 1892-1896

Reviews

Kato T, Inui Y, Nakamura A, Ito K: Brain fluorodeoxyglucose (FDG) PET in dementia. Ageing Res Rev. 2016; Sep; 30: 73-84

2015

Original Papers

Ito K, Fukuyama H, Senda M, Ishii K, Maeda K, Yamamoto Y, Ouchi Y, Ishii K, Okumura A, Fujiwara K, Kato T, Arahata Y, Washimi Y, Mitsuyama Y, Meguro K, Ikeda M, SEAD-J Study Group: Prediction of outcomes in MCI by using 18F-FDG-PET: A multicenter study. J Alzheimers Dis, 2015; 45(2):543-52. 

Hatano K, Sekimata K, Yamada T, Abe J, Ito K, Ogawa M, Magata Y, Toyohara J, Ishiwata K, Biggio G, Serra M, Laquintana V, Denora N, Latrofa A, Trapani G, Liso G, Suzuki H, Sawada M, Nomura M, Toyama H: Radiosynthesis and in vivo evaluation of two imidazopyridineacetamides, [11C]CB184 and [ 11C]CB190, as a PET tracer for 18 kDa translocator protein: direct comparison with [ 11C](R)-PK11195. Ann Nucl Med, 2015 May; 29(4):325-35.

Nakashima T, Sugiura S, Naganawa S, Yasue M, Inui Y, Sakurai T, Uchida Y, Sone M, Teranishi M, Yoshida T, Ito K, Toba K: Cerumen impaction shown by brain magnetic resonance imaging in patients with cognitive impairment. Geriatr Gerontol Int, 2016 Mar;16(3):392-5.

Doi H, Mawatari A, Kanazawa M, Nozaki S, Nomura Y, Kitayoshi T, Akimoto K, Suzuki M, Ninomiya S, Watanabe Y: Synthesis of 11C-Labeled Thiamine and Fursulthiamine for in Vivo Molecular Imaging of Vitamin B1 and Its Prodrug Using Positron Emission Tomography. J. Org. Chem, 2015 Jun 19;80(12):6250-8.

Onishi H, Hatazawa J, Nakagawara J, Ito K, Ha-Kawa SK, Masuda Y, Sugibayashi K, Takahashi M, Kikuchi K, Katsuta N: Impact of injected dose and acquisition time on a normal database by use of 3D-SSP in SPECT images: quantitative simulation studies. Radiol Phys Technol, 2015 Jul;8(2):224-31.

Maestu F, Peña JM, Garces P, Gonzalez S, Bajo R, Bagic A, Cuesta P, Funke M, Mäkelä J, Menasalvas E, Nakamura A, Parkkonen L, Lopez ME, del Pozo F, Sudre G, Zamrini E, Pekkonnen E, Henson R, Becker J: A multicenter study of the early detection of synaptic dysfunction in mild cognitive impairment using magnetoencephalography-derived functional connectivity. NeuroImage Clinical, 2015 Aug 1; 9:103-9.

Cuesta P, Garces P, Castellanos N P, Lopez ME, Aurtenetxe S, Bajo R, Pineda J, Bruna R, Marin A G, Delgado M, Barabash A, Ancin I, Cabranes J A, Fernandez A, Sancho M, Marcos A, Nakamura A, Maestu F: Influence of the APOE ε4 allele and MCI diagnosis in the disruption of the MEG resting state functional connectivity at sources space. J Alzheimers Dis. 2015; 44(2):493-505.

Mishima A, Nihashi T, Ando Y, Kawai H, Kato T, Ito K, Terasawa T: Biomarkers Differentiating Dementia with Lewy Bodies from Other Dementias: A Meta-Analysis. J Alzheimers Dis, 2015 Nov 30;50(1):161-74.

Kitaguchi N, Hasegawa M, Ito S, Kawaguchi K, Hiki Y, Nakai S, Suzuki N, Shimano Y, Ishida O, Kushimoto H, Kato M, Koide S, Kanayama K, Kato T, Ito K, Takahashi H, Mutoh T, Sugiyama S, Yuzawa Y: A prospective study on blood Aβ levels and the cognitive function of patients with hemodialysis: a potential therapeutic strategy for Alzheimer's disease. J Neural Transm, 2015 Nov; 122(11):1593-607.

Ota K, Oishi N, Ito K, Fukuyama H; SEAD-J Study Group; Alzheimer's Disease Neuroimaging Initiative: Effects of imaging modalities, brain atlases and feature selection on prediction of Alzheimer's disease. Journal Neurosci Methods, 2015 Dec 30; 256:168-83.

Soeda Y, Yoshikawa M, Almeida OF, Sumioka A, Maeda S, Osada H, Kondoh Y, Saito A, Miyasaka T, Kimura T, Suzuki M, Koyama H, Yoshiike Y, Sugimoto H, Ihara Y, Takashima A: Toxic tau oligomer formation blocked by capping of cysteine residue with 1, 2-dihydroxybenzene groups. Nature communications, 2015 Dec 16; 6:10216.

Tahara T, Zhang Z, Ohno M, Hirano Y, Hasaka N, Doi H, Suzuki M, Onoe H, EJNMMI Res: A novel [11C]-labeled thymidine analog, [11C] AZT, for tumor imaging by positron emission tomography. EJNMMI Res 2015, Dec; 5(1):124.

Shukuri M, Mawatari A, Ohno M, Suzuki M, Doi H, Watanabe Y, Onoe H: Detection of cyclooxygenase-1 in activated microglia during amyloid plaque progression: PET studies in Alzheimer’s disease model mice. Journal Nucler Med, 2016 Feb; 57(2):291-6.

Goto M, Mizuma H, Wada Y, Suzuki M, Watanabe Y, Onoe H, Doi H: Synthesis of 11C-Labeled Capsaicin and Its Application for In Vivo Molecular imaging in Rats by Positron Emission. Food Nutrit.Sci, 2015(6), 216-220.

Hagiwara K, Ishii H, Murakami T, Takeshima SN, Chutiwitoonchai N, Kodama EN, Kawaji K, Kondoh Y, Honda K, Osada H, Tsunetsugu-Yokota Y, Suzuki M, Aida Y: Synthesis of a Vpr-Binding Derivative for Use as a Novel HIV-1 Inhibitor. PLoS One, 2015 Dec 23;10(12) :e0145573.

Reviews

Kato T, Inui Y, Nakamura A, Ito K: Brain Fluorodeoxyglucose (FDG) PET in dementia. Ageing Research Review, 2016 Feb 11. pii: S1568-1637(16)30011-3.

2014

Original Papers

Ishii K, Ito K, Nakanishi A, Kitamura S, Terashima A: Computer-assisted system for diagnosing degenerative dementia using cerebral blood flow SPECT and 3D-SSP: a multicenter study. Jpn J Radiol. Jul, 32(7):383-90. 2014 [Epub ahead of print 2014 May 17]

Cuesta P, Barabash A, Aurtenetxe S, Garcés P, López ME, Bajo R, Llanero-Luque M, Ancín I, Cabranes JA,  Marcos A, Sancho M, Nakamura A, Maestú F, Fernandez A: Source Analysis of Spontaneous Magnetoencephalograpic Activity in Healthy Aging and Mild Cognitive Impairment: Influence of Apolipoprotein E Polymorphism. J. Alzheimer Dis, 43(1):259-73, 2015 [Epub ahead of print 2014 Jul 30]

Ito K, Fukuyama H, Senda M, Ishii K, Maeda K, Yamamoto Y, Ouchi Y, Ishii K, Okumura A, Fujiwara K, Kato T, Arahata Y, Washimi Y, Mitsuyama Y, Meguro K, Ikeda M, SEAD-J Study Group: Prediction of outcomes in MCI by using 18F-FDG-PET: A multicenter study. J Alzheimers Dis, Jan 7. 2015 [Epub ahead of print] 

Cuesta P, Garces P, Castellanos N P, Lopez ME, Aurtenetxe S, Bajo R, Pineda J, Bruna R, Marin A G, Delgado M, Barabash A, Ancin I, Cabranes J A, Fernandez A, Sancho M, Marcos A, Nakamura A, Maestu F: Influence of the APOE ε4 allele and MCI diagnosis in the disruption of the MEG resting state functional connectivity at sources space. J. Alzheimer Dis, 44(2):493-505. 2015 [Epub ahead of print 2014 Oct 3.]

Mueller J, Rueschemeyer SA, Ono K, Sugiura M, Sadato N, Nakamura A: Neural networks involved in learning lexical-semantic and syntactic information in a second language. Front. Psychol, Oct 30 vol.5 1209. 2014

Kaneko N, Nakamura A, Washimi Y, Kato T, Sakurai T, Arahata Y, Bundo M, Takeda A, Niida S, Ito K, Toba K, Tanaka K, and Yanagisawa K: Novel plasma biomarker surrogating cerebral amyloid deposition. Proc Jpn Acad Ser B, 90(9): 353-64. 2014

Hatano K, Sekimata K, Yamada T, Abe J, Ito K, Ogawa M, Magata Y, Toyohara J, Ishiwata K, Biggio G, Serra M, Laquintana V, Denora N, Latrofa A, Trapani G, Liso G, Suzuki H, Sawada M, Nomura M, Toyama H: Radiosynthesis and in vivo evaluation of two imidazopyridineacetamides, [11C]CB184 and [ 11C]CB190, as a PET tracer for 18 kDa translocator protein: direct comparison with [ 11C](R)-PK11195. Ann Nucl Med, 2015 Jan 24. 2015 [Epub ahead of print]

Onishi H, Hatazawa J, Nakagawara J, Ito K, Ha-Kawa SK, Masuda Y, Sugibayashi K, Takahashi M, Kikuchi K, Katsuta N: Impact of injected dose and acquisition time on a normal database by use of 3D-SSP in SPECT images: quantitative simulation studies. Radiol Phys Technol, Mar 11. 2015 [Epub ahead of print]

Ono K, Nakamura A, Maess B: Keeping an Eye on the Conductor: Neural Correlates of Visuo-motor Synchronization. Frontiers. Hum. Neurosci, In press

Suzuki M, Doi H, Koyama H, Zhang Z, Hosoya T, Onoe H, Watanabe Y: Pd0-mediated rapid cross-coupling reactions, the rapid C-[11C]methylations, revolutionarily advancing the syntheses of short-lived PET molecular probes. Chem Rec, Jun; 14(3):516-41. 2014

Suzuki M, Takashima-Hirano M, Ishii H, Watanabe C, Sumi K, Koyama H, Doi H: Synthesis of (11)C-labeled retinoic acid, [(11)C]ATRA, via an alkenylboron precursor by Pd(0)-mediated rapid C-[(11)C]methylation. Bioorg Med Chem Lett., Aug 1; 24(15):3622-5. 2014 Epub 2014 Jun 2.

Han C, Doi H, Kimura J, Nakao Y, Suzuki M: 11C-Labeling of the C(1)-C(10) Dihydroxy Acid Moiety for the Study on the Synthesis of Kulokekahilide-2 PET Tracer. International Journal of Organic Chemistry [2161-4687], 4 (04), 269 -277 2014

Goto M, Mizuma H, Wada Y, Suzuki M, Watanabe Y, Onoe H, Doi H: 11C-Labeled Capsaicin and Its in Vivo Molecular Imaging in Rats by Positron Emission Tomography. Food and Nutrition Sciences, 6, 216-220, 2015

Zhang Z, Doi H, Koyama H, Watanabe Y, Suzuki M: Efficient syntheses of [¹¹C]zidovudine and its analogs by convenient one-pot palladium(0)-copper(I) co-mediated rapid C-[¹¹C]methylation. J Labelled Comp Radiopharm., Jun 30;57(8):540-9, 2014 Epub 2014 Jul

2013

Original Papers

Suzuki T, Shimada H, Makizako H, Doi T, Yoshida D, Ito K, Shimokata H, Washimi Y, Endo H, Kato T: A randomized controlled trial of multicomponent exercise in older adults with mild cognitive impairment. PLoS One. 2013 Apr 9;8(4):e61483. doi: 10.1371/journal.pone.0061483. Print 2013.

Yamane T, Ikari Y,  Nishio T, Ishii K, Ishii K, Kato T, Ito K, D.H.S. Silverman, Senda M, Asada T, Arai H, Sugishita M, Iwatsubo T, and the J-ADNI Study Group: Visual-Statistical Interpretation of 18F-FDG-PET Images for Characteristic Alzheimer Patterns in a Multicenter Study: Inter-Rater Concordance and Relationship to Automated Quantitative Evaluation AJNR Am J Neuroradiol. 2014 Feb; 35(2):244-9. doi: 10.3174/ajnr.A3665. Epub 2013 Aug 1.

Ito K, Mori E, Fukuyama H, Ishii K, Washimi Y, Asada T, Mori S, Meguro K, Kitamura S, Hanyu H, Nakano S, Matsuda H, Kuwabara Y, Hashikawa K, Momose T, Uchida Y, Hatazawa J, Minoshima S, Kosaka K, Yamada T, Yonekura Y; J-COSMIC Study Group. Prediction of outcomes in MCI with 123I-IMP-CBF SPECT: a multicenter prospective cohort study. Ann Nucl Med. 2013 Dec; 27(10):898-906. 2013 Sep 6. [Epub ahead of print]

Ota K, Oishi N, Ito K, Fukuyama H; the SEAD-J Study Group. A comparison of three brain atlases for MCI prediction. J Neurosci Methods. 2014 Jan 15; 221:139-50, 2013 Oct 16. [Epub ahead of print]

Takahashi R, Ishii K, Senda M, Ito K, Ishii K, Kato T, Makishi Y, Nishio T, Ikari Y, Iwatsubo T; Japanese Alzheimer’s Disease Neuroimaging Initiative. Equal sensitivity of early and late scans after injection of FDG for the detection of Alzheimer pattern: an analysis of 3D PET data from J-ADNI, a multi-center study. Ann Nucl Med. 2013 Jun; 27(5):452-9.

Hakamata Y, Iwase M, Kato T, Senda K, Inada T, The neural correlates of mindful awareness: a possible buffering effect on anxiety-related reduction in subgenual anterior cingulate cortex activity. PLoS One. 2013 Oct 9; 8(10):e75526. doi: 10.1371/journal.pone.0075526.

Nakamura A, Maess B, Knoesche T, Friederici A. Different Hemispheric Roles in Recognition of Happy Expressions. PLoS One. 9(2):e88628, 2014.

2012

Original Papers

Kawashima S, Ito K, Kato T, the SEAD-J Study Group: Inclusion criteria provide heterogeneity in baseline profiles of patients with mild cognitive impairment: comparison of two prospective cohort studies. BMJ Open. 2012 Apr 24;2(2):e000773.Print 2012.

Doi T, Shimada H, Makizako H, Yoshida D, Shimokata H, Ito K, Washimi Y, Endo H, Suzuki T: Characteristics of cognitive function in early and late stages of amnestic mild cognitive impairment. Geriatr Gerontol Int. 2013 Jan;13(1):83-9.Epub 2012 Jun 4.

Shidahara M, Tsoumpas C, McGinnity CJ, Kato T, Tamura H, Hammers A, Watabe H, Turkheimer FE: Wavelet-based resolution recovery using an anatomical prior provides quantitative recovery for human population phantom PET [C-11]raclopride data. Phys Med Biol. 2012 ;57(10):3107-22.

Ikari Y, Nishio T, Makishi Y, Miya Y, Ito K, Koeppe RA, Senda M: Head motion evaluation and correction for PET scans with 18F-FDG in the Japanese Alzheimer's disease neuroimaging initiative (J-ADNI) multi-center study. Ann Nucl Med. 2012 Aug;26(7):535-44. Epub 2012 Jul 5.

Yamagishi M, Jingu H, Kashiwase N, Kasamatsu K, Kiso H, Fukuzumi S: Estimation of awareness of unconsciousness based on physiological responses. ICIC Express Letters, 2012 Dec. vol 6, No.12, pp.3041-3048.

Ando H, Natsume A, Iwami K, Ohka F, Kuchimaru T, Kizaka-Kondoh S, Ito K, Saito K, Sugita S, Hoshino T, Wakabayashi T: A hypoxia-inducible factor (HIF)-3α splicing variant, HIF-3α4 impairs angiogenesis in hypervascular malignant meningiomas with epigenetically silenced HIF-3α4. Biochem Biophys Res Commun. 2013 Mar 29;433(1):139-44. doi: 10.1016/j.bbrc.2013.02.044. Epub 2013 Feb 26.

Takahashi R, Ishii K, Senda M, Ito K, Ishii K, Kato T, Makishi Y, Nishio T, Ikari Y, Iwatsubo T; Japanese Alzheimer’s Disease Neuroimaging Initiative : Equal sensitivity of early and late scans after injection of FDG for the detection of Alzheimer pattern: an analysis of 3D PET data from J-ADNI, a multi-center study. Ann Nucl Med. 2013 Mar 13. [Epub ahead of print]

2011

Original Papers

Kawashima S, Ueki Y, Kato T, Matsukawa N, Mima T, Hallett M, Ito K, Ojika K: Changes in striatal dopamine release associated with human motor-skill acquisition. PLoS One, 7(2): e31728, Epub 2012 Feb 15. 2012

Murano T, Minamimoto R, Senda M, Uno K, Jinnouchi S, Fukuda H, Iinuma T, Tsukamoto E, Terauchi T, Yoshida T, Oku S, Nishizawa S, Ito K, Oguchi K, Kawamoto M, Nakashima R, Iwata H, Inoue T: Radiation exposure and risk-benefit analysis in cancer screening using FDG-PET: results of a Japanese nationwide survey. Ann Nucl Med, Nov; 25(9): 657-66, 2011

Ogata Y, Ishigure N, Mochizuki S, Ito K, Hatano K, Abe J, Miyahara H, Masumoto K, Nakamura H: Distribution of Thermal Neutron Flux Around a PET Cyclotron. Health Physics, 100 (5) S60-S66 May, 2011              

Ogata Y, Ishigure N, Mochizuki S, Ito K, Hatano K, Abe J, Miyahara H, Masumoto K, Nakamura H, Ito Y, Yamashita E Kobayashi T: Estimation of thermal neutron flux in pet cyclotron rooms by means of radioactive analysis of bolts in the rooms. Proc. Radiochim. Acta, 1:55-61, 2011

Makizako H, Shimada H, Doi T, Yoshida D, Ito K, Kato T, Shimokata H, Washimi Y, Endo H, Suzuki T: The association between decline in physical functioning and atrophy of medial temporal areas in community-dwelling older adults with amnestic and nonamnestic mild cognitive impairment. Arch Phys Med Rehabil, Dec; 92(12): 1992-9, 2011

Doi T, Makizako H, Shimada H, Yoshida D, Ito K, Kato T, Ando H, Suzuki T: Brain Atrophy and Trunk Stability During Dual-Task Walking Among Older Adults. J Gerontol A Biol Sci Med Sci, Dec 15, 2011

Shimada H, Kato T, Ito K, Makizako H, Doi T, Yoshida D, Shimokata H, Washimi Y, Endo H, Suzuki T: Relationship between Atrophy of the Medial Temporal Areas and Cognitive Functions in Elderly Adults with Mild Cognitive Impairment. Eur Neurol, Jan 26;67(3):168-177. 2012  [Epub ahead of print]

Ono K, Nakamura A, Yoshiyama K, Kinkori T, Bundo M, Kato T, Ito K: The effect of musical experience on hemispheric lateralization in musical feature processing. Neurosci Lett, Jun 1;496(2):141-5, 2011

Kawaguchi T, Hirata Y, Bundo M, Kondo T, Owaki H, Ito S, Hashimoto M, Ishikawa M: Role of computerized tomographic cisternography in idiopathic normal pressure hydrocephalus. Acta Neurochir, May; 153:2041-8, 2011

 

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NCGG

  • National Center for Geriatrics and Gerontology
  • National Hospital for Geriatric Medicine, NCGG
  • Research Institute, NCGG
  • Center for Gerontology and Social Science

National Center for Geriatrics and Gerontology

7-430 Morioka-cho, Obu City, Aichi Prefecture, Japan